Glycolist – march-april 2010

Nutrients and cell death

AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis
Caoimhín G. Concannon, Liam P. Tuffy, Petronela Weisová, Helena P. Bonner, David Dávila, Caroline Bonner, Marc C. Devocelle, Andreas Strasser, Manus W. Ward, and Jochen H.M. Prehn
http://jcb.rupress.org/cgi/content/abstract/189/1/83?etoc

Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytes.
Marambio P, Toro B, Sanhueza C, Troncoso R, Parra V, Verdejo H, García L, Quiroga C, Munafo D, Díaz-Elizondo J, Bravo R, González J, Diaz-Araya G, Pedrozo Z, Chiong M, Colombo MI, Lavandero S.
http://dx.doi.org/10.1016/j.bbadis.2010.02.002

MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells
J. Godlewski, M.O. Nowicki, A. Bronisz, G. Nuovo, J. Palatini, M. De Lay, J. Van Brocklyn, M.C. Ostrowski, E.A. Chiocca, and S.E. Lawler
http://dx.doi.org/10.1016/j.molcel.2010.02.018

Activation of the AMP-activated protein kinase alpha 1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins BCL-2 and survivin
Chao Liu, Bin Liang, Qilong Wang, Jiliang Wu, and Ming-Hui Zou
http://www.jbc.org/cgi/content/abstract/M110.102491v1

AMP-activated protein kinase antagonizes pro-apoptotic extracellular signal-regulated kinase activation by inducing dual-specificity protein phosphatases in response to glucose deprivation in HCT116 carcinoma
Min-Jung Kim, In-Ja Park, Hee Yun, Insug Kang, Wonchae Choe, Sung-Soo Kim, and Joohun Ha
http://www.jbc.org/cgi/content/abstract/M109.085456v1

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells
Issam Ben Sahra, Kathiane Laurent, Sandy Giuliano, Frédéric Larbret, Gilles Ponzio, Pierre Gounon, Yannick Le Marchand-Brustel, Sophie Giorgetti-Peraldi, Mireille Cormont, Corine Bertolotto, Marcel Deckert, Patrick Auberger, Jean-François Tanti, and Frédéric Bost
http://cancerres.aacrjournals.org/cgi/content/abstract/70/6/2465

RAGE Modulates Hypoxia/Reoxygenation Injury in Adult Murine Cardiomyocytes via JNK and GSK-3β Signaling Pathways
Linshan Shang, Radha Ananthakrishnan, Qing Li, Nosirudeen Quadri, Mariane Abdillahi, Zhengbin Zhu, Wu Qu, Rosa Rosario, Fatouma Touré, Shi Fang Yan, Ann Marie Schmidt, Ravichandran Ramasamy
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0010092

Akt and c-Myc Differentially Activate Cellular Metabolic Programs and Prime Cells to Bioenergetic Inhibition
Fan, YJ; Dickman, KG; Zong, WX
http://www.jbc.org/content/285/10/7324

Mtl1 is required to activate general stress response through Tor1 and Ras2 inhibition under conditions of glucose starvation and oxidative stress
Mima Ivanova Petkova, Nuria Pujol-Carrion, Javier Arroyo, Jesus Garcia-Cantalejo, and Maria Angeles de la Torre-Ruiz
http://www.jbc.org/cgi/content/abstract/M109.085282v1

Regulation of metabolism

IL-7 Is Essential for Homeostatic Control of T Cell Metabolism In Vivo
Jacobs, SR; Michalek, RD; Rathmell, JC
http://www.jimmunol.org/cgi/content/full/184/7/3461

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
Y. Sancak, L. Bar-Peled, R. Zoncu, A.L. Markhard, S. Nada, and D.M. Sabatini
http://www.cell.com/abstract/S0092-8674%2810%2900177-7

