MetaboList – January 2013

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Cancer metabolism
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AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
Brandon Faubert, Gino Boily, Said Izreig, Takla Griss, Bozena Samborska, Zhifeng Dong, Fanny Dupuy, Christopher Chambers, Benjamin J. Fuerth, Benoit Viollet, Orval A. Mamer, Daina Avizonis, Ralph J. DeBerardinis, Peter M. Siegel, Russell G. Jones
http://www.cell.com/cell-metabolism/abstract/S1550-4131(12)00492-5

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
Peng Jiang, Wenjing Du, Anthony Mancuso, Kathryn E. Wellen & Xiaolu Yang
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11776.html

S6K1 determines the metabolic requirements for BCR-ABL survival
J F Barger, C A Gallo, P Tandon, H Liu, A Sullivan, H L Grimes and D R Plas
http://www.nature.com/onc/journal/v32/n4/abs/onc201270a.html

M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth
Marta Cortés-Cros, Christelle Hemmerlin, Stephane Ferretti, Juan Zhang, John S. Gounarides, Hong Yin, Alban Muller, Anne Haberkorn, Patrick Chene, William R. Sellers, and Francesco Hofmann
http://www.pnas.org/content/110/2/489.abstract.html?etoc

Disruption of Wild-Type IDH1 Suppresses Production in IDH1-Mutated Gliomas
Genglin Jin, Zachary J. Reitman, Christopher G. Duncan, Ivan Spasojevic, David M. Gooden, B. Ahmed Rasheed, Rui Yang, Giselle Y. Lopez, Yiping He, Roger E. McLendon, Darell D. Bigner, and Hai Yan
http://cancerres.aacrjournals.org/content/73/2/496.abstract.html

Loss of RBF1 changes glutamine catabolism
Brandon N. Nicolay, Paulo A. Gameiro, Katrin Tschöp, Michael Korenjak, Andreas M. Heilmann, John M. Asara, Gregory Stephanopoulos, Othon Iliopoulos, and Nicholas J. Dyson
http://genesdev.cshlp.org/content/27/2/182.abstract.html

Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma
N Syed, J Langer, K Janczar, P Singh, C Lo Nigro, L Lattanzio, H M Coley, E Hatzimichael, J Bomalaski, P Szlosarek, M Awad, K O’Neil, F Roncaroli and T Crook
http://www.nature.com/cddis/journal/v4/n1/abs/cddis2012197a.html

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Starvation / hypoxia
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Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.
Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H, Wolfson RL, Kirak O, Sabatini DD, Sabatini DM.
http://www.nature.com/nature/journal/v493/n7434/full/nature11745.html

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy
Joungmok Kim, Young Chul Kim, Chong Fang, Ryan C. Russell, Jeong Hee Kim, Weiliang Fan, Rong Liu, Qing Zhong, Kun-Liang Guan
http://www.cell.com/abstract/S0092-8674(12)01538-3

Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex
Sang Gyun Kim, Gregory R. Hoffman, George Poulogiannis, Gwen R. Buel, Young Jin Jang, Ki Won Lee, Bo-Yeon Kim, Raymond L. Erikson, Lewis C. Cantley, Andrew Y. Choo, John Blenis
http://www.cell.com/molecular-cell/abstract/S1097-2765%2812%2900855-6

Glucose induces autophagy under starvation conditions by a p38 MAPK-dependent pathway
Jose Félix Moruno Manchón, Eva Pérez Jiménez and Erwin Knecht
http://www.biochemj.org/bj/449/bj4490497.htm

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival
Luke R. G. Pike, Dean C. Singleton, Francesca Buffa, Olga Abramczyk, Kanchan Phadwal, Ji Liang Li, Anna Katharina Simon, James T. Murray and Adrian L. Harris
http://www.biochemj.org/bj/449/bj4490389.htm

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Anti-metabolic drugs
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Overexpression of the Mitochondrial Folate and Glycine–Serine Pathway: A New Determinant of Methotrexate Selectivity in Tumors
Alexei Vazquez, Philip M. Tedeschi, and Joseph R. Bertino
http://cancerres.aacrjournals.org/content/73/2/478.abstract.html

Anti-mitochondrial therapy in human breast cancer multi-cellular spheroids
Edna Ayerim Mandujano-Tinocoa, Juan Carlos Gallardo-Péreza, Alvaro Marín-Hernándeza, Rafael Moreno-Sáncheza, Sara Rodríguez-Enríquez
http://www.sciencedirect.com/science/article/pii/S0167488912003345

Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
Heather A. Hirsch, Dimitrios Iliopoulos, and Kevin Struhl
http://www.pnas.org/content/110/3/972.abstract.html?etoc

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mTOR
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mTOR Inhibitor RAD001 Promotes Metastasis in a Rat Model of Pancreatic Neuroendocrine Cancer
Stefan E. Pool, Sander Bison, Stuart J. Koelewijn, Linda M. van der Graaf, Marleen Melis, Eric P. Krenning, and Marion de Jong
http://cancerres.aacrjournals.org/content/73/1/12.abstract.html

S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1
Vered Ben-Hur, Polina Denichenko, Zahava Siegfried, Avi Maimon, Adrian Krainer, Ben Davidson, Rotem Karni
http://www.cell.com/cell-reports/abstract/S2211-1247(12)00417-2

