MetaboList – March 2013

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Cancer metabolism
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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
Jaekyoung Son, Costas A. Lyssiotis, Haoqiang Ying, Xiaoxu Wang, Sujun Hua, Matteo Ligorio, Rushika M. Perera, Cristina R. Ferrone, Edouard Mullarky, Ng Shyh-Chang, Ya’an Kang, Jason B. Fleming, Nabeel Bardeesy, John M. Asara, Marcia C. Haigis, Ronald A. DePinho, Lewis C. Cantley  & Alec C. Kimmelman
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12040.html

Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma
Fabienne Guillaumond, Julie Leca, Orianne Olivares, Marie-Noëlle Lavaut, Nicolas Vidal, Patrice Berthezène, Nelson Javier Dusetti, Céline Loncle, Ezequiel Calvo, Olivier Turrini, Juan Lucio Iovanna, Richard Tomasini, and Sophie Vasseur
http://www.pnas.org/content/110/10/3919.abstract.html?etoc

How the PI3K signalling pathway and polyamine production interact in tumour cell growth
Vinothini Rajeeve, Wayne Pearce, Marta Cascante, Bart Vanhaesebroeck and Pedro R. Cutillas
http://www.biochemj.org/bj/450/0619/bj4500619.htm

Proliferation-Independent Control of Tumor Glycolysis by PDGFR-Mediated AKT Activation
Cong Ran, Huan Liu, Yasuyuki Hitoshi, and Mark A. Israel
http://cancerres.aacrjournals.org/content/73/6/1831.abstract.html

Caveolin-1–LRP6 Signaling Module Stimulates Aerobic Glycolysis in Prostate Cancer
Salahaldin A. Tahir, Guang Yang, Alexei Goltsov, Ki-Duk Song, Chengzhen Ren, Jianxiang Wang, Wenjun Chang, and Timothy C. Thompson
http://cancerres.aacrjournals.org/content/73/6/1900.abstract.html

Loss of lkb1 Expression Reduces the Latency of ErbB2-Mediated Mammary Gland Tumorigenesis, Promoting Changes in Metabolic Pathways
Rafaela Andrade-Vieira, Zhaolin Xu, Patricia Colp, Paola A. Marignani
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056567

Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells
Calabrese C, Iommarini L, Kurelac I, Calvaruso M, Capristo M, Lollini P, Nanni P, Bergamini C, Nicoletti G, De Giovanni C, Ghelli A, Giorgio V, Caratozzolo M, Marzano F, Manzari C, Betts CM, Carelli V, Ceccarelli C, Attimonelli M, Romeo G, Fato R, Rugolo M, Tullo A, Gasparre G, Porcelli A
http://www.cancerandmetabolism.com/content/1/1/11/abstract

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress
Francisca Vazquez, Ji-Hong Lim, Helen Chim, Kavita Bhalla, Geoff Girnun, Kerry Pierce, Clary B. Clish, Scott R. Granter, Hans R. Widlund, Bruce M. Spiegelman, Pere Puigserver
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00034-2

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
Rizwan Haq, Jonathan Shoag, Pedro Andreu-Perez, Satoru Yokoyama, Hannah Edelman, Glenn C. Rowe, Dennie T. Frederick, Aeron D. Hurley, Abhinav Nellore, Andrew L. Kung, Jennifer A. Wargo, Jun S. Song, David E. Fisher, Zolt Arany, Hans R. Widlund
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00067-6

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer
Chenfang Dong, Tingting Yuan, Yadi Wu, Yifan Wang, Teresa W.M. Fan, Sumitra Miriyala, Yiwei Lin, Jun Yao, Jian Shi, Tiebang Kang, Pawel Lorkiewicz, Daret St Clair, Mien-Chie Hung, B. Mark Evers, Binhua P. Zhou
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00042-1

