MetaboList – march 2012

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Cancer metabolism
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Deregulated MYC expression induces dependence upon AMPK-related kinase 5
Lidan Liu, Jannes Ulbrich, Judith Müller, Torsten Wüstefeld, Lukas Aeberhard, Theresia R. Kress, Nathiya Muthalagu, Lukas Rycak, Ramona Rudalska, Roland Moll, Stefan Kempa, Lars Zender, Martin Eilers & Daniel J. Murphy
 
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Chao Lu, Patrick S. Ward, Gurpreet S. Kapoor, Dan Rohle, Sevin Turcan, Omar Abdel-Wahab, Christopher R. Edwards, Raya Khanin, Maria E. Figueroa, Ari Melnick, Kathryn E. Wellen, Donald M. O’Rourke, Shelley L. Berger, Timothy A. Chan, Ross L. Levine, Ingo K. Mellinghoff & Craig B. Thompson
 
Mouse Genetics Suggests Cell-Context Dependency for Myc-Regulated Metabolic Enzymes during Tumorigenesis
Lisa M. Nilsson, Tacha Zi Plym Forshell, Sara Rimpi, Christiane Kreutzer, Walter Pretsch, Georg W. Bornkamm, Jonas A. Nilsson
 
Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia
Wan Zhang, Dunyaporn Trachootham, Jinyun Liu, Gang Chen, Helene Pelicano, Celia Garcia-Prieto, Weiqin Lu, Jan A. Burger, Carlo M. Croce, William Plunkett, Michael J. Keating and Peng Huang
 
Differential Expression of Metabolic Genes in Tumor and Stromal Components of Primary and Metastatic Loci in Pancreatic Adenocarcinoma
Nina V. Chaika, Fang Yu, Vinee Purohit, Kamiya Mehla, Audrey J. Lazenby, Dominick DiMaio, Judy M. Anderson, Jen Jen Yeh, Keith R. Johnson, Michael A. Hollingsworth, Pankaj K. Singh
 
Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells
Mayumi Tamada, Osamu Nagano, Seiji Tateyama, Mitsuyo Ohmura, Toshifumi Yae, Takatsugu Ishimoto, Eiji Sugihara, Nobuyuki Onishi, Takehiro Yamamoto, Hiroshi Yanagawa, Makoto Suematsu, and Hideyuki Saya
 
 
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AMPK / mTOR / Akt and metabolism
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Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice
Suchithra Menon, Jessica L. Yecies, Hui H. Zhang, Jessica J. Howell, Justin Nicholatos, Eylul Harputlugil, Roderick T. Bronson, David J. Kwiatkowski, Brendan D. Manning
Aberrant activation of the mammalian target of rapamycin complex 1 disrupts tissue homeostasis, leading to carcinogenesis.
 
Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
Dudley W. Lamming, Lan Ye, Pekka Katajisto, Marcus D. Goncalves, Maki Saitoh, Deanna M. Stevens, James G. Davis, Adam B. Salmon, Arlan Richardson, Rexford S. Ahima, David A. Guertin, David M. Sabatini, Joseph A. Baur
The effect of the drug rapamycin on life span can be separated from its effects on metabolism.
 
Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity
Ana Ortega-Molina, Alejo Efeyan, Elena Lopez-Guadamillas, Maribel Muñoz-Martin, Gonzalo Gómez-López, Marta Cañamero, Francisca Mulero, Joaquin Pastor, Sonia Martinez, Eduardo Romanos, M. Mar Gonzalez-Barroso, Eduardo Rial, Angela M. Valverde, James R. Bischoff, Manuel Serrano
 
Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State
I. Garcia-Cao, M.S. Song, R.M. Hobbs, G. Laurent, C. Giorgi, V.C.J. de Boer, D. Anastasiou, K. Ito, A.T. Sasaki, L. Rameh, A. Carracedo, M.G. Vander Heiden, L.C. Cantley, P. Pinton, M.C. Haigis, and P.P. Pandolfi
 
p85α SH2 Domain Phosphorylation by IKK Promotes Feedback Inhibition of PI3K and Akt in Response to Cellular Starvation
William C. Comb, Jessica E. Hutti, Patricia Cogswell, Lewis C. Cantley, Albert S. Baldwin
 
