Metabolism and cancer articles – may 2011

Metabolic stress

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
Ligia C. Gomes, Giulietta Di Benedetto and Luca Scorrano

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
Kathrin Zaugg, Yi Yao, Patrick T. Reilly, Karuppiah Kannan, Reza Kiarash, Jacqueline Mason, Ping Huang, Suzanne K. Sawyer, Benjamin Fuerth, Brandon Faubert, Tuula Kalliomäki, Andrew Elia, Xunyi Luo, Vincent Nadeem, David Bungard, Sireesha Yalavarthi, Joseph D. Growney, Andrew Wakeham, Yasmin Moolani, Jennifer Silvester, Annick You Ten, Walbert Bakker, Katsuya Tsuchihara, Shelley L. Berger, Richard P. Hill, Russell G. Jones, Ming Tsao, Murray O. Robinson, Craig B. Thompson, Guohua Pan, and Tak W. Mak

Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo
J.-H. Sheen, R. Zoncu, D. Kim, and D.M. Sabatini

Glucose deprivation is associated with Chk1 degradation through the ubiquitin–proteasome pathway and effective checkpoint response to replication blocks
Ae Jeong Kim, Hyun-Ju Kim, Hye Jin Jee, Naree Song, Minjee Kim, Yoe-Sik Bae, Jay H. Chung, Jeanho Yun

Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation
Yueguang Rong, Christina McPhee, Shuangshen Deng, Lei Huang, Lilian Chen, Mei Liu, Kirsten Tracy, Eric H. Baehreck, Li Yu, and Michael J. Lenardo

2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion.
Xi H, Kurtoglu M, Liu H, Wangpaichitr M, You M, Liu X, Savaraj N, Lampidis TJ.

IFI16 Induction by Glucose Restriction in Human Fibroblasts Contributes to Autophagy through Activation of the ATM/AMPK/p53 Pathway
Xin Duan, Larissa Ponomareva, Sudhakar Veeranki, Divaker Choubey

Cancer metabolism

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
Tzuling Cheng, Jessica Sudderth, Chendong Yang, Andrew R. Mullen, Eunsook S. Jin, José M. Matés, and Ralph J. DeBerardinis

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
W. Luo, H. Hu, R. Chang, J. Zhong, M. Knabel, R. O’Meally, R.N. Cole, A. Pandey, and G.L. Semenza

Posttranslational Modification of 6-phosphofructo-1-kinase as an Important Feature of Cancer Metabolism
Andreja Šmerc, Eva Sodja, Matic Legiša

Inhibition of alanine aminotransferase (ALAT) in silico and in vivo promotes mitochondrial metabolism to impair malignant growth
Gregor Beuster, Kim Zarse, Christoph Kaleta, Rene Thierbach, Michael Kiehntopf, Pablo Steinberg, Stefan Schuster, and Michael Ristow
J. Biol. Chem. published 3 May 2011, 10.1074/jbc.M110.205229

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes
L. Cai, B.M. Sutter, B. Li, and B.P. Tu


Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12
N Badiola, C Penas, A Miñano-Molina, B Barneda-Zahonero, R Fadó, G Sánchez-Opazo, J X Comella, J Sabriá, C Zhu, K Blomgren, C Casas and J Rodríguez-Alvarez

RTEF-1, an upstream gene of HIF-1α, accelerates recovery from Ischemia
Yi Jin, Jiaping Wu, Xiaoxiao Song, Qinhui Song, Brittany L. Cully, Angela Messmer-Blust, Ming Xu, Shi-Yin Foo, Anthony Rosenzweig, and Jian Li

The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia
Philippe Pasdois, Joanne E. Parker, Elinor J. Griffiths and Andrew P. Halestrap


Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death
B Kucejova, N E Sunny, A D Nguyen, R Hallac, X Fu, S Peña-Llopis, R P Mason, R J DeBerardinis, X-J Xie, R DeBose-Boyd, V D Kodibagkar, S C Burgess and J Brugarolas

Metabolic reprogramming by HIF-1 promotes the survival of bone marrow–derived angiogenic cells in ischemic tissue
Sergio Rey, Weibo Luo, Larissa A. Shimoda, and Gregg L. Semenza

A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia
Fanny Bouquet, Marielle Ousset, Denis Biard, Frédérique Fallone, Stéphanie Dauvillier, Philippe Frit, Bernard Salles, and Catherine Muller

Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells
D Trisciuoglio, C Gabellini, M Desideri, Y Ragazzoni, T De Luca, E Ziparo and D Del Bufalo


Autophagy in the Cellular Energetic Balance
R. Singh and A.M. Cuervo

Reciprocal influence of the p53 and the hypoxic pathways
A Sermeus and C Michiels

Targeting hypoxia in cancer therapy
William R. Wilson & Michael P. Hay

The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling
W van Veelen, S E Korsse, L van de Laar and M P Peppelenbosch

Special issue:
Bioenergetics of Cancer – Edited by Rodrigue Rossignol
Biochimica et Biophysica Acta (BBA) – Bioenergetics

• Oxidative phosphorylation in cancer cells
Giancarlo Solaini, Gianluca Sgarbi, Alessandra Baracca
• Post-transcriptional regulation of the mitochondrial H+-ATP synthase: A key regulator of the metabolic phenotype in cancer
Imke M. Willers, José M. Cuezva
• Choosing between glycolysis and oxidative phosphorylation: A tumor’s dilemma?
Caroline Jose, Nadège Bellance, Rodrigue Rossignol
• Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism
Arnaud Chevrollier, Dominique Loiseau, Pascal Reynier, Georges Stepien
• The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression
Rodrigo Diaz-Ruiz, Michel Rigoulet, Anne Devin
• Metabolic management of brain cancer
Thomas N. Seyfried, Michael A. Kiebish, Jeremy Marsh, Laura M. Shelton, Leanne C. Huysentruyt, Purna Mukherjee
• Mitochondrial proteases and cancer
Anne-Laure Bulteau, Aurelien Bayot
• Electron microscopy morphology of the mitochondrial network in gliomas and their vascular microenvironment
Gabriel Arismendi-Morillo
• Genetic insights into OXPHOS defect and its role in cancer
Dhyan Chandra, Keshav K. Singh
• Learning from oncocytic tumors: Why choose inefficient mitochondria?
Giuseppe Gasparre, Giovanni Romeo, Michela Rugolo, Anna Maria Porcelli
• Metabolomics for mitochondrial and cancer studies
Deepak Nagrath, Christine Caneba, Thasni Karedath, Nadege Bellance
• Role of obesity-associated dysfunctional adipose tissue in cancer: A molecular nutrition approach
Pedro L. Prieto-Hontoria, Patricia Pérez-Matute, Marta Fernández-Galilea, Matilde Bustos, J. Alfredo Martínez, María J. Moreno-Aliaga
• Approaches for targeting mitochondria in cancer therapy
Gerard G.M. D’Souza, Mayura A Wagle, Vaibhav Saxena, Anee Shah
• Bioactive food components, cancer cell growth limitation and reversal of glycolytic metabolism   Review Article
Jaap Keijer, Melissa Bekkenkamp-Grovenstein, Dini Venema, Yvonne E.M. Dommels
• Recent advances in apoptosis, mitochondria and drug resistance in cancer cells
Inthrani R. Indran, Grégory Tufo, Shazib Pervaiz, Catherine Brenner

News and views

Autophagy: Shaping the fate of mitochondria

Mitochondria unite to survive
Craig Blackstone and Chuang-Rung Chang

PK-M2 Makes Cells Sweeter on HIF1
D.A. Tennant

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