MetaboList – October 2012

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Cancer, proliferation and metabolism
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Serine is a natural ligand and allosteric activator of pyruvate kinase M2
Barbara Chaneton, Petra Hillmann, Liang Zheng, Agnès C. L. Martin, Oliver D. K. Maddocks, Achuthanunni Chokkathukalam, Joseph E. Coyle, Andris Jankevics,Finn P. Holding, Karen H. Vousden, Christian Frezza, Marc O’Reilly & Eyal Gottlieb
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11540.html

A metabolic prosurvival role for PML in breast cancer.
Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP.
http://www.jci.org/articles/view/62129

Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma
Pilar Caro, Amar U. Kishan, Erik Norberg, Illana A. Stanley, Bjoern Chapuy, Scott B. Ficarro, Klaudia Polak, Daniel Tondera, John Gounarides, Hong Yin, Feng Zhou, Michael R. Green, Linfeng Chen, Stefano Monti, Jarrod A. Marto, Margaret A. Shipp, Nika N. Danial
http://www.cell.com/cancer-cell/abstract/S1535-6108%2812%2900356-X

Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides
Zhenxun Wang, Hyun Yong Jeon, Frank Rigo, C. Frank Bennett and Adrian R. Krainer
http://rsob.royalsocietypublishing.org/content/2/10/120133.short?rss=1

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation
Dallas R. Donohoe, Leonard B. Collins, Aminah Wali, Rebecca Bigler, Wei Sun, Scott J. Bultman
http://www.cell.com/molecular-cell/abstract/S1097-2765%2812%2900777-0

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mTOR, starvation
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HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5.
Elorza A, Soro-Arnáiz I, Meléndez-Rodríguez F, Rodríguez-Vaello V, Marsboom G, de Cárcer G, Acosta-Iborra B, Albacete-Albacete L, Ordóñez A, Serrano-Oviedo L, Giménez-Bachs JM, Vara-Vega A, Salinas A, Sánchez-Prieto R, Martín Del Río R, Sánchez-Madrid F, Malumbres M, Landázuri MO, Aragonés J.
http://www.sciencedirect.com/science/article/pii/S1097276512008179

Genome Sequencing Identifies a Basis for Everolimus Sensitivity
Gopa Iyer,  Aphrothiti J. Hanrahan, Matthew I. Milowsky, Hikmat Al-Ahmadie, Sasinya N. Scott, Manickam Janakiraman, Mono Pirun, Chris Sander, Nicholas D. Socci, Irina Ostrovnaya, Agnes Viale, Adriana Heguy, Luke Peng, Timothy A. Chan, Bernard Bochner, Dean F. Bajorin, Michael F. Berger, Barry S. Taylor, David B. Solit
http://www.sciencemag.org/content/338/6104/221.short

Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition
Michele Cea, Antonia Cagnetta, Mariateresa Fulciniti, Yu-Tzu Tai, Teru Hideshima, Dharminder Chauhan, Aldo Roccaro, Antonio Sacco, Teresa Calimeri, Francesca Cottini, Jana Jakubikova, Sun-Young Kong, Franco Patrone, Alessio Nencioni, Marco Gobbi, Paul Richardson, Nikhil Munshi, and Kenneth C. Anderson
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/120/17/3519

Autophagy: Resetting glutamine-dependent metabolism and oxygen consumption
Tsung-Chin Lin, Yun-Ru Chen, Elizabeth Kensicki, Angela Ying-Jian Li, Mei Kong, Yang Li, Robert P. Mohney, Han-Ming Shen, Bangyan Stiles, Noboru Mizushima, Liang-In Lin and David K. Ann
http://www.landesbioscience.com/journals/autophagy/article/21228/

Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death.
Hamidi T, Cano CE, Grasso D, Garcia MN, Sandi MJ, Calvo EL, Dagorn JC, Lomberk G, Urrutia R, Goruppi S, Carracedo A, Velasco G, Iovanna JL.
http://clincancerres.aacrjournals.org/content/18/19/5234.long