TOR Signaling Regulates Ribosome and tRNA Synthesis via LAMMER/Clk and GSK-3 Family Kinases
Jaehoon Lee, Robyn D. Moir, Kerri B. McIntosh, Ian M. Willis
 
The TOR Complex 1 Is a Direct Target of Rho1 GTPase
[in yeast]
G. Yan, Y. Lai, and Y. Jiang
 
Metabolic Control by S6 Kinases Depends on Dietary Lipids
Tamara R. Castañeda, William Abplanalp, Sung Hee Um, Paul T. Pfluger, Brigitte Schrott, Kimberly Brown, Erin Grant, Larissa Carnevalli, Stephen C. Benoit, Donald A. Morgan, Dean Gilham, David Y. Hui, Kamal Rahmouni, George Thomas, Sara C. Kozma, Deborah J. Clegg, Matthias H. Tschöp
 
PI3K/AKT/mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies Harboring PIK3CA Mutations
Filip Janku, Jennifer J. Wheler, Shannon N. Westin, Stacy L. Moulder, Aung Naing, Apostolia M. Tsimberidou, Siqing Fu, Gerald S. Falchook, David S. Hong, Ignacio Garrido-Laguna, Rajyalakshmi Luthra, J. Jack Lee, Karen H. Lu and Razelle Kurzrock
 
Therapeutic Trial of Metformin and Bortezomib in a Mouse Model of Tuberous Sclerosis Complex (TSC).
Auricchio N, Malinowska I, Shaw R, Manning BD, Kwiatkowski DJ.
 
Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
W-Y Shi, D Xiao, L Wang, L-H Dong, Z-X Yan, Z-X Shen, S-J Chen, Y Chen and W-L Zhao
 
Correspondence (metformin and ATM)
– The role of ATM in response to metformin treatment and activation of AMPK
Sook Wah Yee, Ligong Chen and Kathleen M Giacomini
– To the Editor
Angela Woods, James M Leiper and David Carling
– Zhou et al. reply
Kaixin Zhou, Celine Bellenguez, Calum Sutherland, Grahame Hardie, Colin Palmer, Peter Donnelly and Ewan Pearson
 
 
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Starvation / ischemia / hypoxia
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Cell-free reconstitution of vacuole membrane fragmentation reveals regulation of vacuole size and number by TORC1
Lydie Michaillat, Tonie Luise Baars, and Andreas Mayer
 
Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
Ana Luísa De Sousa Coelho, Pedro F. Marrero and Diego Haro
 
The unfolded protein response regulates an angiogenic response by the kidney epithelium during ischemic stress
Nicolas Bouvier, Sophie Fougeray, Philippe Beaune, Eric Thervet, and Nicolas Pallet
 
Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival
Nathalie M. Mazure, Joffrey Pelletier, Gregory Bellot, Pierre Gounon, Jacques Pouyssegur, and Sandra Lacas-Gervais
 
Re-oxygenation causes hypoxic tumor regression through restoration of p53 wild-type conformation and post-translational modifications
R Gogna, E Madan, P Kuppusamy and U Pati
 
FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice
L Goldberg, R Israeli and Y Kloog
 
 
 
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Lipids
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Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets
Anoop Kumar G. Velikkakath, Taki Nishimura, Eiko Oita, Naotada Ishihara, and Noboru Mizushima
 
Inhibition of fatty acid oxidation enhances oxidative protein folding and protects hepatocytes from endoplasmic reticulum stress
Heather M. Tyra, Douglas R. Spitz, and D. Thomas Rutkowski
 
Inhibitory effect of dietary lipids on chaperone-mediated autophagy
Jose Antonio Rodriguez-Navarro, Susmita Kaushik, Hiroshi Koga, Claudia Dall’Armi, Guanghou Shui, Markus R. Wenk, Gilbert Di Paolo, and Ana Maria Cuervo http://www.pnas.org/content/109/12/E705.abstract?etoc
 
 
 
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Miscellaneous
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Chronic expression of RCAN1-1L induces mitochondrial autophagy and a metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells
Gennady Ermak, Sonal Sojitra, Fei Yin, Enrique Cadenas, Ana Maria Cuervo, and Kelvin J. A. Davies
 
SIRT3 deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status
Wei Yu, Kristin E. Dittenhafer-Reed, and John M. Denu
 
 
 
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Reviews
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Metabolic Pathway Alterations that Support Cell Proliferation.
Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM, Locasale JW.
 
