Metabolism and cancer articles – october 2011

 

——————————————————
Transformation / cancer metabolism
——————————————————

NF-κB controls energy homeostasis and metabolic adaptation by
upregulating mitochondrial respiration
Claudio Mauro, Shi Chi Leow, Elena Anso, Sonia Rocha, Anil K.
Thotakura, Laura Tornatore, Marta Moretti, Enrico De Smaele, Amer A.
Beg, Vinay Tergaonkar, Navdeep S. Chandel and Guido Franzoso
http://www.nature.com/ncb/journal/v13/n10/full/ncb2324.html

Involvement of mitophagy in oncogenic K-Ras-induced transformation:
Overcoming a cellular energy deficit from glucose deficiency
June-Hyung Kim, Hee Young Kim, Young-Kyoung Lee, Young-Sil Yoon, Wei
Guang Xu, Joon-Kee Yoon, Sung-E Choi, Young-Gyu Ko, Min-Jung Kim,
Su-Jae Lee, Hee-Jung Wang and Gyesoon Yoon
http://www.landesbioscience.com/journals/autophagy/article/16643/

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4
is critical for energetics and growth of glycolytic tumors   OPEN
ACCESS ARTICLE
Renaud Le Floch, Johanna Chiche, Ibtissam Marchiq, Tanesha Naïken,
Karine Ilk, Clare M. Murray, Susan E. Critchlow, Danièle Roux,
Marie-Pierre Simon, and Jacques Pouysségur
http://www.pnas.org/content/108/40/16663.abstract?etoc

Comparative metabolic flux profiling of melanoma cell lines: beyond
the Warburg effect
David A. Scott, Adam D. Richardson, Fabian V. Filipp, Christine A.
Knutzen, Gary G. Chiang, Ze’ev A. Ronai, Andrei L. Osterman, and
Jeffrey W. Smith
J. Biol. Chem. published 13 October 2011, 10.1074/jbc.M111.282046
http://www.jbc.org/cgi/content/abstract/M111.282046v1

 

————————————————————————-

starvation – anti-metabolic drugs – nutrient sensing

————————————————————————-

Class III PI-3-kinase activates phospholipase D in an amino
acid–sensing mTORC1 pathway
Mee-Sup Yoon, Guangwei Du, Jonathan M. Backer, Michael A. Frohman, and Jie Chen
In response to amino acid availability, the class III PI-3-kinase
hVps34 activates the phospholipase PLD and mTORC1 signaling to
regulate mammalian cell size.
http://jcb.rupress.org/cgi/content/abstract/jcb.201107033v1?etoc

Impaired autophagy due to constitutive mTOR activation sensitizes
TSC2-null cells to cell death under stress
Shukie Ng, You-Tong Wu, Bo Chen, Jing Zhou and Han-Ming Shen
http://www.landesbioscience.com/journals/autophagy/article/16681/

Metabolic utilization of exogenous pyruvate by mutant p53 (R175H)
human melanoma cells promotes survival under glucose depletion
Chavez-Perez, Valery A.; Strasberg-Rieber, Mary; Rieber, Manuel
http://www.landesbioscience.com/journals/cbt/article/16566/

Shikonin and its analogs inhibit cancer cell glycolysis by targeting
tumor pyruvate kinase-M2
J Chen, J Xie, Z Jiang, B Wang, Y Wang and X Hu
http://www.nature.com/onc/journal/v30/n42/full/onc2011137a.html?WT.ec_id=ONC-201110

 

—————————————————
Crosstalk metabolism-apoptosis
—————————————————-

Bcl-xL regulates metabolic efficiency of neurons through interaction
with the mitochondrial F1FO ATP synthase
Kambiz N. Alavian, Hongmei Li, Leon Collis, Laura Bonanni, Lu Zeng,
Silvio Sacchetti, Emma Lazrove, Panah Nabili, Benjamin Flaherty,
Morven Graham, Yingbei Chen, Shanta M. Messerli, Maria A. Mariggio,
Christoph Rahner, Ewan McNay, Gordon C. Shore, Peter J. S. Smith, J.
Marie Hardwick and Elizabeth A. Jonas
http://www.nature.com/ncb/journal/v13/n10/full/ncb2330.html