PIK3CA Mutation H1047R Is Associated with Response to PI3K/AKT/mTOR Signaling Pathway Inhibitors in Early-Phase Clinical Trials
Filip Janku, Jennifer J. Wheler, Aung Naing, Gerald S. Falchook, David S. Hong, Vanda M. Stepanek, Siqing Fu, Sarina A. Piha-Paul, J. Jack Lee, Rajyalakshmi Luthra, Apostolia M. Tsimberidou, and Razelle Kurzrock
http://cancerres.aacrjournals.org/content/73/1/276.abstract.html

Inhibition of Rapamycin-Induced AKT Activation Elicits Differential Antitumor Response in Head and Neck Cancers
Padhma Radhakrishnan, Ulaganathan Baraneedharan, Subhadra Veluchamy, Muthu Dhandapani, Dency D. Pinto, Saravanan Thiyagarajan, Allen Thayakumar, Arun Prasath, Kamal A, Ayyappan Velu, Misti Jain, Nilesh Brijwani, Prasad Narayanan, Vikram D. Kekatpure, Biswanath Majumder, and Pradip K. Majumder
http://cancerres.aacrjournals.org/content/73/3/1118.abstract.html?etoc

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Reviews
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Metabolic reprogramming by class I and II histone deacetylases
Maria M. Mihaylova, Reuben J. Shaw
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(12)00163-4

Re-thinking cell cycle regulators: the cross-talk with metabolism
Lluis Fajas
http://www.frontiersin.org/molecular_and_cellular_oncology/10.3389/fonc.2013.00004/abstract

PTEN in cancer, metabolism, and aging
Ana Ortega-Molina, Manuel Serrano
http://www.cell.com/trends/endocrinology-metabolism//retrieve/pii/S1043276012002020

Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells
Mayumi Tamada, Makoto Suematsu, and Hideyuki Saya
http://clincancerres.aacrjournals.org/content/18/20/5554.abstract

Targeting Cancer Metabolism
Beverly A. Teicher, W. Marston Linehan, and Lee J. Helman
http://clincancerres.aacrjournals.org/content/18/20/5537.abstract

mTOR in aging, metabolism, and cancer
Marion Cornu, Verena Albert, Michael N Hall
http://www.sciencedirect.com/science/article/pii/S0959437X12001499

NRF2 and p53: Januses in cancer?
Rotblat, Barak; Melino, Gerry; Knight, Richard A.
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=754

Cholesterol accumulation in prostate cancer: A classic observation from a modern perspective
James Robert Krycer, Andrew John Brown
http://www.sciencedirect.com/science/article/pii/S0304419X13000036

Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects
Arian Emami Riedmaier, Pascale Fisel, Anne T. Nies, Elke Schaeffeler, Matthias Schwab
http://www.cell.com/trends/pharmacological-sciences/abstract/S0165-6147%2812%2900197-6

Life, death, and the metabolically controlled protein acetylome
Erika Segear Johnson, Sally Kornbluth
http://www.sciencedirect.com/science/article/pii/S0955067412001561

Metabolism of inflammation limited by AMPK and pseudo-starvation
Luke A. J. O’Neill & D. Grahame Hardie
http://www.nature.com/nature/journal/v493/n7432/full/nature11862.html

Matched and mismatched metabolic fuels in lymphocyte function.
Caro-Maldonado A, Gerriets VA, Rathmell JC.
http://www.sciencedirect.com/science/article/pii/S1044532312001078

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Comments
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Metabolic Gatekeeper
Loss of the kinase AMPK promotes the Warburg effect in cancer cells.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/260/ec27

Metabolism: Sensitivity to serine starvation
http://www.nature.com/nrc/journal/v13/n2/full/nrc3457.html

Role of aerobic glycolysis in genetically engineered mouse models of cancer
Dang CV
http://www.biomedcentral.com/1741-7007/11/3

NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells
Tewfik Hamidi, Carla E. Cano, Daniel Grasso, Maria Noé Garcia, Maria José Sandi, Ezequiel L. Calvo, Jean-Charles Dagorn, Gwen Lomberk, Sandro Goruppi, Raul Urrutia, Arkaitz Carracedo, Guillermo Velasco and Juan L. Iovanna
http://dx.doi.org/10.4161/auto.22258

A metabolic hub in cancer
http://www.nature.com/nm/journal/v19/n1/full/nm.3063.html

Can Statins Help to Reduce Cancer Deaths?
http://cancerdiscovery.aacrjournals.org/content/3/1/OF9.abstract.html

MYCN-Amplified Neuroblastomas Are Glutamine Dependent
http://cancerdiscovery.aacrjournals.org/content/3/1/OF25.abstract.html

EGFR and NF-κB Cooperatively Regulate Tumor Metabolism
http://cancerdiscovery.aacrjournals.org/content/3/1/OF30.abstract.html

Stem cells: A metabolic switch
http://www.nature.com/nrm/journal/v14/n2/full/nrm3515.html

Autophagy controls everolimus (RAD001) activity in mantle cell lymphoma
Laia Rosich, Dolors Colomer and Gael Roue
http://dx.doi.org/10.4161/auto.22483

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