Glycolist – june/july 2010

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Death induced by nutrient depletion
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Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply
A.Y. Choo, S.G. Kim, M.G. Vander Heiden,S.J. Mahoney, H. Vu, S.-O. Yoon, L.C. Cantley, and J. Blenis
http://www.cell.com/molecular-cell/abstract/S1097-2765%2810%2900369-2

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner
A. Kalender, A. Selvaraj, S.Y. Kim, P. Gulati, S. Brûlé, B. Viollet, B.E. Kemp, N. Bardeesy, P. Dennis, J.J. Schlager, A. Marette, S.C. Kozma, and G. Thomas
http://www.cell.com/cell-metabolism/abstract/S1550-4131%2810%2900084-7

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
Jiangbin Ye, Monika Kumanova, Lori S Hart, Kelly Sloane, Haiyan Zhang, Diego N De Panis, Ekaterina Bobrovnikova-Marjon, J Alan Diehl, David Ron and Constantinos Koumenis
http://www.nature.com/emboj/journal/v29/n12/full/emboj201081a.html

AMP-activated protein kinase supports the NGF-induced viability of human HeLa cells to glucose starvation
Luo Ting, Wan Bo, Ruwei Li, Xinya Chen, Yingli Wang, Zhou Jun and Long Yu
http://www.springerlink.com/content/c48l352725355v1l/fulltext.html

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Cross-talk autophagy/apoptosis
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The BH3-mimetic gossypol induces both beclin 1-dependent and beclin 1-independent cytoprotective autophagy in cancer cells
Ping Gao, Chantal Bauvy, Sylvie Souquere, Giovanni Tonelli, Lei Liu, Yushan Zhu, Zhenzhen Qiao, Daniela Bakula, Tassula Proikas-Cezanne, Gerard Pierron, Patrice Codogno, Quan Chen, and Maryam Mehrpour
J. Biol. Chem. published 7 June 2010, 10.1074/jbc.M110.118125
http://www.jbc.org/cgi/content/abstract/M110.118125v1

Nix is critical to two distinct phases of mitophagy: reactive oxygen species (ROS)-mediated autophagy induction and Parkin-ubiqutin-p62-mediated mitochondria priming
Wen-Xing Ding, Hong-Min Ni, Min Li, Yong Liao, Xiaoyun Chen, Donna B. Stolz, Gerald W. Dorn II, and Xiao-Ming Yin
J. Biol. Chem. published 23 June 2010, 10.1074/jbc.M110.119537
http://www.jbc.org/cgi/content/abstract/M110.119537v1

The Epidermal Growth Factor Receptor Antibody Cetuximab Induces Autophagy in Cancer Cells by Downregulating HIF-1  and Bcl-2 and Activating the Beclin 1/hVps34 Complex
Xinqun Li and Zhen Fan
http://cancerres.aacrjournals.org/cgi/content/abstract/70/14/5942

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Regulation of metabolism
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Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming
F Zhao, A Mancuso, T V Bui, X Tong, J J Gruber, C R Swider, P V Sanchez, J J Lum, N Sayed, J V Melo, A E Perl, M Carroll, S W Tuttle and C B Thompson
http://www.nature.com/onc/journal/v29/n20/full/onc201067a.html

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
Frank Weinberg, Robert Hamanaka, William W. Wheaton, Samuel Weinberg, Joy Joseph, Marcos Lopez, Balaraman Kalyanaraman, Gökhan M. Mutlu, G. R. Scott Budinger, and Navdeep S. Chandel
http://www.pnas.org/content/107/19/8788.abstract?etoc

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Glucose sensing and reactions
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Glucose Controls Nuclear Accumulation, Promoter Binding, and Transcriptional Activity of the MondoA-Mlx Heterodimer
Christopher W. Peterson, Carrie A. Stoltzman, Michael P. Sighinolfi, Kyoung-Sim Han, and Donald E. Ayer
http://mcb.asm.org/cgi/content/full/30/12/2887

Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression
Li, Yuanyuan; Liu, Liang; Tollefsbol, Trygve O.
http://www.fasebj.org/cgi/content/full/24/5/1442

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Tumor metabolism
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Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1
S A Caldwell, S R Jackson, K S Shahriari, T P Lynch, G Sethi, S Walker, K Vosseller and M J Reginato
http://www.nature.com/onc/journal/v29/n19/full/onc201041a.html

Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited
Alexei Vazquez , Jiangxia Liu, Yi Zhou  and Zoltán N Oltvai
http://www.biomedcentral.com/1752-0509/4/58/

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AMPK, mTor, autophagy
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mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs
R. J. O. Dowling et al.
Control of cell proliferation and cell size is separately regulated in mammals.
http://www.sciencemag.org/cgi/content/abstract/328/5982/1172

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
S.A. Hawley, F.A. Ross, C. Chevtzoff, K.A. Green, A. Evans, S. Fogarty, M.C. Towler, L.J. Brown, O.A. Ogunbayo, A.M. Evans, and D.G. Hardie
http://www.cell.com/cell-metabolism/abstract/S1550-4131%2810%2900112-9#Summary

Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition
C.K. Yip, K. Murata, T. Walz, D.M. Sabatini, and S.A. Kang
http://www.cell.com/molecular-cell/abstract/S1097-2765%2810%2900379-5

DAP1, a Novel Substrate of mTOR, Negatively Regulates Autophagy
I. Koren, E. Reem, and A. Kimchi
http://www.cell.com/current-biology/abstract/S0960-9822%2810%2900520-8

Termination of autophagy and reformation of lysosomes regulated by mTOR
Li Yu,Christina K. McPhee,Lixin Zheng,Gonzalo A. Mardones,Yueguang Rong,Junya Peng,Na Mi,Ying Zhao,Zhihua Liu,Fengyi Wan,Dale W. Hailey,Viola Oorschot,Judith Klumperman,Eric H. Baehrecke& Michael J. Lenardo
http://www.nature.com/nature/journal/v465/n7300/full/nature09076.html
[I think at this point we should stop calling “starvation” or “nutrient deprivation” to incubation in serum-free medium, since medium obviously contains nutrients. What happened to the term “serum withdrawal”, is it not fashionable enough now and “starvation” sounds trendy…?]

A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions
M.M. Lipinski, G. Hoffman, A. Ng, W. Zhou, B.F. Py, E. Hsu, X. Liu, J. Eisenberg, J. Liu, J. Blenis, R.J. Xavier, and J. Yuan
http://www.cell.com/developmental-cell/abstract/S1534-5807%2810%2900213-3
[huh, caspase-1 and RIPK1]

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Hypoxia
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HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase
Ataman Sendoel, Ines Kohler, Christof Fellmann, Scott W. Lowe & Michael O. Hengartner
http://www.nature.com/nature/journal/v465/n7298/full/nature09141.html

AKT loss in human epithelial cells treated with severe hypoxia
Pages 951-959
Adrian Harold Box, Sun-Myoung Kim, Douglas James Demetrick
http://dx.doi.org/10.1016/j.bbamcr.2010.03.011

Glucose is necessary for stabilization of hypoxia-inducible factor-1α under hypoxia: Contribution of the pentose phosphate pathway to this stabilization
Pages 3073-3079
Mayuko Osada-Oka, Yasushi Hashiba, Satoshi Akiba, Susumu Imaoka, Takashi Sato
http://dx.doi.org/10.1016/j.febslet.2010.05.046

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REVIEWS – very didactic and comprehensive
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Q&A: Cancer: Clues from cell metabolism
William G. Kaelin Jr and Craig B. Thompson
http://www.nature.com/nature/journal/v465/n7298/full/465562a.html

The metabolic life and times of a T-cell.
Michalek RD, Rathmell JC.
http://www3.interscience.wiley.com/journal/123526696/abstract

