MetaboList – August 2013

—————
Methods
—————

In vivo imaging of glucose uptake and metabolism in tumors
Simon Walker-Samuel, Rajiv Ramasawmy, Francisco Torrealdea, Marilena Rega, Vineeth Rajkumar,  S Peter Johnson, Simon Richardson, Miguel Gonçalves, Harold G Parkes, Erik Årstad, David L Thomas, R Barbara Pedley, Mark F Lythgoe & Xavier Golay
http://www.nature.com/nm/journal/v19/n8/full/nm.3252.html

Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate
S. J. Nelson, J. Kurhanewicz, D. B. Vigneron, P. E. Z. Larson, A. L. Harzstark, M. Ferrone, M. v. Criekinge, J. W. Chang, R. Bok, I. Park, G. Reed, L. Carvajal, E. J. Small, P. Munster, V. K. Weinberg, J. H. Ardenkjaer-Larsen, A. P. Chen, R. E. Hurd, L.-I. Odegardstuen, F. J. Robb, J. Tropp, J. A. Murray
http://stm.sciencemag.org/content/5/198/198ra108.abstract

Quantitative In Vivo Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis
Norbert W. Lutz, Yann Le Fur, Johanna Chiche, Jacques Pouysségur, and Patrick J. Cozzone
http://cancerres.aacrjournals.org/content/73/15/4616.abstract.html?etoc

——————————–
Cancer metabolism
——————————–

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BRAFV600E-Driven Lung Tumors.
Strohecker AM, Guo JY, Karsli-Uzunbas G, Price SM, Chen GJ, Mathew R, McMahon M, White E.
http://cancerdiscovery.aacrjournals.org/content/early/2013/08/21/2159-8290.CD-13-0397.abstract

Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer
Yan Liu, Kevin Marks, Glenn S. Cowley, Julian Carretero, Qingsong Liu,  Thomas J.F. Nieland, Chunxiao Xu, Travis J. Cohoon, Peng Gao, Yong Zhang, Zhao Chen, Abigail B. Altabef, Jeremy H. Tchaicha, Xiaoxu Wang, Sung Choe, Edward M. Driggers, Jianming Zhang, Sean T. Bailey, Norman E. Sharpless, D. Neil Hayes, Nirali M. Patel, Pasi A. Janne, Nabeel  Bardeesy, Jeffrey A. Engelman, Brendan D. Manning, Reuben J. Shaw, John M. Asara, Ralph Scully, Alec Kimmelman, Lauren A. Byers, Don L. Gibbons, Ignacio I. Wistuba, John V. Heymach, David J. Kwiatkowski, William Y. Kim, Andrew L. Kung, Nathanael S. Gray, David E. Root, Lewis C. Cantley, and Kwok-Kin Wong
http://cancerdiscovery.aacrjournals.org/content/3/8/870.abstract.html?etoc

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
Jan R. Dörr, Yong Yu, Maja Milanovic, Gregor Beuster, Christin Zasada, J. Henry M. Däbritz, Jan Lisec, Dido Lenze, Anne Gerhardt, Katharina Schleicher, Susanne Kratzat, Bettina Purfürst, Stefan Walenta, Wolfgang Mueller-Klieser, Markus Gräler, Michael Hummel, Ulrich Keller, Andreas K. Buck, Bernd Dörken, Lothar Willmitzer, Maurice Reimann, Stefan Kempa, Soyoung Lee & Clemens A. Schmitt
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12437.html

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer
Krushna C. Patra, Qi Wang, Prashanth T. Bhaskar, Luke Miller, Zebin Wang, Will Wheaton, Navdeep Chandel, Markku Laakso, William J. Muller, Eric L. Allen, Abhishek K. Jha, Gromoslaw A. Smolen, Michelle F. Clasquin, R. Brooks Robey, Nissim Hay
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00288-2

Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics
Qiang Huang, Yexiong Tan, Peiyuan Yin, Guozhu Ye, Peng Gao, Xin Lu,   Hongyang Wang, and Guowang Xu
http://cancerres.aacrjournals.org/content/73/16/4992.abstract.html?etoc

O-GlcNAc Transferase Integrates Metabolic Pathways to Regulate the Stability of c-MYC in Human Prostate Cancer Cells
Harri M. Itkonen, Sarah Minner, Ingrid J. Guldvik, Mareike Julia   Sandmann, Maria Christina Tsourlakis, Viktor Berge, Aud Svindland, Thorsten Schlomm, and Ian G. Mills
http://cancerres.aacrjournals.org/content/73/16/5277.abstract.html?etoc

LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer
Dupuy F, Griss T, Blagih J, Bridon G, Avizonis D, Ling C, Dong Z, Siwak DR, Annis MG, Mills GB, Muller WJ, Siegel PM, Jones RG
http://www.cancerandmetabolism.com/content/1/1/18/abstract

Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFkB target stromal MCT4
Ubaldo E Martinez-Outschoorn, Joseph M Curry, Ying-Hui Ko, Zhao Lin, Madalina Tuluc, David Cognetti, Ruth C Birbe, Edmund Pribitkin, Alessandro Bombonati, Richard G Pestell, Anthony Howell, Federica Sotgia and Michael P Lisanti
http://dx.doi.org/10.4161/cc.25510

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth
Ruiting Lin, Ren Tao, Xue Gao, Tingting Li, Xin Zhou, Kun-Liang Guan, Yue Xiong, Qun-Ying Lei
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00501-7

——————————————————————————
Dietary restriction, starvation, ischemia, hypoxia
——————————————————————————

Pten-Null Tumors Cohabiting the Same Lung Display Differential AKT Activation and Sensitivity to Dietary Restriction
Natasha L. Curry, Mari Mino-Kenudson, Trudy G. Oliver, Ömer H. Yilmaz, Vedat O. Yilmaz, Jade Y. Moon, Tyler Jacks, David M. Sabatini, and Nada Y. Kalaany
http://cancerdiscovery.aacrjournals.org/content/3/8/908.abstract.html?etoc

Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts
Qiuli Liang, Gloria A. Benavides, Athanassios Vassilopoulos, David Gius, Victor Darley Usmar and Jianhua Zhang
http://www.biochemj.org/bj/454/bj4540249.htm

Cell survival during complete nutrient deprivation depends on lipid droplet-fueled {beta}-oxidation of fatty acids
Ainara G. Cabodevilla, Laura Sanchez-Caballero, Eleni Nintou, Violeta G. Boiadjieva, Albert Gubern, Fernando Picatoste, and Enrique Claro
http://www.jbc.org/cgi/content/abstract/M113.466656v1?papetoc

AMPK-Regulated and Akt-Dependent Enhancement of Glucose Uptake Is Essential in Ischemic Preconditioning-Alleviated Reperfusion Injury
Lele Ji, Xing Zhang, Wenchong Liu, Qichao Huang, Weidong Yang, Feng Fu, Heng Ma, Hui Su, Haichang Wang, Jing Wang, Haifeng Zhang, Feng Gao
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0069910

MYC Degradation under Low O2 Tension Promotes Survival by Evading Hypoxia-Induced Cell Death
Waihay J. Wong, Bo Qiu, Michael S. Nakazawa, Guoliang Qing, and M. Celeste Simon
http://mcb.asm.org/cgi/content/abstract/33/17/3494?etoc

—————
mTOR
—————

Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells
Kathrin Thedieck, Birgit Holzwarth, Mirja Tamara Prentzell, Christopher Boehlke, Kathrin Kläsener, Stefanie Ruf, Annika Gwendolin Sonntag, Lars Maerz, Sushma-Nagaraja Grellscheid, Elisabeth Kremmer, Roland Nitschke, E. Wolfgang Kuehn, Johan W. Jonker, Albert K. Groen, Michael Reth, Michael N. Hall, Ralf Baumeister
http://www.cell.com/abstract/S0092-8674(13)00902-1

K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells
Juan F. Linares, Angeles Duran, Tomoko Yajima, Manolis Pasparakis, Jorge Moscat, Maria T. Diaz-Meco
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00477-2

Rapamycin regulates biochemical metabolites
Paola Tucci, Giovanni Porta, Massimiliano Agostini, Alexey Antonov, Alexander Vasilievich Garabadgiu, Gerry Melino and Anne E Willis
http://www.landesbioscience.com/journals/cc/article/25450/

Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo
Michael G Garelick, Vivian MacKay, Aya Yanagida, Emmeline C Academia, Katherine H Schreiber, Warren C Ladiges and Brian K Kennedy
http://www.landesbioscience.com/journals/cc/article/25512/

mTOR Signaling Feedback Modulates Mammary Epithelial Differentiation and Restrains Invasion Downstream of PTEN Loss
Susmita Ghosh, Lidenys Varela, Akshay Sood, Ben Ho Park, and Tamara L. Lotan
http://cancerres.aacrjournals.org/content/73/16/5218.abstract.html?etoc

