MetaboList – October 2012

Cancer, proliferation and metabolism

Serine is a natural ligand and allosteric activator of pyruvate kinase M2
Barbara Chaneton, Petra Hillmann, Liang Zheng, Agnès C. L. Martin, Oliver D. K. Maddocks, Achuthanunni Chokkathukalam, Joseph E. Coyle, Andris Jankevics,Finn P. Holding, Karen H. Vousden, Christian Frezza, Marc O’Reilly & Eyal Gottlieb

A metabolic prosurvival role for PML in breast cancer.
Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP.

Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma
Pilar Caro, Amar U. Kishan, Erik Norberg, Illana A. Stanley, Bjoern Chapuy, Scott B. Ficarro, Klaudia Polak, Daniel Tondera, John Gounarides, Hong Yin, Feng Zhou, Michael R. Green, Linfeng Chen, Stefano Monti, Jarrod A. Marto, Margaret A. Shipp, Nika N. Danial

Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides
Zhenxun Wang, Hyun Yong Jeon, Frank Rigo, C. Frank Bennett and Adrian R. Krainer

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation
Dallas R. Donohoe, Leonard B. Collins, Aminah Wali, Rebecca Bigler, Wei Sun, Scott J. Bultman

mTOR, starvation

HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5.
Elorza A, Soro-Arnáiz I, Meléndez-Rodríguez F, Rodríguez-Vaello V, Marsboom G, de Cárcer G, Acosta-Iborra B, Albacete-Albacete L, Ordóñez A, Serrano-Oviedo L, Giménez-Bachs JM, Vara-Vega A, Salinas A, Sánchez-Prieto R, Martín Del Río R, Sánchez-Madrid F, Malumbres M, Landázuri MO, Aragonés J.

Genome Sequencing Identifies a Basis for Everolimus Sensitivity
Gopa Iyer,  Aphrothiti J. Hanrahan, Matthew I. Milowsky, Hikmat Al-Ahmadie, Sasinya N. Scott, Manickam Janakiraman, Mono Pirun, Chris Sander, Nicholas D. Socci, Irina Ostrovnaya, Agnes Viale, Adriana Heguy, Luke Peng, Timothy A. Chan, Bernard Bochner, Dean F. Bajorin, Michael F. Berger, Barry S. Taylor, David B. Solit

Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition
Michele Cea, Antonia Cagnetta, Mariateresa Fulciniti, Yu-Tzu Tai, Teru Hideshima, Dharminder Chauhan, Aldo Roccaro, Antonio Sacco, Teresa Calimeri, Francesca Cottini, Jana Jakubikova, Sun-Young Kong, Franco Patrone, Alessio Nencioni, Marco Gobbi, Paul Richardson, Nikhil Munshi, and Kenneth C. Anderson

Autophagy: Resetting glutamine-dependent metabolism and oxygen consumption
Tsung-Chin Lin, Yun-Ru Chen, Elizabeth Kensicki, Angela Ying-Jian Li, Mei Kong, Yang Li, Robert P. Mohney, Han-Ming Shen, Bangyan Stiles, Noboru Mizushima, Liang-In Lin and David K. Ann

Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death.
Hamidi T, Cano CE, Grasso D, Garcia MN, Sandi MJ, Calvo EL, Dagorn JC, Lomberk G, Urrutia R, Goruppi S, Carracedo A, Velasco G, Iovanna JL.

The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway
Yugang Wang, Goleeta N. Alam, Yu Ning, Fernanda Visioli, Zhihong Dong, Jacques E. Nör, and Peter J. Polverini


Targeting of several glycolytic enzymes using RNAi reveals aldolase affects cancer-cell proliferation through a non-glycolytic metabolism
Carolyn Ritterson Lew and Dean R. Tolan

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.
Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, Schafer ZT, Evans RM, Suda T, Lee CH, Pandolfi PP.

An NMR Metabolomics Approach for the Diagnosis of Leptomeningeal Carcinomatosis
Hye Rim Cho, He Wen, Young Jin Ryu, Yong Jin An, Hyo Cheol Kim, Woo Kyung Moon, Moon Hee Han, Sunghyouk Park, and Seung Hong Choi


Cancer Cell Metabolism: One Hallmark, Many Faces
Jason R. Cantor and David M. Sabatini

Global Profiling Strategies for Mapping Dysregulated Metabolic Pathways in Cancer
Daniel I. Benjamin, Benjamin F. Cravatt, Daniel K. Nomura

Anticancer agents that counteract tumor glycolysis.
Granchi C, Minutolo F.

The NAD metabolome — a key determinant of cancer cell biology
Alberto Chiarugi, Christian Dolle, Roberta Felici & Mathias Ziegler

Fructose consumption and cancer: is there a connection?
Port AM, Ruth MR, Istfan NW.

The bio-energetic theory of carcinogenesis.
Gonzalez MJ, Miranda Massari JR, Duconge J, Riordan NH, Ichim T, Quintero-Del-Rio AI, Ortiz N

Physiological Roles of Mitochondrial Reactive Oxygen Species
L.A. Sena and N.S. Chandel

Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion
Michael Platten, Wolfgang Wick, and Benoît J. Van den Eynde

Purines, Purinergic Receptors, and Cancer
Francesco Di Virgilio

Previews / comments / other

A Mitochondrial Power Play in Lymphoma
Ralph J. DeBerardinis

Tasting Amino Acids Limits Autophagy;5/245/ec261

Metabolism: TAp63 tips the energy balance?

Hypoxia-Activated Drugs Gain Clinical Ground

The PHD2 Oxygen Sensor Modulates Chemotherapy Response

Pyruvate Kinase M2 Phosphorylates Histone H3

Pyruvate Kinase M2 Activators Inhibit Tumor Growth

Post-translational Modification of PFK1 Modulates Cancer Metabolism

Fat helps tumours to grow

Q&A: Eileen White on Understanding Autophagy

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