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency
Nicola Ternette, Ming Yang, Mahima Laroyia, Mitsuhiro Kitagawa, Linda O’Flaherty, Kathryn Wolhulter, Kaori Igarashi, Kaori Saito, Keiko Kato, Roman Fischer, Alexandre Berquand, Benedikt M. Kessler, Terry Lappin, Norma Frizzell, Tomoyoshi Soga, Julie Adam, Patrick J. Pollard
http://www.cell.com/cell-reports/abstract/S2211-1247(13)00072-7

Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
Zheng L, MacKenzie ED, Karim SA, Hedley A, Blyth K, Kalna G, Watson DG, Szlosarek P, Frezza C, Gottlieb E
http://www.cancerandmetabolism.com/content/1/1/12/abstract

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Hypoxia
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In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation
Paulo A. Gameiro, Juanjuan Yang, Ana M. Metelo, Rocio Pérez-Carro, Rania Baker, Zongwei Wang, Alexandra Arreola, W. Kimryn Rathmell, Aria Olumi, Pilar López-Larrubia, Gregory Stephanopoulos, Othon Iliopoulos
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00050-8

Chaperone-mediated autophagy targets HIF-1α for lysosomal degradation
Maimon E. Hubbi, Hongxia Hu, FNU Kshitiz, Ishrat Ahmed, Andre Levchenko, and Gregg L. Semenza
http://www.jbc.org/cgi/content/abstract/M112.414771v1

Transcription Factor YY1 Contributes to Tumor Growth by Stabilizing Hypoxia Factor HIF-1α in a p53-Independent Manner
Shourong Wu, Vivi Kasim, Mitsunobu R. Kano, Sayaka Tanaka, Shinsuke Ohba, Yutaka Miura, Kanjiro Miyata, Xueying Liu, Ako Matsuhashi, Ung-il Chung, Li Yang, Kazunori Kataoka, Nobuhiro Nishiyama, and Makoto Miyagishi
http://cancerres.aacrjournals.org/content/73/6/1787.abstract.html

PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS
Kasper M. Rouschop, Ludwig J. Dubois, Tom G. Keulers, Twan van den Beucken, Philippe Lambin, Johan Bussink, Albert J. van der Kogel, Marianne Koritzinsky, and Bradly G. Wouters
http://www.pnas.org/content/110/12/4622.abstract.html?etoc

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Starvation / Ischemia
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AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1
Ning Wu, Bin Zheng, Adam Shaywitz, Yossi Dagon, Christine Tower, Gary Bellinger, Che-Hung Shen, Jennifer Wen, John Asara, Timothy E. McGraw, Barbara B. Kahn, Lewis C. Cantley
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00099-3

p58IPK-Mediated Attenuation of the Proapoptotic PERK-CHOP Pathway Allows Malignant Progression upon Low Glucose
Anne-Laure Huber, Justine Lebeau, Patricia Guillaumot, Virginie Pétrilli, Mouhannad Malek, Julien Chilloux, Frédérique Fauvet, Léa Payen, Alain Kfoury, Toufic Renno, Eric Chevet, Serge N. Manié
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00042-7

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy
Michalis Papadakis, Gina Hadley, Maria Xilouri, Lisa C Hoyte, Simon Nagel, M Mary McMenamin, Grigorios Tsaknakis, Suzanne M Watt, Cynthia Wright Drakesmith, Ruoli Chen, Matthew J A Wood, Zonghang Zhao, Benedikt Kessler, Kostas Vekrellis and Alastair M Buchan
http://www.nature.com/nm/journal/v19/n3/full/nm.3097.html

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death
I Ben-Sahra, B Dirat, K Laurent, A Puissant, P Auberger, A Budanov, J-F Tanti and F Bost
http://www.nature.com/cdd/journal/v20/n4/abs/cdd2012157a.html

Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model
N Sanchez-Macedo, J Feng, B Faubert, N Chang, A Elia, E J Rushing, K Tsuchihara, D Bungard, S L Berger, R G Jones, T W Mak and K Zaugg
http://www.nature.com/cdd/journal/v20/n4/abs/cdd2012168a.html

