Metabolism and cancer articles – august 2011

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Metabolism and proliferation/cancer
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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer ▶
Richard Possemato, Kevin M. Marks, Yoav D. Shaul, Michael E. Pacold, Dohoon Kim, Kıvanç Birsoy, Shalini Sethumadhavan, Hin-Koon Woo, Hyun G. Jang, Abhishek K. Jha, Walter W. Chen, Francesca G. Barrett, Nicolas Stransky, Zhi-Yang Tsun, Glenn S. Cowley, Jordi Barretina, Nada Y. Kalaany, Peggy P. Hsu, Kathleen Ottina, Albert M. Chan, Bingbing Yuan, Levi A. Garraway, David E. Root, Mari Mino-Kenudson, Elena F. Brachtel, Edward M. Driggers & David M. Sabatini
http://www.nature.com/nature/journal/v476/n7360/full/nature10350.html

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase ▶
Christian Frezza, Liang Zheng, Ori Folger, Kartik N. Rajagopalan, Elaine D. MacKenzie, Livnat Jerby, Massimo Micaroni, Barbara Chaneton, Julie Adam, Ann Hedley, Gabriela Kalna, Ian P. M. Tomlinson, Patrick J. Pollard, Dave G. Watson, Ralph J. Deberardinis, Tomer Shlomi, Eytan Ruppin & Eyal Gottlieb
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10363.html

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation
Alexandra R. Grassian, Christian M. Metallo, Jonathan L. Coloff, Gregory Stephanopoulos, and Joan S. Brugge
http://genesdev.cshlp.org/cgi/content/abstract/25/16/1716

p53-Dependent Regulation of Mitochondrial Energy Production by the RelA Subunit of NF-B
Renée F. Johnson, Ini-Isabée Witzel, and Neil D. Perkins
http://cancerres.aacrjournals.org/cgi/content/abstract/71/16/5588

Inhibition of glycolytic enzymes mediated by pharmacologically activated p53: targeting Warburg effect to fight cancer
Joanna Zawacka-Pankau, Vera V. Grinkevich, Sabine Hunten, Fedor Nikulenkov, Angela Gluch, Hai Li, Martin Enge, Alexander Kel, and Galina Selivanova
http://www.jbc.org/cgi/content/abstract/M111.240812v1

Modulation of Glucose Transporter 1 (GLUT1) Expression Levels Alters Mouse Mammary Tumor Cell Growth In Vitro and In Vivo
Christian D. Young, Andrew S. Lewis, Michael C. Rudolph, Marisa D. Ruehle, Matthew R. Jackman, Ui J. Yun, Olesya Ilkun, Renata Pereira, E. Dale Abel, Steven M. Anderson
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023205

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Cell metabolism
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mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
T.R. Peterson, S.S. Sengupta, T.E. Harris, A.E. Carmack, S.A. Kang, E. Balderas, D.A. Guertin, K.L. Madden, A.E. Carpenter, B.N. Finck, and D.M. Sabatini
http://www.cell.com/abstract/S0092-8674%2811%2900709-4

Regulation of TFEB and V-ATPases by mTORC1
Samuel Peña-Llopis, Silvia Vega-Rubin-de-Celis, Jacob C Schwartz, Nicholas C Wolff, Tram Anh T Tran, Lihua Zou, Xian-Jin Xie, David R Corey and James Brugarolas
http://www.nature.com/emboj/journal/v30/n16/full/emboj2011257a.html

ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis
Houkai Li, Qingshu Meng, Fei Xiao, Shanghai Chen, Ying Du, Junjie Yu, Chunxia Wang and Feifan Guo
http://www.biochemj.org/bj/438/bj4380283.htm

Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival
C.H. Yi, H. Pan, J. Seebacher, I.-H. Jang, S.G. Hyberts, G.J. Heffron, M.G. Vander Heiden, R. Yang, F. Li, J.W. Locasale, H. Sharfi, B. Zhai, R. Rodriguez-Mias, H. Luithardt, L.C. Cantley, G.Q. Daley, J.M. Asara, S.P. Gygi, G. Wagner, C.-F. Liu, and J. Yuan
http://dx.doi.org/10.1016/j.cell.2011.06.050

Crystal structure of the Gtr1p–Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation
Rui Gong, Li Li, Yi Liu, Ping Wang, Huirong Yang, Ling Wang, Jingdong Cheng, Kun-Liang Guan, and Yanhui Xu
http://genesdev.cshlp.org/cgi/content/abstract/25/16/1668

