Glycolist – august-september 2010

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cross-talk cell death / metabolism
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Bcl-2 Regulates HIF-1α Protein Stabilization in Hypoxic Melanoma Cells
via the Molecular Chaperone HSP90
Daniela Trisciuoglio, Chiara Gabellini, Marianna Desideri, Elio
Ziparo, Gabriella Zupi, Donatella Del Bufalo
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011772

Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal
Tumor Cells through a Ca2+-De novo Ceramide-PP2A-Reactive Oxygen
Species–Dependent Signaling Pathway
Margaret A. Park, Clint Mitchell, Guo Zhang, Adly Yacoub, Jeremy
Allegood, Dieter Häussinger, Roland Reinehr, Andrew Larner, Sarah
Spiegel, Paul B. Fisher, Christina Voelkel-Johnson, Besim Ogretmen,
Steven Grant, and Paul Dent
http://cancerres.aacrjournals.org/cgi/content/abstract/70/15/6313

Lithium reduces apoptosis and autophagy after neonatal hypoxia–ischemia
Q Li, H Li, K Roughton, X Wang, G Kroemer, K Blomgren and C Zhu
http://www.nature.com/cddis/journal/v1/n7/full/cddis201033a.html

Endoplasmic reticulum stress inhibition protects steatotic and
non-steatotic livers in partial hepatectomy under ischemia–reperfusion
I Ben Mosbah, I Alfany-Fernández, C Martel, M A Zaouali, M
Bintanel-Morcillo, A Rimola, J Rodés, C Brenner, J Roselló-Catafau and
C Peralta
http://www.nature.com/cddis/journal/v1/n7/full/cddis201029a.html

Activated macrophages utilize glycolytic ATP to maintain mitochondrial
membrane potential and prevent apoptotic cell death
A Garedew, S O Henderson and S Moncada
http://www.nature.com/cdd/journal/v17/n10/full/cdd201027a.html

Metabolic regulation of Drosophila apoptosis through inhibitory
phosphorylation of Dronc
Chih-Sheng Yang, Michael J Thomenius, Eugene C Gan, Wanli Tang,
Christopher D Freel, Thomas J S Merritt, Leta K Nutt and Sally
Kornbluth
http://www.nature.com/emboj/journal/v29/n18/full/emboj2010191a.html

AMP-activated protein kinase mediates apoptosis in response to
bioenergetic stress through the activation of the pro-apoptotic
BH3-only protein BMF
Sean M. Kilbride, Angela M. Farrelly, Caroline Bonner, Manus W. Ward,
Kristine C. Nyhan, Caoimhin G. Concannon, Claes B. Wollheim, Maria M.
Byrne, and Jochen H. M. Prehn
http://www.jbc.org/cgi/content/abstract/M110.138107v1

Nucleolar follistatin promotes cancer cell survival under
glucose-deprived condition through inhibiting cellular rRNA synthesis
Xiangwei Gao, Saisai Wei, Kairan Lai, Jinghao Sheng, Jinfeng Su,
Junqiao Zhu, Haojie Dong, Hu Hu, and Zhengping Xu
http://www.jbc.org/cgi/content/abstract/M110.144477v1

AMPK negatively regulates NOX4-dependent activation of p53 and
epithelial cell apoptosis in diabetes
Assaad Antoine Eid, Bridget Marie Ford, Karen Block, Balakuntalam S.
Kasinath, Yves Gorin, Goutam Ghosh Choudhury, Jeffrey L. Barnes, and
Hanna E. Abboud
http://www.jbc.org/cgi/content/abstract/M110.136796v1

Phosphorylation of eIF2a at Serine 51 Is an Important Determinant of
Cell Survival and Adaptation to Glucose Deficiency

Hala Muaddi, Mithu Majumder, Philippos Peidis, Andreas I. Papadakis, Martin Holcik,
Donalyn Scheuner, Randal J. Kaufman, Maria Hatzoglou, and Antonis E.
Koromilas
http://www.molbiolcell.org/cgi/content/abstract/21/18/3220?etoc

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Autophagy / metabolism

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ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death
L. Radoshevich, L. Murrow, N. Chen, E. Fernandez, S. Roy, C. Fung, and
J. Debnath
http://www.cell.com/abstract/S0092-8674%2810%2900787-7

Regulation of autophagy by ATF4 in response to severe hypoxia
T Rzymski, M Milani, L Pike, F Buffa, H R Mellor, L Winchester, I
Pires, E Hammond, I Ragoussis and A L Harris
http://www.nature.com/onc/journal/v29/n31/full/onc2010191a.html