Dietary downregulation of mutant p53 levels via glucose restriction: Mechanisms and implications for tumor therapy
Olga Catalina Rodriguez, Sujatra Choudhury, Vamsi K. Kolukula, Eveline E. Vietsch, Jason Catania, Anju Preet, Katherine Reynoso, Jill Bargonetti, Anton Wellstein, Chris Albanese and Maria Laura Avantaggiati
http://dx.doi.org/10.4161/cc.22778

Hypoxia Antagonizes Glucose Deprivation on Interleukin 6 Expression in an Akt Dependent, but HIF-1/2α Independent Manner
Sung Ji Choi, Ik Jae Shin, Kang-Hoon Je, Eun Kyoung Min, Eun Ji Kim, Hee-Sun Kim, Senyon Choe, Dong-Eog Kim, Dong Kun Lee
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0058662

TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons
Yasunori Shintani, Amar Kapoor, Masahiro Kaneko, Ryszard T. Smolenski, Fulvio D’Acquisto, Steven R. Coppen, Narumi Harada-Shoji, Hack Jae Lee, Christoph Thiemermann, Seiji Takashima, Kenta Yashiro, and Ken Suzuki
http://www.pnas.org/content/110/13/5109.abstract.html?etoc

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AMPK/mTOR
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α-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKα in vitro
Lifu Wang and David L. Brautigan
http://www.nature.com/ncomms/journal/v4/n3/abs/ncomms2565.html

PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies
Akio Iwanami, Beatrice Gini, Ciro Zanca, Tomoo Matsutani, Alvaro Assuncao, Ali Nael, Julie Dang, Huijun Yang, Shaojun Zhu, Jun Kohyama, Issay Kitabayashi, Webster K. Cavenee, Timothy F. Cloughesy, Frank B. Furnari, Masaya Nakamura, Yoshiaki Toyama, Hideyuki Okano, and Paul S. Mischel
http://www.pnas.org/content/110/11/4339.abstract.html?etoc

Everolimus in Advanced Pancreatic Neuroendocrine Tumors: The Clinical Experience
James C. Yao, Alexandria T. Phan, Valentine Jehl, Gaurav Shah, and Funda Meric-Bernstam
http://cancerres.aacrjournals.org/content/73/5/1449.abstract.html

Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation
Yikun Li, Xuerong Wang, Ping Yue, Hui Tao, Suresh S. Ramalingam, Taofeek K. Owonikoko, Xingming Deng, Ya Wang, Haian Fu, Fadlo R. Khuri, and Shi-Yong Sun
http://www.jbc.org/cgi/content/abstract/M113.463679v1

Phosphorylation of Ribosomal Protein S6 Attenuates DNA Damage and Tumor Suppression during Development of Pancreatic Cancer
Abed Khalaileh, Avigail Dreazen, Areej Khatib, Roy Apel, Avital Swisa, Norma Kidess-Bassir, Anirban Maitra, Oded Meyuhas, Yuval Dor, and Gideon Zamir
http://cancerres.aacrjournals.org/content/73/6/1811.abstract.html

AMP-activated protein kinase (AMPK)–induced preconditioning in primary cortical neurons involves activation of MCL-1
Ujval Anilkumar, Petronela Weisová, Heiko Düssmann, Caoimhín G. Concannon, Hans-Georg König, Jochen H. M. Prehn
http://onlinelibrary.wiley.com/doi/10.1111/jnc.12108/abstract

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Miscellaneous
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Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Veronica Estrella, Tingan Chen, Mark Lloyd, Jonathan Wojtkowiak, Heather H. Cornnell, Arig Ibrahim-Hashim, Kate Bailey, Yoganand Balagurunathan, Jennifer M. Rothberg, Bonnie F. Sloane, Joseph Johnson, Robert A. Gatenby, and Robert J. Gillies
http://cancerres.aacrjournals.org/content/73/5/1524.abstract.html

Akt-dependent activation of heart 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids
Laura Novellasdemunt, Irantzu Tato, Aurea Navarro-Sabate, Marisol Ruiz-Meana, Andres Mendez-Lucas, Jose Carlos Perales, David Garcia-Dorado, Francesc Ventura, Ramon Bartrons, and Jose Luis Rosa
http://www.jbc.org/cgi/content/abstract/M113.455998v1