Regulation of mammalian target of rapamycin complex 1 by Bcl-2 and Bcl-XL
Huafei Zou, Yumei Lai, Xuwen Zhao, Gonghong Yan, Dongzhu Ma, Nayra Cardenes, Sruti Shiva, Yongjian Liu, Xiaochun Bai, Yong Jiang, and Yu Jiang
http://www.jbc.org/cgi/content/abstract/M113.505370v1?papetoc

————————-
Miscellaneous
————————-

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
Sarah-Maria Fendt, Eric L. Bell, Mark A. Keibler, Benjamin A. Olenchock, Jared R. Mayers, Thomas M. Wasylenko, Natalie I. Vokes, Leonard Guarente, Matthew G. Vander Heiden and Gregory Stephanopoulos
http://www.nature.com/ncomms/2013/130731/ncomms3236/full/ncomms3236.html

Functional Lysine Modification by an Intrinsically Reactive Primary Glycolytic Metabolite
Raymond E. Moellering, Benjamin F. Cravatt
http://www.sciencemag.org/content/341/6145/549.abstract

Resolution of the direct interaction with and inhibition of the human GLUT1 hexose transporter by resveratrol from its effect on glucose accumulation
Salas, Monica; Obando, Patricia; Ojeda, Lorena; Ojeda, Paola; Perez, Alejandra; Vargas-Uribe, Mauricio; Rivas, Coralia I.; Vera, Juan C.; Reyes, Alejandro M.
http://ajpcell.physiology.org/content/early/2013/04/18/ajpcell.00387.2012.long

LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap
H B Nguyen, J T Babcock, C D Wells and L A Quilliam
http://www.nature.com/onc/journal/v32/n35/abs/onc2012431a.html

—————–
Reviews
—————–

Cellular Fatty Acid Metabolism and Cancer
Erin Currie, Almut Schulze, Rudolf Zechner, Tobias C. Walther, Robert V. Farese
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00207-6

Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis
G L Semenza
http://www.nature.com/onc/journal/v32/n35/abs/onc2012578a.html

Disrupting proton dynamics and energy metabolism for cancer therapy
Scott K. Parks, Johanna Chiche & Jacques Pouysségur
http://www.nature.com/nrc/journal/v13/n9/abs/nrc3579.html

The growing complexity of HIF-1α’s role in tumorigenesis: DNA repair and beyond
N Rohwer, C Zasada, S Kempa and T Cramer
http://www.nature.com/onc/journal/v32/n31/abs/onc2012510a.html

Repositioning metformin for cancer prevention and treatment
Brendan J. Quinn, Hiroshi Kitagawa, Regan M. Memmott, Joell J. Gills, and Phillip A. Dennis
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(13)00083-0

Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy
InYoung Kim and Yu-Ying He
http://www.frontiersin.org/cancer_molecular_targets_and_therapeutics/10.3389/fonc.2013.00175/full

———————————————–
Previews / comments / other
———————————————–

p73 keeps metabolic control in the family
Louise Fets and Dimitrios Anastasiou
http://www.nature.com/ncb/journal/v15/n8/full/ncb2810.html

Energizing the Search to Target LKB1-Mutant Tumors
Adam I. Marcus and Fadlo R. Khuri
http://cancerdiscovery.aacrjournals.org/content/3/8/843.abstract.html?etoc

mTOR, AMBRA1, and autophagy: An intricate relationship
Francesca Nazio and Francesco Cecconi
http://dx.doi.org/10.4161/cc.25835

Targeting cancer cells resistant to hypoxia and nutrient starvation to improve anti-angiogeneic therapy
Tsuyoshi Osawa and Masabumi Shibuya
http://dx.doi.org/10.4161/cc.25729

Inhibition of Mitochondrial Respiration by TRAP1 Is Oncogenic
http://cancerdiscovery.aacrjournals.org/content/3/8/OF13.abstract.html?etoc

Hexokinase 2 required in tumors
http://www.nature.com/ng/journal/v45/n9/full/ng.2751.html

How to Stop Responding to Stressful Conditions
Astrin prevents the association of mTOR and raptor to limit mTORC1 activation in response to stress.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/289/ec198

Cancer metabolism
Metabolic silencing
http://www.nature.com/nm/journal/v19/n8/full/nm.3310.html

Retraction Notice to: GAMT, a p53-Inducible Modulator of Apoptosis, Is Critical for the Adaptive Response to Nutrient Stress
Takao Ide, Lauren Brown-Endres, Kiki Chu, Pat P. Ongusaha, Takao Ohtsuka, Wafik S. El-Deiry, Stuart A. Aaronson, Sam W. Lee
http://www.cell.com/molecular-cell/fulltext/S1097-2765(13)00578-9

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: