MetaboList – May 2012

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Cancer metabolism
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Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
Mohit Jain, Roland Nilsson, Sonia Sharma, Nikhil Madhusudhan, Toshimori Kitami, Amanda L. Souza, Ran Kafri, Marc W. Kirschner, Clary B. Clish, and Vamsi K. Mootha
http://www.sciencemag.org/content/336/6084/1040.abstract

Identification of additional IDH mutations associated with oncometabolite R(−)-2-hydroxyglutarate production
P S Ward, J R Cross, C Lu, O Weigert, O Abel-Wahab, R L Levine, D M Weinstock, K A Sharp and C B Thompson
http://www.nature.com/onc/journal/v31/n19/abs/onc2011416a.html

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism
K. Thangavelu, Catherine Qiurong Pan, Tobias Karlberg, Ganapathy Balaji, Mahesh Uttamchandani, Valiyaveettil Suresh, Herwig Schüler, Boon Chuan Low, and J. Sivaraman
http://www.pnas.org/content/109/20/7705.abstract?etoc

miR-143 regulates cancer glycolysis via targeting hexokinase 2
Rong Fang, Tian Xiao, Zhaoyuan Fang, Yihua Sun, Fei Li, Yijun Gao, Yan Feng, Li Li, Ye Wang, Xiaolong Liu, Haiquan Chen, Xin Yuan Liu, and Hongbin Ji
http://www.jbc.org/cgi/content/abstract/M112.373084v1

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Nutrient sensing, starvation
——————————————-Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
Jiangbin Ye, Anthony Mancuso, Xuemei Tong, Patrick S. Ward, Jing Fan, Joshua D. Rabinowitz, and Craig B. Thompson
http://www.pnas.org/content/109/18/6904.abstract?etoc

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
Sang-Min Jeon, Navdeep S. Chandel & Nissim Hay
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11066.html

SH3BP4 Is a Negative Regulator of Amino Acid-Rag GTPase-mTORC1 Signaling
Young-Mi Kim, Matthew Stone, Tae Hyun Hwang, Yeon-Gil Kim, Jane R. Dunlevy, Timothy J. Griffin, and Do-Hyung Kim
http://www.cell.com/molecular-cell/abstract/S1097-2765(12)00303-6

The Vam6 and Gtr1–Gtr2 pathway activates TORC1 in response to amino acids in fission yeast
Noelia Valbuena, Kun-Liang Guan, and Sergio Moreno
http://jcs.biologists.org/cgi/content/abstract/125/8/1920

Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death
Wu, Hao; Ding, Zonghui; Hu, Danqing; Sun, Feifei; Dai, Chunyan; Xie,
Jiansheng; Hu, Xun
http://onlinelibrary.wiley.com/doi/10.1002/path.3978/abstract

AMPK and GCN2–ATF4 signal the repression of mitochondria in colon cancer cells
Inmaculada Martínez Reyes, María Sánchez Aragó and José M. Cuezva
http://www.biochemj.org/bj/444/bj4440249.htm

Role of the insulin/Tor signaling network in starvation-induced programmed cell death in Drosophila oogenesis
T L Pritchett and K McCall
http://www.nature.com/cdd/journal/v19/n6/abs/cdd2011200a.html

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Drugs targeting metabolism/mTOR
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mTOR Inhibitors Synergize on Regression, Reversal of Gene Expression, and Autophagy in Hepatocellular Carcinoma
Hala Elnakat Thomas, Carol A. Mercer, Larissa S. Carnevalli, Jongsun Park, Jesper B. Andersen, Elizabeth A. Conner, Kazuhiro Tanaka, Tomoo Matsutani, Akio Iwanami, Bruce J. Aronow, Liu Manway, S. Michel Maira, Snorri S. Thorgeirsson, Paul S. Mischel, George Thomas, and Sara C. Kozma
http://stm.sciencemag.org/content/early/2012/04/27/scitranslmed.3003923.abstract

Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death
Gang Cheng, Jacek Zielonka, Brian P. Dranka, Donna McAllister, A. Craig Mackinnon, Jr, Joy Joseph, and Balaraman Kalyanaraman
http://cancerres.aacrjournals.org/cgi/content/abstract/72/10/2634

The combination of the novel glycolysis inhibitor 3-BrOP and rapamycin is effective against neuroblastoma
Alejandro G. Levy, Peter E. Zage, Lauren J. Akers, Maurizio L. Ghisoli, Zhao Chen, Wendy Fang6, Sankaranarayanan Kannan, Timothy Graham, Lizhi Zeng, Anna R. Franklin, Peng Huang and Patrick A. Zweidler-McKay
http://www.springerlink.com/content/63vn3wtlrq0575u1/?MUD=MP

Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells
Wen-Bin Tsai, Isamu Aiba, Yan Long, Hui-Kuan Lin, Lynn Feun, Niramol Savaraj, and Macus Tien Kuo
http://cancerres.aacrjournals.org/cgi/content/abstract/72/10/2622

Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC
Giovanni Blandino, Maria cristina Valerio, Mario Cioce, Federica Mori, Luca Casadei, Claudio Pulito, Andrea Sacconi, Francesca Biagioni, Giancarlo Cortese, Sergio Galanti, Cesare Manetti, Gennaro Citro, Paola Muti & Sabrina Strano
http://www.nature.com/ncomms/journal/v3/n5/abs/ncomms1859.html

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AMPK/mTOR
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A unifying model for mTORC1-mediated regulation of mRNA translation
Carson C. Thoreen, Lynne Chantranupong, Heather R. Keys, Tim Wang, Nathanael S. Gray & David M. Sabatini
http://www.nature.com/nature/journal/v485/n7396/full/nature11083.html

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
Asami Hagiwara, Marion Cornu, Nadine Cybulski, Pazit Polak, Charles Betz, Francesca Trapani, Luigi Terracciano, Markus H. Heim, Markus A. Rüegg, Michael N. Hall
http://www.cell.com/cell-metabolism/abstract/S1550-4131%2812%2900135-0

Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes
Margrét H. Ögmundsdóttir, Sabine Heublein, Shubana Kazi, Bruno Reynolds, Shivanthy M. Visvalingam, Michael K. Shaw, Deborah C. I. Goberdhan
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0036616

AMPKα Modulation in Cancer Progression: Multilayer Integrative Analysis of the Whole Transcriptome in Asian Gastric Cancer
Yon Hui Kim, Han Liang, Xiuping Liu, Ju-Seog Lee, Jae Yong Cho, Jae-Ho Cheong, Hoguen Kim, Min Li, Thomas J. Downey, Matthew D. Dyer, Yongming Sun, Jingtao Sun, Ellen M. Beasley, Hyun Cheol Chung, Sung Hoon Noh, John N. Weinstein, Chang-Gong Liu, and Garth Powis
http://cancerres.aacrjournals.org/cgi/content/abstract/72/10/2512

Role of deleted in breast cancer 1 (DBC1) in SIRT1 activation induced by protein kinase A and AMP activated protein kinase
Veronica Nin, Carlos Escande, Claudia C. Chini, Shailendra Giri, Juliana Camacho-Pereira, Jonathan Matalonga, Zhenkun Lou, and Eduardo N. Chini
http://www.jbc.org/cgi/content/abstract/M112.365874v2

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Differentiation and metabolism
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HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition
Wenyu Zhou, Michael Choi, Daciana Margineantu, Lilyana Margaretha, Jennifer Hesson, Christopher Cavanaugh, C Anthony Blau, Marshall S Horwitz, David Hockenbery, Carol Ware and Hannele Ruohola-Baker
http://www.nature.com/emboj/journal/v31/n9/full/emboj201271a.html

