MetaboList – July 2013

Cancer metabolism

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
Jessie Yanxiang Guo, Gizem Karsli-Uzunbas, Robin Mathew, Seena C. Aisner, Jurre J. Kamphorst, Anne M. Strohecker, Guanghua Chen, Sandy Price, Wenyun Lu, Xin Teng, Eric Snyder, Urmila Santanam, Robert S. DiPaola, Tyler Jacks, Joshua D. Rabinowitz, and Eileen White

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling p236
Lucas B. Sullivan, Eva Martinez-Garcia, Hien Nguyen, Andrew R. Mullen, Eric Dufour, Sunil Sudarshan, Jonathan D. Licht, Ralph J. Deberardinis, Navdeep S. Chandel

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1
Martje Tönjes, Sebastian Barbus, Yoon Jung Park, Wei Wang, Magdalena Schlotter, Anders M Lindroth, Sabrina V Pleier, Alfa H C Bai, Daniela Karra, Rosario M Piro, Jörg Felsberg, Adele Addington, Dieter Lemke, Irene Weibrecht, Volker Hovestadt, Claudio G Rolli, Benito Campos, Sevin Turcan, Dominik Sturm, Hendrik Witt, Timothy A Chan, Christel Herold-Mende, Ralf Kemkemer, Rainer König, Kathrin Schmidt, William-Edmund Hull, Stefan M Pfister, Manfred Jugold, Susan M Hutson, Christoph Plass, Jürgen G Okun, Guido Reifenberger, Peter Lichter & Bernhard Radlwimmer

Ets-1 global gene expression profile reveals associations with metabolism and oxidative stress in ovarian and breast cancers
Verschoor ML, Verschoor CP, Singh G

Metabolic stress / Nutrient sensing / Antimetabolic drugs

Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein response
R Palorini, F Cammarata, C Balestrieri, A Monestiroli, M Vasso, C Gelfi, L Alberghina and F Chiaradonna

Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells
M. Cecilia Caino, Young Chan Chae, Valentina Vaira, Stefano Ferrero, Mario Nosotti, Nina M. Martin, Ashani Weeraratna, Michael O’Connell, Danielle Jernigan, Alessandro Fatatis, Lucia R. Languino, Silvano Bosari, Dario C. Altieri

Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress
Aditi U. Gurkar, Kiki Chu, Lakshmi Raj, Richard Bouley, Seung-Hwan Lee, Young-Bum Kim, Sandra E. Dunn, Anna Mandinova and Sam W. Lee

MondoA senses adenine nucleotides: transcriptional induction of thioredoxin-interacting protein
Kyoung Sim Han and Donald E. Ayer

New roles of the fission yeast eIF2α kinases Hri1 and Gcn2 in response to nutritional stress
Ruth Martín, Juan José Berlanga, and César de Haro

Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State
Sandro Santagata, Marc L. Mendillo, Yun-chi Tang, Aravind Subramanian, Casey C. Perley, Stéphane P. Roche, Bang Wong, Rajiv Narayan, Hyoungtae Kwon, Martina Koeva, Angelika Amon, Todd R. Golub, John A. Porco Jr., Luke Whitesell, Susan Lindquist

Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism
Sarah-Maria Fendt, Eric L. Bell, Mark A. Keibler, Shawn M. Davidson, Gregory J. Wirth, Brian Fiske, Jared R. Mayers, Matthias Schwab, Gary Bellinger, Alfredo Csibi, Akash Patnaik, Marie Jose Blouin, Lewis C. Cantley, Leonard Guarente, John Blenis, Michael N. Pollak, Aria F. Olumi, Matthew G. Vander Heiden, and Gregory Stephanopoulos


mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin
Seong A. Kang, Michael E. Pacold, Christopher L. Cervantes, Daniel Lim, Hua Jane Lou,
Kathleen Ottina, Nathanael S. Gray, Benjamin E. Turk, Michael B. Yaffe, David M. Sabatini

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
Hu Zeng, Kai Yang, Caryn Cloer, Geoffrey Neale, Peter Vogel & Hongbo Chi

Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations
Wei Sun, Ye Julia Zhu, Zhizhi Wang, Qiang Zhong, Feng Gao, Jizhong Lou, Weimin Gong and Wenqing Xu

Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish.
Kim SH, Kowalski ML, Carson RP, Bridges LR, Ess KC.

Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
Michael Pourdehnad, Morgan L. Truitt, Imran N. Siddiqi, Gregory S. Ducker, Kevan M. Shokat, and Davide Ruggero

The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling
K Sully, O Akinduro, M P Philpott, A S Naeem, C A Harwood, V E Reeve, R F O’Shaughnessy and C Byrne

Extended treatment with selective PI 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength
G. C. Smith, W. K. Ong, J. L. Costa, M. Watson, J. Cornish, A. Grey, G.D. Gamble, M. Dickinson, S. Leung, G. W. Rewcastle, W. Han and P. R. Shepherd

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology
Charles Betz, Daniele Stracka, Cristina Prescianotto-Baschong, Maud Frieden, Nicolas Demaurex, and Michael N. Hall


GAPDH binds to active Akt, leading to Bcl-xL increase and escape from caspase-independent cell death
M A Jacquin, J Chiche, B Zunino, M Bénéteau, O Meynet, L A Pradelli, S Marchetti, A Cornille, M Carles and J-E Ricci

MicroRNA 33 Regulates Glucose Metabolism
Cristina M. Ramírez, Leigh Goedeke, Noemi Rotllan, Je-Hyun Yoon, Daniel Cirera-Salinas, Julie A. Mattison, Yajaira Suárez, Rafael de Cabo, Myriam Gorospe, and Carlos Fernández-Hernando

Evaluation of LDH-A and Glutaminase Inhibition In Vivo by Hyperpolarized ^13C-Pyruvate Magnetic Resonance Spectroscopy of Tumors
Prasanta Dutta, Anne Le, David L. Vander Jagt, Takashi Tsukamoto, Gary V. Martinez, Chi V. Dang, and Robert J. Gillies

Mass spectrometry-based metabolomics of single yeast cells
Alfredo J. Ibáñez, Stephan R. Fagerer, Anna Mareike Schmidt, Pawel L. Urban, Konstantins Jefimovs, Philipp Geiger, Reinhard Dechant, Matthias Heinemann, and Renato Zenobi

Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling
Alexander V. Zhdanov, Alicia H.C. Waters, Anna V. Golubeva, Ruslan I. Dmitriev, Dmitri B. Papkovsky


Serine, glycine and one-carbon units: cancer metabolism in full circle
Jason W. Locasale

Oncogenic Isocitrate Dehydrogenase Mutations: Mechanisms, Models, and Clinical Opportunities
Rob A. Cairns and Tak W. Mak

A growing role for mTOR in promoting anabolic metabolism.
Howell JJ, Ricoult SJ, Ben-Sahra I, Manning BD.

Metabolic signaling by lactate in the brain
L. Felipe Barros

AMPKbeta subunits: more than just a scaffold in the formation of AMPK complex
Pascual Sanz, Teresa Rubio and Maria Adelaida Garcia-Gimeno

Emerging regulation and functions of autophagy 
Patricia Boya, Fulvio Reggiori and Patrice Codogno


Sweet Nothings: Sensing of Sugar Metabolites Controls T Cell Function
Douglas R. Green, Jeffrey Rathmell

Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance
Costas A. Lyssiotis, Jaekyoung Son, Lewis C. Cantley and Alec C. Kimmelman

AMPK connects energy stress to PIK3C3/VPS34 regulation
Joungmok Kim and Kun-Liang Guan

Cancer Metabolism: Feeding a Worm to Starve a Tumor
David S. Fay

Metabolism: A TIGAR tale
Data recently published by Karen Vousden and colleagues indicate that TIGAR aids tumour development in the intestine.

Metabolic control of cytokines

A Multiprotein Complex Negatively Regulates RAG GTPases and mTORC1

Pyruvate Dehydrogenase Mediates Oncogene-Induced Senescence

Macropinocytosis Supports Cancer Cell Metabolism

mTORC1 Regulates Glutamine Metabolism

Meeting report
Exploiting Tumor Vulnerabilities: Epigenetics, Cancer Metabolism and the mTOR Pathway in the Era of Personalized Medicine
Cristina Muñoz-Pinedo, Eva González-Suárez, Anna Portela, Antonio Gentilella, and Manel Esteller

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