Metabolism and cancer articles – september 2011

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Cancer metabolism
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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
Jason W Locasale, Alexandra R Grassian, Tamar Melman, Costas A Lyssiotis, Katherine R Mattaini, Adam J Bass, Gregory Heffron, Christian M Metallo, Taru Muranen, Hadar Sharfi, Atsuo T Sasaki, Dimitrios Anastasiou, Edouard Mullarky, Natalie I Vokes, Mika Sasaki, Rameen Beroukhim, Gregory Stephanopoulos, Azra H Ligon, Matthew Meyerson, Andrea L Richardson, Lynda Chin, Gerhard Wagner, John M Asara, Joan S Brugge, Lewis C Cantley and Matthew G Vander Heiden
http://www.nature.com/ng/journal/v43/n9/full/ng.890.html

The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels
W.-H. Tong, C. Sourbier, G. Kovtunovych, S.Y. Jeong, M. Vira, M. Ghosh, V.V. Romero, R. Sougrat, S. Vaulont, B. Viollet, Y.-S. Kim, S. Lee, J. Trepel, R. Srinivasan, G. Bratslavsky, Y. Yang, W.M. Linehan, and T.A. Rouault
http://www.cell.com/cancer-cell/abstract/S1535-6108%2811%2900268-6

E2F transcription factor-1 regulates oxidative metabolism
Emilie Blanchet, Jean-Sébastien Annicotte, Sylviane Lagarrigue, Victor Aguilar, Cyrielle Clapé, Carine Chavey, Vanessa Fritz, François Casas, Florence Apparailly, Johan Auwerx and Lluis Fajas
http://www.nature.com/ncb/journal/v13/n9/abs/ncb2309.html?lang=en

Oncogenic Stress Induced by Acute Hyper-Activation of Bcr-Abl Leads to Cell Death upon Induction of Excessive Aerobic Glycolysis
Michael A. Dengler, Annette M. Staiger, Matthias Gutekunst, Ute Hofmann, Malgorzata Doszczak, Peter Scheurich, Matthias Schwab, Walter E. Aulitzky, Heiko van der Kuip
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0025139

PPAR-delta Mediates a Ski-induced Shift from Glycolysis to Oxidative Energy Metabolism
Fang Ye, Helene Lemieux, Charles L. Hoppel, Richard W. Hanson, Parvin Hakimi, Colleen M. Croniger, Michelle Puchowicz, Vernon E. Anderson, Hisashi Fujioka, and Ed Stavnezer
http://www.jbc.org/cgi/content/abstract/M111.292029v1

Metabolic state of glioma stem cells and nontumorigenic cells
Erina Vlashi, Chann Lagadec, Laurent Vergnes, Tomoo Matsutani, Kenta Masui, Maria Poulou, Ruxandra Popescu, Lorenza Della Donna, Patrick Evers, Carmen Dekmezian, Karen Reue, Heather Christofk, Paul S. Mischel, and Frank Pajonk
http://www.pnas.org/content/108/38/16062.abstract?etoc

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect
Cen Zhang, Meihua Lin, Rui Wu, Xiaowen Wang, Bo Yang, Arnold J. Levine, Wenwei Hu, and Zhaohui Feng
http://www.pnas.org/content/108/39/16259.abstract?etoc

Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism
Anna N. Cvrljevic, David Akhavan, Min Wu, Paul Martinello, Frank B. Furnari, Amelia J. Johnston, Deliang Guo, Lisa Pike, Webster K. Cavenee, Andrew M. Scott, Paul S. Mischel, Nick J. Hoogenraad, and Terrance G. Johns
http://jcs.biologists.org/content/124/17/2938.abstract

PPAR  Mediates a Ski-induced Shift from Glycolysis to Oxidative Energy Metabolism
Fang Ye, Helene Lemieux, Charles L. Hoppel, Richard W. Hanson, Parvin Hakimi, Colleen M. Croniger, Michelle Puchowicz, Vernon E. Anderson, Hisashi Fujioka, and Ed Stavnezer
http://www.jbc.org/cgi/content/abstract/M111.292029v2

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Antimetabolites / starvation / ischemia
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2-deoxyglucose induces Noxa-dependent apoptosis in alveolar rhabdomyosarcoma
Silvia Ramírez-Peinado, Fermín Alcázar-Limones, Laura Lagares-Tena, Nadia El Mjiyad, Alfredo Caro-Maldonado, Oscar M Tirado, and Cristina Muñoz-Pinedo
http://cancerres.aacrjournals.org/cgi/content/abstract/0008-5472.CAN-11-0759v1

