Metabolism and cancer articles – august 2011

Metabolism and proliferation/cancer

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer ▶
Richard Possemato, Kevin M. Marks, Yoav D. Shaul, Michael E. Pacold, Dohoon Kim, Kıvanç Birsoy, Shalini Sethumadhavan, Hin-Koon Woo, Hyun G. Jang, Abhishek K. Jha, Walter W. Chen, Francesca G. Barrett, Nicolas Stransky, Zhi-Yang Tsun, Glenn S. Cowley, Jordi Barretina, Nada Y. Kalaany, Peggy P. Hsu, Kathleen Ottina, Albert M. Chan, Bingbing Yuan, Levi A. Garraway, David E. Root, Mari Mino-Kenudson, Elena F. Brachtel, Edward M. Driggers & David M. Sabatini

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase ▶
Christian Frezza, Liang Zheng, Ori Folger, Kartik N. Rajagopalan, Elaine D. MacKenzie, Livnat Jerby, Massimo Micaroni, Barbara Chaneton, Julie Adam, Ann Hedley, Gabriela Kalna, Ian P. M. Tomlinson, Patrick J. Pollard, Dave G. Watson, Ralph J. Deberardinis, Tomer Shlomi, Eytan Ruppin & Eyal Gottlieb

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation
Alexandra R. Grassian, Christian M. Metallo, Jonathan L. Coloff, Gregory Stephanopoulos, and Joan S. Brugge

p53-Dependent Regulation of Mitochondrial Energy Production by the RelA Subunit of NF-B
Renée F. Johnson, Ini-Isabée Witzel, and Neil D. Perkins

Inhibition of glycolytic enzymes mediated by pharmacologically activated p53: targeting Warburg effect to fight cancer
Joanna Zawacka-Pankau, Vera V. Grinkevich, Sabine Hunten, Fedor Nikulenkov, Angela Gluch, Hai Li, Martin Enge, Alexander Kel, and Galina Selivanova

Modulation of Glucose Transporter 1 (GLUT1) Expression Levels Alters Mouse Mammary Tumor Cell Growth In Vitro and In Vivo
Christian D. Young, Andrew S. Lewis, Michael C. Rudolph, Marisa D. Ruehle, Matthew R. Jackman, Ui J. Yun, Olesya Ilkun, Renata Pereira, E. Dale Abel, Steven M. Anderson

Cell metabolism

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
T.R. Peterson, S.S. Sengupta, T.E. Harris, A.E. Carmack, S.A. Kang, E. Balderas, D.A. Guertin, K.L. Madden, A.E. Carpenter, B.N. Finck, and D.M. Sabatini

Regulation of TFEB and V-ATPases by mTORC1
Samuel Peña-Llopis, Silvia Vega-Rubin-de-Celis, Jacob C Schwartz, Nicholas C Wolff, Tram Anh T Tran, Lihua Zou, Xian-Jin Xie, David R Corey and James Brugarolas

ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis
Houkai Li, Qingshu Meng, Fei Xiao, Shanghai Chen, Ying Du, Junjie Yu, Chunxia Wang and Feifan Guo

Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival
C.H. Yi, H. Pan, J. Seebacher, I.-H. Jang, S.G. Hyberts, G.J. Heffron, M.G. Vander Heiden, R. Yang, F. Li, J.W. Locasale, H. Sharfi, B. Zhai, R. Rodriguez-Mias, H. Luithardt, L.C. Cantley, G.Q. Daley, J.M. Asara, S.P. Gygi, G. Wagner, C.-F. Liu, and J. Yuan

Crystal structure of the Gtr1p–Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation
Rui Gong, Li Li, Yi Liu, Ping Wang, Huirong Yang, Ling Wang, Jingdong Cheng, Kun-Liang Guan, and Yanhui Xu

Metabolism-targeting drugs, starvation

Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality
D. A. Chan, P. D. Sutphin, P. Nguyen, S. Turcotte, E. W. Lai, A. Banh, G. E. Reynolds, J.-T. Chi, J. Wu, D. E. Solow-Cordero, M. Bonnet, J. U. Flanagan, D. M. Bouley, E. E. Graves, W. A. Denny, M. P. Hay, A. J. Giaccia

Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
J Huelsenbeck, C Henninger, A Schad, K J Lackner, B Kaina and G Fritz

The Chemotherapeutic Drug 5-Fluorouracil Promotes PKR-Mediated Apoptosis in a p53- Independent Manner in Colon and Breast Cancer Cells
María Angel García, Esther Carrasco, Margarita Aguilera, Pablo Alvarez, Carmen Rivas, Joaquin María Campos, Jose Carlos Prados, Miguel Angel Calleja, Mariano Esteban, Juan Antonio Marchal, Antonia Aránega

Auto-activation of cJUN by amino acid deprivation of hepatocellular carcinoma cells reveals a novel cJUN-mediated signaling pathway
Lingchen Fu, Mukundh Balasubramanian, Jixiu Shan, Elizabeth Dudenhausen, and Michael S. Kilberg

Hypoxia / ischemia / oxidative stress

Hypoxia Leads to Na,K-ATPase Downregulation via Ca2+ Release-Activated Ca2+ Channels and AMPK Activation
Galina A. Gusarova, Humberto E. Trejo, Laura A. Dada, Arturo Briva, Lynn C. Welch, Robert B. Hamanaka, Gökhan M. Mutlu, Navdeep S. Chandel, Murali Prakriya, and Jacob I. Sznajder

Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels
Paul T. Mungai, Gregory B. Waypa, Amit Jairaman, Murali Prakriya, Danijela Dokic, Molly K. Ball, and Paul T. Schumacker

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment
Alvaro Avivar-Valderas, Eduardo Salas, Ekaterina Bobrovnikova-Marjon, J. Alan Diehl, Chandandeep Nagi, Jayanta Debnath, and Julio A. Aguirre-Ghiso

p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death
Xi Feng, Xing Liu, Wei Zhang and Wuhan Xiao

Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia
M Neubert, D A Ridder, P Bargiotas, S Akira and M Schwaninger

Reviews / comments

The Logic Linking Protein Acetylation and Metabolism
L. Guarente

From the urea cycle to autophagy: Alfred J. Meijer
Daniel J. Klionsky and Alfred J. Meijer

AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation
Libin Shang and Xiaodong Wang

Regulation of autophagy by lysosomal positioning
Viktor I. Korolchuk and David C. Rubinsztein

Death by Acetylation
Nancy R. Gough
Reduction in acetyl-CoA and protein N-acetylation is one mechanism by which Bcl-xL exerts its antiapoptotic effect.;4/187/ec231

Metabolism: Flexible flux
Using unbiased functional genomics and metabolomics methods, two groups have demonstrated the importance of the serine synthesis pathway for tumorigenesis.

Metabolic regulation by ERK
A novel role for ERK signalling in the regulation of PDH flux

Meeting the (N-Terminal) End with Acetylation
J.L. Andersen and S. Kornbluth




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