Metabolism and cancer articles: dec 2010-jan 2011

The Proapoptotic Function of Noxa in Human Leukemia Cells Is Regulated by the Kinase Cdk5 and by Glucose
X.H. Lowman, M.A. McDonnell, A. Kosloske, O.A. Odumade, C. Jenness, C.B. Karim, R. Jemmerson, and A. Kelekar
http://www.cell.com/molecular-cell/abstract/S1097-2765%2810%2900925-1

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
D. F. Egan, David B. Shackelford, Maria M. Mihaylova, Sara Gelino, Rebecca A. Kohnz, William Mair, Debbie S. Vasquez, Aashish Joshi, Dana M. Gwinn, Rebecca Taylor, John M. Asara, James Fitzpatrick, Andrew Dillin, Benoit Viollet, Mondira Kundu, Malene Hansen, and Reuben J. Shaw
http://www.sciencemag.org/cgi/content/abstract/331/6016/456

 

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Crosstalk metabolism-cell death

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AKT requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells
Jonathan L. Coloff, Emily F. Mason, Brian J. Altman, Valerie A. Gerriets, Tingyu Liu, Amanda N. Nichols, Yuxing Zhao, Jessica A. Wofford, Sarah R. Jacobs, Olga Ilkayeva, Sean P. Garrison, Gerard P. Zambetti, and Jeffrey C. Rathmell
http://www.jbc.org/cgi/content/abstract/M110.179101v1

Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition
C Ji, B Yang, Y-L Yang, S-H He, D-S Miao, L He and Z-G Bi
http://www.nature.com/onc/journal/v29/n50/full/onc2010379a.html

A role for mitochondria in NLRP3 inflammasome activation
Rongbin Zhou, Amir S. Yazdi, Philippe Menu & Jürg Tschopp
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature09663.html

Lucanthone: A novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis
Jennifer S. Carew, Claudia M. Espitia, Juan A. Esquivel, II, Devalingam Mahalingam, Kevin R. Kelly, Guru Reddy, Francis J. Giles, and Steffan T. Nawrocki
http://www.jbc.org/cgi/content/abstract/M110.151324v1

A role for mitochondria in NLRP3 inflammasome activation.
Zhou R, Yazdi AS, Menu P, Tschopp J.
http://www.nature.com/nature/journal/v469/n7329/full/nature09663.html

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AMPK / mTOR
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mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
Won Jun Oh, Chang -chih Wu, Sung Jin Kim, Valeria Facchinetti, Louis -André Julien, Monica Finlan, Philippe P Roux, Bing Su and Estela Jacinto
http://www.nature.com/emboj/journal/v29/n23/full/emboj2010271a.html

Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis
M D Lacher, R Pincheira, Z Zhu, B Camoretti-Mercado, M Matli, R S Warren and A F Castro
http://www.nature.com/onc/journal/v29/n50/full/onc2010393a.html

Pemetrexed Indirectly Activates the Metabolic Kinase AMPK in Human Carcinomas
Scott B. Rothbart, Alexandra C. Racanelli, and Richard G. Moran
Cancer Res 2010;70 10299-10309
http://cancerres.aacrjournals.org/cgi/content/abstract/70/24/10299

mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells
Jianyu Liu, Payton D. Stevens, and Tianyan Gao
J. Biol. Chem. published 22 December 2010, 10.1074/jbc.M110.183087
http://www.jbc.org/cgi/content/abstract/M110.183087v1

Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway
Ljubica Vucicevic, Maja Misirkic, Janjetovic Kristina, Urosh Vilimanovich, Emina Sudar, Esma Isenovic, Marko Prica, Ljubica Harhaji-Trajkovic, Tamara Kravic-Stevovic, Bumbasirevic Vladimir and Vladimir Trajkovic
http://www.landesbioscience.com/journals/autophagy/article/13851

E2F1 Regulates Cellular Growth by mTORC1 Signaling
Sebastian Real, Nathalie Meo-Evoli, Lilia Espada, Albert Tauler
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0016163

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Nutrients / Starvation / Hypoxia
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Amino acids activate mTOR complex 2 via PI3K/Akt signalling
Irantzu Tato, Ramon Bartrons, Francesc Ventura, and Jose Luis Rosa
http://www.jbc.org/cgi/content/abstract/M110.166991v1

Mechanisms involved in the coordinate regulation of the mammalian target of rapamycin complex 1 (mTORC1) by insulin and amino acids
Michael D. Dennis, Jamie I. Baum, Scot R. Kimball, and Leonard S. Jefferson
http://www.jbc.org/cgi/content/abstract/M110.209171v1

Downregulation of c-MYC Protein Levels Contributes to Cancer Cell Survival under Dual Deficiency of Oxygen and Glucose
Hiroaki Okuyama, Hiroko Endo, Tamaki Akashika, Kikuya Kato, and Masahiro Inoue
http://cancerres.aacrjournals.org/cgi/content/abstract/70/24/10213

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
Shomit Sengupta, Timothy R. Peterson, Mathieu Laplante, Stephanie Oh & David M. Sabatini
http://www.nature.com/nature/journal/v468/n7327/full/nature09584.html

Combinatorial Regulation of Neuroblastoma Tumor Progression by N-Myc and Hypoxia Inducible Factor HIF-1
Guoliang Qing, Nicolas Skuli, Patrick A. Mayes, Bruce Pawel, Daniel Martinez, John M. Maris, and M. Celeste Simon
http://cancerres.aacrjournals.org/cgi/content/abstract/70/24/10351

