MetaboList – february 2012

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Cancer metabolism
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The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type
M.O. Yuneva, T.W.M. Fan, T.D. Allen, R.M. Higashi, D.V. Ferraris, T. Tsukamoto, J.M. Matés, F.J. Alonso, C. Wang, Y. Seo, X. Chen, and J.M. Bishop
http://www.cell.com/cell-metabolism/abstract/S1550-4131(12)00002-2

The Mitochondrial ATPase Inhibitory Factor 1 Triggers a ROS-Mediated Retrograde Prosurvival and Proliferative Response
Laura Formentini, María Sánchez-Aragó, Laura Sánchez-Cenizo, and José M. Cuezva
http://www.cell.com/molecular-cell/abstract/S1097-2765%2812%2900049-4

Ornithine decarboxylase mRNA is stabilized in an mTORC1-dependent manner in Ras-transformed cells
Sofia Origanti, Shannon L. Nowotarski, Theresa D. Carr, Suzanne Sass Kuhn, Lan Xiao, Jian Ying Wang and Lisa M. Shantz
http://www.biochemj.org/bj/442/bj4420199.htm

Progestins activate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) in breast cancer cells
Laura Novellasdemunt, Mercè Obach, Lluís Millán Ariño, Anna Manzano, Francesc Ventura, Jose Luis Rosa, Albert Jordan, Àurea Navarro Sabate and Ramon Bartrons
http://www.biochemj.org/bj/442/bj4420345.htm

Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors
Romain Boidot, Frédérique Végran, Aline Meulle, Aude Le Breton, Chantal Dessy, Pierre Sonveaux, Sarab Lizard-Nacol, and Olivier Feron
http://cancerres.aacrjournals.org/cgi/content/abstract/72/4/939

IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma
Rob A. Cairns, Javeed Iqbal, François Lemonnier, Can Kucuk, Laurence de Leval, Jean-Philippe Jais, Marie Parrens, Antoine Martin, Luc Xerri, Pierre Brousset, Li Chong Chan, Wing-Chung Chan, Philippe Gaulard, and Tak W. Mak
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/119/8/1901

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
Sevin Turcan, Daniel Rohle, Anuj Goenka, Logan A. Walsh, Fang Fang, Emrullah Yilmaz, Carl Campos, Armida W. M. Fabius, Chao Lu, Patrick S. Ward,  Craig B. Thompson, Andrew Kaufman, Olga Guryanova, Ross Levine, Adriana Heguy, Agnes Viale, Luc G. T. Morris, Jason T. Huse, Ingo K. Mellinghoff & Timothy A. Chan
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10866.html

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression
Michael S. Goldberg and Phillip A. Sharp
http://jem.rupress.org/cgi/content/abstract/209/2/217?etoc

Myc Posttranscriptionally Induces HIF1 Protein and Target Gene Expression in Normal and Cancer Cells
Megan R. Doe, Janice M. Ascano, Mandeep Kaur, and Michael D. Cole
http://cancerres.aacrjournals.org/cgi/content/abstract/72/4/949

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Starvation / anti-metabolic drugs / ischemia / hypoxia
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Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy
Changhan Lee, Lizzia Raffaghello, Sebastian Brandhorst, Fernando M. Safdie, Giovanna Bianchi, Alejandro Martin-Montalvo, Vito Pistoia, Min Wei, Saewon Hwang, Annalisa Merlino, Laura Emionite, Rafael de Cabo and Valter D. Longo
http://stm.sciencemag.org/content/early/2012/02/06/scitranslmed.3003293