Autophagy was activated in injured astrocytes and mildly decreased
cell survival following glucose and oxygen deprivation and focal
cerebral ischemia
Ai-Ping Qin, Chun-Feng Liu, Yuan-Yuan Qin, Li-Zhi Hong, Min Xu, Lei
Yang, Jianqing Liu, Zheng-Hong Qin and Hui-Ling Zhang
http://www.landesbioscience.com/journals/autophagy/article/12510

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CANCER METABOLISM
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Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
K. Düvel, J.L. Yecies, S. Menon, P. Raman, A.I. Lipovsky, A.L. Souza,
E. Triantafellow, Q. Ma, R. Gorski, S. Cleaver, M.G. Vander Heiden,
J.P. MacKeigan, P.M. Finan, C.B. Clish, L.O. Murphy, and B.D. Manning
http://www.cell.com/molecular-cell/abstract/S1097-2765%2810%2900463-6

Dysregulation of the mevalonate pathway promotes transformation
James W. Clendening, Aleks Pandyra, Paul C. Boutros, Samah El
Ghamrasni, Fereshteh Khosravi, Grace A. Trentin, Anna Martirosyan,
Anne Hakem, Razqallah Hakem, Igor Jurisica, and Linda Z. Penn
http://www.pnas.org/content/107/34/15051.abstract?etoc

Fructose Induces Transketolase Flux to Promote Pancreatic Cancer Growth
Haibo Liu, Danshan Huang, David L. McArthur, Laszlo G. Boros, Nicholas
Nissen, and Anthony P. Heaney
Cancer Res 2010;70 6368-6376
http://cancerres.aacrjournals.org/cgi/content/abstract/70/15/6368

Human G3BP1 interacts with β-F1-ATPase mRNA and inhibits its translation
Álvaro D. Ortega, Imke M. Willers, Sandra Sala, and José M. Cuezva
J Cell Sci 2010;123 2685-2696
http://jcs.biologists.org/cgi/content/abstract/123/16/2685

Up-regulation of the ATPase inhibitory factor 1 (IF1) of the
mitochondrial H+-ATP synthase in human tumors mediates the metabolic
shift of cancer cells to a Warburg phenotype.
Sánchez-Cenizo L, Formentini L, Aldea M, Ortega AD, García-Huerta P,
Sánchez-Aragó M, Cuezva JM.
http://www.jbc.org/content/285/33/25308.long

Lipid accumulation and dendritic cell dysfunction in cancer
Donna L Herber, Wei Cao, Yulia Nefedova, Sergey V Novitskiy, Srinivas
Nagaraj, Vladimir A Tyurin, Alex Corzo, Hyun-Il Cho, Esteban Celis,
Brianna Lennox, Stella C Knight, Tapan Padhya, Thomas V McCaffrey,
Judith C McCaffrey, Scott Antonia, Mayer Fishman, Robert L Ferris,
Valerian E Kagan and Dmitry I Gabrilovich
http://www.nature.com/nm/journal/v16/n8/abs/nm.2172.html?lang=en

MYC-dependent mitochondrial generation of acetyl-coa contributes to
fatty acid biosynthesis and histone acetylation during cell cycle
entry
Fionnuala Morrish, Jhoanna Noonan, Carissa L. Perez, Philip R. Gafken,
Matthew P. Fitzgibbon, Joanne K. Kelleher, Marc R. Van Gilst, and
David M. Hockenbery
http://www.jbc.org/cgi/content/abstract/M110.141606v1

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation
J.-B. Wang, J.W. Erickson, R. Fuji, S. Ramachandran, P. Gao, R.
Dinavahi, K.F. Wilson, A.L.B. Ambrosio, S.M.G. Dias, C.V. Dang, and
R.A. Cerione
http://www.cell.com/cancer-cell/abstract/S1535-6108(10)00306-5


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AMPK/Tor
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AICAR induces apoptosis independently of AMPK and p53 through
upregulation of the BH3-only proteins BIM and NOXA in chronic
lymphocytic leukemia cells.
Santidrián AF, González-Gironès DM, Iglesias-Serret D, Coll-Mulet L,
Cosialls AM, de Frias M, Campàs C, González-Barca E, Alonso E, Labi V,
Viollet B, Benito A, Pons G, Villunger A, Gil J.
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/blood-2010-05-283960v1

S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status
and DNA damage response
Keng Po Lai, Wai Fook Leong, Jenny Fung Ling Chau, Deyong Jia, Li
Zeng, Huijuan Liu, Lin He, Aijun Hao, Hongbing Zhang, David Meek,
Chakradhar Velagapudi, Samy L Habib and Baojie Li
http://www.nature.com/emboj/journal/v29/n17/full/emboj2010166a.html

