Glycolist – jan-feb 2010

2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2
Liu, H; Jiang, CC; Lavis, CJ; Croft, A; Dong, L; Tseng, HY; Yang, F; Tay, KH; Hersey, P; Zhang, XD
http://www.molecular-cancer.com/content/8/1/122

AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators.
García-García C, Fumarola C, Navaratnam N, Carling D, López-Rivas A.
http://dx.doi.org/10.1016/j.bcp.2009.10.022

Energy restriction as an antitumor target of thiazolidinediones
Shuo Wei, Samuel K. Kulp, and Ching-Shih Chen
J. Biol. Chem. published 21 January 2010, 10.1074/jbc.M109.065466
http://www.jbc.org/cgi/content/abstract/M109.065466v1

Rheb GTPase controls apoptosis by regulating the interaction of FKBP38 with Bcl-2 and Bcl-XL
Dongzhu Ma, Xiaochun Bai, Huafei Zou, Yumei Lai, and Yu Jiang
J. Biol. Chem. published 4 January 2010, 10.1074/jbc.M109.092353
http://www.jbc.org/cgi/content/abstract/M109.092353v1

The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis
Leah J. Siskind, Thomas D. Mullen, Kimberly Romero Rosales, Christopher J. Clarke, Maria José Hernandez-Corbacho, Aimee L. Edinger, and Lina M. Obeid
http://www.jbc.org/cgi/content/abstract/M109.078121v1

Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2
Z X Chen and S Pervaiz
http://www.nature.com/cdd/journal/v17/n3/full/cdd2009132a.html

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glycolysis
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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
Charles J. David, Mo Chen, Marcela Assanah, Peter Canoll & James L. Manley
http://www.nature.com/nature/journal/v463/n7279/abs/nature08697.html?lang=en

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism
Cynthia V. Clower, Deblina Chatterjee, Zhenxun Wang, Lewis C. Cantley, Matthew G. Vander Heiden, and Adrian R. Krainer
http://www.pnas.org/content/107/5/1894.abstract?etoc

Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis
X Liu, X Wang, J Zhang, E K Y Lam, V Y Shin, A S L Cheng, J Yu, F K L Chan, J J Y Sung and H C Jin
http://www.nature.com/onc/journal/v29/n3/full/onc2009332a.html

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
Anne Le, Charles R. Cooper, Arvin M. Gouw, Ramani Dinavahi, Anirban Maitra, Lorraine M. Deck, Robert E. Royer, David L. Vander Jagt, Gregg L. Semenza, and Chi V. Dang
http://www.pnas.org/content/107/5/2037.abstract?etoc

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hypoxia and autophagy
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Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation
Alexandre Puissant, Guillaume Robert, Nina Fenouille, Frederic Luciano, Jill-Patrice Cassuto, Sophie Raynaud, and Patrick Auberger
Cancer Res 2010;70 1042-1052
http://cancerres.aacrjournals.org/cgi/content/abstract/70/3/1042

Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-κB activity in hypoxic tumor cells
G -Y Jang, J -H Jeon, S -Y Cho, D -M Shin, C -W Kim, E M Jeong, H C Bae, T W Kim, S -H Lee, Y Choi, D -S Lee, S -C Park and I -G Kim
http://www.nature.com/onc/journal/v29/n3/abs/onc2009342a.html

Differential Dependence on Beclin 1 for the Regulation of Pro-Survival Autophagy by Bcl-2 and Bcl-xL in HCT116 Colorectal Cancer Cells
Muriel Priault, Erika Hue, Fanny Marhuenda, Paul Pilet, Lisa Oliver, François M. Vallette
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008755

The IKK complex contributes to the induction of autophagy
Alfredo Criollo, Laura Senovilla, Hélène Authier, Maria Chiara Maiuri, Eugenia Morselli, Ilio Vitale, Oliver Kepp, Ezgi Tasdemir, Lorenzo Galluzzi, Shensi Shen, Maximilien Tailler, Nicolas Delahaye, Antoine Tesniere, Daniela De Stefano, Aména Ben Younes, Francis Harper, Gérard Pierron, Sergio Lavandero, Laurence Zitvogel, Alain Israel, Véronique Baud and Guido Kroemer
http://www.nature.com/emboj/journal/v29/n3/full/emboj2009364a.html

Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1
Natasha C Chang, Mai Nguyen, Marc Germain and Gordon C Shore
http://www.nature.com/emboj/journal/v29/n3/full/emboj2009369a.html

Carcinoma cells activate AMP-activated protein kinase-dependent autophagy
as survival response to kaempferol-mediated energetic impairment
Giuseppe Filomeni, Enrico Desideri, Simone Cardaci, Ilaria Graziani, Sara
Piccirillo, Giuseppe Rotilio and Maria R. Ciriolo
http://www.landesbioscience.com/journals/autophagy/article/10971

