MetaboList – July 2013

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Cancer metabolism
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Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
Jessie Yanxiang Guo, Gizem Karsli-Uzunbas, Robin Mathew, Seena C. Aisner, Jurre J. Kamphorst, Anne M. Strohecker, Guanghua Chen, Sandy Price, Wenyun Lu, Xin Teng, Eric Snyder, Urmila Santanam, Robert S. DiPaola, Tyler Jacks, Joshua D. Rabinowitz, and Eileen White
http://genesdev.cshlp.org/content/27/13/1447.abstract.html

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling p236
Lucas B. Sullivan, Eva Martinez-Garcia, Hien Nguyen, Andrew R. Mullen, Eric Dufour, Sunil Sudarshan, Jonathan D. Licht, Ralph J. Deberardinis, Navdeep S. Chandel
http://www.cell.com/molecular-cell/abstract/S1097-2765%2813%2900366-3

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1
Martje Tönjes, Sebastian Barbus, Yoon Jung Park, Wei Wang, Magdalena Schlotter, Anders M Lindroth, Sabrina V Pleier, Alfa H C Bai, Daniela Karra, Rosario M Piro, Jörg Felsberg, Adele Addington, Dieter Lemke, Irene Weibrecht, Volker Hovestadt, Claudio G Rolli, Benito Campos, Sevin Turcan, Dominik Sturm, Hendrik Witt, Timothy A Chan, Christel Herold-Mende, Ralf Kemkemer, Rainer König, Kathrin Schmidt, William-Edmund Hull, Stefan M Pfister, Manfred Jugold, Susan M Hutson, Christoph Plass, Jürgen G Okun, Guido Reifenberger, Peter Lichter & Bernhard Radlwimmer
http://www.nature.com/nm/journal/v19/n7/full/nm.3217.html

Ets-1 global gene expression profile reveals associations with metabolism and oxidative stress in ovarian and breast cancers
Verschoor ML, Verschoor CP, Singh G
http://www.cancerandmetabolism.com/content/1/1/17/abstract

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Metabolic stress / Nutrient sensing / Antimetabolic drugs
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Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein response
R Palorini, F Cammarata, C Balestrieri, A Monestiroli, M Vasso, C Gelfi, L Alberghina and F Chiaradonna
http://www.nature.com/cddis/journal/v4/n7/abs/cddis2013257a.html

Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells
M. Cecilia Caino, Young Chan Chae, Valentina Vaira, Stefano Ferrero, Mario Nosotti, Nina M. Martin, Ashani Weeraratna, Michael O’Connell, Danielle Jernigan, Alessandro Fatatis, Lucia R. Languino, Silvano Bosari, Dario C. Altieri
http://www.jci.org/articles/view/67841

Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress
Aditi U. Gurkar, Kiki Chu, Lakshmi Raj, Richard Bouley, Seung-Hwan Lee, Young-Bum Kim, Sandra E. Dunn, Anna Mandinova and Sam W. Lee 
http://www.nature.com/ncomms/2013/130723/ncomms3189/full/ncomms3189.html

MondoA senses adenine nucleotides: transcriptional induction of thioredoxin-interacting protein
Kyoung Sim Han and Donald E. Ayer
http://www.biochemj.org/bj/453/bj4530209.htm

New roles of the fission yeast eIF2α kinases Hri1 and Gcn2 in response to nutritional stress
Ruth Martín, Juan José Berlanga, and César de Haro
http://jcs.biologists.org/content/126/14/3010.abstract.html?etoc

Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State
Sandro Santagata, Marc L. Mendillo, Yun-chi Tang, Aravind Subramanian, Casey C. Perley, Stéphane P. Roche, Bang Wong, Rajiv Narayan, Hyoungtae Kwon, Martina Koeva, Angelika Amon, Todd R. Golub, John A. Porco Jr., Luke Whitesell, Susan Lindquist
http://www.sciencemag.org/content/341/6143/1238303.abstract

Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism
Sarah-Maria Fendt, Eric L. Bell, Mark A. Keibler, Shawn M. Davidson, Gregory J. Wirth, Brian Fiske, Jared R. Mayers, Matthias Schwab, Gary Bellinger, Alfredo Csibi, Akash Patnaik, Marie Jose Blouin, Lewis C. Cantley, Leonard Guarente, John Blenis, Michael N. Pollak, Aria F. Olumi, Matthew G. Vander Heiden, and Gregory Stephanopoulos
http://cancerres.aacrjournals.org/content/73/14/4429.abstract.html?etoc

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mTOR
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mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin
Seong A. Kang, Michael E. Pacold, Christopher L. Cervantes, Daniel Lim, Hua Jane Lou,
Kathleen Ottina, Nathanael S. Gray, Benjamin E. Turk, Michael B. Yaffe, David M. Sabatini
http://www.sciencemag.org/content/341/6144/1236566.abstract

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
Hu Zeng, Kai Yang, Caryn Cloer, Geoffrey Neale, Peter Vogel & Hongbo Chi
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12297.html

Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations
Wei Sun, Ye Julia Zhu, Zhizhi Wang, Qiang Zhong, Feng Gao, Jizhong Lou, Weimin Gong and Wenqing Xu 
http://www.nature.com/ncomms/2013/130716/ncomms3135/full/ncomms3135.html

Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish.
Kim SH, Kowalski ML, Carson RP, Bridges LR, Ess KC.
http://dmm.biologists.org/cgi/pmidlookup?view=long&pmid=23580196

Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
Michael Pourdehnad, Morgan L. Truitt, Imran N. Siddiqi, Gregory S. Ducker, Kevan M. Shokat, and Davide Ruggero
http://www.pnas.org/content/110/29/11988.abstract.html?etoc

The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling
K Sully, O Akinduro, M P Philpott, A S Naeem, C A Harwood, V E Reeve, R F O’Shaughnessy and C Byrne
http://www.nature.com/onc/journal/v32/n27/abs/onc2012338a.html

Extended treatment with selective PI 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength
G. C. Smith, W. K. Ong, J. L. Costa, M. Watson, J. Cornish, A. Grey, G.D. Gamble, M. Dickinson, S. Leung, G. W. Rewcastle, W. Han and P. R. Shepherd
http://onlinelibrary.wiley.com/doi/10.1111/febs.12428/abstract

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology
Charles Betz, Daniele Stracka, Cristina Prescianotto-Baschong, Maud Frieden, Nicolas Demaurex, and Michael N. Hall
http://www.pnas.org/content/110/31/12526.abstract.html?etoc

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Miscellaneous
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GAPDH binds to active Akt, leading to Bcl-xL increase and escape from caspase-independent cell death
M A Jacquin, J Chiche, B Zunino, M Bénéteau, O Meynet, L A Pradelli, S Marchetti, A Cornille, M Carles and J-E Ricci
http://www.nature.com/cdd/journal/v20/n8/abs/cdd201332a.html

MicroRNA 33 Regulates Glucose Metabolism
Cristina M. Ramírez, Leigh Goedeke, Noemi Rotllan, Je-Hyun Yoon, Daniel Cirera-Salinas, Julie A. Mattison, Yajaira Suárez, Rafael de Cabo, Myriam Gorospe, and Carlos Fernández-Hernando
http://mcb.asm.org/cgi/content/abstract/33/15/2891

Evaluation of LDH-A and Glutaminase Inhibition In Vivo by Hyperpolarized ^13C-Pyruvate Magnetic Resonance Spectroscopy of Tumors
Prasanta Dutta, Anne Le, David L. Vander Jagt, Takashi Tsukamoto, Gary V. Martinez, Chi V. Dang, and Robert J. Gillies
http://cancerres.aacrjournals.org/content/73/14/4190.abstract.html?etoc

