Metabolism and cancer – december 2011

 

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Metabolic reprogramming
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The Transcription Factor Myc Controls Metabolic Reprogramming upon T
Lymphocyte Activation
R. Wang, C.P. Dillon, L.Z. Shi, S. Milasta, R. Carter, D. Finkelstein,
L.L. McCormick, P. Fitzgerald, H. Chi, J. Munger, and D.R. Green
http://www.cell.com/immunity/abstract/S1074-7613%2811%2900515-2

UCP2 regulates energy metabolism and differentiation potential of
human pluripotent stem cells
While studying metabolic fluxes in human pluripotent stem cells, this
paper reveals UCP2 as metabolic switch from glycolysis to OXPHOS,
facilitating early differentiation events.
Jin Zhang, Ivan Khvorostov, Jason S Hong, Yavuz Oktay, Laurent
Vergnes, Esther Nuebel, Paulin N Wahjudi, Kiyoko Setoguchi, Geng Wang,
Anna Do, Hea-Jin Jung, J Michael McCaffery, Irwin J Kurland, Karen
Reue, Wai-Nang P Lee, Carla M Koehler and Michael A Teitell
http://www.nature.com/emboj/journal/v30/n24/full/emboj2011401a.html

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Cancer metabolism
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Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species
Contributes to Cellular Antioxidant Responses
Dimitrios Anastasiou George Poulogiannis, John M. Asara, Matthew B.
Boxer, Jian-kang Jiang, Min Shen, Gary Bellinger, Atsuo T. Sasaki,
Jason W. Locasale, Douglas S. Auld, Craig J. Thomas, Matthew G. Vander
Heiden, Lewis C. Cantley
The glycolytic metabolism of cancers differs from normal tissues,
allowing tumor cells to survive under oxidative stress.
http://www.sciencemag.org/cgi/content/summary/334/6060/1278

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase
Kinase 1 Is Important for Cancer Metabolism
T. Hitosugi, J. Fan, T.-W. Chung, K. Lythgoe, X. Wang, J. Xie, Q. Ge,
T.-L. Gu, R.D. Polakiewicz, J.L. Roesel, G.Z. Chen, T.J. Boggon, S.
Lonial, H. Fu, F.R. Khuri, S. Kang, and J. Chen
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900891-4

Metabolomic Profiling Reveals Potential Markers and Bioprocesses
Altered in Bladder Cancer Progression
Nagireddy Putluri, Ali Shojaie, Vihas T. Vasu, Shaiju K. Vareed,
Srilatha Nalluri, Vasanta Putluri, Gagan Singh Thangjam, Katrin
Panzitt, Christopher T. Tallman, Charles Butler, Theodore R. Sana,
Steven M. Fischer, Gabriel Sica, Daniel J. Brat, Huidong Shi, Ganesh
S. Palapattu, Yair Lotan, Alon Z. Weizer, Martha K. Terris, Shahrokh
F. Shariat, George Michailidis, and Arun Sreekumar
http://cancerres.aacrjournals.org/cgi/content/abstract/71/24/7376

Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma
and spindle cell hemangioma in Ollier disease and Maffucci syndrome
Twinkal C Pansuriya, Ronald van Eijk, Pio d’Adamo, Maayke A J H van
Ruler, Marieke L Kuijjer, Jan Oosting, Anne-Marie Cleton-Jansen,
Jolieke G van Oosterwijk, Sofie L J Verbeke, Daniëlle Meijer, Tom van
Wezel, Karolin H Nord, Luca Sangiorgi, Berkin Toker, Bernadette
Liegl-Atzwanger, Mikel San-Julian, Raf Sciot, Nisha Limaye, Lars-Gunnar Kindblom, Soeren Daugaard, Catherine Godfraind, Laurence M
Boon, Miikka Vikkula, Kyle C Kurek, Karoly Szuhai, Pim J French & Judith V M G Bovée
http://www.nature.com/ng/journal/v43/n12/full/ng.1004.html

Ollier disease and Maffucci syndrome are caused by somatic mosaic
mutations of IDH1 and IDH2
M Fernanda Amary, Stephen Damato, Dina Halai, Malihe Eskandarpour,
Fitim Berisha, Fiona Bonar, Stan McCarthy, Valeria R Fantin, Kimberly
S Straley, Samira Lobo, Will Aston, Claire L Green, Rosemary E Gale, Roberto Tirabosco, Andrew Futreal, Peter Campbell, Nadege Presneau and Adrienne M Flanagan
http://www.nature.com/ng/journal/v43/n12/full/ng.994.html?