Bcl-xL regulates mitochondrial energetics by stabilizing the inner
membrane potential
Ying-bei Chen, Miguel A. Aon, Yi-Te Hsu, Lucian Soane, Xinchen Teng,
J. Michael McCaffery, Wen-Chih Cheng, Bing Qi, Hongmei Li, Kambiz N.
Alavian, Margaret Dayhoff-Brannigan, Shifa Zou, Fernando J. Pineda,
Brian O’Rourke, Young H. Ko, Peter L. Pedersen, Leonard K. Kaczmarek,
Elizabeth A. Jonas, and J. Marie Hardwick
http://jcb.rupress.org/cgi/content/abstract/jcb.201108059v1?etoc

———————-
AMPK/mTOR
———————-

ULK1 inhibits the kinase activity of mTORC1 and cell proliferation
Chang Hwa Jung, Minchul Seo, Neil Michael Otto and Do-Hyung Kim
http://www.landesbioscience.com/journals/autophagy/article/16660/

The AMPK stress response pathway mediates anoikis resistance through
inhibition of mTOR and suppression of protein synthesis.
Ng TL, Leprivier, G, Robertson MD, Chow C, Martin MJ, Laderoute KR,
Davicioni E, Triche TJ, Sorensen PH.
http://www.nature.com/cdd/journal/vaop/ncurrent/full/cdd2011119a.html

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway
A. Duran, R. Amanchy, J.F. Linares, J. Joshi, S. Abu-Baker, A.
Porollo, M. Hansen, J. Moscat, and M.T. Diaz-Meco
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900713-1

Rapamycin protects against dominant negative-HNF1A-induced apoptosis
in INS-1 cells
Angela M. Farrelly, Seán M. Kilbride, Caroline Bonner, Jochen H. M.
Prehn & Maria M. Byrne
http://www.springerlink.com/content/j72214451056k31p/fulltext.html

——————————–
Reviews / Comments
——————————–

Mitochondrial elongation during autophagy: A stereotypical response to survive in difficult times
Ligia C. Gomes and Luca Scorrano
http://www.landesbioscience.com/journals/autophagy/article/16771/

Appetite for destruction: the inhibition of glycolysis as a therapy
for tuberous sclerosis complex-related tumors
Alfredo Csibi and John Blenis
http://www.biomedcentral.com/1741-7007/9/69

Hydrogen peroxide: a Jekyll and Hyde signalling molecule
D R Gough and T G Cotter
http://www.nature.com/cddis/journal/v2/n10/abs/cddis201196a.html?WT.ec_id=CDDIS-201110

Gettin’ Hungry: Regulation of Cellular Starvation Response by
Translation Elongation Factor 1A : Evidence That Eukaryotic
Translation Elongation Factor 1A (eEF1A) Binds the Gcn2 Protein C
Terminus and Inhibits Gcn2 Activity
http://www.jbc.org/content/286/42/e99968.full?etoc

Metabolism: Letting glucose take hold
Daley and colleagues show that LIN28-mediated suppression of let-7
microRNAs activates the insulin–PI3K–mTOR pathway to regulate glucose
metabolism, connecting type 2 diabetes and cancer.
http://www.nature.com/nrc/journal/v11/n11/full/nrc3159.html?WT.ec_id=NRC-201111

Tryptophan Fix
John F. Foley
A tumor-derived tryptophan metabolite activates the aryl hydrocarbon
receptor in an autocrine and paracrine manner to promote tumor
progression.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/195/ec289

A New Link in the Chain from Amino Acids to mTORC1 Activation
C.G. Proud
http://www.sciencedirect.com/science/article/pii/S1097276511007155

Metabolic signals regulate SIRT1 expression
SIRT1 is a key metabolic regulator in response to nutrient
availability. Here, Chalkiadaki and Guarente comment on a report
published online this month in which J. Auwerx and colleagues show how
SIRT1 transcription is controlled by the antagonistic actions of CREB
and ChREBP in response to the energetic status of the cell.
Angeliki Chalkiadaki and Leonard Guarente
http://www.nature.com/embor/journal/v12/n10/full/embor2011179a.html

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: