MetaboList – February 2013

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Cancer Metabolism
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Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1
Issam Ben-Sahra, Jessica J. Howell, John M. Asara, and Brendan D. Manning
http://www.sciencemag.org/content/early/2013/02/20/science.1228792.abstract

Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis
Aaron M. Robitaille, Stefan Christen, Mitsugu Shimobayashi, Marion Cornu, Luca L. Fava, Suzette Moes, Cristina Prescianotto-Baschong, Uwe Sauer, Paul Jenoe, and Michael N. Hall
http://www.sciencemag.org/content/early/2013/02/20/science.1228771.abstract

Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis
Li Ma, Yongzhen Tao, Angeles Duran, Victoria Llado, Anita Galvez, Jennifer F. Barger, Elias A. Castilla, Jing Chen, Tomoko Yajima, Aleksey Porollo, Mario Medvedovic, Laurence M. Brill, David R. Plas, Stefan J. Riedl, Michael Leitges, Maria T. Diaz-Meco, Adam D. Richardson, Jorge Moscat
http://www.cell.com/abstract/S0092-8674(12)01550-4

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression
Antonio F. Santidrian, Akemi Matsuno-Yagi, Melissa Ritland, Byoung B. Seo, Sarah E. LeBoeuf, Laurie J. Gay, Takao Yagi and Brunhilde Felding-Habermann
http://www.jci.org/articles/view/64264

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth
Beatrice Griffiths, Caroline A Lewis, Karim Bensaad, Susana Ros, Qifeng Zhang, Emma C Ferber, Sofia Konisti, Barrie Peck, Heike Miess, Philip East, Michael Wakelam, Adrian L Harris, Almut Schulze
http://www.cancerandmetabolism.com/content/1/1/3

p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production
Ido Goldstein, Keren Yizhak, Shalom Madar, Naomi Goldfinger, Eytan Ruppin, Varda Rotter
http://www.cancerandmetabolism.com/content/1/1/9

Metabolic changes in cancer cells upon suppression of MYC
Elena Anso, Andrew R Mullen, Dean W Felsher, José M Matés, Ralph J DeBerardinis, Navdeep S Chandel
http://www.cancerandmetabolism.com/content/1/1/7/abstract

miR-143 regulates hexokinase 2 expression in cancer cells
A Peschiaroli, A Giacobbe, A Formosa, E K Markert, L Bongiorno-Borbone, A J Levine, E Candi, A D’Alessandro, L Zolla, A Finazzi Agrò and G Melino
http://www.nature.com/onc/journal/v32/n6/abs/onc2012100a.html

Prostate cancer cells metabolize d-lactate inside mitochondria via a d-lactate dehydrogenase which is more active and highly expressed than in normal cells
Lidia de Bari, Loredana Moro, Salvatore Passarella
http://www.sciencedirect.com/science/article/pii/S0014579313000306

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Nutrient sensing / mTOR and autophagy
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mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State
Chunlei Cang, Yandong Zhou, Betsy Navarro, Young-jun Seo, Kimberly Aranda, Lucy Shi, Shyuefang Battaglia-Hsu, Itzhak Nissim, David E. Clapham, Dejian Ren
http://www.cell.com/abstract/S0092-8674(13)00075-5

Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase
Ching-An Wu, Yee Chao, Shine-Gwo Shiah, Wan-Wan Lin
http://www.sciencedirect.com/science/article/pii/S0167488913000402

Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling
Frank Wippich, Bernd Bodenmiller, Maria Gustafsson Trajkovska, Stefanie Wanka, Ruedi Aebersold, Lucas Pelkmans
http://www.cell.com/abstract/S0092-8674(13)00085-8

BNIP3 is degraded by ULK1-dependent autophagy via MTORC1 and AMPK
Chang Wook Park, Sun Mi Hong, Eung-Sam Kim, Jung Hee Kwon, Kyong-Tai Kim, Hong Gil Nam and Kwan Yong Choi
http://dx.doi.org/10.4161/auto.23072

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2
Fiona McAlpine, Leon E. Williamson, Sharon A. Tooze and Edmond Y.W. Chan
http://dx.doi.org/10.4161/auto.23066

MIR181A regulates starvation- and rapamycin-induced autophagy through targeting of ATG5
Kumsal Ayse Tekirdag, Gozde Korkmaz, Deniz Gulfem Ozturk, Reuven Agami and Devrim Gozuacik
http://dx.doi.org/10.4161/auto.23117

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Hypoxia / ROS
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Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients
Brooke M. Emerling, Cyril H. Benes, George Poulogiannis, Eric L. Bell, Kevin Courtney, Hui Liu, Rayman Choo-Wing, Gary Bellinger, Kazumi S. Tsukazawa, Victoria Brown, Sabina Signoretti, Stephen P. Soltoff, and Lewis C. Cantley
http://www.pnas.org/content/110/9/3483.abstract.html?etoc

Peroxiredoxin 2 specifically regulates the oxidative and metabolic stress response of human metastatic breast cancer cells in lungs
V Stresing, E Baltziskueta, N Rubio, J Blanco, MaC Arriba, J Valls, M Janier, P Clézardin, R Sanz-Pamplona, C Nieva, M Marro, P Dmitri and A Sierra
http://www.nature.com/onc/journal/v32/n6/abs/onc201293a.html

