MetaboList – October 2013

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Cancer Metabolism
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PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells
William J. Israelsen, Talya L. Dayton, Shawn M. Davidson, Brian P. Fiske, Aaron M. Hosios, Gary Bellinger, Jie Li, Yimin Yu, Mika Sasaki, James W. Horner, Laura N. Burga, Jianxin Xie, Michael J. Jurczak, Ronald A. DePinho, Clary B. Clish, Tyler Jacks, Richard G. Kibbey, Gerburg M. Wulf, Dolores Di Vizio, Gordon B. Mills, Lewis C. Cantley, Matthew G. Vander Heiden
http://www.cell.com/abstract/S0092-8674(13)01162-8
[paperClip available]

Mitochondrial dynamics regulates migration and invasion of breast cancer cells
J Zhao, J Zhang, M Yu, Y Xie, Y Huang, D W Wolff, P W Abel and Y Tu
http://www.nature.com/onc/journal/v32/n40/abs/onc2012494a.html

Mitochondrial dysfunction and permeability transition in osteosarcoma cells showing the Warburg effect
An-Hoa Giang, Tamara Raymond, Paul Brookes, Karen DeMesy-Bentley, Edward Schwarz, Regis O’Keefe, and Roman Eliseev
http://www.jbc.org/content/early/2013/10/07/jbc.M113.507129.abstract.html?papetoc

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML
Anuhar Chaturvedi, Michelle Maria Araujo Cruz, Nidhi Jyotsana, Amit Sharma, Haiyang Yun, Kerstin Görlich, Martin Wichmann, Adrian Schwarzer, Matthias Preller, Felicitas Thol, Johann Meyer, Reinhard Haemmerle, Eduard A. Struys, Erwin E. Jansen, Ute Modlich, Zhixiong Li, Laura M. Sly, Robert Geffers, Robert Lindner, Dietmar J. Manstein, Ulrich Lehmann,Jürgen Krauter, Arnold Ganser, and Michael Heuser
http://bloodjournal.hematologylibrary.org/content/122/16/2877.abstract.html?etoc

Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death
Isabelle Vanessa Mohrenz , Patrick Antonietti , Stefan Pusch , David Capper , Jörg Balss , Sophia Voigt , Susanne Weissert , Alicia Mukrowsky , Jan Frank , Christian Senft , Volker Seifert , Andreas von Deimling & Donat Kögel
http://link.springer.com/article/10.1007/s10495-013-0877-8

PIM2 phosphorylates PKM2 and promotes Glycolysis in Cancer Cells
Zhenhai Yu, Liangqian Huang, Teng Zhang, Fajun Yang, Lei Xie, Jianjun Liu, Shaoli Song, Ping Miao, Li Zhao, Xiaoping Zhao, and Gang Huang
http://www.jbc.org/content/early/2013/10/18/jbc.M113.508226.abstract.html?papetoc

Increased concentrations of Fructose-2,6-bisphosphate contribute to the Warburg effect in PTEN-deficient cells
Lucia Cordero-Espinoza and Thilo Hagen
http://www.jbc.org/content/early/2013/10/29/jbc.M113.510289.abstract.html?papetoc

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Starvation / drugs
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Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice
Ophélie Meynet, Barbara Zunino, Lina Happo, Ludivine A. Pradelli, Johanna Chiche, Marie A. Jacquin, Laura Mondragón, Jean-François Tanti, Bruno Taillan, Georges Garnier, Julie Reverso-Meinietti, Nicolas Mounier, Jean-François Michiels, Ewa M. Michalak, Michel Carles, Clare L. Scott, and Jean-Ehrland Ricci
http://bloodjournal.hematologylibrary.org/content/122/14/2402.abstract.html?etoc

Metabolic intervention on lipid synthesis converging pathways abrogates prostate cancer growth
V Fritz, Z Benfodda, C Henriquet, S Hure, J-P Cristol, F Michel, M-A Carbonneau, F Casas and L Fajas
http://www.nature.com/onc/journal/v32/n42/abs/onc2012523a.html

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target
Luika A. Timmerman, Thomas Holton, Mariia Yuneva, Raymond J. Louie, Mercè Padró, Anneleen Daemen, Min Hu, Denise A. Chan, Stephen P. Ethier, Laura J. van ‘t Veer, Kornelia Polyak, Frank McCormick, Joe W. Gray
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00366-8

Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1.
Andrade-Vieira R, Han JH, Marignani PA.
https://www.landesbioscience.com/journals/cbt/article/26206/

Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis in response to oxidative stress and energy restriction
Iman van den Bout, David R. Jones, Zahid H. Shah, Jonathan R. Halstead, Willem Jan Keune, Shabaz Mohammed, Clive S. D’Santos and Nullin Divecha
http://www.biochemj.org/bj/455/bj4550347.htm

Glucose promotes breast cancer aggression and reduces metformin efficacy
Reema Wahdan-Alaswad, Zeying Fan, Susan M Edgerton, Bolin Liu, Xin-Sheng Deng, Sigrid Salling Arnadottir, Jennifer K Richer, Steven M Anderson and Ann D Thor
https://www.landesbioscience.com/journals/cc/article/26641/

Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma
Ruihua Ma, Wanguang Zhang, Ke Tang, Huafeng Zhang, Yi Zhang, Dapeng Li, Yong Li, Pingwei Xu, Shunqun Luo, Wenqian Cai, Tiantian Ji, Foad Katirai, Duyun Ye and Bo Huang
http://www.nature.com/ncomms/2013/131022/ncomms3508/full/ncomms3508.html