Signaling Kinase AMPK Activates Stress-Promoted Transcription via
Histone H2B Phosphorylation
David Bungard, Benjamin J. Fuerth, Ping-Yao Zeng, Brandon Faubert,
Nancy L. Maas, Benoit Viollet, David Carling, Craig B. Thompson,
Russell G. Jones, and Shelley L. Berger
http://www.sciencemag.org/cgi/content/abstract/329/5996/1201

Whole-body deletion of AMPK β2 reduces muscle AMPK and exercise capacity
Gregory R. Steinberg, Hayley M. O’Neill, Nicolas L. Dzamko, Sandra
Galic, Tim Naim, Rene Koopman, Sebastian B. Jorgensen, Jane Honeyman,
Kimberly Hewitt, Zhi-Ping Chen, Jonathan D. Schertzer, John Scott,
Frank Koentgen, Gordon S. Lynch, Matthew J. Watt, Bryce J. W.
vanDenderen, Duncan J. Campbell, and Bruce E. Kemp
http://www.jbc.org/cgi/content/abstract/M110.102434v1

Resveratrol inhibits mTOR signaling by promoting the interaction
between mTOR and DEPTOR
Meilian Liu, Sarah Ann Wilk, Anping Wang, Lijun Zhou, Rui-Hong Wang,
Wataru Ogawa, Chuxia Deng, Lily Q. Dong, and Feng Liu
http://www.jbc.org/cgi/content/abstract/M110.169284v1

Altered Metabolism and Persistent Starvation Behaviors Caused by
Reduced AMPK Function in Drosophila
Erik C. Johnson, Nevzat Kazgan, Colin A. Bretz, Lawrence J. Forsberg,
Clare E. Hector, Ryan J. Worthen, Rob Onyenwoke, Jay E. Brenman
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012799

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Glucose and anti-glycolytics
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Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells
M. G. Vander Heiden et al.
http://www.sciencemag.org/cgi/content/abstract/329/5998/1492

Cytosolic pH is a second messenger for glucose and regulates the PKA
pathway through V-ATPase
Reinhard Dechant, Matteo Binda, Sung Sik Lee, Serge Pelet, Joris
Winderickx and Matthias Peter
http://www.nature.com/emboj/journal/v29/n15/full/emboj2010138a.html

2-Deoxy-D-glucose regulates dedifferentiation through beta-catenin
pathway in rabbit articular chondrocytes
Yu, Sean-Mi; Kim, Hyun Ah; Kim, Song-Ja
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912477/

Toll-like receptor-induced changes in glycolytic metabolism regulate
dendritic cell activation.
Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ,
Cross JR, Jung E, Thompson CB, Jones RG, Pearce EJ.
http://bloodjournal.hematologylibrary.org/cgi/content/full/115/23/4742

SIRT6 deficiency results in severe hypoglycemia by enhancing both
basal and insulin-stimulated glucose uptake in mice
Cuiying Xiao, Hyun-Seok Kim, Tyler Lahusen, Rui-Hong Wang, Xiaoling
Xu, Oksana Gavrilova, William Jou, David Gius, and Chu-Xia Deng
http://www.jbc.org/cgi/content/abstract/M110.168039v1

Focal, Periocular Delivery of 2-deoxy-D-glucose as an Adjuvant to
Chemotherapy for the Treatment of Advanced Retinoblastoma.
Pina Y, Houston SK, Murray T, Boutrid H, Celdran M, Feuer WJ, Shi W,
Hernandez E, Lampidis TJ.
http://www.ncbi.nlm.nih.gov/pubmed/20702830

Targeting Tumor Metabolism With 2-Deoxyglucose in Patients With
Castrate-Resistant Prostate Cancer and Advanced Malignancies

– Hide quoted text –
Stein, M; Lin, HX; Jeyamohan, C; Dvorzhinski, D; Gounder, M; Bray, K;
Eddy, S; Goodin, S; White, E; DiPaola, RS
http://onlinelibrary.wiley.com/doi/10.1002/pros.21172/abstract

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HYPOXIA
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Mechanism of Hypoxia-Induced NF- B
Carolyn Culver, Anders Sundqvist, Sharon Mudie, Andrew Melvin,
Dimitris Xirodimas, and Sonia Rocha
http://mcb.asm.org/cgi/content/abstract/30/20/4901