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Anti-metabolic drugs
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LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin
David B. Shackelford, Evan Abt, Laurie Gerken, Debbie S. Vasquez, Atsuko Seki, Mathias Leblanc, Liu Wei, Michael C. Fishbein, Johannes Czernin, Paul S. Mischel, Reuben J. Shaw
http://www.cell.com/cancer-cell/abstract/S1535-6108(12)00518-1

Reversing the Warburg Effect as a Treatment for Glioblastoma
Ethan Poteet, Gourav Roy Choudhury, Ali Winters, Wenjun Li, Myoung-Gwi Ryou, Ran Liu, Lin Tang, Anuja Ghorpade, Yi Wen, Fang Yuan, Stephen T. Keir, Hai Yan, Darell D. Bigner, James W. Simpkins, and Shao-Hua Yang
http://www.jbc.org/cgi/content/abstract/M112.440354v1

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Miscellaneous
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Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging
Peter J O’Brien, Michelle Lee, Mary E Spilker, Cathy C Zhang, Zhengming Yan, Timothy C Nichols, Wenlin Li, Caroline H Johnson, Gary J Patti, Gary Siuzdak
http://www.cancerandmetabolism.com/content/1/1/4

Heat Shock Factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of Autophagy -related Protein 7 (ATG7)
Shruti Desai, Zixing Liu, Jun Yao, Nishant Patel, Jieqing Chen, Yun Wu, Erin Eun-Young Ahn, Oystein Fodstad, and Ming Tan
http://www.jbc.org/cgi/content/abstract/M112.422071v1

Proteomics of genetically engineered mouse mammary tumors identifies fatty acid metabolism members as predictive markers for cisplatin resistance
Marc Warmoes, Janneke E. Jaspers,Guotai Xu, Bharath K. Sampadi, Thang V. Pham, Jaco C. Knol, Sander R. Piersma, Epie Boven, Jos Jonkers, Sven Rottenberg and Connie R. Jimenez
http://www.mcponline.org/content/early/2013/02/08/mcp.M112.024182.abstract

Targeted Cancer Therapy with a 2-Deoxyglucose–Based Adriamycin Complex
Jie Cao, Sisi Cui, Siwen Li, Changli Du, Junmei Tian, Shunan Wan, Zhiyu Qian, Yueqing Gu, Wei R. Chen, and Guangji Wang
http://cancerres.aacrjournals.org/content/73/4/1362.abstract.html

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Reviews
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Cancer metabolism: fatty acid oxidation in the limelight
Arkaitz Carracedo, Lewis C. Cantley & Pier Paolo Pandolfi
http://www.nature.com/nrc/journal/vaop/ncurrent/full/nrc3483.html

Understanding Metabolic Regulation and Its Influence on Cell Physiology
Christian M. Metallo, Matthew G. Vander Heiden
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00052-X

Nutrient Sensing, Metabolism, and Cell Growth Control
Hai-Xin Yuan, Yue Xiong, Kun-Liang Guan
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00053-1

The multifaceted role of mTORC1 in the control of lipid metabolism.
Stéphane J H Ricoult & Brendan D Manning
http://www.nature.com/embor/journal/v14/n3/abs/embor20135a.html

The Tangled Circuitry of Metabolism and Apoptosis
Joshua L. Andersen, Sally Kornbluth
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00051-8

Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism
Susana Ros, Almut Schulze
http://www.cancerandmetabolism.com/content/1/1/8/abstract

The long and winding road to the mitochondrial pyruvate carrier
John C Schell, Jared Rutter
http://www.cancerandmetabolism.com/content/1/1/6

Activated lymphocytes as a metabolic model for carcinogenesis
Andrew N Macintyre, Jeffrey C Rathmell
http://www.cancerandmetabolism.com/content/1/1/5

Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate
Victoria A. Rafalski, Elena Mancini, and Anne Brunet
http://jcs.biologists.org/content/125/23/5597.abstract.html

The ULK1 complex: Sensing nutrient signals for autophagy activation
Pui-Mun Wong, Cindy Puente, Ian G. Ganley and Xuejun Jiang
http://dx.doi.org/10.4161/auto.23323

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Comments
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Allosteric Regulation of PKM2 Allows Cellular Adaptation to Different Physiological States
Dan Y. Gui, Caroline A. Lewis, and Matthew G. Vander Heiden
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/263/pe7

The LKB1-AMPK Pathway-Friend or Foe in Cancer?
D. Grahame Hardie
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00035-4

Amino acid signalling upstream of mTOR
Jenna L. Jewell, Ryan C. Russell & Kun-Liang Guan
http://www.nature.com/nrm/journal/v14/n3/full/nrm3522.html

The Hunger Games: p53 Regulates Metabolism upon Serine Starvation
Omid Tavana, Wei Gu
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00020-X

METABOLISM – Surviving Birth
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/261/ec33

PKCζ is a metabolic tumor suppressor
http://www.nature.com/ng/journal/v45/n3/full/ng.2574.html

p53 Is Required for the Metabolic Response to Serine Depletion
http://cancerdiscovery.aacrjournals.org/content/3/2/135.1.abstract.html

Revisiting Metformin
Biguanides suppress hepatic glucagon signaling by decreasing production of cyclic AMP.
http://stm.sciencemag.org/content/5/172/172ec31.short

Another Player in Amino Acid Sensing
FTO contributes to the ability of mTORC1 to respond to amino acid availability.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/263/ec46

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