MetaboList – August 2013


In vivo imaging of glucose uptake and metabolism in tumors
Simon Walker-Samuel, Rajiv Ramasawmy, Francisco Torrealdea, Marilena Rega, Vineeth Rajkumar,  S Peter Johnson, Simon Richardson, Miguel Gonçalves, Harold G Parkes, Erik Årstad, David L Thomas, R Barbara Pedley, Mark F Lythgoe & Xavier Golay

Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate
S. J. Nelson, J. Kurhanewicz, D. B. Vigneron, P. E. Z. Larson, A. L. Harzstark, M. Ferrone, M. v. Criekinge, J. W. Chang, R. Bok, I. Park, G. Reed, L. Carvajal, E. J. Small, P. Munster, V. K. Weinberg, J. H. Ardenkjaer-Larsen, A. P. Chen, R. E. Hurd, L.-I. Odegardstuen, F. J. Robb, J. Tropp, J. A. Murray

Quantitative In Vivo Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis
Norbert W. Lutz, Yann Le Fur, Johanna Chiche, Jacques Pouysségur, and Patrick J. Cozzone

Cancer metabolism

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BRAFV600E-Driven Lung Tumors.
Strohecker AM, Guo JY, Karsli-Uzunbas G, Price SM, Chen GJ, Mathew R, McMahon M, White E.

Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer
Yan Liu, Kevin Marks, Glenn S. Cowley, Julian Carretero, Qingsong Liu,  Thomas J.F. Nieland, Chunxiao Xu, Travis J. Cohoon, Peng Gao, Yong Zhang, Zhao Chen, Abigail B. Altabef, Jeremy H. Tchaicha, Xiaoxu Wang, Sung Choe, Edward M. Driggers, Jianming Zhang, Sean T. Bailey, Norman E. Sharpless, D. Neil Hayes, Nirali M. Patel, Pasi A. Janne, Nabeel  Bardeesy, Jeffrey A. Engelman, Brendan D. Manning, Reuben J. Shaw, John M. Asara, Ralph Scully, Alec Kimmelman, Lauren A. Byers, Don L. Gibbons, Ignacio I. Wistuba, John V. Heymach, David J. Kwiatkowski, William Y. Kim, Andrew L. Kung, Nathanael S. Gray, David E. Root, Lewis C. Cantley, and Kwok-Kin Wong

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
Jan R. Dörr, Yong Yu, Maja Milanovic, Gregor Beuster, Christin Zasada, J. Henry M. Däbritz, Jan Lisec, Dido Lenze, Anne Gerhardt, Katharina Schleicher, Susanne Kratzat, Bettina Purfürst, Stefan Walenta, Wolfgang Mueller-Klieser, Markus Gräler, Michael Hummel, Ulrich Keller, Andreas K. Buck, Bernd Dörken, Lothar Willmitzer, Maurice Reimann, Stefan Kempa, Soyoung Lee & Clemens A. Schmitt

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer
Krushna C. Patra, Qi Wang, Prashanth T. Bhaskar, Luke Miller, Zebin Wang, Will Wheaton, Navdeep Chandel, Markku Laakso, William J. Muller, Eric L. Allen, Abhishek K. Jha, Gromoslaw A. Smolen, Michelle F. Clasquin, R. Brooks Robey, Nissim Hay

Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics
Qiang Huang, Yexiong Tan, Peiyuan Yin, Guozhu Ye, Peng Gao, Xin Lu,   Hongyang Wang, and Guowang Xu

O-GlcNAc Transferase Integrates Metabolic Pathways to Regulate the Stability of c-MYC in Human Prostate Cancer Cells
Harri M. Itkonen, Sarah Minner, Ingrid J. Guldvik, Mareike Julia   Sandmann, Maria Christina Tsourlakis, Viktor Berge, Aud Svindland, Thorsten Schlomm, and Ian G. Mills

LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer
Dupuy F, Griss T, Blagih J, Bridon G, Avizonis D, Ling C, Dong Z, Siwak DR, Annis MG, Mills GB, Muller WJ, Siegel PM, Jones RG

Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFkB target stromal MCT4
Ubaldo E Martinez-Outschoorn, Joseph M Curry, Ying-Hui Ko, Zhao Lin, Madalina Tuluc, David Cognetti, Ruth C Birbe, Edmund Pribitkin, Alessandro Bombonati, Richard G Pestell, Anthony Howell, Federica Sotgia and Michael P Lisanti

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth
Ruiting Lin, Ren Tao, Xue Gao, Tingting Li, Xin Zhou, Kun-Liang Guan, Yue Xiong, Qun-Ying Lei

Dietary restriction, starvation, ischemia, hypoxia

Pten-Null Tumors Cohabiting the Same Lung Display Differential AKT Activation and Sensitivity to Dietary Restriction
Natasha L. Curry, Mari Mino-Kenudson, Trudy G. Oliver, Ömer H. Yilmaz, Vedat O. Yilmaz, Jade Y. Moon, Tyler Jacks, David M. Sabatini, and Nada Y. Kalaany

Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts
Qiuli Liang, Gloria A. Benavides, Athanassios Vassilopoulos, David Gius, Victor Darley Usmar and Jianhua Zhang

