Metabolism and cancer articles – june 2011

————————————–
Nutrients and starvation
————————————–

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation
Angelika S. Rambold, Brenda Kostelecky, Natalie Elia, and Jennifer Lippincott-Schwartz
http://www.pnas.org/content/108/25/10190.abstract?etoc

Mitochondria regulate autophagy by conserved signalling pathways
Martin Graef and Jodi Nunnari
http://www.nature.com/emboj/journal/v30/n11/full/emboj2011104a.html

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase
J. S. Oakhill et al.
The cellular energy sensor adenosine monophosphate–activated protein kinase also binds and is regulated by adenosine diphosphate.
http://www.sciencemag.org/cgi/content/abstract/332/6036/1433

Phospholipase D mediates nutrient input to mTORC1
Limei Xu, Darin Salloum, Phil S. Medlin, Mahesh Saqcena, Paige Yellen, Benjamin Perrella, and David A Foster
http://www.jbc.org/cgi/content/abstract/M111.249631v2

—————————–
Cancer metabolism
—————————–

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth
L. Lv, D. Li, D. Zhao, R. Lin, Y. Chu, H. Zhang, Z. Zha, Y. Liu, Z. Li, Y. Xu, G. Wang, Y. Huang, Y. Xiong, K.-L. Guan, and Q.-Y. Lei
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900371-6

Mitochondrial Dysfunction in Cancer Cells Due to Aberrant Mitochondrial Replication
Yuriy Shapovalov, David Hoffman, Daniel Zuch, Karen L. de Mesy Bentley, and Roman A. Eliseev
http://www.jbc.org/content/286/25/22331.abstract?sid=1372cbd0-db93-4f43-b9a7-6ed7962bb639

Glycolytic Phenotype and AMP Kinase Modify the Pathologic Response of Tumor Xenografts to VEGF Neutralization
Giorgia Nardo, Elena Favaro, Matteo Curtarello, Lidia Moserle, Elisabetta Zulato, Luca Persano, Elisabetta Rossi, Giovanni Esposito, Marika Crescenzi, Oriol Casanovas, Ulrike Sattler, Wolfgang Mueller-Klieser, Barbara Biesalski, Oliver Thews, Rossella Canese, Egidio Iorio, Paola Zanovello, Alberto Amadori, and Stefano Indraccolo
http://cancerres.aacrjournals.org/cgi/content/abstract/71/12/4214

——————
Hypoxia
——————

A HIF-1 Target, ATIA, Protects Cells from Apoptosis by Modulating the Mitochondrial Thioredoxin, TRX2
S. Choksi, Y. Lin, Y. Pobezinskaya, L. Chen, C. Park, M. Morgan, T. Li, S. Jitkaew, X. Cao, Y.-S. Kim, H.-S. Kim, P. Levitt, G. Shih, M. Birre, C.-X. Deng, and Z.-g. Liu
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900335-2

HIF-1α Mediates Tumor Hypoxia to Confer a Perpetual Mesenchymal Phenotype for Malignant Progression
Young-Gun Yoo, Jared Christensen, Jie Gu, L. Eric Huang
Hypoxia-induced genetic alterations induce epithelial-mesenchymal transition and tumor progression.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/178/pt4?etoc

———————–
Ischemia
———————-

Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death
Shaida A Andrabi, Ho Chul Kang, Jean-Francois Haince, Yun-Il Lee, Jian Zhang, Zhikai Chi, Andrew B West, Raymond C Koehler, Guy G Poirier, Ted M Dawson and Valina L Dawson
http://www.nature.com/nm/journal/v17/n6/full/nm.2387.html

Preconditioning Involves Selective Mitophagy Mediated by Parkin and p62/SQSTM1
Chengqun Huang, Allen M. Andres, Eric P. Ratliff, Genaro Hernandez, Pamela Lee, Roberta A. Gottlieb
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0020975

———————-
Autophagy
———————-

TFEB Links Autophagy to Lysosomal Biogenesis
C. Settembre et al.
Starvation activates a transcriptional program controlling autophagosome formation, lysosome fusion, and substrate degradation.
http://www.sciencemag.org/cgi/content/abstract/332/6036/1429