A comprehensive glossary of autophagy-related molecules and processes
Daniel J. Klionsky, Patrice Codogno, Ana Maria Cuervo, Vojo Deretic, Zvulun
Elazar, Juan Fueyo-Margareto, David A. Gewirtz, Guido Kroemer, Beth Levine,
Noboru Mizushima, David C. Rubinsztein, Michael Thumm and Sharon A. Tooze
http://www.landesbioscience.com/journals/autophagy/article/12244

Targeting metabolic transformation for cancer therapy
Daniel A. Tennant, Raúl V. Durán & Eyal Gottlieb
http://www.nature.com/nrc/journal/v10/n4/abs/nrc2817.html?lang=en

Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death.
Montero J, Mari M, Colell A, Morales A, Basañez G, Garcia-Ruiz C, Fernández-Checa JC.
http://dx.doi.org/10.1016/j.bbabio.2010.02.010

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COMMENTS / REVIEWS / ADDENDA / MEETING REPORTS
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Cell signalling: Of Rags and Ragulator
Ragulator is a new, crucial component of the mTORC1 signalling pathway.
http://www.nature.com/nrm/journal/v11/n6/full/nrm2907.html

Fueling the Cancer Cell
L. Bryan Ray
Sci. Signal. 3 (122), ec153. [DOI: 10.1126/scisignal.3122ec153]
Altered metabolic needs of cancer cells may provide a means to selectively inhibit their growth.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;3/122/ec153?etoc

Ammonia: A Diffusible Factor Released by Proliferating Cells That Induces Autophagy
Guillermo Mariño and Guido Kroemer
Sci. Signal. 3 (124), pe19. [DOI: 10.1126/scisignal.3124pe19]
A volatile metabolic by-product can induce autophagy in an autocrine and paracrine fashion.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;3/124/pe19?etoc

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
Zhaohui Feng, Arnold J. Levine
http://www.cell.com/trends/cell-biology/abstract/S0962-8924(10)00055-3

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging
P. Kapahi, D. Chen, A.N. Rogers, S.D. Katewa, P.W.-L. Li, E.L. Thomas, and L. Kockel
http://www.cell.com/cell-metabolism/abstract/S1550-4131%2810%2900153-1

Apoptosis: Lack of oxygen aids cell survival
Jo Anne Powell-Coffman and Clark R. Coffman
http://www.nature.com/nature/journal/v465/n7298/edsumm/e100603-03.html

Altered metabolism in cancer
Locasale JW, Cantley LC
http://www.biomedcentral.com/1741-7007/8/88

Evolution of the TSC1/TSC2-TOR Signaling Pathway
Jaco Serfontein, R. Ellen R. Nisbet, Christopher J. Howe, and Petrus J. de Vries
The TSC1/TSC2-TOR signaling pathway evolved from a primitive signaling pathway linking adenosine monophosphate abundance to cell growth.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;3/128/ra49?etoc

Metabolism and Cancer in La Jolla
Reuben J. Shaw, Ronald M. Evans, and M. Celeste Simon
Cancer Res 2010;70 3864-3869
http://cancerres.aacrjournals.org/cgi/content/full/70/10/3864

A Metabolic (Re-)Balancing Act
R.T. Abraham and C.H. Eng
http://www.cell.com/molecular-cell/abstract/S1097-2765%2810%2900370-9

How do tumours adapt to nutrient stress?
Ronald C Wek and Kirk A Staschke
http://www.nature.com/emboj/journal/v29/n12/full/emboj2010110a.html

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang et al.
http://www.nature.com/nature/journal/v465/n7300/full/nature09132.html

The combination of metformin and 2 deoxyglucose inhibits autophagy and
induces AMPK-dependent apoptosis in prostate cancer cells
Issam Ben Sahra, Jean-François Tanti and Frédéric Bost
http://www.landesbioscience.com/journals/autophagy/article/12434



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