Metabolism and cancer articles – july 2011

Cancer metabolism

13C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression
S. Hu, A. Balakrishnan, R.A. Bok, B. Anderton, P.E.Z. Larson, S.J. Nelson, J. Kurhanewicz, D.B. Vigneron, and A. Goga

The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
Claire L. Green, Catherine M. Evans, Lu Zhao, Robert K. Hills, Alan K. Burnett, David C. Linch, and Rosemary E. Gale

Glucose, Not Glutamine, Is the Dominant Energy Source Required for Proliferation and Survival of Head and Neck Squamous Carcinoma Cells
Sandulache, VC; Ow, TJ; Pickering, CR; Frederick, MJ; Zhou, G; Fokt, I; Davis-Malesevich, M; Priebe, W; Myers, JN

Energy Metabolism in H460 Lung Cancer Cells: Effects of Histone Deacetylase Inhibitors
Nívea Dias Amoêdo, Mariana Figueiredo Rodrigues, Paula Pezzuto, Antonio Galina, Rodrigo Madeiro da Costa, Fábio Ceneviva Lacerda de Almeida, Tatiana El-Bacha, Franklin David Rumjanek

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent
Andrey Parkhitko, Faina Myachina, Tasha A. Morrison, Khadijah M. Hindi, Neil Auricchio, Magdalena Karbowniczek, J. Julia Wu, Toren Finkel, David J. Kwiatkowski, Jane J. Yu, and Elizabeth Petri Henske

Metabolic alterations in highly tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis
Yunfei Zhou, Yan Zhou, Takashi Shingu, Li Feng, Zhao Chen, Marcia Ogasawara, Michael J. Keating, Seiji Kondo, and Peng Huang

Cell metabolism

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Lewis Z. Shi, Ruoning Wang, Gonghua Huang, Peter Vogel, Geoffrey Neale, Douglas R. Green, and Hongbo Chi
HIF1α induction by mTOR represents a metabolic checkpoint for the differentiation of TH17 and Treg cells.

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
J.L. Yecies, H.H. Zhang, S. Menon, S. Liu, D. Yecies, A.I. Lipovsky, C. Gorgun, D.J. Kwiatkowski, G.S. Hotamisligil, C.-H. Lee, and B.D. Manning


A Low Carbohydrate, High Protein Diet Slows Tumor Growth and Prevents Cancer Initiation
Victor W. Ho, Kelvin Leung, Anderson Hsu, Beryl Luk, June Lai, Sung Yuan Shen, Andrew I. Minchinton, Dawn Waterhouse, Marcel B. Bally, Wendy Lin, Brad H. Nelson, Laura M. Sly, and Gerald Krystal

Ammonia-induced autophagy is independent of ULK1/ULK2 kinases
Heesun Cheong, Tullia Lindsten, Junmin Wu, Chao Lu, and Craig B. Thompson

Metabolic inhibitors

Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism
Yuhua Zhao, Hao Liu, Zixing Liu, Yan Ding, Susan P. LeDoux, Glenn L. Wilson, Richard Voellmy, Yifeng Lin, Wensheng Lin, Rita Nahta, Bolin Liu, Oystein Fodstad, Jieqing Chen, Yun Wu, Janet E. Price, and Ming Tan

Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment
Giuseppe Filomeni, Simone Cardaci, Ana Maria Da Costa Ferreira, Giuseppe Rotilio and Maria Rosa Ciriolo

Poly(ADP-Ribose) Polymerase Inhibition Synergizes with 5-Fluorodeoxyuridine but not 5-Fluorouracil in Ovarian Cancer Cells
Amelia M. Huehls, Jill M. Wagner, Catherine J. Huntoon, Liyi Geng, Charles Erlichman, Anand G. Patel, Scott H. Kaufmann, and Larry M. Karnitz

Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC.
Yamasaki T, Tran TA, Oz OK, Raj GV, Schwarz RE, Deberardinis RJ, Zhang X, Brugarolas J.

NF- B mediates a protective response in cancer cells treated with inhibitors of fatty acid synthase
Colleen R. M. Lemmon, Ju-Hyung Woo, Ellen Tully, Kathleen Wilsbach, and Edward Gabrielson

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1
Isaam Ben Sahra, Claire Regazzetti, Guillaume Robert, Kathiane Laurent, Yannick Le Marchand-Brustel, Patrick Auberger, Jean-François Tanti, Sophie Giorgetti-Peraldi, and Frédéric Bost


Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop
Antje S. Löffler, Sebastian Alers, Alexandra M. Dieterle, Hildegard Keppeler, Mirita Franz-Wachtel, Mondira Kundu, David G. Campbell, Sebastian Wesselborg, Dario R. Alessi and Björn Stork

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding
Elaine A. Dunlop, David K. Hunt, Hugo A. Acosta-Jaquez, Diane C. Fingar and Andrew R. Tee

Sei Yoshida, Sungki Hong, Tsukasa Suzuki, Shigeyuki Nada, Aristotle Mannar Mannan, Junying Wang, Masato Okada, Kun-Liang Guan, and Ken Inoki

Hypoxia / ischemia

Overcoming Hypoxia-Induced Apoptotic Resistance through Combinatorial Inhibition of GSK-3β and CDK1
Patrick A. Mayes, Nathan G. Dolloff, Colin J. Daniel, J. Judy Liu, Lori S. Hart, Kageaki Kuribayashi, Joshua E. Allen, David I.H. Jee, Jay F. Dorsey, Yingqiu Y. Liu, David T. Dicker, J. Martin Brown, Emma E. Furth, Peter S. Klein, Rosalie C. Sears, and Wafik S. El-Deiry

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
E L Bell, B M Emerling, S J H Ricoult and L Guarente

Adenosine kinase determines the degree of brain injury after ischemic stroke in mice
Hai-Ying Shen, Theresa A Lusardi, Rebecca L Williams-Karnesky, Jing-Quan Lan, David J Poulsen and Detlev Boison

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells ▶
Andrea Facciabene, Xiaohui Peng, Ian S. Hagemann, Klara Balint, Andrea Barchetti et al.

Caspase-mediated cleavage of RNA-binding protein HuR regulates c-Myc expression after hypoxic stress
Sudha Talwar, Junfei Jin, Brittany Carroll, Angen Liu, Boyd Marion Gillespie, and Viswanathan Palanisamy

miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia
Chad Siegel, Jun Li, Fudong Liu, Sharon E. Benashski, and Louise D. McCullough

Reviews / News and views
——————————————–Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients
C Lee and V D Longo

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction
Esteban N. Gurzov, Decio L. Eizirik

Extending Biochemical Databases by Metabolomic Surveys
Oliver Fiehn, Dinesh K. Barupal, and Tobias Kind

AMPK – ULK1 – Autophagy
Peter J. Roach



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