The combination of the novel glycolysis inhibitor 3-BrOP and rapamycin is effective against neuroblastoma.
Levy AG, Zage PE, Akers LJ, Ghisoli ML, Chen Z, Fang W, Kannan S, Graham T, Zeng L, Franklin AR, Huang P, Zweidler-McKay PA.
http://www.springerlink.com/content/63vn3wtlrq0575u1/fulltext.html

p85α SH2 Domain Phosphorylation by IKK Promotes Feedback Inhibition of PI3K and Akt in Response to Cellular Starvation
William C. Comb, Jessica E. Hutti, Patricia Cogswell, Lewis C. Cantley, and Albert S. Baldwin
http://www.sciencedirect.com/science/article/pii/S1097276512000524

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
Sarah J. Conley, Elizabeth Gheordunescu, Pramod Kakarala, Bryan Newman, Hasan Korkaya, Amber N. Heath, Shawn G. Clouthier, and Max S. Wicha
http://www.pnas.org/content/109/8/2784.abstract?etoc

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia
Pei Wang, Yun-Feng Guan, Hui Du, Qi-Wei Zhai, Ding-Feng Su and Chao-Yu Miao
http://www.landesbioscience.com/journals/autophagy/article/18274/

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Crosstalk metabolism-cell death
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Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state
Philipp Mergenthaler, Anja Kahl, Anne Kamitz, Vincent van Laak, Katharina Stohlmann, Susanne Thomsen, Heiko Klawitter, Ingo Przesdzing, Lars Neeb, Dorette Freyer, Josef Priller, Tony J. Collins, Dirk Megow, Ulrich Dirnagl, David W. Andrews, and Andreas Meisel
http://www.pnas.org/content/109/5/1518.abstract?etoc

Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase
I Mor, R Carlessi, T Ast, E Feinstein and A Kimchi
http://www.nature.com/onc/journal/v31/n6/full/onc2011264a.html

Carbon monoxide modulates apoptosis by reinforcing oxidative metabolism in astrocytes: role of BCL-2
Sofia S. Almeida, Claudia S. F. Queiroga, Marcos F. Q. Sousa, Paula M. Alves, and Helena L. A. Vieira
http://www.jbc.org/cgi/content/abstract/M111.306738v1

BAD modulates counterregulatory responses to hypoglycemia and protective glucoprivic feeding.
Osundiji MA, Godes ML, Evans ML, Danial NN.
http://www.ncbi.nlm.nih.gov/pubmed/22162752

The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis
T L Ng, G Leprivier, M D Robertson, C Chow, M J Martin, K R Laderoute, E Davicioni, T J Triche and P H B Sorensen
http://www.nature.com/cdd/journal/v19/n3/abs/cdd2011119a.html

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AMPK/mTOR
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The translational landscape of mTOR signalling steers cancer initiation and metastasis ▶
Andrew C. Hsieh, Yi Liu, Merritt P. Edlind, Nicholas T. Ingolia, Matthew R. Janes, Annie Sher, Evan Y. Shi, Craig R. Stumpf, Carly Christensen, Michael J. Bonham, Shunyou Wang, Pingda Ren, Michael Martin, Katti Jessen, Morris E. Feldman, Jonathan S. Weissman, Kevan M. Shokat, Christian Rommel & Davide Ruggero
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10912.html

TOR Signaling Regulates Ribosome and tRNA Synthesis via LAMMER/Clk and GSK-3 Family Kinases
Jaehoon Lee, Robyn D. Moir, Kerri B. McIntosh, and Ian M. Willis
http://www.cell.com/molecular-cell/abstract/S1097-2765(12)00084-6

A Sterol-Binding Protein Integrates Endosomal Lipid Metabolism with TOR Signaling and Nitrogen Sensing
[in yeast]
C.J. Mousley, P. Yuan, N.A. Gaur, K.D. Trettin, A.H. Nile, S.J. Deminoff, B.J. Dewar, M. Wolpert, J.M. Macdonald, P.K. Herman, A.G. Hinnebusch, and V.A. Bankaitis
http://www.sciencedirect.com/science/article/pii/S0092867412000232

Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK ▶
Yu-yi Lin, Samara Kiihl, Yasir Suhail, Shang-Yun Liu, Yi-hsuan Chou, Zheng Kuang, Jin-ying Lu, Chin Ni Khor, Chi-Long Lin, Joel S. Bader, Rafael Irizarry & Jef D. Boeke
http://www.nature.com/nature/journal/v482/n7384/full/nature10804.html

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Miscellaneous
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Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase
Xueliang Gao, Haizhen Wang, Jenny J. Yang, Xiaowei Liu, Zhi-Ren Liu
http://www.sciencedirect.com/science/article/pii/S1097276512000032

PPARγ contributes to PKM2 and HK2 expression in fatty liver
Ganna Panasyuk, Catherine Espeillac, Céline Chauvin, Ludivine A. Pradelli, Yasuo Horie, Akira Suzuki, Jean-Sebastien Annicotte, Lluis Fajas, Marc Foretz, Francisco Verdeguer, Marco Pontoglio, Pascal Ferré, Jean-Yves Scoazec, Morris J. Birnbaum, Jean-Ehrland Ricci and Mario Pende
http://www.nature.com/ncomms/journal/v3/n2/abs/ncomms1667.html

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Reviews
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Metabolic pathways in T cell fate and function.
Gerriets VA, Rathmell JC.
http://www.ncbi.nlm.nih.gov/pubmed/22342741

Targeting glucose metabolism for cancer therapy
Robert B. Hamanaka and Navdeep S. Chandel
http://jem.rupress.org/cgi/content/abstract/209/2/211?etoc

Regulation of TOR by small GTPases
Raúl V Durán and Michael N Hall
http://www.nature.com/embor/journal/v13/n2/full/embor2011257a.html

Hypoxia-Inducible Factors in Physiology and Medicine
G.L. Semenza
http://www.cell.com/fulltext/S0092-8674%2812%2900087-6

Oncogenic viruses and tumor glucose metabolism: like kids in a candy store.
Noch E, Khalili K.
http://mct.aacrjournals.org/content/11/1/14.long

The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention
Jeffrey M. Peters, Yatrik M. Shah & Frank J. Gonzalez
http://www.nature.com/nrc/journal/v12/n3/abs/nrc3214.html

Cell signalling by reactive lipid species: new concepts and molecular mechanisms
Ashlee Higdon, Anne R. Diers, Joo Yeun Oh, Aimee Landar and Victor M. Darley-Usmar
In this BJ Signal review, Victor Darley-Usmar and colleagues discuss the potential role for modulation of cell signalling via covalent adduction of lipid oxidation products to nucleophilic sites on critical target proteins.
http://www.biochemj.org/bj/442/bj4420453.htm

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Commments
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METabolic Adaptations in the Tumor MYCroenvironment
S.M. Davidson and M.G. Vander Heiden
http://www.sciencedirect.com/science/article/pii/S1550413112000095

Fasting Heightens Chemotherapy Benefits
By Hannah Waters
http://the-scientist.com/2012/02/08/fasting-heightens-chemotherapy-benefits/

Glycine Decarboxylase Cleaves a ”Malignant” Metabolic Path to Promote Tumor Initiation
J.E. Dominy, F. Vazquez, and P. Puigserver
http://www.cell.com/cancer-cell/abstract/S1535-6108%2812%2900049-9

Metabolism: Context-specific metabolism
http://www.nature.com/nrc/journal/v12/n3/full/nrc3234.html

Select – Cancer Metabolism
http://www.sciencedirect.com/science/article/pii/S0092867412000979

Transcription: PKM2 as a protein kinase
http://www.nature.com/nrm/journal/v13/n3/full/nrm3302.html

Screening for Interactions
An RNAi-based screen reveals that the energy-sensing protein AMPK is acetylated by p300 and deacetylated by HDAC1.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/211/ec52

Coupling Lipid and Amino Acid Metabolism
A lipid-binding protein in yeast integrates lipid and amino acid metabolism to establish growth or quiescence as appropriate.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/213/ec65

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