Cell metabolism and cell death
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Felix M. Wensveen, Nuno L. Alves, Ingrid A. M. Derks, Kris A. Reedquist and Eric Eldering
http://www.springerlink.com/content/7hr20718545812v4/fulltext.html
Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
Flavie Strappazzon, Matteo Vietri-Rudan, Silvia Campello, Francesca Nazio, Fulvio Florenzano, Gian Maria Fimia, Mauro Piacentini, Beth Levine and Francesco Cecconi
http://www.nature.com/emboj/journal/v30/n7/abs/emboj201149a.html
Caloric restriction mimetic 2-deoxy-glucose antagonizes doxorubicin-induced cardiomyocyte death through multiple mechanisms
Kai Chen, Xianmin Xu, Satoru Kobayashi, Derek Timm, Tyler Jepperson, and Qiangrong Liang
http://www.jbc.org/cgi/content/abstract/M111.225805v1
Caveolin-1 Deficiency Causes Cholesterol-Dependent Mitochondrial Dysfunction and Apoptotic Susceptibility
M. Bosch, M. Marí, A. Herms, A. Fernández, A. Fajardo, A. Kassan, A. Giralt, A. Colell, D. Balgoma, E. Barbero, E. Gonzaález-Moreno, N. Matias, F. Tebar, J. Balsinde, M. Camps, C. Enrich, S.P. Gross, C. García-Ruiz, E. Pérez-Navarro, J.C. Fernández-Checa, and A. Pol
http://www.cell.com/current-biology/abstract/S0960-9822%2811%2900302-2
Citrate Induces Apoptotic Cell Death: A Promising Way to Treat Gastric Carcinoma?
Lu, Yunfei; Zhang, Xiaodong; Zhang, Haitian; Lan, Jiao; Huang, Guangwu; Varin, Emilie; Lincet, Hubert; Poulain, Laurent; Icard, Philippe
http://ar.iiarjournals.org/content/31/3/797.abstract
Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells
Lisa S. Pike, Amy L. Smift, Nicole J. Croteau, David A. Ferrick, Min Wu
http://dx.doi.org/10.1016/j.bbabio.2010.10.022
AICAR inhibits cancer cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and Akt activation
Caroline, Jose | Etienne, Hébert-Chatelain | Nadège, Bellance | Anaïs, Larendra | Melser, Su | Karine, Nouette-Gaulain | Rodrigue, Rossignol
http://dx.doi.org/10.1016/j.bbabio.2010.12.002
Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types
Dimitrios Iliopoulos, Heather A. Hirsch, and Kevin Struhl
http://cancerres.aacrjournals.org/cgi/content/abstract/71/9/3196
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Cell metabolism and cancer
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Autophagy-deficient mice develop multiple liver tumors
Akito Takamura, Masaaki Komatsu, Taichi Hara, Ayako Sakamoto, Chieko Kishi, Satoshi Waguri, Yoshinobu Eishi, Okio Hino, Keiji Tanaka, and Noboru Mizushima
Genes Dev. 2011;25 795-800
http://genesdev.cshlp.org/cgi/content/abstract/25/8/795
ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
The DNA damage-induced ATM kinase is linked to the metabolic pentose phosphate pathway, thus boosting biosynthesis of nucleotide precursors required for DNA repair and stimulating generation of the anti-oxidant NADPH, which may explain neurological defects of ataxia telangiectasia patients lacking ATM function.
