Glycolist – july-september 2009

Metabolic Control of Oocyte Apoptosis Mediated by 14-3-3ζ-Regulated Dephosphorylation of Caspase-2
L.K. Nutt, M.R. Buchakjian, E. Gan, R. Darbandi, S.-Y. Yoon, J.Q. Wu, Y.J. Miyamoto, J.A. Gibbon, J.L. Andersen, C.D. Freel, W. Tang, C. He, M. Kurokawa, Y. Wang, S.S. Margolis, R.A. Fissore, and S. Kornbluth
http://www.cell.com/developmental-cell/fulltext/S1534-5807(09)00167-1?large_figure=true

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
J. Yun et al.
Glucose deprivation can drive the acquisition of certain oncogenic mutations in human cancer cells.
http://www.sciencemag.org/cgi/content/abstract/325/5947/1555

The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R
Diansheng Zhong, Li Xiong, Tongrui Liu, Xiuju Liu, Xiangguo Liu, Jing Chen, Shi-Yong Sun, Fadlo R. Khuri, Yaping Zong, Qinghua Zhou, and Wei Zhou
http://www.jbc.org/cgi/content/abstract/M109.005280v1

Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy
You-Tong Wu, Hui-Ling Tan, Qing Huang, Choon-Nam Ong and Han-Ming Shen
http://www.landesbioscience.com/journals/autophagy/article/9099

mTORC1 Hyperactivity Inhibits Serum Deprivation-Induced Apoptosis via Increased Hexokinase II and GLUT1 Expression, Sustained Mcl-1 Expression, and Glycogen Synthase Kinase 3β Inhibition
Prashanth T. Bhaskar, Veronique Nogueira, Krushna C. Patra, Sang-Min Jeon, Youngkyu Park, R. Brooks Robey, and Nissim Hay
http://mcb.asm.org/cgi/content/abstract/29/18/5136

mTOR and HIF-1-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
David B. Shackelford, Debbie S. Vasquez, Jacqueline Corbeil, Shulin Wu, Mathias Leblanc, Chin-Lee Wu, David R. Vera, and Reuben J. Shaw
http://www.pnas.org/content/106/27/11137.abstract?etoc

Longitudinal and multimodal in vivo imaging of tumor hypoxia and its downstream molecular events
Steffi Lehmann, Daniel P. Stiehl, Michael Honer, Marco Dominietto, Ruth Keist, Ivana Kotevic, Kristin Wollenick, Simon Ametamey, Roland H. Wenger, and Markus Rudin
http://www.pnas.org/content/106/33/14004.abstract?etoc

HIF2 alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
Jessica A. Bertout, Amar J. Majmundar, John D. Gordan, Jennifer C. Lam, Dara Ditsworth, Brian Keith, Eric J. Brown, Katherine L. Nathanson, and M. Celeste Simon
http://www.pnas.org/content/106/34/14391.abstract?etoc

Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Erika L. Pearce, Matthew C. Walsh, Pedro J. Cejas, Gretchen M. Harms, Hao Shen, Li-San Wang, Russell G. Jones & Yongwon Choi
http://www.nature.com/nature/journal/v460/n7251/full/nature08097.html

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase
Benjamin Yazdanpanah1,2, Katja Wiegmann1, Vladimir Tchikov4, Oleg Krut1,2, Carola Pongratz1, Michael Schramm1, Andre Kleinridders3, Thomas Wunderlich3, Hamid Kashkar1,2,5, Olaf Utermöhlen1,2, Jens C. Brüning2,3,5, Stefan Schütze4 & Martin Krönke
http://www.nature.com/nature/journal/v460/n7259/full/nature08206.html

Modulation of intracellular ROS levels by TIGAR controls autophagy
Karim Bensaad, Eric C Cheung and Karen H Vousden
http://www.nature.com/emboj/journal/v28/n19/abs/emboj2009242a.html

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
Zachary T. Schafer1,4, Alexandra R. Grassian1,5, Loling Song1,5, Zhenyang Jiang1, Zachary Gerhart-Hines2,3, Hanna Y. Irie1, Sizhen Gao1, Pere Puigserver1,2 & Joan S. Brugge
http://www.nature.com/nature/journal/v461/n7260/full/nature08268.html

Oxygen Consumption Can Regulate the Growth of Tumors, a New Perspective on the Warburg Effect
Yijun Chen, Rob Cairns, Ioanna Papandreou, Albert Koong, Nicholas C. Denko
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0007033

REVIEWS / COMMENTS

Lots of reviews on autophagy (and autophagic cell death); its role in cancer, etc.;  in BBA-Molecular Cell Research:
http://www.sciencedirect.com/science/issue/4904-2009-982069990-1484090

p53 and metabolism
Karen H. Vousden & Kevin M. Ryan
http://www.nature.com/nrc/journal/v9/n10/full/nrc2715.html

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
David B. Shackelford & Reuben J. Shaw
http://www.nature.com/nrc/journal/v9/n8/full/nrc2676.html

Considering the role of pyruvate in tumor cells during hypoxia
Emilie Roudier, Anne Perrin
http://dx.doi.org/10.1016/j.bbcan.2009.02.003

Growth factor signaling permits hypoxia-induced autophagy by a
HIF1?-dependent, BNIP3/3L-independent transcriptional program in human
cancer cells
Simon Wilkinson and Kevin M. Ryan
http://www.landesbioscience.com/journals/autophagy/article/9821

Tumor cell energy metabolism and its common features with yeast metabolism
R. Diaz-Ruiz, S. Uribe-Carvajal, A. Devin, M. Rigoulet
http://dx.doi.org/10.1016/j.bbcan.2009.07.003

Eating p62 Is Good for You
Wei Wong
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2/75/ec201?etoc

TGF-β: A New Role for an Old AktTOR
P. Goraksha-Hicks and J.C. Rathmell
http://www.cell.com/developmental-cell/abstract/S1534-5807%2809%2900262-7

Cancer biology: Cancer’s metabolic roots p554
doi:10.1038/460554d
http://www.nature.com/nature/journal/v460/n7255/full/460554d.html

Cancer: The fat and the furious
Eyal Gottlieb
http://www.nature.com/nature/journal/v461/n7260/full/461044a.html

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