5-Hydroxymethylcytosine Is Strongly Depleted in Human Cancers but Its
Levels Do Not Correlate with IDH1 Mutations
Seung-Gi Jin, Yong Jiang, Runxiang Qiu, Tibor A. Rauch, Yinsheng Wang,
Gabriele Schackert, Dietmar Krex, Qiang Lu, and Gerd P. Pfeifer
http://cancerres.aacrjournals.org/cgi/content/abstract/71/24/7360

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AMPK / mTOR
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Chemical Genetic Screen for AMPKalpha2 Substrates Uncovers a Network
of Proteins Involved in Mitosis
Max R. Banko, Jasmina J. Allen, Bethany E. Schaffer, Erik W. Wilker,
Peiling Tsou, Jamie L. White, Judit Villén, Beatrice Wang, Sara R.
Kim, Kei Sakamoto, Steven P. Gygi, Lewis C. Cantley, Michael B. Yaffe,
Kevan M. Shokat, and Anne Brunet
http://www.cell.com/molecular-cell/fulltext/S1097-2765(11)00855-0

Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1)
inactivation is not reversed by restoring mitochondrial function
Klaas Romanino, Laetitia Mazelin, Verena Albert, Agnès
Conjard-Duplany, Shuo Lin, C. Florian Bentzinger, Christoph Handschin,
Pere Puigserver, Francesco Zorzato, Laurent Schaeffer, Yann-Gaël Gangloff, and Markus A. Rüegg
http://www.pnas.org/content/108/51/20808.abstract?etoc

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Starvation / hypoxia
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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of ?-ketoglutarate to citrate to support cell growth and viability
David R. Wise, Patrick S. Ward, Jessica E. S. Shay, Justin R. Cross, Joshua J. Gruber, Uma M. Sachdeva, Jesse M. Platt, Raymond G.
DeMatteo, M. Celeste Simon, and Craig B. Thompson
http://www.pnas.org/content/108/49/19611.abstract?etoc

Lysosomal Transmembrane Protein LAPTM4B Promotes Autophagy and Tolerance to Metabolic Stress in Cancer Cells
Yang Li, Qing Zhang, Ruiyang Tian, Qi Wang, Jean J. Zhao, J. Dirk
Iglehart, Zhigang Charles Wang, and Andrea L. Richardson
http://cancerres.aacrjournals.org/cgi/content/abstract/71/24/7481

Phosphorylation of Carbonic Anhydrase IX Controls Its Ability to
Mediate Extracellular Acidification in Hypoxic Tumors
Peter Ditte, Franck Dequiedt, Eliska Svastova, Alzbeta Hulikova, Anna
Ohradanova-Repic, Miriam Zatovicova, Lucia Csaderova, Juraj Kopacek,
Claudiu T. Supuran, Silvia Pastorekova, and Jaromir Pastorek
http://cancerres.aacrjournals.org/cgi/content/abstract/71/24/7558

Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: Functional analysis of p62 and autophagy in hypoxic neuronal cells
Fumito Tanabe, Kazunori Yone, Naoya Kawabata, Harutoshi Sakakima,
Fumiyo Matsuda, Yasuhiro Ishidou, Shingo Maeda, Masahiko Abematsu,
Setsuro Komiya and Takao Setoguchi
http://dx.doi.org/10.4161/auto.7.12.17892

The ubiquitin specific protease 19 (USP19) regulates the hypoxia inducible factor 1? (HIF-1?) during hypoxia
Mikael Altun, Bin Zhao, Kelly Velasco, Haiyin Liu, Gerco Hassink, Julia Paschke, Teresa Pereira, and Kristina Lindsten
http://www.jbc.org/cgi/content/abstract/M111.305615v1

