Metabolism and cancer articles – march 2011

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Starvation / antiglycolytics
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Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1
Min Zheng, Yan-Hai Wang, Xiao-Nan Wu, Su-Qin Wu, Bao-Ju Lu, Meng-Qiu Dong, Hongbing Zhang, Peiqing Sun, Sheng-Cai Lin, Kun-Liang Guan and Jiahuai Han
http://www.nature.com/ncb/journal/v13/n3/full/ncb2168.html

Gcn4p-mediated transcriptional repression of ribosomal protein genes under amino-acid starvation
Yoo JinJoo, Jin-Ha Kim, Un-Beom Kang, Myeong-Hee Yu and Joon Kim
http://www.nature.com/emboj/journal/v30/n5/abs/emboj2010332a.html

The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish
Yme U. van der Velden, Liqin Wang, John Zevenhoven, Ellen van Rooijen, Maarten van Lohuizen, Rachel H. Giles, Hans Clevers, and Anna-Pavlina G. Haramis
http://www.pnas.org/content/108/11/4358.abstract?etoc

Starvation Induced Cell Death in Autophagy-Defective Yeast Mutants Is Caused by Mitochondria Dysfunction
Sho W. Suzuki, Jun Onodera, Yoshinori Ohsumi
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017412

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK
Libin Shang, She Chen, Fenghe Du, Shen Li, Liping Zhao, and Xiaodong Wang
http://www.pnas.org/content/108/12/4788.abstract?etoc

Implication of Snail in Metabolic Stress-Induced Necrosis
Cho Hee Kim, Hyun Min Jeon, Su Yeon Lee, Min Kyung Ju, Ji Young Moon, Hye Gyeong Park, Mi-Ae Yoo, Byung Tae Choi, Jong In Yook, Sung-Chul Lim, Song Iy Han, Ho Sung Kang
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018000

2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces Autophagy by Reactive Oxygen Species-Mediated Activation of the AMP-Activated Protein Kinase
Qilong Wang, Bin Liang, Najeeb A. Shirwany, Ming-Hui Zou
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017234

Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
C Algire, L Amrein, M Bazile, S David, M Zakikhani and M Pollak
http://www.nature.com/onc/journal/v30/n10/abs/onc2010483a.html

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Ischemia
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EndoG Links Bnip3-Induced Mitochondrial Damage and Caspase-Independent DNA Fragmentation in Ischemic Cardiomyocytes
Jisheng Zhang, Junmei Ye, Albert Altafaj, Maria Cardona, Núria Bahi, Marta Llovera, Xavier Cañas, Stuart A. Cook, Joan X. Comella, Daniel Sanchis
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017998

The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke
Jose C. Gomez-Sanchez, Maria Delgado-Esteban, Irene Rodriguez-Hernandez, Tomas Sobrino, Natalia Perez de la Ossa, Silvia Reverte, Juan P. Bolaños, Rogelio Gonzalez-Sarmiento, Jose Castillo, and Angeles Almeida
http://jem.rupress.org/cgi/content/abstract/208/3/429?etoc

miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes
Li Qian, Linda W. Van Laake, Yu Huang, Siyuan Liu, Michael F. Wendland, and Deepak Srivastava
http://jem.rupress.org/cgi/content/abstract/208/3/549?etoc

Blockade of electron transport during ischemia preserves bcl-2 and inhibits opening of the mitochondrial permeability transition pore
Qun Chen, Edward J. Lesnefsky
http://dx.doi.org/10.1016/j.febslet.2011.02.029

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Cross-talk apoptosis – metabolism
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Short-chain fatty acids induced autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death
Y Tang, Y Chen, H Jiang and D Nie
http://www.nature.com/cdd/journal/v18/n4/full/cdd2010117a.html

Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover
SRikka, M N Quinsay, R L Thomas, D A Kubli, X Zhang, A N Murphy and Å B Gustafsson
http://www.nature.com/cdd/journal/v18/n4/abs/cdd2010146a.html