The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway
Yugang Wang, Goleeta N. Alam, Yu Ning, Fernanda Visioli, Zhihong Dong, Jacques E. Nör, and Peter J. Polverini
http://cancerres.aacrjournals.org/cgi/content/abstract/72/20/5396

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Miscellaneous
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Targeting of several glycolytic enzymes using RNAi reveals aldolase affects cancer-cell proliferation through a non-glycolytic metabolism
Carolyn Ritterson Lew and Dean R. Tolan
http://www.jbc.org/cgi/content/abstract/M112.405969v1

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.
Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, Schafer ZT, Evans RM, Suda T, Lee CH, Pandolfi PP.
http://www.nature.com/nm/journal/v18/n9/full/nm.2882.html

An NMR Metabolomics Approach for the Diagnosis of Leptomeningeal Carcinomatosis
Hye Rim Cho, He Wen, Young Jin Ryu, Yong Jin An, Hyo Cheol Kim, Woo Kyung Moon, Moon Hee Han, Sunghyouk Park, and Seung Hong Choi
http://cancerres.aacrjournals.org/cgi/content/abstract/72/20/5179

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Reviews
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Cancer Cell Metabolism: One Hallmark, Many Faces
Jason R. Cantor and David M. Sabatini
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/2/10/881

Global Profiling Strategies for Mapping Dysregulated Metabolic Pathways in Cancer
Daniel I. Benjamin, Benjamin F. Cravatt, Daniel K. Nomura
http://www.cell.com/cell-metabolism/abstract/S1550-4131%2812%2900373-7

Anticancer agents that counteract tumor glycolysis.
Granchi C, Minutolo F.
http://onlinelibrary.wiley.com/doi/10.1002/cmdc.201200176/full

The NAD metabolome — a key determinant of cancer cell biology
Alberto Chiarugi, Christian Dolle, Roberta Felici & Mathias Ziegler
http://www.nature.com/nrc/journal/v12/n11/abs/nrc3340.html

Fructose consumption and cancer: is there a connection?
Port AM, Ruth MR, Istfan NW.
http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=1752-296X&volume=19&issue=5&spage=367

The bio-energetic theory of carcinogenesis.
Gonzalez MJ, Miranda Massari JR, Duconge J, Riordan NH, Ichim T, Quintero-Del-Rio AI, Ortiz N
http://www.medical-hypotheses.com/article/S0306-9877%2812%2900291-5/abstract

Physiological Roles of Mitochondrial Reactive Oxygen Species
L.A. Sena and N.S. Chandel
http://www.cell.com/molecular-cell/abstract/S1097-2765%2812%2900825-8

Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion
Michael Platten, Wolfgang Wick, and Benoît J. Van den Eynde
http://cancerres.aacrjournals.org/cgi/content/abstract/72/21/5435

Purines, Purinergic Receptors, and Cancer
Francesco Di Virgilio
http://cancerres.aacrjournals.org/cgi/content/abstract/72/21/5441

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Previews / comments / other
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A Mitochondrial Power Play in Lymphoma
Ralph J. DeBerardinis
http://www.cell.com/cancer-cell/abstract/S1535-6108%2812%2900401-1

Tasting Amino Acids Limits Autophagy
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/245/ec261

Metabolism: TAp63 tips the energy balance?
http://www.nature.com/nrc/journal/v12/n11/full/nrc3386.html

Hypoxia-Activated Drugs Gain Clinical Ground
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/2/10/862-a

The PHD2 Oxygen Sensor Modulates Chemotherapy Response
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/2/10/OF12

Pyruvate Kinase M2 Phosphorylates Histone H3
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/2/10/OF19

Pyruvate Kinase M2 Activators Inhibit Tumor Growth
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/2/10/866-a

Post-translational Modification of PFK1 Modulates Cancer Metabolism
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/2/10/OF25

Fat helps tumours to grow
http://www.nature.com/nature/journal/v490/n7420/full/490312c.html

Q&A: Eileen White on Understanding Autophagy
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/2/10/863

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