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Metabolism-targeting drugs, starvation
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Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality
D. A. Chan, P. D. Sutphin, P. Nguyen, S. Turcotte, E. W. Lai, A. Banh, G. E. Reynolds, J.-T. Chi, J. Wu, D. E. Solow-Cordero, M. Bonnet, J. U. Flanagan, D. M. Bouley, E. E. Graves, W. A. Denny, M. P. Hay, A. J. Giaccia
http://stm.sciencemag.org/content/3/94/94ra70

Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
J Huelsenbeck, C Henninger, A Schad, K J Lackner, B Kaina and G Fritz
http://www.nature.com/cddis/journal/v2/n8/full/cddis201165a.html

The Chemotherapeutic Drug 5-Fluorouracil Promotes PKR-Mediated Apoptosis in a p53- Independent Manner in Colon and Breast Cancer Cells
María Angel García, Esther Carrasco, Margarita Aguilera, Pablo Alvarez, Carmen Rivas, Joaquin María Campos, Jose Carlos Prados, Miguel Angel Calleja, Mariano Esteban, Juan Antonio Marchal, Antonia Aránega
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023887

Auto-activation of cJUN by amino acid deprivation of hepatocellular carcinoma cells reveals a novel cJUN-mediated signaling pathway
Lingchen Fu, Mukundh Balasubramanian, Jixiu Shan, Elizabeth Dudenhausen, and Michael S. Kilberg
http://www.jbc.org/cgi/content/abstract/M111.277673v1

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Hypoxia / ischemia / oxidative stress
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Hypoxia Leads to Na,K-ATPase Downregulation via Ca2+ Release-Activated Ca2+ Channels and AMPK Activation
Galina A. Gusarova, Humberto E. Trejo, Laura A. Dada, Arturo Briva, Lynn C. Welch, Robert B. Hamanaka, Gökhan M. Mutlu, Navdeep S. Chandel, Murali Prakriya, and Jacob I. Sznajder
http://mcb.asm.org/cgi/content/abstract/31/17/3546

Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels
Paul T. Mungai, Gregory B. Waypa, Amit Jairaman, Murali Prakriya, Danijela Dokic, Molly K. Ball, and Paul T. Schumacker
http://mcb.asm.org/cgi/content/abstract/31/17/3531

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment
Alvaro Avivar-Valderas, Eduardo Salas, Ekaterina Bobrovnikova-Marjon, J. Alan Diehl, Chandandeep Nagi, Jayanta Debnath, and Julio A. Aguirre-Ghiso
http://mcb.asm.org/cgi/content/abstract/31/17/3616

p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death
Xi Feng, Xing Liu, Wei Zhang and Wuhan Xiao
http://www.nature.com/emboj/journal/v30/n16/full/emboj2011248a.html

Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia
M Neubert, D A Ridder, P Bargiotas, S Akira and M Schwaninger
http://www.nature.com/cdd/journal/v18/n9/full/cdd201129a.html

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Reviews / comments
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The Logic Linking Protein Acetylation and Metabolism
L. Guarente
http://www.sciencedirect.com/science/article/pii/S1550413111002695

From the urea cycle to autophagy: Alfred J. Meijer
Daniel J. Klionsky and Alfred J. Meijer
http://www.landesbioscience.com/journals/autophagy/article/15192/

AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation
Libin Shang and Xiaodong Wang
http://www.landesbioscience.com/journals/autophagy/article/15860/

Regulation of autophagy by lysosomal positioning
Viktor I. Korolchuk and David C. Rubinsztein
http://www.landesbioscience.com/journals/autophagy/article/15862/

Death by Acetylation
Nancy R. Gough
Reduction in acetyl-CoA and protein N-acetylation is one mechanism by which Bcl-xL exerts its antiapoptotic effect.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/187/ec231

Metabolism: Flexible flux
Using unbiased functional genomics and metabolomics methods, two groups have demonstrated the importance of the serine synthesis pathway for tumorigenesis.
http://www.nature.com/nrc/journal/v11/n9/full/nrc3128.html

Metabolic regulation by ERK
A novel role for ERK signalling in the regulation of PDH flux
http://www.nature.com/nrm/journal/v12/n9/full/nrm3179.html

Meeting the (N-Terminal) End with Acetylation
J.L. Andersen and S. Kornbluth
http://dx.doi.org/10.1016/j.cell.2011.07.024

 

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