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy
Liang Qin, Zheng Wang, Lianyuan Tao and Yun Wang
http://www.landesbioscience.com/journals/autophagy/article/11062

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mitochondria
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Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells
Alessandra Baracca, Ferdinando Chiaradonna, Gianluca Sgarbi, Giancarlo Solaini, Lilia Alberghina, Giorgio Lenaz
http://dx.doi.org/10.1016/j.bbabio.2009.11.006

Evidence for Mitochondrial Respiratory Deficiency in Rat Rhabdomyosarcoma Cells
Vanessa E. Jahnke, Odile Sabido, Aurélia Defour, Josiane Castells, Etienne Lefai, Damien Roussel, Damien Freyssenet
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008637

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
H.-S. Kim, K. Patel, K. Muldoon-Jacobs, K.S. Bisht, N. Aykin-Burns, J.D. Pennington, R. van der Meer, P. Nguyen, J. Savage, K.M. Owens, A. Vassilopoulos, O. Ozden, S.-H. Park, K.K. Singh, S.A. Abdulkadir, D.R. Spitz, C.-X. Deng, and D. Gius
http://www.cell.com/cancer-cell/abstract/S1535-6108%2809%2900428-0

Oligomycin-induced bioenergetic adaptation in cancer cells with heterogeneous bioenergetic organization
Wenshan Hao, Chao-Pei Betty Chang, Cheng-Chung Tsao, and Jun Xu
http://www.jbc.org/cgi/content/abstract/M109.084194v1

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Metabolic regulation
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Regulation of Cellular Metabolism by Protein Lysine Acetylation
S. Zhao et al.
Regulation of enzymes by acetylation controls metabolic function in human liver cells.
http://www.sciencemag.org/cgi/content/abstract/327/5968/1000

Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux
Q. Wang et al.
Reversible acetylation of metabolic enzymes helps bacteria adjust to changes in food resources.
http://www.sciencemag.org/cgi/content/abstract/327/5968/1004

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis
D.K. Nomura, J.Z. Long, S. Niessen, H.S. Hoover, S.-W. Ng, and B.F. Cravatt
http://www.cell.com/abstract/S0092-8674%2809%2901439-1

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
L. Zhong, A. D’Urso, D. Toiber, C. Sebastian, R.E. Henry, D.D. Vadysirisack, A. Guimaraes, B. Marinelli, J.D. Wikstrom, T. Nir, C.B. Clish, B. Vaitheesvaran, O. Iliopoulos, I. Kurland, Y. Dor, R. Weissleder, O.S. Shirihai, L.W. Ellisen, J.M. Espinosa, and R. Mostoslavsky
http://www.cell.com/abstract/S0092-8674%2809%2901627-4

C1qTNF-related protein-6 mediates fatty acid oxidation via the activation of the AMP-activated protein kinase
Wan Lee, Mi-Jin Kim, Eun-Ju Park, Young-Jin Choi, Seung-Yoon Park
http://dx.doi.org/10.1016/j.febslet.2010.01.040

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
Stefan Gross, Rob A. Cairns, Mark D. Minden, Edward M. Driggers, Mark A. Bittinger, Hyun Gyung Jang, Masato Sasaki, Shengfang Jin, David P. Schenkein, Shinsan M. Su, Lenny Dang, Valeria R. Fantin, and Tak W. Mak
http://jem.rupress.org/cgi/content/abstract/207/2/339?etoc

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REVIEWS
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Autophagy: an adaptable modifier of tumourigenesis
Simon Wilkinson, Kevin M Ryan
http://dx.doi.org/10.1016/j.gde.2009.12.004

Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism
Chi V. Dang
Cancer Res 2010;70 859-862
http://cancerres.aacrjournals.org/cgi/content/abstract/70/3/859

Crosstalk between apoptosis and autophagy within the Beclin 1 interactome
Maria Chiara Maiuri, Alfredo Criollo and Guido Kroemer
http://www.nature.com/emboj/journal/v29/n3/full/emboj2009377a.html

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
G L Semenza
http://www.nature.com/onc/journal/v29/n5/full/onc2009441a.html

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?
K. Schroder et al.
http://www.sciencemag.org/cgi/content/abstract/327/5963/296

Q’s next: the diverse functions of glutamine in metabolism, cell biology and cancer
R J DeBerardinis and T Cheng
http://www.nature.com/onc/journal/v29/n3/full/onc2009358a.html

The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma.
Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F, Lisanti MP.
http://www.landesbioscience.com/journals/cc/article/10238/

HIF-1: upstream and downstream of cancer metabolism
Gregg L Semenza
http://dx.doi.org/10.1016/j.gde.2009.10.009

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Comments
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Chewing the Fat on Tumor Cell Metabolism
J.L. Yecies and B.D. Manning
http://dx.doi.org/10.1016/j.cell.2009.12.037

Lipidomics: Growing on a free-fat diet
http://www.nature.com/nrc/journal/v10/n3/full/nrc2811.html



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