Efficient Elimination of Cancer Cells by Deoxyglucose-ABT-263/737 Combination Therapy
Ryuji Yamaguchi, Edith Janssen, Guy Perkins, Mark Ellisman, Shinichi Kitada, John C. Reed
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0024102

Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity
Manuela Polimeni, Claudia Voena, Joanna Kopecka, Chiara Riganti, Gianpiero Pescarmona, Amalia Bosia and Dario Ghigo
http://www.biochemj.org/bj/439/bj4390141.htm

Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated
[in yeast]
Lydia M. Castelli, Jennifer Lui, Susan G. Campbell, William Rowe, Leo A. H. Zeef, Leah E. A. Holmes, Nathaniel P. Hoyle, Jonathon Bone, Julian N. Selley, Paul F. G. Sims, and Mark P. Ashe
http://www.molbiolcell.org/content/22/18/3379.abstract?etoc

MondoA senses non-glucose sugars: regulation of TXNIP and the hexose transport curb
Carrie A. Stoltzman, Mohan R. Kaadige, Christopher W. Peterson, and Donald E. Ayer
http://www.jbc.org/cgi/content/abstract/M111.275503v1

Targeted killing of a mammalian cell based upon its specialized metabolic state
Peter B. Alexander, Jian Wang, and Steven L. McKnight
http://www.pnas.org/content/108/38/15828.abstract?etoc

Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy
Thomas Farkas, Mads Daugaard, and Marja Jaattela
http://www.jbc.org/cgi/content/abstract/M111.269134v1

Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress
X Liu and G Hajnóczky
http://www.nature.com/cdd/journal/v18/n10/full/cdd201113a.html

Intracellular zinc release-activated ERK-dependent GSK-3β–p53 and Noxa–Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury
C-L Lin, H-C Tseng, W-P Chen, M-J Su, K-M Fang, R-F Chen and M-L Wu
http://www.nature.com/cdd/journal/v18/n10/abs/cdd201180a.html

Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor
D Chauvier, S Renolleau, S Holifanjaniaina, S Ankri, M Bezault, L Schwendimann, C Rousset, R Casimir, J Hoebeke, M Smirnova, G Debret, A-P Trichet, Y Carlsson, X Wang, E Bernard, M Hébert, J-M Rauzier, S Matecki, A Lacampagne, P Rustin, J Mariani, H Hagberg, P Gressens, C Charriaut-Marlangue and E Jacotot
http://www.nature.com/cddis/journal/v2/n9/full/cddis201187a.html

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AMPK/mTOR
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Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer cells by a novel AMPK activator
Kuen-Haur Lee, En-Chi Hsu, Jih-Hwa Guh, Hsiao-Ching Yang, Dasheng Wang, Samuel K. Kulp, Charles L. Shapiro, and Ching-Shih Chen
http://www.jbc.org/cgi/content/abstract/M111.264598v1

The Liver Kinase B1 Is a Central Regulator of T Cell Development, Activation, and Metabolism.
Maciver NJ, Blagih J, Saucillo DC, Tonelli L, Griss T, Rathmell JC, Jones RG.
http://www.ncbi.nlm.nih.gov/pubmed/21930968

Acetylation of Yeast AMPK Controls Intrinsic Aging Independently of Caloric Restriction
J.-Y. Lu, Y.-Y. Lin, J.-C. Sheu, J.-T. Wu, F.-J. Lee, Y. Chen, M.-I. Lin, F.-T. Chiang, T.-Y. Tai, S.L. Berger, Y. Zhao, K.-S. Tsai, H. Zhu, L.-M. Chuang, and J.D. Boeke
http://www.cell.com/abstract/S0092-8674%2811%2900888-9

Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop
Y. Yang, D. Atasoy, H.H. Su, and S.M. Sternson
http://www.cell.com/abstract/S0092-8674%2811%2900882-8

Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors
T. De Raedt, Z. Walton, J.L. Yecies, D. Li, Y. Chen, C.F. Malone, O. Maertens, S.M. Jeong, R.T. Bronson, V. Lebleu, R. Kalluri, E. Normant, M.C. Haigis, B.D. Manning, K.-K. Wong, K.F. Macleod, and K. Cichowski
http://www.sciencedirect.com/science/article/pii/S1535610811003114

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile
Beatrice T. Wang, Gregory S. Ducker, Andrea J. Barczak, Rebecca Barbeau, David J. Erle, and Kevan M. Shokat
http://www.pnas.org/content/108/37/15201.abstract?etoc

