MetaboList – April 2012

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Cancer metabolism
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Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
H. Ying, A.C. Kimmelman, C.A. Lyssiotis, S. Hua, G.C. Chu, E. Fletcher-Sananikone, J.W. Locasale, J. Son, H. Zhang, J.L. Coloff, H. Yan, W. Wang, S. Chen, A. Viale, H. Zheng, J.-h. Paik, C. Lim, A.R. Guimaraes, E.S. Martin, J. Chang, A.F. Hezel, S.R. Perry, J. Hu, B. Gan, Y. Xiao, J.M. Asara, R. Weissleder, Y.A. Wang, L. Chin, L.C. Cantley, and R.A. DePinho
http://www.sciencedirect.com/science/article/pii/S0092867412003522

Functional Metabolic Screen Identifies 6-Phosphofructo-2-Kinase/

Fructose-2,6-Biphosphatase 4 as an Important Regulator of Prostate Cancer Cell Survival
Susana Ros, Claudio R. Santos, Sofia Moco, Franziska Baenke, Gavin Kelly, Michael Howell, Nicola Zamboni, and Almut Schulze
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/2/4/328

Glucose Oxidation Modulates Anoikis and Tumor Metastasis
Sushama Kamarajugadda, Lauren Stemboroski, Qingsong Cai, Nicholas E. Simpson, Sushrusha Nayak, Ming Tan and Jianrong Lu
http://mcb.asm.org/content/early/2012/03/14/MCB.06248-11.abstract

A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells
Shuai Jiang, Ling-Fei Zhang, Hong-Wei Zhang, Song Hu, Ming-Hua Lu, Sheng Liang, Biao Li, Yong Li, Dangsheng Li, En-Duo Wang and Mo-Fang Liu
http://www.nature.com/emboj/journal/v31/n8/full/emboj201245a.html

1H NMR metabolomics analysis of glioblastoma subtypes: correlation between metabolomics and gene expression characteristics
Miroslava Cuperlovic-Culf, Dean Ferguson, Adrian Culf, Pier Jr Morin, and Mohamed Touaibia
http://www.jbc.org/cgi/content/abstract/M111.337196v1

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Hypoxia / Ischemia
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Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma
Yu-Long Hu, Michael DeLay, Arman Jahangiri, Annette M. Molinaro, Samuel D. Rose, W. Shawn Carbonell, and Manish K. Aghi
http://cancerres.aacrjournals.org/cgi/content/abstract/72/7/1773

Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis
J C Estrada, C Albo, A Benguría, A Dopazo, P López-Romero, L Carrera-Quintanar, E Roche, E P Clemente, J A Enríquez, A Bernad and E Samper
http://www.nature.com/cdd/journal/v19/n5/abs/cdd2011172a.html

Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning
Rui Sheng, Xiao-Qian Liu, Li-Sha Zhang, Bo Gao, Rong Han, Ying-Qiu Wu, Xiang-Yang Zhang and Zheng-Hong Qin
http://dx.doi.org/10.4161/auto.18673

Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells
R Elanchezhian, P Palsamy, C J Madson, M L Mulhern, D W Lynch, A M Troia, J Usukura and T Shinohara
http://www.nature.com/cddis/journal/v3/n4/abs/cddis201240a.html

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Nutrient sensing, starvation
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Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway
J.M. Han, S.J. Jeong, M.C. Park, G. Kim, N.H. Kwon, H.K. Kim, S.H. Ha, S.H. Ryu, and S. Kim
http://www.cell.com/abstract/S0092-8674(12)00282-6

Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex
G. Bonfils, M. Jaquenoud, S. Bontron, C. Ostrowicz, C. Ungermann, and C. De Virgilio
http://www.cell.com/molecular-cell/abstract/S1097-2765(12)00166-9

Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress
In Hye Lee, Yoshichika Kawai, Maria M. Fergusson, Ilsa I. Rovira, Alexander J. R. Bishop2, Noboru Motoyama, Liu Cao, Toren Finkel
http://www.sciencemag.org/cgi/content/summary/336/6078/225

Protein kinase A signals apoptotic activation in glucose-deprived hepatocytes: participation of reactive oxygen species
Anabela C. Ferretti, Stella M. Mattaloni, Justina E. Ochoa, María C. Larocca & Cristián Favre
http://www.springerlink.com/content/l623p53441303204/

Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC
Nicole C McKnight, Harold B J Jefferies, Endalkachew A Alemu, Rebecca E Saunders, Michael Howell, Terje Johansen and Sharon A Tooze
http://www.nature.com/emboj/journal/v31/n8/full/emboj201236a.html

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mTOR / AMPK
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Enhanced Apoptosis and Tumor Growth Suppression Elicited by Combination of MEK (Selumetinib) and mTOR Kinase Inhibitors (AZD8055)
Sarah V. Holt, Armelle Logie, Barry R. Davies, Denis Alferez, Sarah Runswick, Sarah Fenton, Christine M. Chresta, Yi Gu, Jingchuan Zhang, Yi-Long Wu, Robert W. Wilkinson, Sylvie M. Guichard, and Paul D. Smith
http://cancerres.aacrjournals.org/cgi/content/abstract/72/7/1804

Rapamycin Resistance Is Linked to Defective Regulation of Skp2
Hana Totary-Jain, Despina Sanoudou, Cula N. Dautriche, Hillary Schneller, Lester Zambrana, and Andrew R. Marks
http://cancerres.aacrjournals.org/cgi/content/abstract/72/7/1836

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
M V Astle, K M Hannan, P Y Ng, R S Lee, A J George, A K Hsu, Y Haupt, R D Hannan and R B Pearson
http://www.nature.com/onc/journal/v31/n15/full/onc2011394a.html

