Glycolist – july-september 2009

Metabolic Control of Oocyte Apoptosis Mediated by 14-3-3ζ-Regulated Dephosphorylation of Caspase-2
L.K. Nutt, M.R. Buchakjian, E. Gan, R. Darbandi, S.-Y. Yoon, J.Q. Wu, Y.J. Miyamoto, J.A. Gibbon, J.L. Andersen, C.D. Freel, W. Tang, C. He, M. Kurokawa, Y. Wang, S.S. Margolis, R.A. Fissore, and S. Kornbluth

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
J. Yun et al.
Glucose deprivation can drive the acquisition of certain oncogenic mutations in human cancer cells.

The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R
Diansheng Zhong, Li Xiong, Tongrui Liu, Xiuju Liu, Xiangguo Liu, Jing Chen, Shi-Yong Sun, Fadlo R. Khuri, Yaping Zong, Qinghua Zhou, and Wei Zhou

Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy
You-Tong Wu, Hui-Ling Tan, Qing Huang, Choon-Nam Ong and Han-Ming Shen

mTORC1 Hyperactivity Inhibits Serum Deprivation-Induced Apoptosis via Increased Hexokinase II and GLUT1 Expression, Sustained Mcl-1 Expression, and Glycogen Synthase Kinase 3β Inhibition
Prashanth T. Bhaskar, Veronique Nogueira, Krushna C. Patra, Sang-Min Jeon, Youngkyu Park, R. Brooks Robey, and Nissim Hay

mTOR and HIF-1-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
David B. Shackelford, Debbie S. Vasquez, Jacqueline Corbeil, Shulin Wu, Mathias Leblanc, Chin-Lee Wu, David R. Vera, and Reuben J. Shaw

Longitudinal and multimodal in vivo imaging of tumor hypoxia and its downstream molecular events
Steffi Lehmann, Daniel P. Stiehl, Michael Honer, Marco Dominietto, Ruth Keist, Ivana Kotevic, Kristin Wollenick, Simon Ametamey, Roland H. Wenger, and Markus Rudin

HIF2 alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
Jessica A. Bertout, Amar J. Majmundar, John D. Gordan, Jennifer C. Lam, Dara Ditsworth, Brian Keith, Eric J. Brown, Katherine L. Nathanson, and M. Celeste Simon

Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Erika L. Pearce, Matthew C. Walsh, Pedro J. Cejas, Gretchen M. Harms, Hao Shen, Li-San Wang, Russell G. Jones & Yongwon Choi

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase
Benjamin Yazdanpanah1,2, Katja Wiegmann1, Vladimir Tchikov4, Oleg Krut1,2, Carola Pongratz1, Michael Schramm1, Andre Kleinridders3, Thomas Wunderlich3, Hamid Kashkar1,2,5, Olaf Utermöhlen1,2, Jens C. Brüning2,3,5, Stefan Schütze4 & Martin Krönke

Modulation of intracellular ROS levels by TIGAR controls autophagy
Karim Bensaad, Eric C Cheung and Karen H Vousden

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
Zachary T. Schafer1,4, Alexandra R. Grassian1,5, Loling Song1,5, Zhenyang Jiang1, Zachary Gerhart-Hines2,3, Hanna Y. Irie1, Sizhen Gao1, Pere Puigserver1,2 & Joan S. Brugge

Oxygen Consumption Can Regulate the Growth of Tumors, a New Perspective on the Warburg Effect
Yijun Chen, Rob Cairns, Ioanna Papandreou, Albert Koong, Nicholas C. Denko


Lots of reviews on autophagy (and autophagic cell death); its role in cancer, etc.;  in BBA-Molecular Cell Research:

p53 and metabolism
Karen H. Vousden & Kevin M. Ryan

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
David B. Shackelford & Reuben J. Shaw

Considering the role of pyruvate in tumor cells during hypoxia
Emilie Roudier, Anne Perrin

Growth factor signaling permits hypoxia-induced autophagy by a
HIF1?-dependent, BNIP3/3L-independent transcriptional program in human
cancer cells
Simon Wilkinson and Kevin M. Ryan

Tumor cell energy metabolism and its common features with yeast metabolism
R. Diaz-Ruiz, S. Uribe-Carvajal, A. Devin, M. Rigoulet

Eating p62 Is Good for You
Wei Wong;2/75/ec201?etoc

TGF-β: A New Role for an Old AktTOR
P. Goraksha-Hicks and J.C. Rathmell

Cancer biology: Cancer’s metabolic roots p554

Cancer: The fat and the furious
Eyal Gottlieb

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