BAX inhibitor-1 enhances cancer metastasis by altering glucose metabolism and activating the sodium-hydrogen exchanger: the alteration of mitochondrial function
G-H Lee, C Yan, S-J Shin, S-C Hong, T Ahn, A Moon, S J Park, Y C Lee, W H Yoo, H-T Kim, D-S Kim, S-W Chae, H-R Kim and H-J Chae
http://www.nature.com/onc/journal/v29/n14/full/onc2009491a.html

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
Wenwei Hu, Cen Zhang, Rui Wu, Yvonne Sun, Arnold Levine, and Zhaohui Feng
http://www.pnas.org/content/107/16/7455.abstract?etoc

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
Sawako Suzuki, Tomoaki Tanaka, Masha V. Poyurovsky, Hidekazu Nagano, Takafumi Mayama, Shuichi Ohkubo, Maria Lokshin, Hiroyuki Hosokawa, Toshinori Nakayama, Yutaka Suzuki, Sumio Sugano, Eiichi Sato, Toshitaka Nagao, Koutaro Yokote, Ichiro Tatsuno, and Carol Prives
http://www.pnas.org/content/107/16/7461.abstract?etoc

Phospholipase D1 Mediates AMP-Activated Protein Kinase Signaling for Glucose Uptake
Jong Hyun Kim, Ji-Man Park, Kyungmoo Yea, Hyun Wook Kim, Pann-Ghill Suh, Sung Ho Ryu
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009600

Cancer metabolism

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
P.S. Ward, J. Patel, D.R. Wise, O. Abdel-Wahab, B.D. Bennett, H.A. Coller, J.R. Cross, V.R. Fantin, C.V. Hedvat, A.E. Perl, J.D. Rabinowitz, M. Carroll, S.M. Su, K.A. Sharp, R.L. Levine, and C.B. Thompson
http://www.cell.com/cancer-cell/abstract/S1535-6108%2810%2900036-X

Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply
Gilles A. Spoden, Ursula Rosteka, Stefan Lechnera, Maria Mitterbergera, Sybille Mazurek,  and Werner Zwerschke
http://dx.doi.org/10.1016/j.yexcr.2009.06.024

Dominant negative mutations affect oligomerisation of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy
Vibhor Gupta, Ponnusamy Kalaiarasan, Mohd. Faheem, Nishant Singh, Askandar Iqbal, and Rameshwar N. K. Bamezai
J. Biol. Chem. published 19 March 2010, 10.1074/jbc.M109.065029
http://www.jbc.org/cgi/content/abstract/M109.065029v1

Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation
Valentina Fogal, Adam D. Richardson, Priya P. Karmali, Immo E. Scheffler, Jeffrey W. Smith, and Erkki Ruoslahti
Mol. Cell. Biol. 2010;30 1303-1318
http://mcb.asm.org/cgi/content/abstract/30/6/1303

Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation
Wen-Chien Chou, Hsin-An Hou, Chien-Yuan Chen, Jih-Luh Tang, Ming Yao, Woei Tsay, Bor-Shen Ko, Shang-Ju Wu, Shang-Yi Huang, Szu-Chun Hsu, Yao-Chang Chen, Yen-Ning Huang, Yi-Chang Chang, Fen-Yu Lee, Ming-Chi Liu, Chia-Wen Liu, Mei-Hsuan Tseng, Chi-Fei Huang, and Hwei-Fang Tien
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/115/14/2749

A Transcriptional Signature and Common Gene Networks Link Cancer with Lipid Metabolism and Diverse Human Diseases
H.A. Hirsch, D. Iliopoulos, A. Joshi, Y. Zhang, S.A. Jaeger, M. Bulyk, P.N. Tsichlis, X.S. Liu, and K. Struhl
http://www.cell.com/cancer-cell/abstract/S1535-6108%2810%2900069-3

Miscellaneous

Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy
Christina H. Eng, Ker Yu, Judy Lucas, Eileen White, and Robert T. Abraham
A volatile metabolic by-product can promote cell survival through the induction of autophagy.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;3/119/ra31?etoc

