Glycolist oct-dec 09

Areas to Watch
In 2010, Science’s editors will be watching for developments with induced pluripotent stem cells, the Alpha Magnetic Spectrometer, “exome sequencing,” ***disrupting the metabolism of tumor cells***, and human space flight.

Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation.
Pradelli LA, Bénéteau M, Chauvin C, Jacquin MA, Marchetti S, Muñoz-Pinedo C, Auberger P, Pende M, Ricci JE.

GAMT, a p53-Inducible Modulator of Apoptosis, Is Critical for the Adaptive Response to Nutrient Stress
T. Ide, L. Brown-Endres, K. Chu, P.P. Ongusaha, T. Ohtsuka, W.S. El-Deiry, S.A. Aaronson, and S.W. Lee

GAPDH aggregate formation participates in oxidative stress-induced cell death
Hidemitsu Nakajima, Wataru Amano, Takeya Kubo, Ayano Fukuhara, Hideshi Ihara, Yasu-Taka Azuma, Hisao Tajima, Takashi Inui, Akira Sawa, and Tadayoshi Takeuchi
J. Biol. Chem. published 16 October 2009, 10.1074/jbc.M109.027698

AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply
Sven Hoppe, Holger Bierhoff, Ivana Cado, Andrea Weber, Marcel Tiebe, Ingrid Grummt, and Renate Voit

Transcriptional regulation of tumor suppressor p53 by cAMP-responsive element-binding protein/AMP-activated protein kinase complex in response to glucose deprivation
Okoshi, R; Ando, K; Suenaga, Y; Sang, MX; Kubo, N; Kizaki, H; Nakagawara, A; Ozaki, T

AMP-activated protein kinase attenuates nitric oxide induced β-cell death
Gordon P. Meares, Katherine J. Hughes, Kimberly F. Jaimes, Alison S. Salvatori, Christopher J. Rhodes, and John A. Corbett
J. Biol. Chem. published 20 November 2009, 10.1074/jbc.M109.047365

Acadesine Kills Chronic Myelogenous Leukemia (CML) Cells through PKC-Dependent Induction of Autophagic Cell Death
Guillaume Robert, Issam Ben Sahra, Alexandre Puissant, Pascal Colosetti, Nathalie Belhacene, Pierre Gounon, Paul Hofman, Fréderic Bost, Jill-Patrice Cassuto, Patrick Auberger

Basal autophagy induction without AMP-activated protein kinase under low
glucose conditions
Tyisha Williams, Lawrence J. Forsberg, Benoit Viollet and Jay E. Brenman

Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling
Chendong Yang, Jessica Sudderth, Tuyen Dang, Robert G. Bachoo, Jeffrey G. McDonald, and Ralph J. DeBerardinis
Cancer Res 2009;69 7986-7993

The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation
Xuemei Tong, Fangping Zhao, Anthony Mancuso, Joshua J. Gruber, and Craig B. Thompson

GLP-1 mediates anti-apoptotic effect by phosphorylating bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic [beta]-cells
Julie Quoyer, Christine Longuet, Christophe Broca, Nathalie Linck, Safia Costes, Elodie Varin, Joel Bockaert, Gyslaine Bertrand, and Stephane Dalle
J. Biol. Chem. published 13 November 2009, 10.1074/jbc.M109.067207

Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death
D A Tennant, C Frezza, E D MacKenzie, Q D Nguyen, L Zheng, M A Selak, D L Roberts, C Dive, D G Watson, E O Aboagye and E Gottlieb

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
KangAe Lee, Huafeng Zhang, David Z. Qian, Sergio Rey, Jun O. Liu, and Gregg L. Semenza

HSP70 and CHIP selectively mediate Ubiquitination and degradation of hypoxia-inducible factor (HIF)-1 but not HIF-2
Weibo Luo, Jun Zhong, Ryan Chang, Hongxia Hu, Akhilesh Pandey, and Gregg L. Semenza
J. Biol. Chem. published 23 November 2009, 10.1074/jbc.M109.068577

Hypoxia-induced autophagy contributes to the chemoresistance of
hepatocellular carcinoma cells
Jianrui Song, Zengqiang Qu, Xianling Guo, Qiudong Zhao, Xue Zhao, Lu Gao,
Kai Sun, Feng Shen, Mengchao Wu and Lixin Wei

Hypoxia-induced downregulation of autophagy mediator Beclin-1 reduces the
susceptibility of malignant intestinal epithelial cells to
hypoxia-dependent apoptosis
Byong Hoon Yoo, Xue Wu, Mathieu Derouet, Mehnaaz Haniff, Eeva-Liisa
Eskelinen and Kirill Rosen


A journal issue on apoptosis and diabetes:

Mutant Metabolic Enzymes Are at the Origin of Gliomas
Hai Yan, Darell D. Bigner, Victor Velculescu, and D. Williams Parsons
Cancer Res 2009;69 9157-9159

Glucose metabolism and programmed cell death: an evolutionary and mechanistic perspective
Ayala King, Eyal Gottlieb

Autophagy: Autophagy takes an alternative route
Francesca Cesari

Metabolism and cancer: the circadian clock connection
Saurabh Sahar & Paolo Sassone-Corsi

p53 and Metabolism: The GAMT Connection
Y. Zhu and C. Prives

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