‘Mild mitochondrial uncoupling’ induced protection against neuronal excitotoxicity requires AMPK activity
Petronela Weisová, Ujval Anilkumar, Caitriona Ryan, Caoimhín G. Concannon, Jochen H.M. Prehn, Manus W. Ward
http://www.sciencedirect.com/science/article/pii/S0005272812000242

Defining the contribution of AMPK and PKCs in the regulation of glucose uptake by metformin in skeletal muscle cells
Sophie Turban, Clare Stretton, Olivier Drouin, Charlotte J. Green, Maria L. Watson, Alexander Gray, Fiona Ross, Louise Lantier, Benoit Viollet, D. Grahame Hardie, Andre Marette, and Harinder S. Hundal
http://www.jbc.org/content/early/2012/04/17/jbc.M111.330746.abstract?etoc

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Miscellaneous
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Mitochondrial Dynamics, Biogenesis, and Function Are Coordinated with the Cell Cycle by APC/CCDH1
A. Garedew, C. Andreassi, and S. Moncada
http://www.cell.com/cell-metabolism/abstract/S1550-4131(12)00098-8

Cell density-dependent reduction of dihydroceramide desaturase activity in neuroblastoma cells
Stefka D. Spassieva, Mehrdad Rahmaniyan, Jacek Bielawski, Christopher J. Clarke, Jacqueline M. Kraveka and  Lina M. Obeid
http://www.jlr.org/content/53/5/918.abstract?etoc

Concordant Release of Glycolysis Proteins into the Plasma Preceding a Diagnosis of ER+ Breast Cancer
Lynn M. Amon, Sharon J. Pitteri, Christopher I. Li, Martin McIntosh, Jon J. Ladd, Mary Disis, Peggy Porter, Chee Hong Wong, Qing Zhang, Paul Lampe, Ross L. Prentice, and Samir M. Hanash
http://cancerres.aacrjournals.org/cgi/content/abstract/72/8/1935

2-hydroxyglutarate detection by magnetic resonance spectroscopy in subjects with IDH-mutated gliomas
Changho Choi, Sandeep K Ganji, Ralph J DeBerardinis, Kimmo J Hatanpaa, Dinesh Rakheja, Zoltan Kovacs, Xiao-Li Yang, Tomoyuki Mashimo, Jack M Raisanen, Isaac Marin-Valencia, Juan M Pascual, Christopher J Madden, Bruce E Mickey, Craig M Malloy, Robert M Bachoo and Elizabeth A Maher
http://www.nature.com/nm/journal/v18/n4/abs/nm.2682.html

Lactate-Induced IL-8 Pathway in Endothelial Cells—Letter
Céline Pinheiro, Adhemar Longatto-Filho, Rosete Nogueira, Fernando Schmitt, and Fátima Baltazar
http://cancerres.aacrjournals.org/cgi/content/abstract/72/7/1901

Lactate-Induced IL-8 Pathway in Endothelial Cells—Response
Frédérique Végran, Emmanuel Seront, Pierre Sonveaux, and Olivier Feron
http://cancerres.aacrjournals.org/cgi/content/full/72/7/1903

Reply to Nugue and Wion: Targeting cancer stem cells’ hypoxic core
Sarah J. Conley and Max S. Wicha
http://www.pnas.org/content/109/16/E915.extract?etoc

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Reviews
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mTOR Signaling in Growth Control and Disease
M. Laplante and D.M. Sabatini
http://www.cell.com/abstract/S0092-8674(12)00351-0

Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation
John A. Hanover, Michael W. Krause & Dona C. Love
http://www.nature.com/nrm/journal/v13/n5/full/nrm3334.html

From stem cells to cancer stem cells: HIF takes the stage
Kyoung Eun Lee, M Celeste Simon
http://www.sciencedirect.com/science/article/pii/S0955067412000063

Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug
Cardaci, Simone; Desideri, Enrico; Ciriolo, Maria Rosa
http://www.springerlink.com/content/c4370847442x4089/

— Special issue: “3-Bromopyruvate: A Powerful Small Molecule Anti-Cancer Agent”
http://www.springerlink.com/content/0145-479x/44/1/

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Comments
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Proliferation and Metabolism: It’s as Easy as APC
D. Tantin and J. Rutter
http://www.sciencedirect.com/science/article/pii/S1550413112001088

Dissecting Rapamycin Responses
L. Bryan Ray
The effect of the drug rapamycin on life span can be separated from its effects on metabolism.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/218/ec103

IKK Targets PI3K
John F. Foley
During the starvation response, the IκB kinase IKK phosphorylates the regulatory subunit of PI3K, thus inhibiting PI3K activity.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/218/ec100

Cancer: Blocking tumour sugar metabolism
http://www.nature.com/nature/journal/v483/n7391/full/483512b.html

Hijacking Leucyl-tRNA Synthetase for Amino Acid-Dependent Regulation of TORC1
N. Segev and N. Hay
http://www.sciencedirect.com/science/article/pii/S1097276512002651

Starvation and Autophagy
When the autophagy protein Atg7 is absent, nutrient withdrawal does not stop the cell cycle.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/220/ec114

Cancer Cell Metabolism: There Is No ROS for the Weary
Chi V. Dang
http://cancerdiscovery.aacrjournals.org/content/2/4/304.abstract?etoc

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Other
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Science Signaling Podcast: 3 April 2012
David M. Sabatini, Joseph A. Baur, and Annalisa M. VanHook
http://stke.sciencemag.org/cgi/content/full/sigtrans;5/218/pc7

POSTER – MITOCHONDRIAL FUNCTION AND CANCER
Author: Douglas C. Wallace
http://www.nature.com/nrc/posters/mitochondria/index.html

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