Targeting the multiple myeloma hypoxic niche with TH-302, a
hypoxia-activated prodrug
Jinsong Hu, Damian R. Handisides, Els Van Valckenborgh, Hendrik De
Raeve, Eline Menu, Isabelle Vande Broek, Qian Liu, Jessica D. Sun, Ben
Van Camp, Charles P. Hart, and Karin Vanderkerken
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/116/9/1524

Hypoxia-inducible Factor-1 Activation in Nonhypoxic Conditions: The
Essential Role of Mitochondrial-derived Reactive Oxygen Species David
A. Patten, Véronique N. Lafleur, Geneviève A. Robitaille, Denise A.
Chan, Amato J. Giaccia, and Darren E. Richard
http://www.molbiolcell.org/cgi/content/abstract/21/18/3247?etoc

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REVIEWS
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Cell metabolism: An essential link between cell growth and apoptosis
Emily F. Mason and Jeffrey C. Rathmell
http://dx.doi.org/10.1016/j.bbamcr.2010.08.011

Glutamine addiction: a new therapeutic target in cancer
David R. Wise, Craig B. Thompson
http://dx.doi.org/10.1016/j.tibs.2010.05.003

The pivotal roles of mitochondria in cancer: Warburg and beyond and
encouraging prospects for effective therapies
Mathupala, Saroj P.; Ko, Young H.; Pedersen, Peter L.
http://dx.doi.org/10.1016/j.bbabio.2010.03.025

Metabolism and proliferation share common regulatory pathways in cancer cells
V Fritz and L Fajas
http://www.nature.com/onc/journal/v29/n31/full/onc2010182a.html

Reversible acetylation of PGC-1: connecting energy sensors and
effectors to guarantee metabolic flexibility
E H Jeninga, K Schoonjans and J Auwerx
http://www.nature.com/onc/journal/v29/n33/full/onc2010206a.html

The Mammalian Target of Rapamycin: Linking T Cell Differentiation,
Function, and Metabolism
J.D. Powell and G.M. Delgoffe
http://www.cell.com/immunity/abstract/S1074-7613%2810%2900325-0

—————————–
COMMENTS/OTHER
—————————–

Targeting dendritic cell metabolism in cancer
Laurence Zitvogel and Guido Kroemer
http://www.nature.com/nm/journal/v16/n8/full/nm0810-858.html

Profile of Gregg L. Semenza
Farooq Ahmed
http://www.pnas.org/content/107/33/14521.extract?etoc

Journal Club: A cancer biologist weighs up p53, metabolism and cancer.
Gerry Melino
http://www.nature.com/nature/journal/v466/n7309/full/466905d.html

Targeting the Core of Transcription
D. Grahame Hardie
http://www.sciencemag.org/cgi/content/full/329/5996/1158

The glucose signal and metabolic p[H+]lux
Eric M Rubenstein and Martin C Schmidt
http://www.nature.com/emboj/journal/v29/n15/full/emboj2010161a.html

Mapping downstream of the TORC1 complex
http://f1000biology.com/article/5xzsqrzlsgqxx0r/id/4546956/evaluation/sections

Looking Ahead to the Past
Michael B. Yaffe
http://stke.sciencemag.org/cgi/content/full/sigtrans;3/138/eg7

Gene-Associated AMPK
Nancy R. Gough
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;3/138/ec272?etoc

Glucose Metabolism Revisited
L. Bryan Ray
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;3/140/ec289?etoc

Cancer Metabolism: Is Glutamine Sweeter than Glucose?Weiqin Lu, Helene
Pelicano, Peng Huang

 

————————————–
cross-talk cell death / metabolism
————————————– 

Bcl-2 Regulates HIF-1α Protein Stabilization in Hypoxic Melanoma Cells
via the Molecular Chaperone HSP90
Daniela Trisciuoglio, Chiara Gabellini, Marianna Desideri, Elio
Ziparo, Gabriella Zupi, Donatella Del Bufalo
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011772

Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal
Tumor Cells through a Ca2+-De novo Ceramide-PP2A-Reactive Oxygen
Species–Dependent Signaling Pathway
Margaret A. Park, Clint Mitchell, Guo Zhang, Adly Yacoub, Jeremy
Allegood, Dieter Häussinger, Roland Reinehr, Andrew Larner, Sarah
Spiegel, Paul B. Fisher, Christina Voelkel-Johnson, Besim Ogretmen,
Steven Grant, and Paul Dent
http://cancerres.aacrjournals.org/cgi/content/abstract/70/15/6313

Lithium reduces apoptosis and autophagy after neonatal hypoxia–ischemia
Q Li, H Li, K Roughton, X Wang, G Kroemer, K Blomgren and C Zhu
http://www.nature.com/cddis/journal/v1/n7/full/cddis201033a.html

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