Mass spectrometry-based metabolomics of single yeast cells
Alfredo J. Ibáñez, Stephan R. Fagerer, Anna Mareike Schmidt, Pawel L. Urban, Konstantins Jefimovs, Philipp Geiger, Reinhard Dechant, Matthias Heinemann, and Renato Zenobi
http://www.pnas.org/content/110/22/8790.long

Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling
Alexander V. Zhdanov, Alicia H.C. Waters, Anna V. Golubeva, Ruslan I. Dmitriev, Dmitri B. Papkovsky
http://www.sciencedirect.com/science/article/pii/S0005272813001254

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Reviews
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Serine, glycine and one-carbon units: cancer metabolism in full circle
Jason W. Locasale
http://www.nature.com/nrc/journal/vaop/ncurrent/full/nrc3557.html

Oncogenic Isocitrate Dehydrogenase Mutations: Mechanisms, Models, and Clinical Opportunities
Rob A. Cairns and Tak W. Mak
http://cancerdiscovery.aacrjournals.org/content/3/7/730.abstract.html

A growing role for mTOR in promoting anabolic metabolism.
Howell JJ, Ricoult SJ, Ben-Sahra I, Manning BD.
http://www.biochemsoctrans.org/bst/041/0906/bst0410906.htm

Metabolic signaling by lactate in the brain
L. Felipe Barros
http://www.cell.com/trends/neurosciences/abstract/S0166-2236(13)00063-5

AMPKbeta subunits: more than just a scaffold in the formation of AMPK complex
Pascual Sanz, Teresa Rubio and Maria Adelaida Garcia-Gimeno
http://onlinelibrary.wiley.com/doi/10.1111/febs.12364/abstract

Emerging regulation and functions of autophagy 
Patricia Boya, Fulvio Reggiori and Patrice Codogno
http://www.nature.com/ncb/journal/v15/n7/full/ncb2788.html

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Comments
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Sweet Nothings: Sensing of Sugar Metabolites Controls T Cell Function
Douglas R. Green, Jeffrey Rathmell
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00253-2

Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance
Costas A. Lyssiotis, Jaekyoung Son, Lewis C. Cantley and Alec C. Kimmelman
http://www.landesbioscience.com/journals/cc/article/25307/

AMPK connects energy stress to PIK3C3/VPS34 regulation
Joungmok Kim and Kun-Liang Guan
http://dx.doi.org/10.4161/auto.24877

Cancer Metabolism: Feeding a Worm to Starve a Tumor
David S. Fay
http://www.sciencedirect.com/science/article/pii/S096098221300585X

Metabolism: A TIGAR tale
Data recently published by Karen Vousden and colleagues indicate that TIGAR aids tumour development in the intestine.
http://www.nature.com/nrc/journal/v13/n8/full/nrc3567.html

Metabolic control of cytokines
http://www.nature.com/ni/journal/v14/n8/full/ni.2674.html

A Multiprotein Complex Negatively Regulates RAG GTPases and mTORC1
http://cancerdiscovery.aacrjournals.org/content/3/7/OF24.abstract.html

Pyruvate Dehydrogenase Mediates Oncogene-Induced Senescence
http://cancerdiscovery.aacrjournals.org/content/3/7/714.1.abstract.html

Macropinocytosis Supports Cancer Cell Metabolism
http://cancerdiscovery.aacrjournals.org/content/3/7/716.2.abstract.html

mTORC1 Regulates Glutamine Metabolism
http://cancerdiscovery.aacrjournals.org/content/3/7/OF25.abstract.html

Meeting report
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Exploiting Tumor Vulnerabilities: Epigenetics, Cancer Metabolism and the mTOR Pathway in the Era of Personalized Medicine
Cristina Muñoz-Pinedo, Eva González-Suárez, Anna Portela, Antonio Gentilella, and Manel Esteller
http://cancerres.aacrjournals.org/content/73/14/4185.abstract.html?etoc

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