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer
Joanna C. Chan, Katherine M. Hannan, Kim Riddell, Pui Yee Ng, Abigail Peck, Rachel S. Lee, Sandy Hung, Megan V. Astle, Megan Bywater, Meaghan Wall, Gretchen Poortinga, Katarzyna Jastrzebski, Karen E. Sheppard, Brian A. Hemmings, Michael N. Hall, Ricky W. Johnstone, Grant A. McArthur, Ross D. Hannan, Richard B. Pearson
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/188/ra56

Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and downregulation of p62/sequestosome 1
Shengbing Huang, Zhineng J. Yang, Chunrong Yu, and Frank A. Sinicrope
http://www.jbc.org/cgi/content/abstract/M111.297432v1

The Tumor Suppressive MicroRNA miR-218 Targets the mTOR Component Rictor and Inhibits AKT Phosphorylation in Oral Cancer
Atsushi Uesugi, Ken-ichi Kozaki, Tomohiko Tsuruta, Mayuko Furuta, Kei-ichi Morita, Issei Imoto, Ken Omura, and Johji Inazawa
http://cancerres.aacrjournals.org/cgi/content/abstract/71/17/5765

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Hypoxia
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Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival
Christian Frezza, Liang Zheng, Daniel A. Tennant, Dmitri B. Papkovsky, Barbara A. Hedley, Gabriela Kalna, David G. Watson, Eyal Gottlieb
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0024411

HDAC4 regulates HIF1α lysine acetylation and cancer cell response to hypoxia
Hao Geng, Chris T. Harvey, Janet Pittsenbarger, Qiong Liu, Tomasz M. Beer, Changhui Xue, and David Z. Qian
http://www.jbc.org/cgi/content/abstract/M111.257055v1

Analysis of Hypoxia and Hypoxia-Like States through Metabolite Profiling
Julie E. Gleason, David J. Corrigan, James E. Cox, Amit R. Reddi, Lauren A. McGinnis, Valeria C. Culotta
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0024741

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
Carmen Chak-Lui Wong, Daniele M. Gilkes, Huafeng Zhang, Jasper Chen, Hong Wei, Pallavi Chaturvedi, Stephanie I. Fraley, Chun-Ming Wong, Ui-Soon Khoo, Irene Oi-Lin Ng, Denis Wirtz, and Gregg L. Semenza
http://www.pnas.org/content/108/39/16369.abstract?etoc

Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression
Muhammad Zaeem Noman, Bassam Janji, Bozena Kaminska, Kris Van Moer, Sandrine Pierson, Piotr Przanowski, Stéphanie Buart, Guy Berchem, Pedro Romero, Fathia Mami-Chouaib, and Salem Chouaib
http://cancerres.aacrjournals.org/cgi/content/abstract/71/18/5976

Development of a Hypoxia Gene Expression Classifier with Predictive Impact for Hypoxic Modification of Radiotherapy in Head and Neck Cancer
Kasper Toustrup, Brita Singers Sørensen, Marianne Nordsmark, Morten Busk, Carsten Wiuf, Jan Alsner, and Jens Overgaard
http://cancerres.aacrjournals.org/cgi/content/abstract/71/17/5923

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Reviews / Comments
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Targeting cancer metabolism: a therapeutic window opens
Matthew G. Vander Heiden
http://www.nature.com/nrd/journal/v10/n9/full/nrd3504.html

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
Maria M. Mihaylova and Reuben J. Shaw
http://www.nature.com/ncb/journal/v13/n9/abs/ncb2329.html

AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function
D. Grahame Hardie
http://genesdev.cshlp.org/cgi/content/abstract/25/18/1895

AMP-activated protein kinase: also regulated by ADP?
D. Grahame Hardie, David Carling, Steven J. Gamblin
http://www.sciencedirect.com/science/article/pii/S0968000411000958

Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?
A Lemarie and S Grimm
http://www.nature.com/onc/journal/v30/n38/full/onc2011167a.html

ERK to Conserve Resources
Annalisa M. VanHook
ERK7 suppresses protein secretion in response to amino acid starvation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/192/ec271

Cell death: Linking metabolism to apoptotic sensitivity
BCL-XL suppresses acetyl CoA production to protect cells against apoptosis.
http://www.nature.com/nrm/journal/v12/n10/full/nrm3195.html

Removing a Metabolic Roadblock
Annalisa M. VanHook
ERK signaling alters flux through the tricarboxylic acid cycle to influence cell proliferation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/188/ec240

 

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