Ischemic preconditioning induces autophagy and limits necrosis in human recipients of fatty liver grafts, decreasing the incidence of rejection episodes
D Degli Esposti, M Sebagh, P Pham, M Reffas, C Poüs, C Brenner, D Azoulay and A Lemoine
http://www.nature.com/cddis/journal/v2/n1/full/cddis201089a.html

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Cancer metabolism
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Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
Rebecca Lock, Srirupa Roy, Candia M. Kenific, Judy S. Su, Eduardo Salas, Sabrina M. Ronen, and Jayanta Debnath
http://www.molbiolcell.org/cgi/content/abstract/22/2/165?etoc

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
M.E. Figueroa, O. Abdel-Wahab, C. Lu, P.S. Ward, J. Patel, A. Shih, Y. Li, N. Bhagwat, A. Vasanthakumar, H.F. Fernandez, M.S. Tallman, Z. Sun, K. Wolniak, J.K. Peeters, W. Liu, S.E. Choe, V.R. Fantin, E. Paietta, B. Löwenberg, J.D. Licht, L.A. Godley, R. Delwel, P.J.M. Valk, C.B. Thompson, R.L. Levine, and A. Melnick
http://www.cell.com/cancer-cell/abstract/S1535-6108%2810%2900483-6

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
W. Xu, H. Yang, Y. Liu, Y. Yang, P. Wang, S.-H. Kim, S. Ito, C. Yang, P. Wang, M.-T. Xiao, L.-x. Liu, W.-q. Jiang, J. Liu, J.-y. Zhang, B. Wang, S. Frye, Y. Zhang, Y.-h. Xu, Q.-y. Lei, K.-L. Guan, S.-m. Zhao, and Y. Xiong
http://www.cell.com/cancer-cell/abstract/S1535-6108(10)00527-1

Lactate Dehydrogenase B Is Critical for Hyperactive mTOR-Mediated Tumorigenesis
Xiaojun Zha, Fang Wang, Ying Wang, Shaozong He, Yanling Jing, Xueyan Wu, and Hongbing Zhang
Cancer Res 2011;71 13-18
http://cancerres.aacrjournals.org/cgi/content/abstract/71/1/13

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Physiological metabolism
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The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
Kathryn E. Wellen, Chao Lu, Anthony Mancuso, Johanna M.S. Lemons, Michael Ryczko, James W. Dennis, Joshua D. Rabinowitz, Hilary A. Coller, and Craig B. Thompson
http://genesdev.cshlp.org/cgi/content/abstract/24/24/2784

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
Daisuke Nakada, Thomas L. Saunders & Sean J. Morrison
http://www.nature.com/nature/journal/v468/n7324/full/nature09571.html

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
Sushma Gurumurthy, Stephanie Z. Xie, Brinda Alagesan, Judith Kim, Rushdia Z. Yusuf et al.
http://www.nature.com/nature/journal/v468/n7324/full/nature09572.html

The Pim protein kinases regulate energy metabolism and cell growth
Zanna Beharry, Sandeep Mahajan, Marina Zemskova, Ying-Wei Lin, Baby G. Tholanikunnel, Zuping Xia, Charles D. Smith, and Andrew S. Kraft
http://www.pnas.org/content/108/2/528.abstract?etoc

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Reviews
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The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes
A. J. Levine and A. M. Puzio-Kuter
http://www.sciencemag.org/cgi/content/abstract/330/6009/1340

Autophagy and Metabolism
J. D. Rabinowitz and E. White
http://www.sciencemag.org/cgi/content/abstract/330/6009/1344

Manufacturing Molecules Through Metabolic Engineering
Jay D. Keasling
http://www.sciencemag.org/cgi/content/abstract/330/6009/1355

mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu, Alejo Efeyan & David M. Sabatini
http://www.nature.com/nrm/journal/v12/n1/full/nrm3025.html

The regulation of autophagy – unanswered questions
Yongqiang Chen and Daniel J. Klionsky
http://jcs.biologists.org/cgi/content/abstract/124/2/161

Regulation of autophagy by ROS: physiology and pathology
Ruth Scherz-Shouval, Zvulun Elazar
http://dx.doi.org/10.1016/j.tibs.2010.07.007

Sugar-free approaches to cancer cell killing.
El Mjiyad N, Caro-Maldonado A, Ramírez-Peinado S, Muñoz-Pinedo C.
http://www.nature.com/onc/journal/v30/n3/full/onc2010466a.html

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Comments / Perspectives
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Metabolism strikes back: metabolic flux regulates cell signaling
Christian M. Metallo and Matthew G. Vander Heiden
http://genesdev.cshlp.org/cgi/content/abstract/24/24/2717

Why Starving Cells Eat Themselves
D. Grahame Hardie
http://www.sciencemag.org/cgi/content/summary/331/6016/410

Noxa: A Sweet Twist to Survival and More
A. Gimenez-Cassina and N.N. Danial
http://www.nature.com/cdd/journal/vaop/ncurrent/full/cdd2010152a.html

On Getting There from Here
Steven L. McKnight
http://www.sciencemag.org/cgi/content/abstract/330/6009/1338

Metabolism Is Not Boring
L. Bryan Ray
http://www.sciencemag.org/cgi/content/full/330/6009/1337

GlcNAc in Place of Glucose
Nancy R. Gough
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;3/153/ec391?etoc

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