MetaboList – December 2012

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Cancer metabolism / starvation
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Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
Oliver D. K. Maddocks, Celia R. Berkers, Susan M. Mason, Liang Zheng, Karen Blyth, Eyal Gottlieb & Karen H. Vousden
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11743.html

Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism
Yan Ding, Zixing Liu, Shruti Desai, Yuhua Zhao, Hao Liu, Lewis K. Pannell, Hong Yi, Elizabeth R. Wright, Laurie B. Owen, Windy Dean-Colomb, Oystein Fodstad, Jianrong Lu, Susan P. LeDoux, Glenn L. Wilson and Ming Tan
http://www.nature.com/ncomms/journal/v3/n12/abs/ncomms2236.html

Metabolomics Strategy Reveals Subpopulation of Liposarcomas Sensitive to Gemcitabine Treatment
Daniel Braas, Ethan Ahler, Brenna Tam, David Nathanson, Mirielle Riedinger, Matthias R. Benz, Kathleen B. Smith, Fritz C. Eilber, Owen N. Witte, William D. Tap, Hong Wu, and Heather R. Christofk
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/2/12/1109

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
Weiwei Yang, Yanhua Zheng, Yan Xia, Haitao Ji, Xiaomin Chen, Fang Guo, Costas A. Lyssiotis, Kenneth Aldape, Lewis C. Cantley and Zhimin Lu
http://www.nature.com/ncb/journal/v14/n12/full/ncb2629.html

Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells
Elena Favaro, Karim Bensaad, Mei G. Chong, Daniel A. Tennant, David J.P. Ferguson, Cameron Snell, Graham Steers, Helen Turley, Ji-Liang Li, Ulrich L. Günther, Francesca M. Buffa, Alan McIntyre, Adrian L. Harris
http://www.cell.com/cell-metabolism/abstract/S1550-4131%2812%2900451-2

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
Carlos Sebastián, Bernadette M.M. Zwaans, Dafne M. Silberman, Melissa Gymrek, Alon Goren, Lei Zhong, Oren Ram, Jessica Truelove, Alexander R. Guimaraes, Debra Toiber, Claudia Cosentino, Joel K. Greenson, Alasdair I. MacDonald, Liane McGlynn, Fraser Maxwell, Joanne Edwards, Sofia Giacosa, Ernesto Guccione, Ralph Weissleder, Bradley E. Bernstein, Aviv Regev, Paul G. Shiels, David B. Lombard, Raul Mostoslavsky
http://www.cell.com/abstract/S0092-8674(12)01351-7

Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells
Enrico Desideri, Giuseppe Filomeni and Maria Rosa Ciriolo
http://www.landesbioscience.com/journals/autophagy/article/22037/

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Anti-metabolic drugs
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Combination of glycolysis inhibition with chemotherapy results in an antitumor immune response
Marie Bénéteau, Barbara Zunino, Marie A. Jacquin, Ophélie Meynet, Johanna Chiche, Ludivine A. Pradelli, Sandrine Marchetti, Aurore Cornille, Michel Carles, and Jean-Ehrland Ricci
http://www.pnas.org/content/109/49/20071.abstract.html?etoc

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
Kivanç Birsoy, Tim Wang, Richard Possemato, Omer H Yilmaz, Catherine E Koch, Walter W Chen, Amanda W Hutchins, Yetis Gultekin, Tim R Peterson, Jan E Carette, Thijn R Brummelkamp, Clary B Clish & David M Sabatini
http://www.nature.com/ng/journal/v45/n1/full/ng.2471.html

A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors.
Raez LE, Papadopoulos K, Ricart AD, Chiorean EG, Dipaola RS, Stein MN, Rocha Lima CM, Schlesselman JJ, Tolba K, Langmuir VK, Kroll S, Jung DT, Kurtoglu M, Rosenblatt J, Lampidis TJ.
http://link.springer.com/article/10.1007%2Fs00280-012-2045-1#

2-Deoxy-d-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: Involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways
María Cristina Estan, Eva Calviño, Elena de Blas, María del Carmen Boyano-Adánez,
Maria Luz Mena, Milagros Gómez-Gómez, Eduardo Rial, Patricio Aller
http://www.sciencedirect.com/science/article/pii/S0006295212006533

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Nutrient sensing / mTOR
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JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer
Adrian Britschgi, Rita Andraos, Heike Brinkhaus, Ina Klebba, Vincent Romanet, Urs Müller, Masato Murakami, Thomas Radimerski, Mohamed Bentires-Alj
http://www.cell.com/cancer-cell/abstract/S1535-6108%2812%2900447-3

