MetaboList – June 2012

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Cancer metabolism
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Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo
Isaac Marin-Valencia, Chendong Yang, Tomoyuki Mashimo, Steve Cho, Hyeonman Baek, Xiao-Li Yang, Kartik N. Rajagopalan, Melissa Maddie, Vamsidhara Vemireddy, Zhenze Zhao, Ling Cai, Levi Good, Benjamin P. Tu, Kimmo J. Hatanpaa, Bruce E. Mickey, José M. Matés, Juan M. Pascual, Elizabeth A. Maher, Craig R. Malloy, Ralph J. DeBerardinis, Robert M. Bachoo
http://www.cell.com/cell-metabolism/abstract/S1550-4131%2812%2900194-5

Stimulation of MC38 tumor growth by insulin analog X10 involves the serine synthesis pathway.
Hvid H, Fendt SM, Blouin MJ, Birman E, Voisin G, Svendsen AM, Frank R, Vander Heiden MG, Stephanopoulos G, Hansen BF, Pollak MN.
http://erc.endocrinology-journals.org/content/early/2012/06/08/ERC-12-0125.long

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC
Wei Liu, Anne Le, Chad Hancock, Andrew N. Lane, Chi V. Dang, Teresa W.-M. Fan, and James M. Phang
http://www.pnas.org/content/109/23/8983.abstract?etoc

A tumour suppressor network relying on the polyamine–hypusine axis
Claudio Scuoppo, Cornelius Miething, Lisa Lindqvist, José Reyes, Cristian Ruse, Iris Appelmann, Seungtai Yoon, Alexander Krasnitz, Julie Teruya-Feldstein, Darryl Pappin, Jerry Pelletier & Scott W. Lowe
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11126.html

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
Mengtao Xiao, Hui Yang, Wei Xu, Shenghong Ma, Huaipeng Lin, Honguang Zhu, Lixia Liu, Ying Liu, Chen Yang, Yanhui Xu, Shimin Zhao, Dan Ye, Yue Xiong, and Kun-Liang Guan
http://genesdev.cshlp.org/cgi/content/abstract/26/12/1326

L-Lactate metabolism in HEP G2 cell mitochondria due to theL-lactate dehydrogenase determines the occurrence of the lactate/pyruvate shuttle and the appearance of oxaloacetate, malate and citrate outside mitochondria
Roberto Pizzuto, Gianluca Paventi, Carola Porcile, Daniela Sarnataro, Aurora Daniele, Salvatore Passarella
http://www.sciencedirect.com/science/article/pii/S0005272812001673

Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy
Weiqin Lu, Yumin Hu, Gang Chen, Zhao Chen, Hui Zhang, Feng Wang, Li Feng, Helene Pelicano, Hua Wang, Michael J. Keating, Jinsong Liu, Wallace McKeehan, Huamin Wang, Yongde Luo, Peng Huang
http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1001326

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence
[Evidence suggests that p53’s regulation of glucose metabolism and ROS levels are critical for its tumor suppression activity.]
Tongyuan Li, Ning Kon, Le Jiang, Minjia Tan, Thomas Ludwig, Yingming Zhao, Richard Baer, Wei Gu
http://www.cell.com/abstract/S0092-8674%2812%2900533-8

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Hypoxia / metabolic stress
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An oxygen-regulated switch in the protein synthesis machinery
James Uniacke, Chet E. Holterman, Gabriel Lachance, Aleksandra Franovic, Mathieu D. Jacob, Marc R. Fabian, Josianne Payette, Martin Holcik, Arnim Pause & Stephen Lee
http://www.nature.com/nature/journal/v486/n7401/full/nature11055.html

Prevention of acute/severe hypoglycemia-induced neuron death by lactate administration
Seok Joon Won, Bong Geom Jang, Byung Hoon Yoo, Min Sohn, Min Woo Lee, Bo Young Choi, Jin Hee Kim, Hong Ki Song and Sang Won Suh
http://www.nature.com/jcbfm/journal/v32/n6/abs/jcbfm201230a.html?WT.ec_id=JCBFM-201206

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2
Brooke M. Baker, Amrita M. Nargund, Tiffany Sun, Cole M. Haynes
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002760

