Metabolism and cancer – jan 2012

Cancer metabolism

Reductive carboxylation supports growth in tumour cells with defective mitochondria
Andrew R. Mullen, William W. Wheaton, Eunsook S. Jin, Pei-Hsuan Chen, Lucas B. Sullivan, Tzuling Cheng, Youfeng Yang, W. Marston Linehan, Navdeep S. Chandel & Ralph J. DeBerardinis

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells
A. Le, A.N. Lane, M. Hamaker, S. Bose, A. Gouw, J. Barbi, T. Tsukamoto, C.J. Rojas, B.S. Slusher, H. Zhang, L.J. Zimmerman, D.C. Liebler, R.J.C. Slebos, P.K. Lorkiewicz, R.M. Higashi, T.W.M. Fan, and C.V. Dang

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2
Tanupriya Contractor and Chris R. Harris

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway
W.A. Freed-Pastor, H. Mizuno, X. Zhao, A. Langerød, S.-H. Moon, R. Rodriguez-Barrueco, A. Barsotti, A. Chicas, W. Li, A. Polotskaia, M.J. Bissell, T.F. Osborne, B. Tian, S.W. Lowe, J.M. Silva, A.-L. Børresen-Dale, A.J. Levine, J. Bargonetti, and C. Prives

Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis
W.C. Zhang, N. Shyh-Chang, H. Yang, A. Rai, S. Umashankar, S. Ma, B.S. Soh, L.L. Sun, B.C. Tai, M.E. Nga, K.K. Bhakoo, S.R. Jayapal, M. Nichane, Q. Yu, D.A. Ahmed, C. Tan, W.P. Sing, J. Tam, A. Thirugananam, M.S. Noghabi, Y.H. Pang, H.S. Ang, P. Robson, P. Kaldis, R.A. Soo, S. Swarup, E.H. Lim, and B. Lim

Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase 1 and De novo Lipogenesis
Kristen E. N. Scott, Frances B. Wheeler, Amanda L. Davis, Michael J. Thomas, James M. Ntambi, Darren F. Seals, Steven J. Kridel

Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy
O. C. Andronesi, G. S. Kim, E. Gerstner, T. Batchelor, A. A. Tzika, V. R. Fantin, M. G. Heiden, A. G. Sorensen

Magnetic Resonance of 2-Hydroxyglutarate in IDH1-Mutated Low-Grade Gliomas
Adam Elkhaled, Llewellyn E. Jalbert, Joanna J. Phillips, Hikari A. I. Yoshihara, Rupa Parvataneni, Radhika Srinivasan, Gabriela Bourne, Mitchel S. Berger, Susan M. Chang, Soonmee Cha, and Sarah J. Nelson

Cell metabolism

Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells
Sergio L. Colombo, Miriam Palacios-Callender, Nanci Frakich, Saul Carcamo, Istvan Kovacs, Slavica Tudzarova, and Salvador Moncada

Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism
Alexandre Cassago, Amanda P. S. Ferreira, Igor M. Ferreira, Camila Fornezari, Emerson R. M. Gomes, Kai Su Greene, Humberto M. Pereira, Richard C. Garratt, Sandra M. G. Dias, and Andre L. B. Ambrosio


Functional Interaction between Responses to Lactic Acidosis and Hypoxia Regulates Genomic Transcriptional Outputs
Xiaohu Tang, Joseph E. Lucas, Julia Ling-Yu Chen, Gregory LaMonte, Jianli Wu, Michael Changsheng Wang, Constantinos Koumenis, and Jen-Tsan Chi

Hypoxia-inducible factor-1 (HIF-1) promotes LDL and VLDL uptake through inducing VLDLR under hypoxia
Guo Min Shen, Ying Ze Zhao, Ming Tai Chen, Feng Lin Zhang, Xiao Ling Liu, Yi Wang, Chang Zheng Liu, Jia Yu and Jun Wu Zhang

Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer
C C Cook, A Kim1, S Terao2,3, A Gotoh2,3 and M Higuchi



Surgical Stress Resistance Induced by Single Amino Acid Deprivation Requires Gcn2 in Mice
Wei Peng et al.

Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones
Helena Cimarosti, Emi Ashikaga, Nadia Jaafari, Laura Dearden, Philip Rubin, Kevin A Wilkinson and Jeremy M Henley

The combination of tephrosin with 2-deoxy-D-glucose enhances the cytotoxicity via accelerating ATP depletion and blunting autophagy in human cancer cells
Yunjin Choi and Jeong-Hyung Lee

Cross-talk apoptosis/ metabolism

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
Congcong He, 11 Michael C. Bassik,4, 12, 11 Viviana Moresi,5 Kai Sun,2, 6 Yongjie Wei,1, 2, 3 Zhongju Zou,1, 2, 3 Zhenyi An,1, 2 Joy Loh,7 Jill Fisher,4 Qihua Sun,1, 2 Stanley Korsmeyer,4, 13 Milton Packer,8 Herman I. May,2 Joseph A. Hill,2 Herbert W. Virgin,7 Christopher Gilpin,9 Guanghua Xiao,8 Rhonda Bassel-Duby,5 Philipp E. Scherer2, 6 & Beth Levine

Effect of dual inhibition of apoptosis and autophagy in prostate cancer.
Saleem A, Dvorzhinski D, Santanam U, Mathew R, Bray K, Stein M, White E, Dipaola RS.

Externalized glycolytic enzymes are novel, conserved, and early biomarkers of apoptosis
David S. Ucker, Mohit Raja Jain, Goutham Pattabiraman, Karol Palasiewicz, Raymond B. Birge, and Hong Li


Kinome-wide selectivity profiling of ATP-competitive mTOR (mammalian target of rapamycin) inhibitors and characterization of their binding kinetics
Qingsong Liu, Sivapriya Kirubakaran, Wooyoung Hur, Mario Niepel, Kenneth Westover, Carson C. Thoreen, Jinhua Wang, Jing Ni, Matthew P. Patricelli, Kurt Vogel, Steve Riddle, David L. Waller, Ryan Traynor, Takaomi Sanda, Zheng Zhao, Seong A. Kang, Jean Zhao, A. Thomas Look, Peter K. Sorger, David M. Sabatini, and Nathanael S. Gray

Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies
Mamta Gupta, Andrea E. Wahner Hendrickson, Seong Seok Yun, Jing Jing Han, Paula A. Schneider, Brian D. Koh, Mary J. Stenson, Linda E. Wellik, Jennifer C. Shing, Kevin L. Peterson, Karen S. Flatten, Allan D. Hess, B. Douglas Smith, Judith E. Karp, Sharon Barr, Thomas E. Witzig, and Scott H. Kaufmann

AMPK directly inhibits NDPK through a phosphoserine switch to maintain cellular homeostasis
Rob U. Onyenwoke, Lawrence J. Forsberg, Lucy Liu, Tyisha Williams, Oscar Alzate, and Jay E. Brenman
Nucleoside diphosphate kinase (NDPK) is a direct target of AMP-activated protein kinase (AMPK) and is inhibited by AMPK-mediated phosphorylation at a conserved serine residue. This serine residue in NDPK is mutated in neuroblastoma, making the enzyme constitutively active.


Cancer metabolism: current perspectives and future directions
Cristina Muñoz-Pinedo, Nadia El Mjiyad and Jean-Ehrland Ricci

Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice
Reuben J. Shaw, Lewis C. Cantley

Ceramide synthases at the centre of sphingolipid metabolism and biology
Thomas D. Mullen, Yusuf A. Hannun and Lina M. Obeid

The ATM protein kinase and cellular redox signaling: beyond the DNA damage response
Scott Ditch, Tanya T. Paull

Connecting Threads: Epigenetics and Metabolism
Sayako Katada, Axel Imhof, Paolo Sassone-Corsi

Metabolomics and cancer drug discovery: let the cells do the talking
Angelo D’Alessandro, Lello Zolla,

Comments / previews

Myc and Metabolism
The transcription factor Myc controls the metabolic changes required for the proliferation of activated T cells.;5/205/ec2

“Reversed” Krebs Cycle Can Feed Tumors

Power Surge: Supporting Cells ”Fuel” Cancer Cell Mitochondria
U.E. Martinez-Outschoorn, F. Sotgia, and M.P. Lisanti

Unraveling the Obesity-Cancer Connection
Gary Taubes
A growing body of research shows that insulin and a related hormone play a key role in fueling tumors. They also may be a link between obesity, diabetes, and cancer.

Cancer Prevention With a Diabetes Pill?
Gary Taubes
There is a caveat to the observational research linking use of the insulin-lowering drug metformin to a decrease in cancer incidence: Studies of this kind are incapable of establishing a causal relationship.

Ravenous for Glucose
Gary Taubes
Tumor cells can survive without oxygen and generate energy by a relatively inefficient process known as aerobic glycolysis. But researchers still don’t know which comes first: the metabolism change or the cancer.

Magnetic Resonance Metabolic Imaging of Glioma
Philippe Metellus and Dominique Figarella-Branger

AMPK Coordinates Nutrient Status with Cell Division

Ramping Up Mitosis: An AMPKα2-Regulated Signaling Network Promotes Mitotic Progression
A.M. Robitaille and M.N. Hall

SIRT1 Regulation-It Ain’t All NAD
L.C. Chao and P. Tontonoz

Bidirectional Dance of Glutamine
Ashkan Emadi





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