Cell survival during complete nutrient deprivation depends on lipid droplet-fueled {beta}-oxidation of fatty acids
Ainara G. Cabodevilla, Laura Sanchez-Caballero, Eleni Nintou, Violeta G. Boiadjieva, Albert Gubern, Fernando Picatoste, and Enrique Claro

AMPK-Regulated and Akt-Dependent Enhancement of Glucose Uptake Is Essential in Ischemic Preconditioning-Alleviated Reperfusion Injury
Lele Ji, Xing Zhang, Wenchong Liu, Qichao Huang, Weidong Yang, Feng Fu, Heng Ma, Hui Su, Haichang Wang, Jing Wang, Haifeng Zhang, Feng Gao

MYC Degradation under Low O2 Tension Promotes Survival by Evading Hypoxia-Induced Cell Death
Waihay J. Wong, Bo Qiu, Michael S. Nakazawa, Guoliang Qing, and M. Celeste Simon


Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells
Kathrin Thedieck, Birgit Holzwarth, Mirja Tamara Prentzell, Christopher Boehlke, Kathrin Kläsener, Stefanie Ruf, Annika Gwendolin Sonntag, Lars Maerz, Sushma-Nagaraja Grellscheid, Elisabeth Kremmer, Roland Nitschke, E. Wolfgang Kuehn, Johan W. Jonker, Albert K. Groen, Michael Reth, Michael N. Hall, Ralf Baumeister

K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells
Juan F. Linares, Angeles Duran, Tomoko Yajima, Manolis Pasparakis, Jorge Moscat, Maria T. Diaz-Meco

Rapamycin regulates biochemical metabolites
Paola Tucci, Giovanni Porta, Massimiliano Agostini, Alexey Antonov, Alexander Vasilievich Garabadgiu, Gerry Melino and Anne E Willis

Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo
Michael G Garelick, Vivian MacKay, Aya Yanagida, Emmeline C Academia, Katherine H Schreiber, Warren C Ladiges and Brian K Kennedy

mTOR Signaling Feedback Modulates Mammary Epithelial Differentiation and Restrains Invasion Downstream of PTEN Loss
Susmita Ghosh, Lidenys Varela, Akshay Sood, Ben Ho Park, and Tamara L. Lotan

Regulation of mammalian target of rapamycin complex 1 by Bcl-2 and Bcl-XL
Huafei Zou, Yumei Lai, Xuwen Zhao, Gonghong Yan, Dongzhu Ma, Nayra Cardenes, Sruti Shiva, Yongjian Liu, Xiaochun Bai, Yong Jiang, and Yu Jiang


Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
Sarah-Maria Fendt, Eric L. Bell, Mark A. Keibler, Benjamin A. Olenchock, Jared R. Mayers, Thomas M. Wasylenko, Natalie I. Vokes, Leonard Guarente, Matthew G. Vander Heiden and Gregory Stephanopoulos

Functional Lysine Modification by an Intrinsically Reactive Primary Glycolytic Metabolite
Raymond E. Moellering, Benjamin F. Cravatt

Resolution of the direct interaction with and inhibition of the human GLUT1 hexose transporter by resveratrol from its effect on glucose accumulation
Salas, Monica; Obando, Patricia; Ojeda, Lorena; Ojeda, Paola; Perez, Alejandra; Vargas-Uribe, Mauricio; Rivas, Coralia I.; Vera, Juan C.; Reyes, Alejandro M.

LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap
H B Nguyen, J T Babcock, C D Wells and L A Quilliam


Cellular Fatty Acid Metabolism and Cancer
Erin Currie, Almut Schulze, Rudolf Zechner, Tobias C. Walther, Robert V. Farese

Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis
G L Semenza

Disrupting proton dynamics and energy metabolism for cancer therapy
Scott K. Parks, Johanna Chiche & Jacques Pouysségur

The growing complexity of HIF-1α’s role in tumorigenesis: DNA repair and beyond
N Rohwer, C Zasada, S Kempa and T Cramer

Repositioning metformin for cancer prevention and treatment
Brendan J. Quinn, Hiroshi Kitagawa, Regan M. Memmott, Joell J. Gills, and Phillip A. Dennis

Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy
InYoung Kim and Yu-Ying He

Previews / comments / other

p73 keeps metabolic control in the family
Louise Fets and Dimitrios Anastasiou

Energizing the Search to Target LKB1-Mutant Tumors
Adam I. Marcus and Fadlo R. Khuri

mTOR, AMBRA1, and autophagy: An intricate relationship
Francesca Nazio and Francesco Cecconi

Targeting cancer cells resistant to hypoxia and nutrient starvation to improve anti-angiogeneic therapy
Tsuyoshi Osawa and Masabumi Shibuya

Inhibition of Mitochondrial Respiration by TRAP1 Is Oncogenic

Hexokinase 2 required in tumors

How to Stop Responding to Stressful Conditions
Astrin prevents the association of mTOR and raptor to limit mTORC1 activation in response to stress.;6/289/ec198

Cancer metabolism
Metabolic silencing

Retraction Notice to: GAMT, a p53-Inducible Modulator of Apoptosis, Is Critical for the Adaptive Response to Nutrient Stress
Takao Ide, Lauren Brown-Endres, Kiki Chu, Pat P. Ongusaha, Takao Ohtsuka, Wafik S. El-Deiry, Stuart A. Aaronson, Sam W. Lee

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