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Patrick S. Ward, Craig B. Thompson
 
Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?
R.J. DeBerardinis and C.B. Thompson
 
Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis
Dania Daye, Kathryn E. Wellen
 
AMPK: a nutrient and energy sensor that maintains energy homeostasis
D. Grahame Hardie, Fiona A. Ross & Simon A. Hawley
 
Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness
Anabela C Ferretti, Maria C Larocca, Cristian Favre
 
Innovation: Metabolomics: the apogee of the omics trilogy
Gary J. Patti, Oscar Yanes & Gary Siuzdak
 
A two-way street: reciprocal regulation of metabolism and signalling
Kathryn E. Wellen & Craig B. Thompson
 
Autophagy, Stress, and Cancer Metabolism: What Doesn’t Kill You Makes You Stronger.
Mathew R, White E.
 
MYC on the Path to Cancer
C.V. Dang
 
Mitochondrial redox signalling at a glance
Yvonne Collins, Edward T. Chouchani, Andrew M. James, Katja E. Menger, Helena M. Cochemé, and Michael P. Murphy
 
Respiratory chain complex I, a main regulatory target of the cAMP/PKA pathway is defective in different human diseases
Sergio Papa, Domenico De Rasmo, Zuzana Technikova-Dobrova, Damiano Panelli, Anna Signorile, Salvatore Scacco, Vittoria Petruzzella, Francesco Papa, Giuseppe Palmisano, Antonio Gnoni, Loris Micelli, Anna Maria Sardanelli
 
A role for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation?
Haitao Wen, Jenny P-Y Ting and Luke A J O’Neill
 
Endoplasmic Reticulum Stress, the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell Fate
Robert Clarke, Katherine L. Cook, Rong Hu, Caroline O.B. Facey, Iman Tavassoly, Jessica L. Schwartz, William T. Baumann, John J. Tyson, Jianhua Xuan, Yue Wang, Anni Wärri, and Ayesha N. Shajahan
 
Antioxidant and bioenergetic coupling between neurons and astrocytes
Seila Fernandez Fernandez, Angeles Almeida and Juan P. Bolaños
 
 
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Comments / perspectives
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Phospholipase D and mTORC1: Nutrients Are What Bring Them Together
Brian M. Wiczer and George Thomas
Activation of PLD1 by amino acids enables mTORC1 to respond to nutrient abundance.
 
Good neighbours in the tumour stroma reduce oxidative stress
Ralph J. DeBerardinis
 
Rapamycin Paradox Resolved
Katherine J. Hughes, Brian K. Kennedy
A small molecule acts through separate mechanisms to exert very different effects-extend mammalian life span or impair glucose homeostasis.
 
Negative Feedback Loops: Nutrient Starvation Employs a New tr(IKK) to Inhibit PI3K
Richard F. Lamb
 
PKM2 Enters the Morpheein Academy
G. Semenova and J. Chernoff
 
PKM2 Moonlights as a Protein Kinase
Pyruvate kinase M2 phosphorylates the transcription factor STAT3.
 
Linking Aberrant Metabolism to Oncogenesis
Elizabeth M. Adler
Three papers explore the relationship between isocitrate dehydrogenase (IDH) mutation and glioma, with two implicating mutant IDH in aberrant methylation and the third linking (R)-2-hydroxyglutarate to degradation of hypoxia-inducible factor.
 
 
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Other
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– Science webinar, “Metabolic Changes in Cancer: Beyond the Warburg Effect.”
Matthew Vander Heiden, Morris J. Birnbaum, Brendan Manning
 
– HypoxiaNet WG meeting in Bilbao, Spain, 18.-20.04.2012
http://www.hypoxia.es/ now open for registration
 
– Angiogenesis, Metabolic Regulation, and Cancer Biology in association with VIB
July 6 – 8, 2012. Katholieke Universiteit, Leuven, Belgium

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