Glycolist nov-dec 2008

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c
Allyson E. Vaughn and Mohanish Deshmukh
http://www.nature.com/ncb/journal/v10/n12/full/ncb1807.html

A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death
Wood, Tabitha E., Dalili, Shadi, Simpson, Craig D., Hurren, Rose, Mao, Xinliang, Saiz, Fernando Suarez, Gronda, Marcela, Eberhard, Yanina, Minden, Mark D., Bilan, Philip J., Klip, Amira, Batey, Robert A., Schimmer, Aaron D.
http://mct.aacrjournals.org/cgi/content/full/7/11/3546

A catabolic block does not sufficiently explain how 2-deoxy-d-glucose inhibits cell growth
[yeast]
Markus Ralsera,1, Mirjam M. Wamelinkb, Eduard A. Struysb, Christian Joppicha, Sylvia Krobitscha, Cornelis Jakobsb, and Hans Lehrach
http://www.pnas.org/content/105/46/17807.full

Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells : ROS-mediated cell death by 3-BrPA.
Kim JS, Ahn KJ, Kim JA, Kim HM, Lee JD, Lee JM, Kim SJ, Park JH.
http://www.springerlink.com/content/e64p1672u8501883/

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis
V. Nogueira, Y. Park, C.-C. Chen, P.-Z. Xu, M.-L. Chen, I. Tonic, T. Unterman, and N. Hay
http://dx.doi.org/10.1016/j.ccr.2008.11.003

Association of Autophagy Defect with a Malignant Phenotype and Poor Prognosis of Hepatocellular Carcinoma
Zhen-Bin Ding, Ying-Hong Shi, Jian Zhou, Shuang-Jian Qiu, Yang Xu, Zhi Dai, Guo-Ming Shi, Xiao-Ying Wang, Ai-Wu Ke, Bin Wu, and Jia Fan
Cancer Res 2008;68 9167-9175
http://cancerres.aacrjournals.org/cgi/content/abstract/68/22/9167

Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy
Sophie Pattingre, Chantal Bauvy, Stéphane Carpentier, Thierry Levade, Beth Levine, and Patrice Codogno
J. Biol. Chem. published 23 November 2008, 10.1074/jbc.M805920200
http://www.jbc.org/cgi/content/abstract/M805920200v1

Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3
Alfredo Gimenez-Cassina, Filip Lim, Toñi Cerrato, Gloria M. Palomo, and Javier Diaz-Nido
J. Biol. Chem. published 25 November 2008, 10.1074/jbc.M808698200
http://www.jbc.org/cgi/content/abstract/M808698200v1

Voltage-dependent anion channel-1-based peptides interact with hexokinase to prevent its anti-apoptotic activity
Laetitia Arzoine, Noam Zilberberg, Ronit Ben-Romano, and Varda Shoshan-Barmatz
J. Biol. Chem. published 2 December 2008, 10.1074/jbc.M803614200
http://www.jbc.org/cgi/content/abstract/M803614200v1

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Derek Narendra, Atsushi Tanaka, Der-Fen Suen, and Richard J. Youle
J. Cell Biol. 2008;183 795-803, Published online Nov 24 2008, 10.1083/jcb.200809125.
http://jcb.rupress.org/cgi/content/abstract/183/5/795?etoc

Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator)
Hua Li and Gerwald Jogl
J. Biol. Chem. published 17 November 2008, 10.1074/jbc.M807821200
http://www.jbc.org/cgi/content/abstract/M807821200v1

Identification of TIGAR in the equilibrative nucleoside transporter 2-mediated response to fludarabine in chronic lymphocytic leukemia cells.
López-Guerra M, Trigueros-Motos L, Molina-Arcas M, Villamor N, Casado FJ, Montserrat E, Campo E, Colomer D, Pastor-Anglada M.
http://www.haematologica.org/cgi/content/full/93/12/1843

Preferential Cytotoxicity of Bortezomib toward Hypoxic Tumor Cells via Overactivation of Endoplasmic Reticulum Stress Pathways
Diane R. Fels, Jiangbin Ye, Andrew T. Segan, Steven J. Kridel, Michael Spiotto, Michael Olson, Albert C. Koong, and Constantinos Koumenis
Cancer Res 2008;68 9323-9330
http://cancerres.aacrjournals.org/cgi/content/abstract/68/22/9323

Tumor Hypoxia Blocks Wnt Processing and Secretion through the Induction of Endoplasmic Reticulum Stress
Meletios Verras, Ioanna Papandreou, Ai Lin Lim, and Nicholas C. Denko
Mol. Cell. Biol. 2008;28 7212-7224
http://mcb.asm.org/cgi/content/abstract/28/23/7212

Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors
Hiroshi Harada, Satoshi Itasaka, Shinae Kizaka-Kondoh, Keiko Shibuya, Akiyo Morinibu, Kazumi Shinomiya, and Masahiro Hiraoka
J. Biol. Chem. published 19 December 2008, 10.1074/jbc.M806653200
http://www.jbc.org/cgi/content/abstract/M806653200v1

SWI/SNF regulates the cellular response to hypoxia
Niall S. Kenneth, Sharon Mudie, Patrick van Uden, and Sonia Rocha
J. Biol. Chem. published 19 December 2008, 10.1074/jbc.M808491200
http://www.jbc.org/cgi/content/abstract/M808491200v1

Glyceraldehyde-3-Phosphate Dehydrogenase Regulates Endothelin-1 Expression by a Novel, Redox-Sensitive Mechanism Involving mRNA Stability
Fernando Rodríguez-Pascual, Mariano Redondo-Horcajo, Noemi Magán-Marchal, David Lagares, Antonio Martínez-Ruiz, Hartmut Kleinert, and Santiago Lamas
Mol. Cell. Biol. 2008;28 7139-7155
http://mcb.asm.org/cgi/content/abstract/28/23/7139

ARF induces autophagy by virtue of interaction with Bcl-xl
Julia Pimkina, Olivier Humbey, Jack T. Zilfou, Michal Jarnik, and Maureen . Murphy
J. Biol. Chem. published 2 December 2008, 10.1074/jbc.M804705200
http://www.jbc.org/cgi/content/abstract/M804705200v1

REVIEWS / COMMENTS

AKT and Oxidative Stress Team Up to Kill Cancer Cells
I. Dolado and A.R. Nebreda
http://www.cell.com/cancer-cell/abstract/S1535-6108%2808%2900373-5

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