MetaboList – february 2012

Cancer metabolism

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type
M.O. Yuneva, T.W.M. Fan, T.D. Allen, R.M. Higashi, D.V. Ferraris, T. Tsukamoto, J.M. Matés, F.J. Alonso, C. Wang, Y. Seo, X. Chen, and J.M. Bishop

The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response
Laura Formentini, María Sánchez-Aragó, Laura Sánchez-Cenizo, and José M. Cuezva

Ornithine decarboxylase mRNA is stabilized in an mTORC1-dependent manner in Ras-transformed cells
Sofia Origanti, Shannon L. Nowotarski, Theresa D. Carr, Suzanne Sass Kuhn, Lan Xiao, Jian Ying Wang and Lisa M. Shantz

Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells
Laura Novellasdemunt, Mercè Obach, Lluís Millán Ariño, Anna Manzano, Francesc Ventura, Jose Luis Rosa, Albert Jordan, Àurea Navarro Sabate and Ramon Bartrons

Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors
Romain Boidot, Frédérique Végran, Aline Meulle, Aude Le Breton, Chantal Dessy, Pierre Sonveaux, Sarab Lizard-Nacol, and Olivier Feron

IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma
Rob A. Cairns, Javeed Iqbal, François Lemonnier, Can Kucuk, Laurence de Leval, Jean-Philippe Jais, Marie Parrens, Antoine Martin, Luc Xerri, Pierre Brousset, Li Chong Chan, Wing-Chung Chan, Philippe Gaulard, and Tak W. Mak

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
Sevin Turcan, Daniel Rohle, Anuj Goenka, Logan A. Walsh, Fang Fang, Emrullah Yilmaz, Carl Campos, Armida W. M. Fabius, Chao Lu, Patrick S. Ward,  Craig B. Thompson, Andrew Kaufman, Olga Guryanova, Ross Levine, Adriana Heguy, Agnes Viale, Luc G. T. Morris, Jason T. Huse, Ingo K. Mellinghoff & Timothy A. Chan

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression
Michael S. Goldberg and Phillip A. Sharp

Myc Posttranscriptionally Induces HIF1 Protein and Target Gene Expression in Normal and Cancer Cells
Megan R. Doe, Janice M. Ascano, Mandeep Kaur, and Michael D. Cole

Starvation / anti-metabolic drugs / ischemia / hypoxia

Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy
Changhan Lee, Lizzia Raffaghello, Sebastian Brandhorst, Fernando M. Safdie, Giovanna Bianchi, Alejandro Martin-Montalvo, Vito Pistoia, Min Wei, Saewon Hwang, Annalisa Merlino, Laura Emionite, Rafael de Cabo and Valter D. Longo

The combination of the novel glycolysis inhibitor 3-BrOP and rapamycin is effective against neuroblastoma.
Levy AG, Zage PE, Akers LJ, Ghisoli ML, Chen Z, Fang W, Kannan S, Graham T, Zeng L, Franklin AR, Huang P, Zweidler-McKay PA.

p85α SH2 Domain Phosphorylation by IKK Promotes Feedback Inhibition of PI3K and Akt in Response to Cellular Starvation
William C. Comb, Jessica E. Hutti, Patricia Cogswell, Lewis C. Cantley, and Albert S. Baldwin

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
Sarah J. Conley, Elizabeth Gheordunescu, Pramod Kakarala, Bryan Newman, Hasan Korkaya, Amber N. Heath, Shawn G. Clouthier, and Max S. Wicha

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia
Pei Wang, Yun-Feng Guan, Hui Du, Qi-Wei Zhai, Ding-Feng Su and Chao-Yu Miao

Crosstalk metabolism-cell death

Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state
Philipp Mergenthaler, Anja Kahl, Anne Kamitz, Vincent van Laak, Katharina Stohlmann, Susanne Thomsen, Heiko Klawitter, Ingo Przesdzing, Lars Neeb, Dorette Freyer, Josef Priller, Tony J. Collins, Dirk Megow, Ulrich Dirnagl, David W. Andrews, and Andreas Meisel

Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase
I Mor, R Carlessi, T Ast, E Feinstein and A Kimchi

Carbon monoxide modulates apoptosis by reinforcing oxidative metabolism in astrocytes: role of BCL-2
Sofia S. Almeida, Claudia S. F. Queiroga, Marcos F. Q. Sousa, Paula M. Alves, and Helena L. A. Vieira

BAD modulates counterregulatory responses to hypoglycemia and protective glucoprivic feeding.
Osundiji MA, Godes ML, Evans ML, Danial NN.