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Cell metabolism
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Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance
Bavo Heeman, Chris Van den Haute, Sarah-Ann Aelvoet, Federica Valsecchi, Richard J. Rodenburg, Veerle Reumers, Zeger Debyser, Geert Callewaert, Werner J. H. Koopman, Peter H. G. M. Willems, and Veerle Baekelandt
http://jcs.biologists.org/cgi/content/abstract/124/7/1115

Assay of the Multiple Energy-Producing Pathways of Mammalian Cells
Barry R. Bochner, Mark Siri, Richard H. Huang, Shawn Noble, Xiang-He Lei, Paul A. Clemons, Bridget K. Wagner
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018147

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AMPK / mTOR
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Structure of mammalian AMPK and its regulation by ADP
Bing Xiao,1, 3 Matthew J. Sanders,2, 4, 3 Elizabeth Underwood,1, 3 Richard Heath,1, 3 Faith V. Mayer,2, 3 David Carmena,2 Chun Jing,1 Philip A. Walker,1 John F. Eccleston,1, 5 Lesley F. Haire,1 Peter Saiu,1, 4 Steven A. Howell,1 Rein Aasland,1, 4 Stephen R. Martin,1 David Carling2 & Steven J. Gamblin
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature09932.html

Activation of mTORC2 by Association with the Ribosome
V. Zinzalla, D. Stracka, W. Oppliger, and M.N. Hall
http://www.cell.com/abstract/S0092-8674%2811%2900128-0

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Cancer metabolism
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SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
L.W.S. Finley, A. Carracedo, J. Lee, A. Souza, A. Egia, J. Zhang, J. Teruya-Feldstein, P.I. Moreira, S.M. Cardoso, C.B. Clish, P.P. Pandolfi, and M.C. Haigis
http://www.cell.com/cancer-cell/abstract/S1535-6108%2811%2900085-7

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
Qian Sun, Xinxin Chen, Jianhui Ma, Haiyong Peng, Fang Wang, Xiaojun Zha, Yanan Wang, Yanling Jing, Hongwang Yang, Rongrong Chen, Long Chang, Yu Zhang, June Goto, Hiroaki Onda, Tong Chen, Ming-Rong Wang, Youyong Lu, Han You, David Kwiatkowski, and Hongbing Zhang http://www.pnas.org/content/108/10/4129.abstract?etoc

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
Peng Jiang, Wenjing Du, Xingwu Wang, Anthony Mancuso, Xiang Gao, Mian Wu and Xiaolu Yang
http://www.nature.com/ncb/journal/v13/n3/full/ncb2172.html

Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction
MColombi, K D Molle, D Benjamin, K Rattenbacher-Kiser, C Schaefer, C Betz, A Thiemeyer, U Regenass, M N Hall and C Moroni
http://www.nature.com/onc/journal/v30/n13/full/onc2010539a.html?WT.ec_id=ONC-201103

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REVIEWS / News and views
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Cell metabolism: An essential link between cell growth and apoptosis
Emily F. Mason, Jeffrey C. Rathmell
http://dx.doi.org/10.1016/j.bbamcr.2010.08.011

Glycolytic inhibition as a strategy for developing calorie restriction mimetics
Ingram, DK; Roth, GS
http://linkinghub.elsevier.com/retrieve/pii/S0531-5565(10)00447-X

Metabolism unhinged: IDH mutations in cancer
John R Prensner and Arul M Chinnaiyan
http://www.nature.com/nm/journal/v17/n3/full/nm0311-291.html?WT.ec_id=NM-201103

The Beclin 1 network regulates autophagy and apoptosis
R Kang, H J Zeh, M T Lotze and D Tang
http://www.nature.com/cdd/journal/v18/n4/full/cdd2010191a.html

p53 guards the metabolic pathway less travelled
Eyal Gottlieb
http://www.nature.com/ncb/journal/v13/n3/full/ncb2177.html

Autophagy: Regulation by Energy Sensing
A.J. Meijer and P. Codogno
http://www.cell.com/current-biology/abstract/S0960-9822%2811%2900170-9

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