Metabolism and cancer – Feb 2011

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Autophagy and metabolism
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Activated Ras requires autophagy to maintain oxidative metabolism and
tumorigenesis.
Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G,
Kamphorst JJ, Chen G, Lemmons JM, Karantza V, Coller HA, Dipaola RS,
Gelinas C, Rabinowitz JD, White E.
http://genesdev.cshlp.org/content/25/5/460.abstract

Spermidine and resveratrol induce autophagy by distinct pathways
converging on the acetylproteome
Eugenia Morselli, Guillermo Mariño, Martin V. Bennetzen, Tobias
Eisenberg, Evgenia Megalou, Sabrina Schroeder, Sandra Cabrera, Paule
Bénit, Pierre Rustin, Alfredo Criollo, Oliver Kepp, Lorenzo Galluzzi,
Shensi Shen, Shoaib Ahmad Malik, Maria Chiara Maiuri, Yoshiyuki Horio,
Carlos López-Otín, Jens S. Andersen, Nektarios Tavernarakis, Frank
Madeo, and Guido Kroemer
http://jcb.rupress.org/cgi/content/abstract/192/4/615?etoc

Autophagy is essential to suppress cell stress and to allow
BCR-Abl-mediated leukemogenesis.
Altman BJ, Jacobs SR, Mason EF, Michalek RD, Macintyre AN, Coloff JL,
Ilkayeva O, Jia W, He YW, Rathmell JC.
http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2010561a.html

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Metabolism and cell death
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Energy restriction-mimetic agents induce apoptosis in prostate cancer
cells, in part, through epigenetic activation of KLF6 tumor suppressor
gene expression
Chun-Han Chen, Po-Hsien Huang, Po-Chen Chiu, Mei-Chuan Chen,
Chih-Chien Chou, Dasheng Wang, Samuel K. Kulp, Che-Ming Teng, Qianben
Wang, and Ching-Shih Chen
http://www.jbc.org/cgi/content/abstract/M110.203240v1

p53 protects lung cancer cells against metabolic stress
Sinthupibulyakit, C; Ittarat, W; St Clair, WH; St Clair, DK
http://www.spandidos-publications.com/ijo/37/6/1575

Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis
and apoptosis resistance induced by Pten deficiency
Preeti Tandon, Catherine A. Gallo, Shikha Khatri, Jennifer F. Barger,
Hasmik Yepiskoposyan, and David R. Plas
http://www.pnas.org/content/108/6/2361.abstract?etoc

Glucose metabolism determines resistance of cancer cells to
bioenergetic crisis after cytochrome-c release
Heinrich J Huber, Heiko Dussmann, Seán M Kilbrid1, Markus Rehm &
Jochen H M Prehn
http://www.nature.com/msb/journal/v7/n1/full/msb20112.html

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Ischemia / hypoxia
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Chronic inhibition of pyruvate dehydrogenase in heart triggers an
adaptive metabolic response
Kari T. Chambers, Teresa C. Leone, Nandakumar Sambandam, Attila
Kovacs, Cory S. Wagg, Gary D. Lopaschuk, Brian N. Finck, and Daniel P.
Kelly
J. Biol. Chem. published 14 February 2011, 10.1074/jbc.M110.217349
http://www.jbc.org/cgi/content/abstract/M110.217349v1

C-Jun N-terminal kinase (JNK-1) confers protection against brief but
not extended ischemia during acute myocardial infarction.
Jianqin Wei, Weiwen Wang, Ines Chopra, Hui Fang Li, Christopher J.
Dougherty, Jennipher Adi, Nikhil Adi, Huilan Wang, and Keith A.
Webster
J. Biol. Chem. published 15 February 2011, 10.1074/jbc.M110.211334
http://www.jbc.org/cgi/content/abstract/M110.211334v1

Frataxin participates to the hypoxia-induced response in tumors
I Guccini, D Serio, I Condò, A Rufini, B Tomassini, A Mangiola, G
Maira, C Anile, D Fina, F Pallone, M P Mongiardi, A Levi, N Ventura, R
Testi and F Malisan
http://www.nature.com/cddis/journal/v2/n2/abs/cddis20115a.html?WT.ec_id=CDDIS-201102

Hypoxia increases Sirtuin 1 expression in a hypoxia inducible
factor-dependent manner
Rui Chen, Elhadji M. Dioum, Richard T. Hogg, Robert D. Gerard, and
Joseph A. Garcia
http://www.jbc.org/cgi/content/abstract/M110.175414v1