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
Ursula Fünfschilling, Lotti M. Supplie, Don Mahad, Susann Boretius, Aiman S. Saab, Julia Edgar, Bastian G. Brinkmann, Celia M. Kassmann, Iva D. Tzvetanova, Wiebke Möbius, Francisca Diaz, Dies Meijer, Ueli Suter, Bernd Hamprecht, Michael W. Sereda, Carlos T. Moraes, Jens Frahm, Sandra Goebbels & Klaus-Armin Nave
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11007.html

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Hypoxia / ROS
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An oxygen-regulated switch in the protein synthesis machinery
James Uniacke, Chet E. Holterman, Gabriel Lachance, Aleksandra Franovic, Mathieu D. Jacob, Marc R. Fabian, Josianne Payette, Martin Holcik, Arnim Pause & Stephen Lee
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11055.html

FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression
E C Ferber, B Peck, O Delpuech, G P Bell, P East and A Schulze
http://www.nature.com/cdd/journal/v19/n6/abs/cdd2011179a.html

HIF-1α protein is upregulated in HIF-2α depleted cells via enhanced translation
Kathrin Schulz, Larissa Milke, Daniela Rübsamen, Heidi Menrad, Tobias Schmid, Bernhard Brüne
http://www.sciencedirect.com/science/article/pii/S0014579312003286

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Comments / previews
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Cancer biology: The director’s cut
Antonio Gentilella & George Thomas
http://www.nature.com/nature/journal/v485/n7396/full/485050a.html

Cancer metabolism: Tumour friend or foe
Robert U. Svensson & Reuben J. Shaw
http://www.nature.com/nature/journal/v485/n7400/full/485590a.html

I Love Leucine
The leucyl-tRNA synthetase acts as a leucine sensor for mTOR complex 1.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/222/ec121

Targeting hypoxia brings breath of fresh air to cancer therapy
Melinda Wenner Moyer
http://www.nature.com/nm/journal/v18/n5/full/nm0512-636b.html

Cell – Select
mTOR: The Master Regulator
http://www.sciencedirect.com/science/article/pii/S0092867412005855

Systems Biology, Metabolomics, and Cancer Metabolism
Masaru Tomita and Kenjiro Kami
Constructing metabolic profiles of 60 cancer cell lines by integrating metabolomics and systems biology revealed increased glycine consumption in highly proliferative cancer cells.
http://www.sciencemag.org/content/336/6084/990.summary

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Reviews
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Links between metabolism and cancer
Chi V. Dang
http://genesdev.cshlp.org/cgi/content/abstract/26/9/877

The Resurgence of Serine: An often Neglected but Indispensable Amino Acid
Satish C. Kalhan and Richard W. Hanson
http://www.jbc.org/content/early/2012/05/07/jbc.R112.357194.full.pdf+html?sid=90fe0b66-6ce0-4b00-87af-69f7914ace61

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
Christian Appenzeller-Herzog, Michael N. Hall
http://www.cell.com/trends/cell-biology/abstract/S0962-8924(12)00035-9

SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis
Marcia C. Haigis, Chu-Xia Deng, Lydia W.S. Finley, Hyun-Seok Kim, and David Gius
http://cancerres.aacrjournals.org/cgi/content/abstract/72/10/2468

Deconvoluting the context-dependent role for autophagy in cancer
Eileen White
http://www.nature.com/nrc/journal/v12/n6/full/nrc3262.html

The updated biology of hypoxia-inducible factor
Samantha N Greer, Julie L Metcalf, Yi Wang and Michael Ohh
http://www.nature.com/emboj/journal/v31/n11/abs/emboj2012125a.html

Mitochondrial remodeling in cancer metabolism and survival: Potential for new therapies
Inês A. Barbosa, Nuno G. Machado, Andrew J. Skildum, Patricia M. Scott, Paulo J. Oliveira
http://www.sciencedirect.com/science/article/pii/S0304419X12000315

The immune diet: meeting the metabolic demands of lymphocyte activation
Advances in understanding the metabolic control of autoimmune disease point the way to new therapies. F1000 Report by Ruoning Wang and Douglas R. Green
http://f1000.com/reports/b/4/9

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