Relieving Autophagy and 4EBP1 from Rapamycin Resistance
Beat Nyfeler, Philip Bergman, Ellen Triantafellow, Christopher J. Wilson, Yanyi Zhu, Branko Radetich, Peter M. Finan, Daniel J. Klionsky, and Leon O. Murphy
http://mcb.asm.org/cgi/content/abstract/31/14/2867

Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy
Phillip Hundeshagen, Anne Hamacher-Brady, Roland Eils, Nathan R Brady
http://www.biomedcentral.com/1741-7007/9/38

——————-
Reviews
——————-

Biochimica et Biophysica Acta (BBA) – Molecular Cell Research
Volume 1813, Issue 7,  Pages 1261-1394 (July 2011)
Mitochondria and Cardioprotection
Edited by F. Di Lisa, E. Murphy and R. Schulz
http://www.sciencedirect.com/science/journal/01674889

Including:
- Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning
Gregg L. Semenza
http://www.sciencedirect.com/science/article/pii/S0167488910002223
- Targeting fatty acid and carbohydrate oxidation – A novel therapeutic intervention in the ischemic and failing heart
Jagdip S. Jaswal, Wendy Keung, Wei Wang, John R. Ussher, Gary D. Lopaschuk
http://www.sciencedirect.com/science/article/pii/S0167488911000231

Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion
Gabriel Loor, Jyothisri Kondapalli, Hirotaro Iwase, Navdeep S. Chandel, Gregory B. Waypa, Robert D. Guzy, Terry L. Vanden Hoek, Paul T. Schumacker
http://www.sciencedirect.com/science/article/pii/S0167488910003186

————————-
News and views
————————-

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
Dan Egan, Joungmok Kim, Reuben J. Shaw and Kun-Liang Guan
http://www.landesbioscience.com/journals/autophagy/article/15123/

Mitochondria breathe for autophagy
Koji Okamoto
http://www.nature.com/emboj/journal/v30/n11/full/emboj2011149a.html

Mitochondrial Dynamics: A Strategy for Avoiding Autophagy
L. Galluzzi, O. Kepp, and G. Kroemer
http://www.sciencedirect.com/science/article/pii/S096098221100529X

ATIA: A Link between Inflammation and Hypoxia
A. Lin
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900390-X

Shifting the Metabolic Program
Elizabeth M. Adler
Pyruvate kinase M2 interacts directly with hypoxia-inducible factor 1 to promote glycolytic metabolism.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/176/ec157?etoc

Cancer metabolism: Feed it forward
Semenza and colleagues identify a positive feedback loop between the pyruvate kinase PKM2 and HIF1 that may explain how PKM2 can promote metabolic reprogramming of cancer cells.
http://www.nature.com/nrc/journal/v11/n7/full/nrc3094.html?WT.ec_id=NRC-201108

Ramping Up AMPK
L. Bryan Ray
The cellular energy sensor adenosine monophosphate–activated protein kinase also binds and is regulated by adenosine diphosphate.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/178/ec174?etoc

ADaPting to Energetic Stress
M. L. Bland and M. J. Birnbaum
What is the true activator of a key enzyme that controls cell energetics?
http://www.sciencemag.org/cgi/content/summary/332/6036/1387

Coordinating Autophagy and Lysosome Regulation
Stella M. Hurtley
Starvation activates a transcriptional program controlling autophagosome formation, lysosome fusion, and substrate degradation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/178/ec175?etoc

Autophagy’s Top Chef
Ana Maria Cuervo
The transcription factor EB both controls lysosome formation and increases autophagy in cells experiencing starvation.
http://www.sciencemag.org/cgi/content/summary/332/6036/1392

Acetylation for Autophagy
Wei Wong
Acetylation of pyruvate kinase M2 inhibits its activity and triggers its autophagic degradation, leading to increased tumor cell proliferation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/179/ec182?etoc

PKM2 and the Tricky Balance of Growth and Energy in Cancer
A.N. Macintyre and J.C. Rathmell
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900416-3
—————————————————————————————————————————————-