MetaboList – september 2012

Cancer Metabolism

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function
Masato Sasaki, Christiane B. Knobbe, Momoe Itsumi, Andrew J. Elia, Isaac S. Harris, Iok In Christine Chio, Rob A. Cairns, Susan McCracken, Andrew Wakeham, Jillian Haight, Annick You Ten, Bryan Snow, Takeshi Ueda, Satoshi Inoue, Kazuo Yamamoto, Myunggon Ko, Anjana Rao, Katharine E. Yen, Shinsan M. Su, and Tak Wah Mak

Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay
Tania Fiaschi, Alberto Marini, Elisa Giannoni, Maria Letizia Taddei, Paolo Gandellini, Alina De Donatis, Michele Lanciotti, Sergio Serni, Paolo Cirri, and Paola Chiarug

Multiple Metabolic Alterations Exist in Mutant PI3K Cancers, but Only Glucose Is Essential as a Nutrient Source
Rebecca Foster, Sue Griffin, Suzanne Grooby, Ruth Feltell, Cindy Christopherson, Monica Chang, John Sninsky, Shirley Kwok, Chris Torrance

The Alteration of Lipid Metabolism in Burkitt Lymphoma Identifies a Novel Marker: Adipophilin
Maria R. Ambrosio, Pier P. Piccaluga, Maurilio Ponzoni, Bruno J. Rocca, Valeria Malagnino, Monica Onorati, Giulia De Falco, Valeria Calbi, Martin Ogwang, Kikkeri N. Naresh, Stefano A. Pileri, Claudio Doglioni, Lorenzo Leoncini, Stefano Lazzi

Anti-metabolic drugs

Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs.
Corominas-Faja B, Quirantes-Piné R, Oliveras-Ferraros C, Vazquez-Martin A, Cufí S, Martin-Castillo B, Micol V, Joven J, Segura-Carretero A, Menendez JA.

A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo.
Liu Y, Cao Y, Zhang W, Bergmeier S, Qian Y, Akbar H, Colvin R, Ding J, Tong L, Wu S, Hines J, Chen X.

Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants
Jérome Kluza, Paola Corazao-Rozas, Yasmine Touil, Manel Jendoubi, Cyril Maire, Pierre Guerreschi, Aurélie Jonneaux, Caroline Ballot, Stéphane Balayssac, Samuel Valable, Aurélien Corroyer-Dulmont, Myriam Bernaudin, Myriam Malet-Martino, Elisabeth Martin de Lassalle, Patrice Maboudou, Pierre Formstecher, Renata Polakowska, Laurent Mortier, and Philippe Marchetti


Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
Liron Bar-Peled, Lawrence D. Schweitzer, Roberto Zoncu, David M. Sabatini

The G Protein-Coupled Taste Receptor T1R1/T1R3 Regulates mTORC1 and Autophagy
Eric M. Wauson, Elma Zaganjor, A-Young Lee, Marcy L. Guerra, Anwesha B. Ghosh, Angie L. Bookout, Chris P. Chambers, Arif Jivan, Kathleen McGlynn, Michele R. Hutchison, Ralph J. Deberardinis, and Melanie H. Cobb

Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate
D Davila, N M C Connolly, H Bonner, P Weisová, H Dussmann, C G Concannon, H J Huber and J H M Prehn


Autophagy and phagocytosis-like cell cannibalism exert opposing effects on cellular survival during metabolic stress
J Poels, M R Spasić, M Gistelinck, J Mutert, A Schellens, P Callaerts and K K Norga

Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition
Amila Suraweera, Christian Münch, Ariane Hanssum, and Anne Bertolotti

ATF4-Dependent Regulation of the JMJD3 Gene During Amino Acid Deprivation Can be Rescued in Atf4-Deficient Cells by Inhibition of Deacetylation
Jixiu Shan, Lingchen Fu, Mukundh N. Balasubramanian, Tracy Anthony, and Michael S. Kilberg
J. Biol. Chem. published 6 September 2012, 10.1074/jbc.M112.399600


Control of Tumor Bioenergetics and Survival Stress Signaling by Mitochondrial HSP90s
Young Chan Chae, M. Cecilia Caino, Sofia Lisanti, Jagadish C. Ghosh, Takehiko Dohi, Nika N. Danial, Jessie Villanueva, Stefano Ferrero, Valentina Vaira, Luigi Santambrogio, Silvano Bosari, Lucia R. Languino, Meenhard Herlyn, Dario C. Altieri

Stearoyl-CoA desaturase activity modulates the activation of epidermal growth factor receptor in human lung cancer cells
Mary Nashed, Jeffrey W Chisholm and R Ariel Igal


Metabolic checkpoints in activated T cells
Ruoning Wang and Douglas R Green

Metabolic stress in autophagy and cell death pathways
Altman BJ, Rathmell JC.

Investigating Metformin for Cancer Prevention and Treatment: The End of the Beginning
Michael N. Pollak
Cancer Discovery September 2012;2:778-790

Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells
Jin-Qiang Chen, Jose Russo

A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells
Philippe Icard, Hubert Lincet

Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer?
Seyfried, Thomas N.; Marsh, Jeremy; Shelton, Laura M.; Huysentruyt,
Leanne C.; Mukherjee, Purna

Mitochondria and cancer
Douglas C. Wallace

Immunological Reviews Special Issue: Metabolism and Autophagy in the Immune System

Including (for instance)
– The fourth dimension in immunological space: how the struggle for nutrients selects high-affinity lymphocytes
Felix M. Wensveen, Klaas P. J. M. van Gisbergen and Eric Eldering
– Metabolic reprogramming and metabolic dependency in T cells
Ruoning Wang and Douglas R. Green
– LKB1 and AMPK: central regulators of lymphocyte metabolism and function
Julianna Blagih, Connie M. Krawczyk and Russell G. Jones
– Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity
Katelin N. Townsend, Luke R. K. Hughson, Katrin Schlie, Vincent I. Poon, Ashley Westerback and Julian J. Lum

Comments / other

Cancer metabolism: When more is less
Lei Jiang & Ralph J. DeBerardinis

IDH1 Mutations Disrupt Blood, Brain, and Barriers
Alan H. Shih, Ross L. Levine

Proliferation: Multitasking
Two recently published papers examine the metabolic and nonmetabolic functions of PKM2 in greater detail.

Call for papers: Cell Death and Disease (NPG), Cancer Metabolism section.

Call for papers (review and research articles): Metabolism and Carcinogenesis focus issue at Journal of Carcinogenesis:

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