MetaboList – June 2013

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Cancer metabolism
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TAp73 enhances the pentose phosphate pathway and supports cell proliferation
Wenjing Du, Peng Jiang, Anthony Mancuso, Aaron Stonestrom, Michael D. Brewer, Andy J. Minn, Tak W. Mak, Mian Wu & Xiaolu Yang
http://www.nature.com/ncb/journal/vaop/ncurrent/full/ncb2789.html

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis
Eric C. Cheung, Dimitris Athineos, Pearl Lee, Rachel A. Ridgway, Wendy Lambie, Colin Nixon, Douglas Strathdee, Karen Blyth, Owen J. Sansom, Karen H. Vousden
http://www.cell.com/developmental-cell/abstract/S1534-5807(13)00251-7

SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma
Eric Letouzé, Cosimo Martinelli, Céline Loriot, Nelly Burnichon, Nasséra Abermil, Chris Ottolenghi, Maxime Janin, Mélanie Menara, An Thach Nguyen, Paule Benit, Alexandre Buffet, Charles Marcaillou, Jérôme Bertherat, Laurence Amar, Pierre Rustin, Aurélien De Reyniès, Anne-Paule Gimenez-Roqueplo, Judith Favier
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00183-9

The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase
Marco Sciacovelli, Giulia Guzzo, Virginia Morello, Christian Frezza, Liang Zheng, Nazarena Nannini, Fiorella Calabrese, Gabriella Laudiero, Franca Esposito, Matteo Landriscina, Paola Defilippi, Paolo Bernardi, Andrea Rasola
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00190-3

Succinate Dehydrogenase Mutation Underlies Global Epigenomic Divergence in Gastrointestinal Stromal Tumor
J. Keith Killian, Su Young Kim, Markku Miettinen, Carly Smith, Maria Merino, Maria Tsokos, Martha Quezado, William I. Smith, Jr, Mona S. Jahromi, Paraskevi Xekouki, Eva Szarek, Robert L. Walker, Jerzy Lasota, Mark Raffeld, Brandy Klotzle, Zengfeng Wang, Laura Jones, Yuelin Zhu, Yonghong Wang, Joshua J. Waterfall, Maureen J. O’Sullivan, Marina Bibikova, Karel Pacak, Constantine Stratakis, Katherine A. Janeway, Joshua D. Schiffman, Jian-Bing Fan, Lee Helman, and Paul S. Meltzer
http://cancerdiscovery.aacrjournals.org/content/3/6/648.abstract.html

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene
Hall, Arnaldur; Meyle, Kathrine Damm; Lange, Marina Krarup; Klima, Martin; Sanderhoff, May; Dahl, Christina; Abildgaard, Cecilie; Thorup, Katrine; Moghimi, Seyed Moein; Jensen, Per Bo; Bartek, Jiri; Guldberg, Per; Christensen, Claus
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=965

PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli
Laura Novellasdemunt, Laurent Bultot, Anna Manzano, Francesc Ventura, Jose Luis Rosa, Didier Vertommen, Mark H. Rider, Àurea Navarro Sabate and Ramon Bartrons
http://www.biochemj.org/bj/452/bj4520531.htm

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells
Hanna Zirath, Anna Frenzel, Ganna Oliynyk, Lova Segerström, Ulrica K. Westermark, Karin Larsson, Matilda Munksgaard Persson, Kjell Hultenby, Janne Lehtiö, Christer Einvik, Sven Påhlman, Per Kogner, Per-Johan Jakobsson, and Marie Arsenian Henriksson
http://www.pnas.org/content/110/25/10258.abstract.html?etoc

Zinc Finger Nuclease Mediated Knockout of ADP-Dependent Glucokinase in Cancer Cell Lines: Effects on Cell Survival and Mitochondrial Oxidative Metabolism
Susan Richter, Shona Morrison, Tim Connor, Jiechuang Su, Cristin G. Print, Ron S. Ronimus, Sean L. McGee, William R. Wilson
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0065267

Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia
Courtney D. DiNardo, Kathleen J. Propert, Alison W. Loren, Elisabeth Paietta, Zhuoxin Sun, Ross L. Levine, Kimberly S. Straley, Katharine Yen, Jay P. Patel, Samuel Agresta, Omar Abdel-Wahab, Alexander E. Perl, Mark R. Litzow, Jacob M. Rowe, Hillard M. Lazarus, Hugo F. Fernandez, David J. Margolis, Martin S. Tallman, Selina M. Luger, and Martin Carroll
http://bloodjournal.hematologylibrary.org/content/121/24/4917.abstract.html

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas
P Wang, Q Dong, C Zhang, P-F Kuan, Y Liu, W R Jeck, J B Andersen, W Jiang, G L Savich, T-X Tan, J T Auman, J M Hoskins, A D Misher, C D Moser, S M Yourstone, J W Kim, K Cibulskis, G Getz, H V Hunt, S S Thorgeirsson, L R Roberts, D Ye, K-L Guan, Y Xiong, L-X Qin and D Y Chiang
http://www.nature.com/onc/journal/v32/n25/abs/onc2012315a.html

ATP citrate lyase knockdown impacts cancer stem cells in vitro
J-i Hanai, N Doro, P Seth and V P Sukhatme
http://www.nature.com/cddis/journal/v4/n6/abs/cddis2013215a.html?WT.ec_id=CDDIS-201306

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AMPK / mTOR
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Conserved regulatory elements in AMPK
Lei Chen, Feng-Jiao Xin, Jue Wang, Jicheng Hu, Yuan-Yuan Zhang, Shuo Wan, Lu-Sha Cao, Chang Lu, Peng Li, S. Frank Yan, Dietbert Neumann, Uwe Schlattner, Bin Xia, Zhi-Xin Wang & Jia-Wei Wu
http://www.nature.com/nature/journal/v498/n7453/full/nature12189.html