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Anti-metabolic drugs

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2-Deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines
O Zagorodna, S M Martin, D T Rutkowski, T Kuwana, D R Spitz and C M Knudson
http://www.nature.com/onc/journal/v31/n22/abs/onc2011454a.html

Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia.
Desalvo J, Kuznetsov JN, Du J, Leclerc GM, Leclerc GJ, Lampidis TJ, Barredo JC.
http://mcr.aacrjournals.org/cgi/pmidlookup?view=long&pmid=22692960

Distinct perturbation of the translatome by the antidiabetic drug metformin
Ola Larsson, Masahiro Morita, Ivan Topisirovic, Tommy Alain, Marie-Jose Blouin, Michael Pollak, and Nahum Sonenberg
http://www.pnas.org/content/109/23/8977.abstract?etoc

Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC).
Auricchio N, Malinowska I, Shaw R, Manning BD, Kwiatkowski DJ.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0031900

Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism
Louise Egeblad, Martin Welin, Susanne Flodin, Susanne Gräslund, Liya Wang, Jan Balzarini, Staffan Eriksson, Pär Nordlund
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037724

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Miscellaneous
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StearoylCoA Desaturase-5: A Novel Regulator of Neuronal Cell Proliferation and Differentiation
Debora I. Sinner, Gretchun J. Kim, Gregory C. Henderson, R. Ariel Igal
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0039787

Decreased Mitochondrial DNA Mutagenesis in Human Colorectal Cancer
Nolan G. Ericson, Mariola Kulawiec, Marc Vermulst, Kieran Sheahan, Jacintha O’Sullivan, Jesse J. Salk, Jason H. Bielas
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002689

BNip3 Regulates Mitochondrial Function and Lipid Metabolism in the Liver
Danielle Glick, Wenshuo Zhang, Michelle Beaton, Glenn Marsboom, Michaela Gruber, M. Celeste Simon, John Hart, Gerald W. Dorn, II, Matthew J. Brady, and Kay F. Macleod
http://mcb.asm.org/cgi/content/abstract/32/13/2570

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Reviews
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Metabolic pathways in T cell fate and function.
Gerriets VA, Rathmell JC.
http://www.ncbi.nlm.nih.gov/pubmed/22342741

Redox implications of AMPK-mediated signal transduction beyond energetic clues
Simone Cardaci, Giuseppe Filomeni, and Maria Rosa Ciriolo
http://jcs.biologists.org/cgi/content/abstract/125/9/2115

AMP-activated protein kinase: new regulation, new roles?
David Carling, Claire Thornton, Angela Woods and Matthew J. Sanders
http://www.biochemj.org/bj/445/bj4450011.htm

Autophagy and cancer – issues we need to digest
Emma Y. Liu and Kevin M. Ryan
http://jcs.biologists.org/cgi/content/abstract/125/10/2349

Autophagy and cell growth – the yin and yang of nutrient responses
Thomas P. Neufeld
http://jcs.biologists.org/cgi/content/abstract/125/10/2359

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Comments / previews / other
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Meeting report – Keystone Symposium: Banff Springs, Canada, February 2012
Emerging concepts: linking hypoxic signaling and cancer metabolism
C A Lyssiotis, M G Vander Heiden, C Muñoz-Pinedo and B M Emerling
http://www.nature.com/uidfinder/10.1038/cddis.2012.41
Corrigendum http://www.nature.com/cddis/journal/v3/n6/full/cddis201275a.html

 
mTOR Inhibitors Synergize in Hepatocellular Carcinoma
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/2/6/484
[Refers to Thomas et al, final version at http://stm.sciencemag.org/content/4/139/139ra84]

Glycine fuels cancer cells
Emily J. Chenette
http://www.nature.com/ncb/journal/v14/n7/full/ncb2542.html

HOT Models in Flux: Mitochondrial Glucose Oxidation Fuels Glioblastoma Growth
Paul S. Mischel
http://www.cell.com/cell-metabolism/abstract/S1550-4131%2812%2900197-0

Polarizing Macrophages through Reprogramming of Glucose Metabolism
Julianna Blagih, Russell G. Jones
http://www.cell.com/cell-metabolism/abstract/S1550-4131%2812%2900201-X

The NADPH Survival Advantage
John F. Foley
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/227/ec156

 

Cell Death and Disease initial impact factor: 5.33. Submit your papers to the Cancer Metabolism section!
 

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