Differential sensitivity of HIF hydroxylation sites to hypoxia and
hydroxylase inhibitors
Ya-Min Tian, Kar Kheng Yeoh, Myung Kyu Lee, Tuula Eriksson, Benedikt
M. Kessler, Holger B. Kramer, Mariola J. Edelmann, Carsten Willam,
Christopher W. Pugh, Christopher J. Schofield, and Peter J. Ratcliffe
http://www.jbc.org/cgi/content/abstract/M110.211110v2

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Cellular metabolism
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Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic
Programs Are Essential for Effector and Regulatory CD4+ T Cell
Subsets.  Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, Maciver
NJ, Mason EF, Sullivan SA, Nichols AG, Rathmell JC.
http://www.jimmunol.org/content/early/2011/02/11/jimmunol.1003613.abstract

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes
tumor growth in human glioblastoma multiforme
Amparo Wolf, Sameer Agnihotri, Johann Micallef, Joydeep Mukherjee,
Nesrin Sabha, Rob Cairns, Cynthia Hawkins, and Abhijit Guha
http://jem.rupress.org/cgi/content/abstract/208/2/313?etoc

ER stress modulates cellular metabolism.
Wang X, Eno CO, Altman BJ, Zhu Y, Zhao G, Olberding KE, Rathmell JC, Li C.
http://www.biochemj.org/bj/imps/abs/BJ20101864.htm

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AMPK/mTOR
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim, Mondira Kundu, Benoit Viollet and Kun-Liang Guan
http://www.nature.com/ncb/journal/v13/n2/full/ncb2152.html

Identification of Aneuploidy-Selective Antiproliferation Compounds
Y.-C. Tang, B.R. Williams, J.J. Siegel, and A. Amon
http://www.cell.com/issue?pii=S0092-8674(11)X0004-1
[AICAR]

ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3β–Mediated
Phosphorylation of Rictor
Chien-Hung Chen, Tattym Shaikenov, Timothy R. Peterson, Rakhan
Aimbetov, Amangeldy K. Bissenbaev, Szu-Wei Lee, Juan Wu, Hui-Kuan Lin,
and Dos D. Sarbassov
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/161/ra10?etoc

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REVIEWS
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Regulation of cancer cell metabolism
Rob A. Cairns, Isaac S. Harris & Tak W. Mak
http://www.nature.com/nrc/journal/v11/n2/full/nrc2981.html

Regulation of intermediary metabolism by protein acetylation
Kun-Liang Guan, Yue Xiong
http://dx.doi.org/10.1016/j.tibs.2010.09.003

Survival of the fittest: metabolic adaptations in cancer
Marcelo J Berardi, Valeria R Fantin
http://dx.doi.org/10.1016/j.gde.2010.10.001

Hypoxia and energetic tumour metabolism
M Christiane Brahimi-Horn, Gregory Bellot, Jacques Pouysségur
http://dx.doi.org/10.1016/j.gde.2010.10.006

Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night
Robin Mathew, Eileen White
http://dx.doi.org/10.1016/j.gde.2010.12.008

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COMMENTS / OTHER
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AMPK and autophagy get connected
D Grahame Hardie
http://www.nature.com/emboj/journal/v30/n4/full/emboj201112a.html?WT.ec_id=EMBOJ-20110216

Metabolism: Choose your carbon source
http://www.nature.com/nrc/journal/v11/n2/full/nrc3009.html

AMPK-Dependent Phosphorylation of ULK1 Induces Autophagy
M. Zhao and D.J. Klionsky
http://www.cell.com/cell-metabolism/abstract/S1550-4131%2811%2900010-6

So Hungry I Could Eat Myself
L. Bryan Ray
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/158/ec33?etoc

Repair and Protect
Nancy R. Gough
By stimulating metabolic flux through the pentose phosphate pathway,
ATM promotes the production of nucleotides for DNA repair and limits
production of reactive oxygen species.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/159/ec35?etoc

Metabolomics: from small molecules to big ideas
Monya Baker
http://www.nature.com/nmeth/journal/v8/n2/full/nmeth0211-117.html

mTOR Signaling
Cofactor for Amino Acid Stimulation
Wei Wong
Inositol polyphosphate multikinase stabilizes the mTORC1 complex and
enhances amino acid–induced signaling.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/161/ec53?etoc

Meeting report:
Therapeutic targets in cancer cell metabolism and death
I Iaccarino and L M Martins
http://www.nature.com/cdd/journal/v18/n3/full/cdd2010174a.html?WT.ec_id=CDD-201103

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