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Miscellaneous
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The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid
Oxidation Independently of Changes in NAD+
Z. Gerhart-Hines, J.E. Dominy, Jr., S.M. Blättler, M.P. Jedrychowski,
A.S. Banks, J.-H. Lim, H. Chim, S.P. Gygi, and P. Puigserver
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900944-0

A novel role for protein kinase Gcn2 in yeast tolerance to
intracellular acid stress
Guillem Hueso, Rafael Aparicio Sanchis, Consuelo Montesinos, Silvia
Lorenz, José R. Murguía and Ramón Serrano
http://www.biochemj.org/bj/441/bj4410255.htm

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Reviews
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Special issue:
BBA Molecular and Cell Biology of Lipids Volume 1811, Issue 11,  Pages
635-1000, November 2011
Lipidomics and Imaging Mass Spectrometry
http://www.sciencedirect.com/science/issue/271996-1-s2.0-S1388198111X00094

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk,
Shortcuts, and Feedbacks
Sebastian Alers, Antje S. Löffler, Sebastian Wesselborg, and Björn Stork
http://mcb.asm.org/cgi/content/abstract/32/1/2

Regulation and function of ribosomal protein S6 kinase (S6K) within
mTOR signalling networks
Brian Magnuson, Bilgen Ekim and Diane C. Fingar
http://www.biochemj.org/bj/441/bj4410001.htm

HIF1? and HIF2?: sibling rivalry in hypoxic tumour growth and progression
Brian Keith, Randall S. Johnson & M. Celeste Simon
http://www.nature.com/nrc/journal/v12/n1/full/nrc3183.html

Metabolic Connections during Apoptotic Cell Engulfment
C.Z. Han and K.S. Ravichandran
http://www.cell.com/abstract/S0092-8674%2811%2901505-4

Understanding the central role of citrate in the metabolism of cancer cells
Philippe Icard, Laurent Poulain, Hubert Lincet
http://www.sciencedirect.com/science/article/pii/S0304419X11000552

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Comments – other
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T Cell Myc-tabolism
J.C. Rathmell
http://www.cell.com/immunity/abstract/S1074-7613%2811%2900509-7

Flicking the Warburg Switch-Tyrosine Phosphorylation of Pyruvate
Dehydrogenase Kinase Regulates Mitochondrial Activity in Cancer Cells
A. Schulze and J. Downward
http://www.cell.com/molecular-cell/abstract/S1097-2765%2811%2900943-9

Warburg Effect and Redox Balance
Robert B. Hamanaka Navdeep S. Chandel
A glycolytic enzyme maintains cellular redox homeostasis during
metabolic stress.
http://www.sciencemag.org/cgi/content/summary/334/6060/1219

Promoting Proliferation with Nuclear Pyruvate Kinase M2
Nancy R. Gough
Pyruvate kinase M2 interacts with nuclear ?-catenin to promote cell
proliferation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/202/ec337

Metabolism: Working around defective mitochondria
Sarah Seton-Rogers
http://www.nature.com/nrc/journal/v12/n1/full/nrc3201.html

Genetics: IDH mosaicism in enchondromatosis syndromes
Gemma K. Alderton
http://www.nature.com/nrc/journal/v12/n1/full/nrc3194.html?WT.ec_id=NRC-201201

Cancer Cell Vulnerability
L. Bryan Ray
The glycolytic metabolism of cancers differs from normal tissues,
allowing tumor cells to survive under oxidative stress.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/202/ec338

Adipocytes Fuel Tumor Growth at Metastatic Sites
Cancer Discovery December 2011;1:548
http://cancerdiscovery.aacrjournals.org/cgi/content/full/1/7/548

Human pluripotent stem cells decouple respiration from energy production
In human pluripotent stem cells, uncoupling protein 2 switches energy
metabolism from respiration to glycolysis preventing their premature
differentiation.
Ng Shyh-Chang, Yuxiang Zheng, Jason W Locasale and Lewis C Cantley
http://www.nature.com/emboj/journal/v30/n24/full/emboj2011436a.html

Meeting Report
Targeting PI3K/mTOR Signaling in Cancer
Brooke M. Emerling and Argun Akcakanat
http://cancerres.aacrjournals.org/cgi/content/abstract/71/24/7351

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