Metabolist – September 2013

Cancer metabolism

Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State
Sandro Santagata, Marc L. Mendillo, Yun-chi Tang, Aravind Subramanian, Casey C. Perley, Stéphane P. Roche, Bang Wong, Rajiv Narayan, Hyoungtae Kwon, Martina Koeva, Angelika Amon, Todd R. Golub, John A. Porco Jr., Luke Whitesell, Susan Lindquist

Inhibition of AMPK and Krebs Cycle Gene Expression Drives Metabolic Remodeling of Pten-Deficient Preneoplastic Thyroid Cells
Valeria G. Antico Arciuch, Marika A. Russo, Kristy S. Kang, and Antonio Di Cristofano

Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase
Nikolaj H.T. Petersen, Ole D. Olsen, Line Groth-Pedersen, Anne-Marie Ellegaard, Mesut Bilgin, Susanne Redmer, Marie S. Ostenfeld, Danielle Ulanet, Tobias H. Dovmark, Andreas Lønborg, Signe D. Vindeløv, Douglas Hanahan, Christoph Arenz, Christer S. Ejsing, Thomas Kirkegaard, Mikkel Rohde, Jesper Nylandsted, Marja Jäättelä

CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells
Denise K Walters, Bonnie K Arendt and Diane F Jelinek

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition
Chong Chen, Yu Liu, Chao Lu, Justin R. Cross, John P. Morris IV, Aditya S. Shroff, Patrick S. Ward, James E. Bradner, Craig Thompson, and Scott W. Lowe

Induction of sarcomas by mutant IDH2
Chao Lu, Sriram Venneti, Altuna Akalin, Fang Fang, Patrick S. Ward, Raymond G. DeMatteo, Andrew M. Intlekofer, Chong Chen, Jiangbin Ye, MeeraHameed, Khedoudja Nafa, Narasimhan P. Agaram, Justin R. Cross, Raya Khanin, Christopher E. Mason, John H. Healey, Scott W. Lowe, Gary K. Schwartz, Ari Melnick, and Craig B. Thompson

Non-invasive in vivo assessment of IDH1 mutational status in glioma
Myriam M. Chaumeil, Peder E. Z. Larson, Hikari A. I. Yoshihara, Olivia M. Danforth, Daniel B. Vigneron, Sarah J. Nelson, Russell O. Pieper, Joanna J. Phillips and Sabrina M. Ronen

Estrogen receptor β activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo
A G Manente, D Valenti, G Pinton, P V Jithesh, A Daga, L Rossi, S G Gray, K J O’Byrne, D A Fennell, R A Vacca, S Nilsson, L Mutti and L Moro

Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells
Billiard J, Dennison JB, Briand J, Annan RS, Chai D, Colón M, Dodson CS, Gilbert SA, Greshock J, Jing J, Lu H, McSurdy-Freed JE, Orband-Miller LA, Mills GB, Quinn CJ, Schneck JL, Scott GF, Shaw AN, Waitt GM, Wooster RF, Duffy KJ

Starvation, autophagy, mTOR

Glucose starved cells do not engage in pro-survival autophagy
Silvia Ramirez-Peinado, Clara Lucia Leon-Annicchiarico, Javier Galindo-Moreno, Raffaella Iurlaro, Alfredo Caro-Maldonado, Jochen H. M. Prehn, Kevin M. Ryan, and Cristina Munoz-Pinedo

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids
R V Durán, E D MacKenzie, H Boulahbel, C Frezza, L Heiserich, S Tardito, O Bussolati, S Rocha, M N Hall and E Gottlieb

Downregulated adaptor protein p66Shc mitigates autophagy process by low nutrient and enhances apoptotic resistance in human lung adenocarcinoma A549 cells
Zhichao Zheng, Jie Yang, Dan Zhao, Dan Gao, Xiaojie Yan, Zhi Yao, Zhe Liu and Zhenyi Ma

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance
Xiangnan Zhang, Haijing Yan, Yang Yuan, Jieqiong Gao, Zhe Shen, Yun Cheng, Yao Shen, Rong-Rong Wang, Xiaofen Wang, Wei-Wei Hu, Guanghui Wang and Zhong Chen

A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A
Akio Nakashima, Keiko Tanimura-Ito, Noriko Oshiro, Satoshi Eguchi, Takafumi Miyamoto, Ayaka Momonami, Shinji Kamada, Kazuyoshi Yonezawa, Ushio Kikkawa

mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development
H Peng, J Liu, Q Sun, R Chen, Y Wang, J Duan, C Li, B Li, Y Jing, X Chen, Q Mao, K-F Xu, C L Walker, J Li, J Wang and H Zhang


Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive IDH flux
Jing Fan, Jurre J. Kamphorst, Joshua D. Rabinowitz, and Tomer Shlomi

ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression
F Fallone, S Britton, L Nieto, B Salles and C Muller

EPR Oxygen Images Predict Tumor Control by a 50% Tumor Control Radiation Dose
Martyna Elas, Jessica M. Magwood, Brandi Butler, Chanel Li, Rona Wardak, Eugene D. Barth, Boris Epel, Samuel Rubinstein, Charles A. Pelizzari, Ralph R. Weichselbaum, and Howard J. Halpern

A mechanism for induction of a hypoxic response by vaccinia virus.
Mazzon M, Peters NE, Loenarz C, Krysztofinska EM, Ember SW, Ferguson BJ, Smith GL.

Loss of cell adhesion molecule CHL1 improves homeostatic adaptation and survival in hypoxic stress
X Huang, J Sun, W Rong, T Zhao, D-h Li, X Ding, L-y Wu, K Wu, M Schachner, Z-C Xiao, L-l Zhu and M Fan


Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
Adriana Soler, Helena Serra, Wayne Pearce, Ana Angulo, Julie Guillermet-Guibert, Lori S. Friedman, Francesc Viñals, Holger Gerhardt, Oriol Casanovas, Mariona Graupera*, and Bart Vanhaesebroeck

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch
Patrick M Gubser, Glenn R Bantug, Leyla Razik, Marco Fischer, Sarah Dimeloe, Gideon Hoenger, Bojana Durovic, Annaïse Jauch & Christoph Hess

Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism
Nicolas Smadja-Lamere, Michael Shum, Paul Deleris, Philippe P. Roux,
Jun-Ichi Abe, and Andre Marette

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency
Sara Cogliati, Christian Frezza, Maria Eugenia Soriano, Tatiana Varanita, Ruben Quintana-Cabrera, Mauro Corrado, Sara Cipolat, Veronica Costa, Alberto Casarin, Ligia C. Gomes, Ester Perales-Clemente, Leonardo Salviati, Patricio Fernandez-Silva, Jose A. Enriquez, Luca Scorrano

Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance
Marc Schneeberger, Marcelo O. Dietrich, David Sebastián, Mónica Imbernón, Carlos Castaño, Ainhoa Garcia, Yaiza Esteban, Alba Gonzalez-Franquesa, Ignacio Castrillón Rodríguez, Analía Bortolozzi, Pablo M. Garcia-Roves, Ramon Gomis, Ruben Nogueiras, Tamas L. Horvath, Antonio Zorzano, Marc Claret

Unbiased Metabolite Profiling Indicates That a Diminished Thymidine Pool Is the Underlying Mechanism of Colon Cancer Chemoprevention by Alpha-Difluoromethylornithine
Mavee Witherspoon, Qiuying Chen, Levy Kopelovich, Steven S. Gross, and Steven M. Lipkin


Review series in JCI: Cancer metabolism.

-Exploiting tumor metabolism: challenges for clinical translation
Matthew G. Vander Heiden
-Oncometabolites: linking altered metabolism with cancer
Ming Yang, Tomoyoshi Soga, Patrick J. Pollard
-Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate
Ovidiu C. Andronesi, Otto Rapalino, Elizabeth Gerstner, Andrew Chi, Tracy T. Batchelor, Dan P. Cahill, A. Gregory Sorensen, Bruce R. Rosen
-HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
Gregg L. Semenza
-Isocitrate dehydrogenase mutations in leukemia
Anna Sophia McKenney, Ross L. Levine
-Glutamine and cancer: cell biology, physiology, and clinical opportunities
Christopher T. Hensley, Ajla T. Wasti, Ralph J. DeBerardinis
-Targeting lactate metabolism for cancer therapeutics
Joanne R. Doherty, John L. Cleveland
-Potential applications for biguanides in oncology
Michael Pollak

Metabolic Regulation by p53 Family Members
Celia R. Berkers, Oliver D.K. Maddocks, Eric C. Cheung, Inbal Mor, Karen H. Vousden

Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis
G L Semenza

SEACing the GAP that nEGOCiates TORC1 activation: Evolutionary conservation of Rag GTPase regulation
Nicolas Panchaud, Marie-Pierre Péli-Gulli and Claudio De Virgilio

The Relationship between Tumor Blood Flow, Angiogenesis, Tumor Hypoxia, and Aerobic Glycolysis
Leif Østergaard, Anna Tietze, Thomas Nielsen, Kim Ryun Drasbek, Kim   Mouridsen, Sune Nørhøj Jespersen, and Michael R. Horsman

mTORC1 Status Dictates Tumor Response to Targeted Therapeutics
Ilana Kelsey and Brendan D. Manning

Mechanisms of Targeted Therapy Resistance Take a De-TOR
Leanna R. Gentry, Timothy D. Martin, Channing J. Der

Stromal glycolysis and MCT4 are hallmarks of DCIS progression to invasive breast cancer
Michael P Lisanti, Federica Sotgia, Richard G Pestell, Anthony Howell and Ubaldo E Martinez-Outschoorn

Cell signalling: A peroxisomal home for TSC

HSF1 Links Ribosome Activity and Metabolic Reprogramming