Differential contribution of insulin and amino acids to the mTORC1-autophagy pathway in the liver and muscle
Takako Naito, Akiko Kuma, and Noboru Mizushima
http://www.jbc.org/cgi/content/abstract/M113.456228v1

Enhancing the effectiveness of nucleoside analogs with mTORC1 blockers to treat acute myeloid leukemia patients
Alberto M. Martelli, Annalisa Lonetti, Sergio Amadori, James A. McCubrey and Francesca Chiarini
http://www.landesbioscience.com/journals/cc/article/25117/

Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells
I Dando, M Donadelli, C Costanzo, E Dalla Pozza, A D’Alessandro, L Zolla and M Palmieri
http://www.nature.com/cddis/journal/v4/n6/abs/cddis2013151a.html

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Hypoxia / ischemia
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Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation
B K Nayak, D Feliers, S Sudarshan, W E Friedrichs, R T Day, D D New, J P Fitzgerald, A Eid, T DeNapoli, D J Parekh, Y Gorin and K Block
http://www.nature.com/onc/journal/v32/n26/abs/onc2012333a.html?WT.ec_id=ONC-201306

Dual role of chloroquine in liver ischemia reperfusion injury: reduction of liver damage in early phase, but aggravation in late phase
H Fang, A Liu, U Dahmen and O Dirsch
http://www.nature.com/cddis/journal/v4/n6/abs/cddis2013225a.html

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Miscellaneous
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Doxycycline Alters Metabolism and Proliferation of Human Cell Lines
Ethan Ahler, William J. Sullivan, Ashley Cass, Daniel Braas, Autumn G. York, Steven J. Bensinger, Thomas G. Graeber, Heather R. Christofk
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0064561

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
Chih-Hao Chang, Jonathan D. Curtis, Leonard B. Maggi, Brandon Faubert, Alejandro V. Villarino, David O’Sullivan, Stanley Ching-Cheng Huang, Gerritje J.W. van der Windt, Julianna Blagih, Jing Qiu, Jason D. Weber, Edward J. Pearce, Russell G. Jones, Erika L. Pearce
http://www.cell.com/abstract/S0092-8674(13)00582-5

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways
Jeongsoon Park, Yue Chen, Daniel X. Tishkoff, Chao Peng, Minjia Tan, Lunzhai Dai, Zhongyu Xie, Yi Zhang, Bernadette M.M. Zwaans, Mary E. Skinner, David B. Lombard, Yingming Zhao
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00438-3

Caloric restriction augments radiation efficacy in breast cancer
Anthony D. Saleh, Brittany A. Simone, Juan Palazzo, Jason E. Savage, Yuri Sano, Tu Dan, Lianjin Jin, Colin E. Champ, Shuping Zhao, Meng Lim, Frederica Sotgia, Kevin Camphausen, Richard G. Pestell, James B. Mitchell, Michael P. Lisanti and Nicole L. Simone
http://www.landesbioscience.com/journals/cc/article/25016/

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Reviews
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Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
Christian C. Dibble and Brendan D. Manning
http://www.nature.com/ncb/journal/v15/n6/full/ncb2763.html

Central roles of apoptotic proteins in mitochondrial function
S M Kilbride and J H M Prehn
http://www.nature.com/onc/journal/v32/n22/abs/onc2012348a.html

The Relationship between Metabolism and the Autophagy Machinery during the Innate Immune Response
Jennifer Martinez, Katherine Verbist, Ruoning Wang, Douglas R. Green
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00202-7

Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond
Cole M. Haynes, Christopher J. Fiorese, Yi-Fan Lin
http://www.cell.com/trends/cell-biology/abstract/S0962-8924(13)00032-9

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Comments / other
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Pyruvate as a Pivot Point for Oncogene-Induced Senescence
Benjamin A. Olenchock, Matthew G. Vander Heiden
http://www.cell.com/abstract/S0092-8674(13)00702-2

Cell signalling: Nutrient sensing lost in cancer
Suchithra Menon, Brendan D. Manning
http://www.nature.com/nature/journal/v498/n7455/full/498444a.html

Preventing lysosomal fat indigestion
Ana Maria Cuervo
http://www.nature.com/ncb/journal/v15/n6/full/ncb2778.html

Adaptation to Starvation: Translating a Matter of Life or Death
Brendan D. Manning
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00237-7

Succinate: A New Epigenetic Hacker
Ming Yang, Patrick J. Pollard
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00240-7

Adapting glycolysis to cancer cell proliferation: the MAPK pathway focuses on PFKFB3
Juan P. Bolaños
http://www.biochemj.org/bj/452/bj452e007.htm

Agitation by Suffocation: How Hypoxia Activates Innate Immunity via the Warburg Effect
Haitao Wen, Jenny P.-Y. Ting
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00206-4

Limiting mTORC1
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/278/ec131

Metabolism: Metabolic block (SIRT4)
http://www.nature.com/nrc/journal/v13/n7/full/nrc3547.html

Metabolism: Epigenetic links to the web of Krebs
http://www.nature.com/nrc/journal/v13/n7/full/nrc3551.html

GSK3 Negatively Regulates AMPK Function
http://cancerdiscovery.aacrjournals.org/content/3/6/602.1.abstract.html

Other:

Webinar: Oxygen Sensing in Cancer and Metabolism
Celeste Simon, Navdeep S Chandel, Amato Giaccia
http://view6.workcast.net/register?pak=3998850097719807

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