MetaboList – April 2013

 

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Metabolic regulation and cancer
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Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence
Katherine M. Aird, Gao Zhang, Hua Li, Zhigang Tu, Benjamin G. Bitler, Azat Garipov, Hong Wu, Zhi Wei, Stephan N. Wagner, Meenhard Herlyn, Rugang Zhang
http://www.cell.com/cell-reports/abstract/S2211-1247(13)00111-3

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism
Seung Min Jeong, Cuiying Xiao, Lydia W.S. Finley, Tyler Lahusen, Amanda L. Souza, Kerry Pierce, Ying-Hua Li, Xiaoxu Wang, Gaëlle Laurent, Natalie J. German, Xiaoling Xu, Cuiling Li, Rui-Hong Wang, Jaewon Lee, Alfredo Csibi, Richard Cerione, John Blenis, Clary B. Clish, Alec Kimmelman, Chu-Xia Deng, Marcia C. Haigis
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00078-0

Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer
Di Zhao, Shao-Wu Zou, Ying Liu, Xin Zhou, Yan Mo, Ping Wang, Yan-Hui Xu, Bo Dong, Yue Xiong, Qun-Ying Lei, Kun-Liang Guan
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00068-8

Regulation of glycolysis and the Warburg effect by estrogen-related receptors
Q Cai, T Lin, S Kamarajugadda and J Lu
http://www.nature.com/onc/journal/v32/n16/abs/onc2012221a.html

Reciprocal Regulation of Protein Kinase and Pyruvate Kinase Activities of Pyruvate Kinase M2 by Growth Signals
Xueliang Gao, Haizhen Wang, Jenny J. Yang, Jing Chen, Jiang Jie, Liangwei Li, Yinwei Zhang, and Zhi-Ren Liu
http://www.jbc.org/cgi/content/abstract/M112.448753v1

Expression, regulation and clinical relevance of the ATPase inhibitory factor 1 in human cancers
M Sánchez-Aragó, L Formentini, I Martínez-Reyes, J García-Bermudez, F Santacatterina, L Sánchez-Cenizo, I M Willers, M Aldea, L Nájera, Á Juarránz, E C López, J Clofent, C Navarro, E Espinosa and J M Cuezva
http://www.nature.com/oncsis/journal/v2/n4/abs/oncsis20139a.html

Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation
Taro Hitosugi, Lu Zhou, Jun Fan, Shannon Elf, Liang Zhang, Jianxin Xie, Yi Wang, Ting-Lei Gu, Masa Alečović, Gary LeRoy, Yibin Kang, Hee-Bum Kang, Jae-Ho Seo, Changliang Shan, Peng Jin, Weimin Gong, Sagar Lonial, Martha L. Arellano, Hanna J. Khoury, Georgia Z. Chen, Dong M. Shin, Fadlo R. Khuri, Titus J. Boggon, Sumin Kang, Chuan He and Jing Chen
http://www.nature.com/ncomms/journal/v4/n4/abs/ncomms2759.html?WT.ec_id=NCOMMS-20130430

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Starvation/Ischemia
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The B55α Subunit of PP2A Drives a p53-Dependent Metabolic Adaptation to Glutamine Deprivation
Michael A. Reid, Wen-I Wang, Kimberly Romero Rosales, Meng Xu Welliver, Min Pan, Mei Kong
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00136-6

Caspase-1 activation is protective against hepatocyte cell death by up-regulating beclin1 and mitochondrial autophagy in the setting of redox stress
Qian Sun, Wentao Gao, Patricia Loughran, Rick Shapiro, Jie Fan, Timothy R. Billiar, and Melanie J. Scott
http://www.jbc.org/cgi/content/abstract/M112.426791v1

Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF- B activity in pancreatic cancer cells
Zhiyuan Ma, David J. Vocadlo, and Keith Vosseller
http://www.jbc.org/cgi/content/abstract/M113.470047v1

Nucleophosmin, a Critical Bax Cofactor in Ischemia-Induced Cell Death
Zhiyong Wang, Jonathan M. Gall, Ramon Bonegio, Andrea Havasi, Katarina Illanes, John H. Schwartz, and Steven C. Borkan
http://mcb.asm.org/cgi/content/abstract/33/10/1916

