Metabolism and cancer articles – october 2011


Transformation / cancer metabolism

NF-κB controls energy homeostasis and metabolic adaptation by
upregulating mitochondrial respiration
Claudio Mauro, Shi Chi Leow, Elena Anso, Sonia Rocha, Anil K.
Thotakura, Laura Tornatore, Marta Moretti, Enrico De Smaele, Amer A.
Beg, Vinay Tergaonkar, Navdeep S. Chandel and Guido Franzoso

Involvement of mitophagy in oncogenic K-Ras-induced transformation:
Overcoming a cellular energy deficit from glucose deficiency
June-Hyung Kim, Hee Young Kim, Young-Kyoung Lee, Young-Sil Yoon, Wei
Guang Xu, Joon-Kee Yoon, Sung-E Choi, Young-Gyu Ko, Min-Jung Kim,
Su-Jae Lee, Hee-Jung Wang and Gyesoon Yoon

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4
is critical for energetics and growth of glycolytic tumors   OPEN
Renaud Le Floch, Johanna Chiche, Ibtissam Marchiq, Tanesha Naïken,
Karine Ilk, Clare M. Murray, Susan E. Critchlow, Danièle Roux,
Marie-Pierre Simon, and Jacques Pouysségur

Comparative metabolic flux profiling of melanoma cell lines: beyond
the Warburg effect
David A. Scott, Adam D. Richardson, Fabian V. Filipp, Christine A.
Knutzen, Gary G. Chiang, Ze’ev A. Ronai, Andrei L. Osterman, and
Jeffrey W. Smith
J. Biol. Chem. published 13 October 2011, 10.1074/jbc.M111.282046



starvation – anti-metabolic drugs – nutrient sensing


Class III PI-3-kinase activates phospholipase D in an amino
acid–sensing mTORC1 pathway
Mee-Sup Yoon, Guangwei Du, Jonathan M. Backer, Michael A. Frohman, and Jie Chen
In response to amino acid availability, the class III PI-3-kinase
hVps34 activates the phospholipase PLD and mTORC1 signaling to
regulate mammalian cell size.

Impaired autophagy due to constitutive mTOR activation sensitizes
TSC2-null cells to cell death under stress
Shukie Ng, You-Tong Wu, Bo Chen, Jing Zhou and Han-Ming Shen

Metabolic utilization of exogenous pyruvate by mutant p53 (R175H)
human melanoma cells promotes survival under glucose depletion
Chavez-Perez, Valery A.; Strasberg-Rieber, Mary; Rieber, Manuel

Shikonin and its analogs inhibit cancer cell glycolysis by targeting
tumor pyruvate kinase-M2
J Chen, J Xie, Z Jiang, B Wang, Y Wang and X Hu


Crosstalk metabolism-apoptosis

Bcl-xL regulates metabolic efficiency of neurons through interaction
with the mitochondrial F1FO ATP synthase
Kambiz N. Alavian, Hongmei Li, Leon Collis, Laura Bonanni, Lu Zeng,
Silvio Sacchetti, Emma Lazrove, Panah Nabili, Benjamin Flaherty,
Morven Graham, Yingbei Chen, Shanta M. Messerli, Maria A. Mariggio,
Christoph Rahner, Ewan McNay, Gordon C. Shore, Peter J. S. Smith, J.
Marie Hardwick and Elizabeth A. Jonas

Bcl-xL regulates mitochondrial energetics by stabilizing the inner
membrane potential
Ying-bei Chen, Miguel A. Aon, Yi-Te Hsu, Lucian Soane, Xinchen Teng,
J. Michael McCaffery, Wen-Chih Cheng, Bing Qi, Hongmei Li, Kambiz N.
Alavian, Margaret Dayhoff-Brannigan, Shifa Zou, Fernando J. Pineda,
Brian O’Rourke, Young H. Ko, Peter L. Pedersen, Leonard K. Kaczmarek,
Elizabeth A. Jonas, and J. Marie Hardwick


ULK1 inhibits the kinase activity of mTORC1 and cell proliferation
Chang Hwa Jung, Minchul Seo, Neil Michael Otto and Do-Hyung Kim

The AMPK stress response pathway mediates anoikis resistance through
inhibition of mTOR and suppression of protein synthesis.
Ng TL, Leprivier, G, Robertson MD, Chow C, Martin MJ, Laderoute KR,
Davicioni E, Triche TJ, Sorensen PH.

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway
A. Duran, R. Amanchy, J.F. Linares, J. Joshi, S. Abu-Baker, A.
Porollo, M. Hansen, J. Moscat, and M.T. Diaz-Meco

Rapamycin protects against dominant negative-HNF1A-induced apoptosis
in INS-1 cells
Angela M. Farrelly, Seán M. Kilbride, Caroline Bonner, Jochen H. M.
Prehn & Maria M. Byrne

Reviews / Comments

Mitochondrial elongation during autophagy: A stereotypical response to survive in difficult times
Ligia C. Gomes and Luca Scorrano

Appetite for destruction: the inhibition of glycolysis as a therapy
for tuberous sclerosis complex-related tumors
Alfredo Csibi and John Blenis

Hydrogen peroxide: a Jekyll and Hyde signalling molecule
D R Gough and T G Cotter

Gettin’ Hungry: Regulation of Cellular Starvation Response by
Translation Elongation Factor 1A : Evidence That Eukaryotic
Translation Elongation Factor 1A (eEF1A) Binds the Gcn2 Protein C
Terminus and Inhibits Gcn2 Activity

Metabolism: Letting glucose take hold
Daley and colleagues show that LIN28-mediated suppression of let-7
microRNAs activates the insulin–PI3K–mTOR pathway to regulate glucose
metabolism, connecting type 2 diabetes and cancer.

Tryptophan Fix
John F. Foley
A tumor-derived tryptophan metabolite activates the aryl hydrocarbon
receptor in an autocrine and paracrine manner to promote tumor

A New Link in the Chain from Amino Acids to mTORC1 Activation
C.G. Proud

Metabolic signals regulate SIRT1 expression
SIRT1 is a key metabolic regulator in response to nutrient
availability. Here, Chalkiadaki and Guarente comment on a report
published online this month in which J. Auwerx and colleagues show how
SIRT1 transcription is controlled by the antagonistic actions of CREB
and ChREBP in response to the energetic status of the cell.
Angeliki Chalkiadaki and Leonard Guarente

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