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity
Charity Atkins, Qi Liu, Elisabeth Minthorn, Shu-Yun Zhang, David J. Figueroa, Katherine Moss, Thomas B. Stanley, Brent Sanders, Aaron Goetz, Nathan Gaul, Anthony E. Choudhry, Hasan Alsaid, Beat M. Jucker, Jeffrey M. Axten, and Rakesh Kumar
http://cancerres.aacrjournals.org/content/73/6/1993.abstract.html

A new role of p53 in regulating lipid metabolism
Xingwu Wang, Xiaocheng Zhao, Xiang Gao, Yide Mei, and Mian Wu
http://jmcb.oxfordjournals.org/content/5/2/147.full

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Reviews
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Nutrient signaling to mTOR and cell growth
Jenna L. Jewell, Kun-Liang Guan
http://www.sciencedirect.com/science/article/pii/S0968000413000054

Targeting cellular metabolism to improve cancer therapeutics
Y Zhao, E B Butler and M Tan
http://www.nature.com/cddis/journal/v4/n3/full/cddis201360a.html

Calorie restriction and cancer prevention: a mechanistic perspective
Hursting SD, Dunlap SM, Ford NA, Hursting MJ, Lashinger LM
http://www.cancerandmetabolism.com/content/1/1/10/abstract

Expression of glucose transporters in cancers
Leszek Szablewski
http://www.sciencedirect.com/science/article/pii/S0304419X12000881

Targeting LKB1 signaling in cancer
S.E. Korsse, M.P. Peppelenbosch, W. van Veelen
http://www.sciencedirect.com/science/article/pii/S0304419X1200090X

Autophagy: A Targetable Linchpin of Cancer Cell Metabolism
Robert D. Leone, Ravi K. Amaravadi
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760%2813%2900020-9

Cholesterol accumulation in prostate cancer: A classic observation from a modern perspective
James Robert Krycer, Andrew John Brown
http://www.sciencedirect.com/science/article/pii/S0304419X13000036

Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects
M A Pierotti, F Berrino, M Gariboldi, C Melani, A Mogavero, T Negri, P Pasanisi and S Pilotti
http://www.nature.com/onc/journal/v32/n12/abs/onc2012181a.html

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
Gopinath Sutendra and Evangelos D. Michelakis
http://www.frontiersin.org/Journal/Abstract.aspx?ART_DOI=10.3389/fonc.2013.00038&x=y

How HIF-1α Handles Stress
L. Eric Huang
http://www.sciencemag.org/content/339/6125/1285.short

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Comments / other
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Metformin-Acting through Cyclic AMP as well as AMP?
D. Grahame Hardie
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00059-4

ROS Links Glucose Metabolism to Breast Cancer Stem Cell and EMT Phenotype
Michael S. Schieber, Navdeep S. Chandel
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00077-9

R-2-Hydroxyglutarate as the Key Effector of IDH Mutations Promoting Oncogenesis
Dan Ye, Shenghong Ma, Yue Xiong, Kun-Liang Guan
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00084-6

A low-carb diet kills tumor cells with a mutant p53 tumor suppressor gene: The Atkins diet suppresses tumor growth.
Lagory EL, Giaccia AJ.
http://www.landesbioscience.com/journals/cc/article/23948/

Coordinating Metabolism
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/267/ec69

LKB1 Mutation Sensitizes NSCLC Cells to Phenformin
http://cancerdiscovery.aacrjournals.org/content/3/3/OF14.abstract.html

AMPK Can Suppress Tumorigenesis and the Warburg Effect
http://cancerdiscovery.aacrjournals.org/content/3/3/OF15.abstract.html

SnapShot: Cancer Metabolism Pathways
Lydia W.S. Finley, Ji Zhang, Jiangbin Ye, Patrick S. Ward, Craig B. Thompson
http://download.cell.com/cell-metabolism/pdf/PIIS1550413113000648.pdf

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