Glutathionylation of adenine nucleotide translocase induced by carbon monoxide prevents mitochondrial membrane permeabilisation and apoptosis
Claudia S. F. Queiroga, Ana S. Almeida, Cecile Martel, Catherine Brenner, Paula M. Alves, and Helena L. A. Vieira
http://www.jbc.org/cgi/content/abstract/M109.065052v1

AKT2 modulates glucose availability and downstream apoptotic pathways during development
Penny J. Jensen, Laura B. Gunter, and Mary O. Carayannopoulos
http://www.jbc.org/cgi/content/abstract/M109.079343v1

Jun Proteins Are Starvation-Regulated Inhibitors of Autophagy
Orli Yogev, Rachel Goldberg, Shira Anzi, Ohad Yogev, and Eitan Shaulian
http://cancerres.aacrjournals.org/cgi/content/abstract/70/6/2318

Reviews / comments

A whole issue of Current Opinion in Cell Biology on autophagy, including reviews about its role in cancer:
http://www.sciencedirect.com/science/issue/6245-2010-999779997-1860687

A whole issue of FEBS letters on autophagy, including reviews about its role in cancer http://www.febsletters.org/issues/contents?issue_key=S0014-5793(10)X0006-0

Alternative fuel—another role for p53 in the regulation of metabolism
Karen H. Vousden
http://www.pnas.org/content/107/16/7117.full

The role of p53 in glucose metabolism
Eric C Cheung, Karen H Vousden
http://dx.doi.org/10.1016/j.ceb.2009.12.006

Regulatory crosstalk of the metabolic network
Nana-Maria Grüning, Hans Lehrach, Markus Ralser
http://dx.doi.org/10.1016/j.tibs.2009.12.001

The Warburg effect and mitochondrial stability in cancer cells
Vladimir Gogvadzea, Boris Zhivotovskya and Sten Orrenius
http://dx.doi.org/10.1016/j.mam.2009.12.004

Metabolic genes in cancer: Their roles in tumor progression and clinical implications
Eiji Furuta, Hiroshi Okuda, Aya Kobayashi, Kounosuke Watabe http://dx.doi.org/10.1016/j.bbcan.2010.01.005

p32 (C1QBP) and Cancer Cell Metabolism: Is the Warburg Effect a Lot of Hot Air?
Chi V. Dang
http://mcb.asm.org/cgi/content/full/30/6/1300

Glycolysis: a bioenergetic or a survival pathway?
Juan P. Bolaños, Angeles Almeida, Salvador Moncada http://dx.doi.org/10.1016/j.tibs.2009.10.006

IDH1 and IDH2: Not Your Typical Oncogenes
Z.J. Reitman, D.W. Parsons, and H. Yan http://www.cell.com/cancer-cell/abstract/S1535-6108%2810%2900068-1

Metabolism and the leukemic stem cell
Omar Abdel-Wahab and Ross L. Levine
http://jem.rupress.org/cgi/content/abstract/207/4/677?etoc

Targeting the pro-death and pro-survival functions of autophagy as novel
therapeutic strategies in cancer
Kevin Dalby, Ibrahim Tekedereli, Gabriel Lopez-Berestein and Bulent Ozpolat
http://www.landesbioscience.com/journals/autophagy/article/11625

Nix: A receptor protein for mitophagy in mammals
Tomotake Kanki
http://www.landesbioscience.com/journals/autophagy/article/11420

Vertebrate cell death in energy-limited conditions and how to avoid it: what we might learn from mammalian hibernators and other stress-tolerant vertebrates
http://www.springerlink.com/content/fn03477h87815255/

Tumor Suppression Through Metabolic Regulation
Nancy R. Gough
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;3/119/ec126?etoc

Metabolism and cancer mix in Madrid
Reuben J Shaw
http://www.nature.com/embor/journal/v11/n4/full/embor201040.html

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