MetaboList – August 2012

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Cancer Metabolism

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
Dimitrios Anastasiou, Yimin Yu, William J Israelsen, Jian-Kang Jiang, Matthew B Boxer, Bum Soo Hong, Wolfram Tempel, Svetoslav Dimov, Min Shen, Abhishek Jha, Hua Yang, Katherine R Mattaini, Christian M Metallo, Brian P Fiske, Kevin D Courtney, Scott Malstrom, Tahsin M Khan, Charles Kung, Amanda P Skoumbourdis, Henrike Veith, Noel Southall, Martin J Walsh, Kyle R Brimacombe, William Leister, Sophia Y Lunt, Zachary R Johnson, Katharine E Yen, Kaiko Kunii, Shawn M Davidson, Heather R Christofk, Christopher P Austin, James Inglese, Marian H Harris, John M Asara, Gregory Stephanopoulos, Francesco G Salituro, Shengfang Jin, Lenny Dang, Douglas S Auld, Hee-Won Park, Lewis C Cantley, Craig J Thomas & Matthew G Vander Heiden
http://www.nature.com/nchembio/journal/vaop/ncurrent/full/nchembio.1060.html

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism
Wen Yi, Peter M. Clark, Daniel E. Mason, Marie C. Keenan, Collin Hill, William A. Goddard III, Eric C. Peters, Edward M. Driggers, Linda C. Hsieh-Wilson
http://www.sciencemag.org/cgi/content/summary/337/6097/975

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis
Weiwei Yang, Yan Xia, David Hawke, Xinjian Li, Ji Liang, Dongming Xing, Kenneth Aldape, Tony Hunter, W.K. Alfred Yung, Zhimin Lu
http://www.cell.com/abstract/S0092-8674(12)00882-3

MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer
Nina V. Chaika, Teklab Gebregiworgis, Michelle E. Lewallen, Vinee Purohit, Prakash Radhakrishnan, Xiang Liu, Bo Zhang, Kamiya Mehla, Roger B. Brown, Thomas Caffrey, Fang Yu, Keith R. Johnson, Robert Powers, Michael A. Hollingsworth, and Pankaj K. Singh
http://www.pnas.org/content/109/34/13787.abstract?etoc

Caveolin-1 Increases Aerobic Glycolysis in Colorectal Cancers by Stimulating HMGA1-Mediated GLUT3 Transcription
Tae-Kyu Ha, Nam-Gu Her, Min-Goo Lee, Byung-Kyu Ryu, Jin-Hee Lee, Jikhyon Han, Seong-In Jeong, Min-Ju Kang, Nam-Hoon Kim, Hyo-Jong Kim, and Sung-Gil Chi
http://cancerres.aacrjournals.org/cgi/content/abstract/72/16/4097

IDH mutation status in prostate cancer
A F Ghiam, R A Cairns, J Thoms, A Dal Pra, O Ahmed, A Meng, T W Mak and R G Bristow
http://www.nature.com/onc/journal/v31/n33/full/onc2011546a.html

Endoplasmic reticulum factor ERLIN2 regulates cytosolic lipid content in cancer cells
Guohui Wang, Xuebao Zhang, Jin Sook Lee, Xiaogang Wang, Zeng Quan Yang and Kezhong Zhang
http://www.biochemj.org/bj/446/bj4460415.htm

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mTOR, glutamine and autophagy
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Glutaminolysis Activates Rag-mTORC1 Signaling
R.V. Durán, W. Oppliger, A.M. Robitaille, L. Heiserich, R. Skendaj, E. Gottlieb, and M.N. Hall
http://www.cell.com/molecular-cell/abstract/S1097-2765%2812%2900488-1

Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy
Kristan E. van der Vos, Pernilla Eliasson, Tassula Proikas-Cezanne, Stephin J. Vervoort, Ruben van Boxtel, Marrit Putker, Iris J. van Zutphen, Mario Mauthe, Sebastian Zellmer, Cornelieke Pals, Liesbeth P. Verhagen, Marian J. A. Groot Koerkamp, A. Koen Braat, Tobias B. Dansen, Frank C. Holstege, Rolf Gebhardt, Boudewijn M. Burgering and Paul J. Coffer
http://www.nature.com/ncb/journal/v14/n8/full/ncb2536.html

Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition.
Bray K, Mathew R, Lau A, Kamphorst JJ, Fan J, Chen J, Chen HY, Ghavami A, Stein M, Dipaola RS, Zhang D, Rabinowitz JD, White E.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0041831

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Starvation
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Glucose deprivation induced increase in protein O-GlcNAcylation in cardiomyocytes is calcium dependent
Luyun Zou, Xiaoyuan Zhu-Mauldin, Richard B. Marchase, Andrew J. Paterson, Jian Liu, Qinglin Yang, and John C. Chatham
http://www.jbc.org/cgi/content/abstract/M112.393207v1

Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by upregulating respiration and improving cellular redox homeostasis
Christina Wanka, Joachim P. Steinbach, and Johannes Rieger
http://www.jbc.org/cgi/content/abstract/M112.384578v1

Glucose deprivation in tuberous sclerosis complex-related tumors.
Jiang X, Kenerson HL, Yeung RS.
http://www.cellandbioscience.com/content/1/1/34

Induction of the permeability transition pore in cells depleted of mitochondrial DNA
[by glucose/serum deprivation]
Ionica Masgras, Andrea Rasola, Paolo Bernard
http://www.sciencedirect.com/science/article/pii/S0005272812000588

Metformin is synthetically lethal with glucose withdrawal in cancer cells.
Menendez JA, Oliveras-Ferraros C, Cufí S, Corominas-Faja B, Joven J, Martin-Castillo B, Vazquez-Martin A.
http://www.landesbioscience.com/journals/cc/article/20948/

Glutamine Deprivation Enhances Antitumor Activity of 3-Bromopyruvate through the Stabilization of Monocarboxylate Transporter-1
Simone Cardaci, Salvatore Rizza, Giuseppe Filomeni, Roberta Bernardini, Fabio Bertocchi, Maurizio Mattei, Maurizio Paci, Giuseppe Rotilio, and Maria Rosa Ciriolo
http://cancerres.aacrjournals.org/cgi/content/abstract/72/17/4526

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Miscellaneous
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Metabolic differentiation in the embryonic retina
Michalis Agathocleous, Nicola K. Love, Owen Randlett, Julia J. Harris, Jinyue Liu, Andrew J. Murray and William A. Harris
http://www.nature.com/ncb/journal/v14/n8/full/ncb2531.html

Selective growth inhibition by glycogen synthase kinase-3 inhibitors in tumorigenic HeLa hybrid cells is mediated through NF-κB-dependent GLUT3 expression
M Watanabe, N Abe, Y Oshikiri, E J Stanbridge and T Kitagawa
http://www.nature.com/oncsis/journal/v1/n7/abs/oncsis201221a.html

Synthesis of cytochrome c oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death
C Wanka, D P Brucker, O Bähr, M Ronellenfitsch, M Weller, J P Steinbach and J Rieger
http://www.nature.com/onc/journal/v31/n33/abs/onc2011530a.html

Activation of Thermogenesis in Brown Adipose Tissue and Dysregulated Lipid Metabolism Associated with Cancer Cachexia in Mice
Maria Tsoli, Melissa Moore, Dominic Burg, Arran Painter, Ryland Taylor, Sarah H. Lockie, Nigel Turner, Alessandra Warren, Greg Cooney, Brian Oldfield, Stephen Clarke, and Graham Robertson
http://cancerres.aacrjournals.org/cgi/content/abstract/72/17/4372

AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells
Chi-Wai Lee, Leo Lap-Yan Wong, Edith Yuk-Ting Tse, Heong-Fai Liu, Veronica Yee-Law Leong, Joyce Man-Fong Lee, D. Grahame Hardie, Irene Oi-Lin Ng, and Yick-Pang Ching
http://cancerres.aacrjournals.org/cgi/content/abstract/72/17/4394

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Reviews
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Metabolism and autophagy in the immune system: immunometabolism comes of age
Jeffrey C. Rathmell
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-065X.2012.01158.x/abstract

Normal and cancer cell metabolism: lymphocytes and lymphoma
Brian J. Altman, Chi V. Dang
http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2012.08651.x/abstract

Fulfilling the metabolic requirements for cell proliferation
Salvador Moncada, E. Annie Higgs and Sergio L. Colombo
http://www.biochemj.org/bj/446/bj4460001.htm

ATP-Citrate Lyase: A Key Player in Cancer Metabolism
Nousheen Zaidi, Johannes V. Swinnen, and Karine Sman
http://cancerres.aacrjournals.org/cgi/content/abstract/72/15/3709

Passing the baton: the HIF switch
Mei Yee Koh, Garth Powis
http://www.sciencedirect.com/science/article/pii/S0968000412000795

Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways
Kenneth C.H. Fearon, David J. Glass, Denis C. Guttridge
http://www.cell.com/cell-metabolism/abstract/S1550-4131%2812%2900248-3

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Previews / comments
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Glycosylation to Adapt to Stress
Katherine R. Mattaini, Matthew G. Vander Heiden
http://www.sciencemag.org/content/337/6097/925.full

Seeing the Warburg effect in the developing retina
Brian P. Fiske and Matthew G. Vander Heiden
http://www.nature.com/ncb/journal/v14/n8/full/ncb2554.html

FOXOphagy path to inducing stress resistance and cell survival
Marco Sandri
http://www.nature.com/ncb/journal/v14/n8/full/ncb2550.html

Metabolic Sensor
L. Bryan Ray
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/239/ec225

 

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