MetaboList – July 2012

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Cancer metabolism
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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
Masato Sasaki, Christiane B. Knobbe, Joshua C. Munger, Evan F. Lind, Dirk Brenner, Anne Brüstle, Isaac S. Harris, Roxanne Holmes, Andrew Wakeham, Jillian Haight, Annick You-Ten, Wanda Y. Li, Stefanie Schalm, Shinsam M. Su, Carl Virtanen, Guido Reifenberger, Pamela S. Ohashi, Dwayne L. Barber, Maria E. Figueroa, Ari Melnick, Juan-Carlos Zúñiga-Pflücker & Tak W. Mak
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11323.html

Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma.
Bhatt AP, Jacobs SR, Freemerman AJ, Makowski L, Rathmell JC, Dittmer DP, Damania B.
http://www.pnas.org/content/early/2012/06/28/1205995109.long

RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival
V Goidts, J Bageritz, L Puccio, S Nakata, M Zapatka, S Barbus, G Toedt, B Campos, A Korshunov, S Momma, E Van Schaftingen, G Reifenberger, C Herold-Mende, P Lichter and B Radlwimmer
http://www.nature.com/onc/journal/v31/n27/full/onc2011490a.html

Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence
Vikas P. Sukhatme, Barden Chan
http://www.sciencedirect.com/science/article/pii/S0014579312004383

Kidney Tumor Biomarkers Revealed by Simultaneous Multiple Matrix Metabolomics Analysis
Sheila Ganti, Sandra L. Taylor, Omran Abu Aboud, Joy Yang, Christopher Evans, Michael V. Osier, Danny C. Alexander, Kyoungmi Kim, and Robert H. Weiss
http://cancerres.aacrjournals.org/cgi/content/abstract/72/14/3471

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Cellular metabolism and reprogramming
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Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
Yoichiro Mitsuishi, Keiko Taguchi, Yukie Kawatani, Tatsuhiro Shibata, Toshihiro Nukiwa, Hiroyuki Aburatani, Masayuki Yamamoto, Hozumi Motohashi
http://www.cell.com/cancer-cell/abstract/S1535-6108(12)00215-2

Wnt/Snail Signaling Regulates Cytochrome c Oxidase and Glucose Metabolism
Su Yeon Lee, Hyun Min Jeon, Min Kyung Ju, Cho Hee Kim, Gyesoon Yoon, Song Iy Han, Hye Gyeong Park, and Ho Sung Kang
http://cancerres.aacrjournals.org/cgi/content/abstract/72/14/3607

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier
Sébastien Herzig, Etienne Raemy, Sylvie Montessuit, Jean-Luc Veuthey, Nicola Zamboni, Benedikt Westermann, Edmund R. S. Kunji, Jean-Claude Martinou
http://www.sciencemag.org/cgi/content/summary/337/6090/93

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans
Daniel K. Bricker, Eric B. Taylor, John C. Schell, Thomas Orsak, Audrey Boutron, Yu-Chan Chen, James E. Cox, Caleb M. Cardon, Jonathan G. Van Vranken, Noah Dephoure, Claire Redin, Sihem Boudina, Steven P. Gygi, Michèle Brivet, Carl S. Thummel, and Jared Rutter
http://www.sciencemag.org/cgi/content/summary/337/6090/96

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AMPK- mTOR
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TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
Christian C. Dibble, Winfried Elis, Suchithra Menon, Wei Qin, Justin Klekota, John M. Asara, Peter M. Finan, David J. Kwiatkowski, Leon O. Murphy, and Brendan D. Manning
http://www.cell.com/molecular-cell/abstract/S1097-2765%2812%2900504-7

p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin’s Effect on Food Intake
Yossi Dagon, Elizabeth Hur, Bin Zheng, Kerry Wellenstein, Lewis C. Cantley, Barbara B. Kahn
http://www.cell.com/cell-metabolism/abstract/S1550-4131(12)00233-1

Cells Lacking the Fumarase Tumor Suppressor Are Protected from Apoptosis through a Hypoxia-Inducible Factor-Independent, AMPK-Dependent Mechanism
Chiara Bardella, Martina Olivero, Annalisa Lorenzato, Massimo Geuna, Julie Adam, Linda O’Flaherty, Pierre Rustin, Ian Tomlinson, Patrick J. Pollard, and Maria Flavia Di Renzo
http://mcb.asm.org/cgi/content/abstract/32/15/3081

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Starvation, anti-metabolic drugs
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ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy
Manuel Rodriguez-Vargas, Jose; Jose Ruiz-Magana, Maria; Ruiz-Ruiz,
Carmen; Majuelos-Melguizo, Jara; Peralta-Leal, Andreina; Isabel
Rodriguez, Maria; Antonio Munoz-Gamez, Jose; Ruiz de Almodovar, Mariano;
Siles, Eva; Lopez Rivas, Abelardo; Jaattela, Marja; F Javier Oliver.
http://www.nature.com/cr/journal/v22/n7/full/cr201270a.html

Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications
Marie Morfouace, Lisenn Lalier, Muriel Bahut, Virginie Bonamain, Philippe Naveilhan, Catherine Guette, Lisa Oliver, Naig Gueguen, Pascal Reynier, and Francois M. Vallette
http://www.jbc.org/cgi/content/abstract/M111.320028v1

Differential effects of the glycolysis inhibitor 2-deoxy-D-glucose on the activity of pro-apoptotic agents in metastatic melanoma cells, and induction of a cytoprotective autophagic response
Giammarioli, Anna Maria; Gambardella, Lucrezia; Barbati, Cristiana;
Pietraforte, Donatella; Tinari, Antonella; Alberton, Manuela; Gnessi,
Lucio; Griffin, Roger J.; Minetti, Maurizio; Malorni, Walter
http://onlinelibrary.wiley.com/doi/10.1002/ijc.26420/abstract

Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis
B Delage, P Luong, L Maharaj, C O’Riain, N Syed, T Crook, E Hatzimichael, A Papoudou-Bai, T J Mitchell, S J Whittaker, R Cerio, J Gribben, N Lemoine, J Bomalaski, C-F Li, S Joel, J Fitzgibbon, L-T Chen and P W Szlosarek
http://www.nature.com/cddis/journal/v3/n7/abs/cddis201283a.html

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Hypoxia
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Loss of Fibroblast HIF-1α Accelerates Tumorigenesis
Jung-whan Kim, Colin Evans, Alexander Weidemann, Norihiko Takeda, Yun Sok Lee, Christian Stockmann, Cristina Branco-Price, Filip Brandberg, Gustavo Leone, Michael C. Ostrowski, and Randall S. Johnson
http://cancerres.aacrjournals.org/cgi/content/abstract/72/13/3187

Proline Oxidase Promotes Tumor Cell Survival in Hypoxic Tumor Microenvironments
Wei Liu, Kristine Glunde, Zaver M. Bhujwalla, Venu Raman, Anit Sharma, and James M. Phang
http://cancerres.aacrjournals.org/cgi/content/abstract/72/14/3677

SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors
Marco Montagner, Elena Enzo, Mattia Forcato, Francesca Zanconato, Anna Parenti, Elena Rampazzo, Giuseppe Basso, Genesio Leo, Antonio Rosato, Silvio Bicciato, Michelangelo Cordenonsi & Stefano Piccolo
http://www.nature.com/nature/journal/v487/n7407/full/nature11207.html

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Comments / previews / letters
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A Moving Picture of Cancer Metabolism
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/2/7/572-a

AMPK Maintains NADPH Levels during Energy Stress
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/2/7/OF16

A Mitochondrial Mystery, Solved
Ajit S. Divakaruni, Anne N. Murphy
A long-awaited transporter that moves pyruvate into mitochondria has been identified.
http://www.sciencemag.org/content/337/6090/41.summary

Comment on “A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation”: Building a Model of the mTOR Signaling Network with a Potentially Faulty Tool
Brendan D. Manning
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/232/lc3

Response to Comment on “A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation”: Building a Model of the mTOR Signaling Network with a Potentially Faulty Tool
Piero Dalle Pezze, Annika G. Sonntag, Daryl P. Shanley, Kathrin Thedieck
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/232/lc4

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Reviews
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Metabolic Regulation of Epigenetics
Chao Lu, Craig B. Thompson
http://www.cell.com/cell-metabolism/abstract/S1550-4131(12)00236-7

Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer
Barbara Chaneton, Eyal Gottlieb
http://www.sciencedirect.com/science/article/pii/S096800041200059X

Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson
Kivanc Birsoy, David M Sabatini and Richard Possemato
http://www.nature.com/nm/journal/v18/n7/full/nm.2870.html

Untuning the tumor metabolic machine: HIF-[alpha]: pro- and antitumorigenic?
Regina M Young and M Celeste Simon
http://www.nature.com/nm/journal/v18/n7/full/nm.2865.html

Complexity of metabolic cancer control: Can we exploit the superior metabolic position of glucose?
Edward Henry Mathews and Leon Liebenberg
http://www.landesbioscience.com/journals/cbt/article/20085/

The Proline Regulatory Axis and Cancer
James Ming Phang, Wei Liu, Chad Hancock, and Kyle J. Christian
http://www.frontiersin.org/Journal/Abstract.aspx?ART_DOI=10.3389/fonc.2012.00060

Mechanistic insights into the regulation of metabolic enzymes by acetylation
Yue Xiong and Kun-Liang Guan
http://jcb.rupress.org/cgi/content/abstract/198/2/155?etoc

Nuclear factor-κB, p53, and mitochondria: regulation of cellular metabolism and the Warburg effect
Renée F. Johnson, Neil D. Perkins
http://www.cell.com/trends/biochemical-sciences/abstract/S0968-0004(12)00049-7

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