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Hypoxia
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Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells
Barbara Onnis, Nicole Fer, Annamaria Rapisarda, Victor S. Perez, Giovanni Melillo
http://www.jci.org/articles/view/59623

Hypoxia induces a phase transition within a kinase signaling network in cancer cells
Wei Wei, Qihui Shi, Francoise Remacle, Lidong Qin, David B. Shackelford, Young Shik Shin, Paul S. Mischel, R. D. Levine, and James R. Heath
http://www.pnas.org/content/110/15/E1352.abstract.html?etoc

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Anti-metabolic drugs
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Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-β-riboside (AICAr) induced apoptosis in multiple myeloma cells.
Bardeleben C, Sharma S, Reeve JR Jr, Bassilian S, Frost PJ, Hoang B, Shi Y, Lichtenstein A.
http://mct.aacrjournals.org/content/early/2013/04/12/1535-7163.MCT-12-1042.long

Phenformin activates unfolded protein response in an AMP-activated protein kinase (AMPK)-dependent manner
Liu Yang, Haibo Sha, Robin L. Davisson, and Ling Qi
http://www.jbc.org/cgi/content/abstract/M113.462762v1

Development of orally active inhibitors of protein and cellular fucosylation
Nicole M. Okeley, Stephen C. Alley, Martha E. Anderson, Tamar E. Boursalian, Patrick J. Burke, Kim M. Emmerton, Scott C. Jeffrey, Kerry Klussman, Che-Leung Law, Django Sussman, Brian E. Toki, Lori Westendorf, Weiping Zeng, Xinqun Zhang, Dennis R. Benjamin, and Peter D. Senter
http://www.pnas.org/content/110/14/5404.abstract.html?etoc

Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases
Y Zhu, P J Casey, A P Kumar and S Pervaiz
http://www.nature.com/cddis/journal/v4/n4/abs/cddis2013103a.html

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AMPK/mTOR
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mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
Francesca Nazio, Flavie Strappazzon, Manuela Antonioli, Pamela Bielli, Valentina Cianfanelli, Matteo Bordi, Christine Gretzmeier, Joern Dengjel, Mauro Piacentini, Gian Maria Fimia and Francesco Cecconi
http://www.nature.com/ncb/journal/v15/n4/full/ncb2708.html

mTOR Inhibitors Block Kaposi Sarcoma Growth by Inhibiting Essential Autocrine Growth Factors and Tumor Angiogenesis
Debasmita Roy, Sang-Hoon Sin, Amy Lucas, Raman Venkataramanan, Ling Wang, Anthony Eason, Veenadhari Chavakula, Isaac B. Hilton, Kristen M. Tamburro, Blossom Damania, and Dirk P. Dittmer
http://cancerres.aacrjournals.org/content/73/7/2235.abstract.html

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
Qingsong Liu, Chunxiao Xu, Sivapriya Kirubakaran, Xin Zhang, Wooyoung Hur, Yan Liu, Nicholas P. Kwiatkowski, Jinhua Wang, Kenneth D. Westover, Peng Gao, Dalia Ercan, Mario Niepel, Carson C. Thoreen, Seong A. Kang, Matthew P. Patricelli, Yuchuan Wang, Tanya Tupper, Abigail Altabef, Hidemasa Kawamura, Kathryn D. Held, Danny M. Chou, Stephen J. Elledge, Pasi A. Janne, Kwok-Kin Wong, David M. Sabatini, and Nathanael S. Gray
http://cancerres.aacrjournals.org/content/73/8/2574.abstract.html

Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response
Justin T. Babcock, Hoa B. Nguyen, Yujun He, Jeremiah W. Hendricks, Ronald C. Wek, and Lawrence A. Quilliam
http://www.jbc.org/cgi/content/abstract/M112.431056v1

mTOR-Controlled Autophagy Requires Intracellular Ca2+ Signaling
Jean-Paul Decuypere, Dimphny Kindt, Tomas Luyten, Kirsten Welkenhuyzen, Ludwig Missiaen, Humbert De Smedt, Geert Bultynck, Jan B. Parys
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061020

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas
Jake Shortt, Benjamin P. Martin, Andrea Newbold, Katherine M. Hannan, Jennifer R. Devlin, Adele J. Baker, Rachael Ralli, Carleen Cullinane, Clemens A. Schmitt, Maurice Reimann, Michael N. Hall, Meaghan Wall, Ross D. Hannan, Richard B. Pearson, Grant A. McArthur, and Ricky W. Johnstone
http://bloodjournal.hematologylibrary.org/content/121/15/2964.abstract?etoc

AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors
Marcos Ríos, Marc Foretz, Benoit Viollet, Angel Prieto, Máximo Fraga, Jose A. Costoya, and Rosa Señarís
http://cancerres.aacrjournals.org/content/73/8/2628.abstract.html

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Miscellaneous
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M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation
Hugh P. Morgan, Francis J. O’Reilly, Martin A. Wear, J. Robert O’Neill, Linda A. Fothergill-Gilmore, Ted Hupp, and Malcolm D. Walkinshaw
http://www.pnas.org/content/110/15/5881.abstract.html?etoc

Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis
Erika Segear Johnson, Kelly R. Lindblom, Alexander Robeson, Robert D. Stevens, Olga R. Ilkayeva, Christopher B. Newgard, Sally Kornbluth, and Joshua L. Andersen
http://www.jbc.org/cgi/content/abstract/M112.437210v1

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
Linda V Sinclair, Julia Rolf, Elizabeth Emslie, Yun-Bo Shi, Peter M Taylor and Doreen A Cantrell
http://www.nature.com/ni/journal/v14/n5/full/ni.2556.html

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Reviews
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LKB1 and AMPK and the cancer-metabolism link – ten years after
Hardie D, Alessi DR
http://www.biomedcentral.com/1741-7007/11/36

Stalling the Engine of Resistance: Targeting Cancer Metabolism to Overcome Therapeutic Resistance.
Butler EB, Zhao Y, Muñoz-Pinedo C, Lu J, Tan M.
http://cancerres.aacrjournals.org/content/early/2013/04/22/0008-5472.CAN-12-3009.long

Nutrient transporters: the Achilles’ heel of anabolism
Alison N. McCracken, Aimee L. Edinger
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760%2813%2900014-3

Phosphatidic acid and lipid-sensing by mTOR
DA Foster
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(13)00034-9

Novel insights into ChREBP regulation and function
Gaëlle Filhoulaud, Sandra Guilmeau, Renaud Dentin, Jean Girard, and Catherine Postic
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(13)00015-5

Metabolic Pathways in Immune Cell Activation and Quiescence
Erika L. Pearce, Edward J. Pearce
http://www.cell.com/immunity/abstract/S1074-7613(13)00158-1

Mitochondrial Uncoupling and the Reprograming of Intermediary Metabolism in Leukemia Cells
Juliana V?lez, Numsen Hail Jr., Marina Konopleva, Zhihong Zeng, Kensuke Kojima, Ismael Samudio, and Michael Andreeff
http://www.frontiersin.org/Journal/FullText.aspx?ART_DOI=10.3389/fonc.2013.00067&name=molecular_and_cellular_oncology

Mitochondrial complex II, a novel target for anti-cancer agents
Katarina Kluckova, Ayanachew Bezawork-Geleta, Jakub Rohlena, Lanfeng Dong, Jiri Neuzil
http://www.sciencedirect.com/science/article/pii/S0005272812010729

Cancer cachexia: malignant inflammation, tumorkines, and metabolic mayhem
Maria Tsoli, Graham Robertson
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760%2812%2900185-3

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Comments / previews
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The Phosphatase PP2A Links Glutamine to the Tumor Suppressor p53
Dana Gwinn, E. Alejandro Sweet-Cordero
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00291-8

Sirt4: The Glutamine Gatekeeper
Pablo J. Fernandez-Marcos, Manuel Serrano
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00137-2

mTOR regulates pyrimidine synthesis
http://www.nature.com/ncb/journal/v15/n4/full/ncb2733.html

Targeting cancer metabolism
http://www.nature.com/nature/journal/v496/n7444/full/496141b.html

Analyses Suggest Risks with mTOR Inhibitors
http://cancerdiscovery.aacrjournals.org/content/3/4/OF2.abstract.html

mTORC1 Regulates Growth Factor–Induced Nucleotide Synthesis
http://cancerdiscovery.aacrjournals.org/content/3/4/374.2.abstract.html

HIF Stimulates Reductive Glutamine Metabolism in Renal Cell Carcinoma
http://cancerdiscovery.aacrjournals.org/content/3/4/OF22.abstract.html

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