MetaboList – November 2012

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Cancer metabolism
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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth
Taro Hitosugi, Lu Zhou, Shannon Elf, Jun Fan, Hee-Bum Kang, Jae Ho Seo, Changliang Shan, Qing Dai, Liang Zhang, Jianxin Xie, Ting-Lei Gu, Peng Jin, Masa Alečković, Gary LeRoy, Yibin Kang, Jessica A. Sudderth, Ralph J. DeBerardinis, Chi-Hao Luan, Georgia Z. Chen, Susan Muller, Dong M. Shin, Taofeek K. Owonikoko, Sagar Lonial, Martha L. Arellano, Hanna J. Khoury, Fadlo R. Khuri, Benjamin H. Lee, Keqiang Ye, Titus J. Boggon, Sumin Kang, Chuan He, Jing Chen
http://www.cell.com/cancer-cell/abstract/S1535-6108(12)00398-4

Metabolic Associations of Reduced Proliferation and Oxidative Stress in Advanced Breast Cancer
Livnat Jerby, Lior Wolf, Carsten Denkert, Gideon Y. Stein, Mika Hilvo, Matej Oresic, Tamar Geiger, and Eytan Ruppin
http://cancerres.aacrjournals.org/cgi/content/abstract/72/22/5712

An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer
Mark L. McCleland, Adam S. Adler, Yonglei Shang, Thomas Hunsaker, Tom Truong, David Peterson, Eric Torres, Li Li, Benjamin Haley, Jean-Philippe Stephan, Marcia Belvin, Georgia Hatzivassiliou, Elizabeth M. Blackwood, Laura Corson, Marie Evangelista, Jiping Zha, and Ron Firestein
http://cancerres.aacrjournals.org/cgi/content/abstract/72/22/5812

The Metabolomic Signature of Malignant Glioma Reflects Accelerated Anabolic Metabolism
Prakash Chinnaiyan, Elizabeth Kensicki, Gregory Bloom, Antony Prabhu, Bhaswati Sarcar, Soumen Kahali, Steven Eschrich, Xiaotao Qu, Peter Forsyth, and Robert Gillies
http://cancerres.aacrjournals.org/cgi/content/abstract/72/22/5878

Analysis of glutamine dependency in non-small cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth.
van den Heuvel AP, Jing J, Wooster RF, Bachman KE.
http://www.landesbioscience.com/journals/cbt/article/21348/

Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL
G L Robinson, D Dinsdale, M MacFarlane and K Cain
http://www.nature.com/onc/journal/v31/n48/abs/onc201213a.html

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Starvation
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ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation
Guoliang Qing, Bo Li, Annette Vu, Nicolas Skuli, Zandra E. Walton, Xueyuan Liu, Patrick A. Mayes, David R. Wise, Craig B. Thompson, John M. Maris, Michael D. Hogarty, M. Celeste Simon
http://www.cell.com/cancer-cell/abstract/S1535-6108(12)00399-6

SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions
Kirstie E. Keller, Irene S. Tan, Young-Sam Lee
http://www.sciencemag.org/content/338/6110/1069.full

Depletion of L-arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes
Rósula García-Navas, Markus Munder and Faustino Mollinedo
http://dx.doi.org/10.4161/auto.21315

The mRNA-Stabilizing Factor HuR Is Targeted by β-TrCP for Degradation in Response to Glycolysis Inhibition
Po-Chen Chu, Hsiao-Ching Chuang, Samuel K. Kulp, and Ching-Shih Chen
http://www.jbc.org/cgi/content/abstract/M112.393678v1

Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk.
Ryder C, McColl K, Zhong F, Distelhorst CW.
http://www.jbc.org/content/287/33/27863.long

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AMPK / mTOR
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A role of DNA-dependent protein kinase for the activation of AMP-activated protein kinase in response to glucose deprivation
Parmeshwar Narayan Amatya, Hong-Beum Kim, Seon-Joo Park, Cha-Kyung Youn, Jin-Won Hyun, In-Youb Chang, Jung-Hee Lee, Ho Jin You
http://www.sciencedirect.com/science/article/pii/S016748891200256X

Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway
Luisa Garcia-Haro, Maria Adelaida Garcia-Gimeno, Dietbert Neumann, Monique Beullens, Mathieu Bollen, Pascual Sanz
http://www.sciencedirect.com/science/article/pii/S0014579312008150

Mechanistic target of rapamycin in complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor
Michael D. Dennis, Scot R. Kimball, and Leonard S. Jefferson
http://www.jbc.org/cgi/content/abstract/M112.402461v1

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Hypoxia
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Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression.
Luo W, Chang R, Zhong J, Pandey A, Semenza GL.
http://www.pnas.org/content/early/2012/10/31/1217394109.long

Hypoxia-Induced Modulation of Apoptosis and BCL-2 Family Proteins in Different Cancer Cell Types
Audrey Sermeus, Marie Genin, Amélie Maincent, Maude Fransolet, Annick Notte, Lionel Leclere, Hélène Riquier, Thierry Arnould, Carine Michiels
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0047519

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Miscellaneous
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Carbon Source and Myc Expression Influence the Antiproliferative Actions of Metformin
Shiva Javeshghani, Mahvash Zakikhani, Shane Austin, Miguel Bazile, Marie-José Blouin, Ivan Topisirovic, Julie St-Pierre, and Michael N. Pollak
http://cancerres.aacrjournals.org/cgi/content/abstract/72/23/6257

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation
Richard C. Wang, Yongjie Wei,  Zhenyi An, Zhongju Zou, Guanghua Xiao, Govind Bhagat, Michael White, Julia Reichelt, Beth Levine
http://www.sciencemag.org/content/338/6109/956.abstract

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Previews / reviews / other
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PGAMgnam Style: A Glycolytic Switch Controls Biosynthesis
Barbara Chaneton, Eyal Gottlieb
http://www.cell.com/cancer-cell/abstract/S1535-6108(12)00443-6

Targeting tumor cell metabolism with statins
J W Clendening and L Z Penn
http://www.nature.com/onc/journal/v31/n48/full/onc20126a.html

Interactions between epigenetics and metabolism in cancers
Jihye Yun, Jared L. Johnson, Christin L. Hanigan, and Jason W. Locasale
http://www.frontiersin.org/Journal/Abstract.aspx?ART_DOI=10.3389/fonc.2012.00163&name=molecular_and_cellular_oncology

Challenges in targeting cancer metabolism for cancer therapy
R Yamaguchi, G Perkins
http://www.nature.com/embor/journal/vaop/ncurrent/full/embor2012176a.html

Metabolism: Warburg behind the butyrate paradox?
http://www.nature.com/nrc/journal/v12/n12/full/nrc3401.html

A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells
Philippe Icard, Hubert Lincet
http://www.sciencedirect.com/science/article/pii/S0304419X12000534

Promoting Tumorigenesis by Suppressing Autophagy
Itay Koren and Adi Kimchi
http://www.sciencemag.org/content/338/6109/889.short


Recruiting groups leaders: Cancer Metabolism. Beatson Institute in Glasgow.
http://www.beatson.gla.ac.uk/Group-Leaders/

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