The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis
T L Ng, G Leprivier, M D Robertson, C Chow, M J Martin, K R Laderoute, E Davicioni, T J Triche and P H B Sorensen


The translational landscape of mTOR signalling steers cancer initiation and metastasis ▶
Andrew C. Hsieh, Yi Liu, Merritt P. Edlind, Nicholas T. Ingolia, Matthew R. Janes, Annie Sher, Evan Y. Shi, Craig R. Stumpf, Carly Christensen, Michael J. Bonham, Shunyou Wang, Pingda Ren, Michael Martin, Katti Jessen, Morris E. Feldman, Jonathan S. Weissman, Kevan M. Shokat, Christian Rommel & Davide Ruggero

TOR Signaling Regulates Ribosome and tRNA Synthesis via LAMMER/Clk and GSK-3 Family Kinases
Jaehoon Lee, Robyn D. Moir, Kerri B. McIntosh, and Ian M. Willis

A Sterol-Binding Protein Integrates Endosomal Lipid Metabolism with TOR Signaling and Nitrogen Sensing
[in yeast]
C.J. Mousley, P. Yuan, N.A. Gaur, K.D. Trettin, A.H. Nile, S.J. Deminoff, B.J. Dewar, M. Wolpert, J.M. Macdonald, P.K. Herman, A.G. Hinnebusch, and V.A. Bankaitis

Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK ▶
Yu-yi Lin, Samara Kiihl, Yasir Suhail, Shang-Yun Liu, Yi-hsuan Chou, Zheng Kuang, Jin-ying Lu, Chin Ni Khor, Chi-Long Lin, Joel S. Bader, Rafael Irizarry & Jef D. Boeke


Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase
Xueliang Gao, Haizhen Wang, Jenny J. Yang, Xiaowei Liu, Zhi-Ren Liu

PPARγ contributes to PKM2 and HK2 expression in fatty liver
Ganna Panasyuk, Catherine Espeillac, Céline Chauvin, Ludivine A. Pradelli, Yasuo Horie, Akira Suzuki, Jean-Sebastien Annicotte, Lluis Fajas, Marc Foretz, Francisco Verdeguer, Marco Pontoglio, Pascal Ferré, Jean-Yves Scoazec, Morris J. Birnbaum, Jean-Ehrland Ricci and Mario Pende


Metabolic pathways in T cell fate and function.
Gerriets VA, Rathmell JC.

Targeting glucose metabolism for cancer therapy
Robert B. Hamanaka and Navdeep S. Chandel

Regulation of TOR by small GTPases
Raúl V Durán and Michael N Hall

Hypoxia-Inducible Factors in Physiology and Medicine
G.L. Semenza

Oncogenic viruses and tumor glucose metabolism: like kids in a candy store.
Noch E, Khalili K.

The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention
Jeffrey M. Peters, Yatrik M. Shah & Frank J. Gonzalez

Cell signalling by reactive lipid species: new concepts and molecular mechanisms
Ashlee Higdon, Anne R. Diers, Joo Yeun Oh, Aimee Landar and Victor M. Darley-Usmar
In this BJ Signal review, Victor Darley-Usmar and colleagues discuss the potential role for modulation of cell signalling via covalent adduction of lipid oxidation products to nucleophilic sites on critical target proteins.


METabolic Adaptations in the Tumor MYCroenvironment
S.M. Davidson and M.G. Vander Heiden

Fasting Heightens Chemotherapy Benefits
By Hannah Waters

Glycine Decarboxylase Cleaves a ”Malignant” Metabolic Path to Promote Tumor Initiation
J.E. Dominy, F. Vazquez, and P. Puigserver

Metabolism: Context-specific metabolism

Select – Cancer Metabolism

Transcription: PKM2 as a protein kinase

Screening for Interactions
An RNAi-based screen reveals that the energy-sensing protein AMPK is acetylated by p300 and deacetylated by HDAC1.;5/211/ec52

Coupling Lipid and Amino Acid Metabolism
A lipid-binding protein in yeast integrates lipid and amino acid metabolism to establish growth or quiescence as appropriate.;5/213/ec65