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
David K. Finlay, Ella Rosenzweig, Linda V. Sinclair, Carmen Feijoo-Carnero, Jens L. Hukelmann, Julia Rolf, Andrey A. Panteleyev, Klaus Okkenhaug, and Doreen A. Cantrell
http://jem.rupress.org/cgi/content/abstract/209/13/2441?etoc

eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies
Tommy Alain, Masahiro Morita, Bruno D. Fonseca, Akiko Yanagiya, Nadeem Siddiqui, Mamatha Bhat, Domenick Zammit, Victoria Marcus, Peter Metrakos, Lucie-Anne Voyer, Valentina Gandin, Yi Liu, Ivan Topisirovic, and Nahum Sonenberg
http://cancerres.aacrjournals.org/content/72/24/6468.abstract.html

Novel Role for SHP-2 in Nutrient-Responsive Control of S6 Kinase 1 Signaling
Fatih Mercan, Hojin Lee, Sivanagarani Kolli, and Anton M. Bennett
http://mcb.asm.org/cgi/content/abstract/33/2/293

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Miscellaneous
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Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death
Eric C. Cheung, Robert L. Ludwig, and Karen H. Vousden
http://www.pnas.org/content/109/50/20491.abstract.html?etoc

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation
Dallas R. Donohoe, Leonard B. Collins, Aminah Wali, Rebecca Bigler, Wei Sun, Scott J. Bultman
http://www.cell.com/molecular-cell/abstract/S1097-2765%2812%2900777-0

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Reviews
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Glucose-a sweet way to die Metabolic switching modulates tumor cell death
MacFarlane, M; Robinson, GL; Cain, K
http://www.landesbioscience.com/journals/cc/article/21804/

Emerging roles of PKM2 in cell metabolism and cancer progression
W Luo and GL Semenza
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760%2812%2900116-6

Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes
Brian W. Wong, Anna Kuchnio, Ulrike Bruning, Peter Carmeliet
http://www.cell.com/trends/biochemical-sciences/abstract/S0968-0004(12)00159-4

Cancer Metabolism: What we Can Learn from Proteomic Analysis by Mass Spectrometry.
Zhou W, Liotta LA, Petricoin EF.
http://cgp.iiarjournals.org/content/9/6/373.long

Regulation of lipid stores and metabolism by lipophagy
K Liu and M J Czaja
http://www.nature.com/cdd/journal/v20/n1/abs/cdd201263a.html

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Comments / previews
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An Amino Acid Carrier Links the HIF2α Pathway and mTORC1 Regulation
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/2/12/1076-a

SIRT6 Puts Cancer Metabolism in the Driver’s Seat
Costas A. Lyssiotis, Lewis C. Cantley
http://www.cell.com/abstract/S0092-8674(12)01405-5

Linking Glycogen and Senescence in Cancer Cells
Susana Ros, Almut Schulze
http://www.cell.com/cell-metabolism/abstract/S1550-4131%2812%2900463-9

Metabolism: Transporting drugs
http://www.nature.com/nrc/journal/v13/n1/full/nrc3443.html

Metabolism: Nuclear functions
http://www.nature.com/nrc/journal/v13/n1/full/nrc3440.html

Tumorigenic Role for Cancer Metabolism
Loss of the histone deacetylase SIRT6 leads to increased glycolysis and tumorigenesis independently of known oncogenes.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;5/254/ec323

The Warburg Effect Causes a Shift in Histone Acetylation
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/2/12/OF14

Cancer: Metabolism in ‘the driver’s seat
Luisa Tasselli & Katrin F. Chua
http://www.nature.com/nature/journal/v492/n7429/full/492362a.html

Deprive to kill: Glutamine closes the gate to anticancer monocarboxylic drugs
Simone Cardaci and Maria Rosa Ciriolo
http://www.landesbioscience.com/journals/autophagy/article/21795/

Glutamine metabolism links growth factor signaling to the regulation of autophagy
Kristan E. van der Vos and Paul J. Coffer
http://dx.doi.org/10.4161/auto.22152

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Other
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Q&A: Celeste Simon on Hypoxia–Cancer Links
Cancer Discovery December 2012;2:1071
http://cancerdiscovery.aacrjournals.org/cgi/content/abstract/2/12/1071

SnapShot: mTORC1 Signaling at the Lysosomal Surface
Liron Bar-Peled, David M. Sabatini
http://download.cell.com/pdf/PIIS0092867412014237.pdf

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