Claudia Cosentino, Domenico Grieco and Vincenzo Costanzo
http://www.nature.com/emboj/journal/v30/n3/full/emboj2010330a.html
Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression
Mika Hilvo, Carsten Denkert, Laura Lehtinen, Berit Müller, Scarlet Brockmöller, Tuulikki Seppänen-Laakso, Jan Budczies, Elmar Bucher, Laxman Yetukuri, Sandra Castillo, Emilia Berg, Heli Nygren, Marko Sysi-Aho, Julian L. Griffin, Oliver Fiehn, Sibylle Loibl, Christiane Richter-Ehrenstein, Cornelia Radke, Tuulia Hyötyläinen, Olli Kallioniemi, Kristiina Iljin, and Matej Oresic
http://cancerres.aacrjournals.org/cgi/content/abstract/71/9/3236
XPC silencing in normal human keratinocytes triggers metabolic alterations through NOX-1 activation-mediated reactive oxygen species
Hamid Reza Rezvani, Rodrigue Rossignol, Nsrein Ali, Giovanni Benard, Xiuwei Tang, Hee Seung Yang, Thomas Jouary, Hubert de Verneuil, Alain Taïeb, Arianna L. Kim, Frédéric Mazurier
http://dx.doi.org/10.1016/j.bbabio.2010.12.006
Carbon metabolism and the sign of control coefficients in metabolic adaptations underlying K-ras transformation
Pedro de Atauri, Adrian Benito, Pedro Vizán, Miriam Zanuy, Ramón Mangues, Silvia Marín, Marta Cascante
http://dx.doi.org/10.1016/j.bbabio.2010.11.015
Modeling cancer glycolysis
Alvaro Marín-Hernández, Juan Carlos Gallardo-Pérez, Sara Rodríguez-Enríquez, Rusely Encalada, Rafael Moreno-Sánchez, Emma Saavedra
http://dx.doi.org/10.1016/j.bbabio.2010.11.006
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Metabolic and energy stress
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Lysosomal positioning coordinates cellular nutrient responses
Viktor I. Korolchuk, Shinji Saiki, Maike Lichtenberg, Farah H. Siddiqi, Esteban A. Roberts, Sara Imarisio, Luca Jahreiss, Sovan Sarkar, Marie Futter, Fiona M. Menzies, Cahir J. O’Kane, Vojo Deretic and David C. Rubinsztein
http://www.nature.com/ncb/journal/v13/n4/full/ncb2204.html
A Fluorescent Reporter of AMPK Activity and Cellular Energy Stress
P. Tsou, B. Zheng, C.-H. Hsu, A.T. Sasaki, and L.C. Cantley
http://www.cell.com/cell-metabolism/abstract/S1550-4131%2811%2900093-3
Cell-Type-Dependent Regulation of mTORC1 by REDD1 and the Tumor Suppressors TSC1/TSC2 and LKB1 in Response to Hypoxia
Nicholas C. Wolff, Silvia Vega-Rubin-de-Celis, Xian-Jin Xie, Diego H. Castrillon, Wareef Kabbani, and James Brugarolas
http://mcb.asm.org/cgi/content/abstract/31/9/1870
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REVIEWS
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Otto Warburg’s contributions to current concepts of cancer metabolism
Willem H. Koppenol, Patricia L. Bounds & Chi V. Dang
http://www.nature.com/nrc/journal/v11/n5/full/nrc3038.html
Transcriptional Control of Cellular Metabolism by mTOR Signaling
Jessica L. Yecies and Brendan D. Manning
Cancer Res 2011;71 2815-2820
http://cancerres.aacrjournals.org/cgi/content/abstract/71/8/2815
Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2
Shefali Krishna, Ivan Cherh Chiet Low and Shazib Pervaiz
http://www.biochemj.org/bj/435/bj4350545.htm
Focus on … LKB1/AMPK signaling
Wilhelm Just
http://dx.doi.org/10.1016/j.febslet.2011.03.011
Re-evaluating the general(ized) roles of AMPK in cellular metabolism
Julie Mantovani, Richard Roy
http://dx.doi.org/10.1016/j.febslet.2010.12.015
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News and views/other
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A fresh look at cancer metabolism in a historical setting
The IRB Barcelona meeting on cancer metabolism offered an outstanding line-up of acclaimed speakers, within an intimate setting that allowed plenty of opportunity for informal interactions.
Almut Schulze
http://www.nature.com/embor/journal/v12/n4/full/embor201144a.html
Autophagy in Ras-Induced Malignant Transformation: Fatal or Vital?
G. Mariño, I. Martins, and G. Kroemer
http://dx.doi.org/10.1016/j.molcel.2011.03.003
ATM Is a Redox Sensor Linking Genome Stability and Carbon Metabolism
Antje Krüger and Markus Ralser
By linking genome stability, the cell cycle, and carbon catabolism, ATM emerges as a central regulator of cancer cell metabolism.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/167/pe17?etoc
Compartmentalized regulation of autophagy regulators: fine-tuning AMBRA1 by Bcl-2
Sharon A Tooze and Patrice Codogno
http://www.nature.com/emboj/journal/v30/n7/abs/emboj201175a.html
Signal transduction: How cells sense energy ▶
D. Grahame Hardie
http://www.nature.com/nature/journal/v472/n7342/full/472176a.html
Lysosome positioning coordinates mTORC1 activity and autophagy
Christian Poüs and Patrice Codogno
http://www.nature.com/ncb/journal/v13/n4/full/ncb0411-342.html
Astrocyte elevated gene-1 activates AMPK in response to cellular metabolic stress and promotes protective autophagy
Sujit K. Bhutia, Timothy P. Kegelman, Swadesh K. Das, Belal Azab, Zhao-Zhong Su, Seok-Geun Lee, Devanand Sarkar and Paul B. Fisher
http://www.landesbioscience.com/journals/autophagy/article/15078/
I think autophagy controls the death of my cells: What do I do to get my paper published?
Andrew Thorburn
http://www.landesbioscience.com/journals/autophagy/article/14797/