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Hypoxia / ischemia
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Hypoxia-Dependent Modification of Collagen Networks Promotes Sarcoma Metastasis
T.S. Karin Eisinger-Mathason, Minsi Zhang, Qiong Qiu, Nicolas Skuli, Michael S. Nakazawa, Tatiana Karakasheva, Vera Mucaj, Jessica E.S. Shay, Lars Stangenberg, Navid Sadri, Ellen Puré, Sam S. Yoon, David G. Kirsch, and M. Celeste Simon
http://cancerdiscovery.aacrjournals.org/content/3/10/1190.abstract.html?etoc

Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia
Y Xi, Y Wei, B Sennino, A Ulsamer, I Kwan, A N Brumwell, K Tan, M K Aghi, D M McDonald, D M Jablons and H A Chapman
http://www.nature.com/onc/journal/v32/n42/abs/onc2012530a.html

Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart
Zheqing Cai, Weibo Luo, Huiwang Zhan, and Gregg L. Semenza
http://www.pnas.org/content/110/43/17462.abstract.html?etoc

Phagocytosis executes delayed neuronal death after focal brain ischemia
Jonas J. Neher, Julius V. Emmrich, Michael Fricker, Palwinder K. Mander, Clotilde Théry, and Guy C. Brown
http://www.pnas.org/content/110/43/E4098.abstract.html?etoc

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AMPK/mTOR
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The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1.
Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM.
http://www.sciencedirect.com/science/article/pii/S1097276513006862

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation
Graeme J. Gowans, Simon A. Hawley, Fiona A. Ross, D. Grahame Hardie
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00375-6

AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation
Ya-Lin Zhang, Huiling Guo, Chen-Song Zhang, Shu-Yong Lin, Zhenyu Yin, Yongying Peng, Hui Luo, Yuzhe Shi, Guili Lian, Cixiong Zhang, Mengqi Li, Zhiyun Ye, Jing Ye, Jiahuai Han, Peng Li, Jia-Wei Wu, Sheng-Cai Lin
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00373-2

Phosphorylation of BRAF by AMPK Impairs BRAF-KSR1 Association and Cell Proliferation
Che-Hung Shen, Ping Yuan, Rolando Perez-Lorenzo, Yaqing Zhang, Sze Xian Lee, Yang Ou, John M. Asara, Lewis C. Cantley, Bin Zheng
http://www.sciencedirect.com/science/article/pii/S1535610812005181

Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK
A Avivar-Valderas, E Bobrovnikova-Marjon, J Alan Diehl, N Bardeesy, J Debnath and J A Aguirre-Ghiso
http://www.nature.com/onc/journal/v32/n41/abs/onc2012512a.html

Extended treatment with selective phosphatidylinositol 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength
Greg C. Smith, Wee-Kiat Ong, Jessica L. Costa, Maureen Watson, Jillian Cornish, Andrew Grey, Greg D. Gamble, Michelle Dickinson, Sophie Leung, Gordon W. Rewcastle, Weiping Han and Peter R. Shepherd
http://onlinelibrary.wiley.com/doi/10.1111/febs.12428/abstract

Suppression of Lysosome Function Induces Autophagy via a Feedback Downregulation of MTORC1 Activity
Min Li, Bilon Khambu, Hao Zhang, Jeong-Han Kang, Xiaoyun Chen, Daohong Chen, Laura Vollmer, Pei-Qing Liu, Andreas Vogt, and Xiao-Ming Yin
http://www.jbc.org/content/early/2013/10/30/jbc.M113.511212.abstract.html?papetoc

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Miscellaneous
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Optical Metabolic Imaging Identifies Glycolytic Levels, Subtypes, and Early-Treatment Response in Breast Cancer
Alex J. Walsh, Rebecca S. Cook, H. Charles Manning, Donna J. Hicks, Alec Lafontant, Carlos L. Arteaga, and Melissa C. Skala
http://cancerres.aacrjournals.org/content/73/20/6164.abstract.html?etoc

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
Madhusudhanan Sukumar, Jie Liu, Yun Ji, Murugan Subramanian, Joseph G. Crompton, Zhiya Yu, Rahul Roychoudhuri, Douglas C. Palmer, Pawel Muranski, Edward D. Karoly, Robert P. Mohney, Christopher A. Klebanoff, Ashish Lal, Toren Finkel, Nicholas P. Restifo, Luca Gattinoni
http://www.jci.org/articles/view/69589

GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation
Tania Velletri, Francesco Romeo, Paola Tucci, Angelo Peschiaroli, Margherita Annicchiarico-Petruzzelli, Maria Victoria Niklison-Chirou, Ivano Amelio, Richard A Knight, Tak W Mak, Gerry Melino, Massimiliano Agostini
http://dx.doi.org/10.4161/cc.26771

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Reviews
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Exploiting the bad eating habits of Ras-driven cancers
Eileen White
http://genesdev.cshlp.org/content/27/19/2065.abstract.html?etoc

Metabolic targets for cancer therapy.
Galluzzi L, Kepp O, Heiden MG, Kroemer G
http://www.nature.com/nrd/journal/v12/n11/full/nrd4145.html

A Central Role for mTOR in Lipid Homeostasis
Dudley W. Lamming, David M. Sabatini
http://www.sciencedirect.com/science/article/pii/S1550413113003264

Fueling Immunity: Insights into Metabolism and Lymphocyte Function
Erika L. Pearce, Maya C. Poffenberger, Chih-Hao Chang, Russell G. Jones
http://www.sciencemag.org/content/342/6155/1242454.abstract

AMPK: mediating the metabolic effects of salicylate-based drugs?
Gregory R. Steinberg, Madhumita Dandapani, and D. Grahame Hardie
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(13)00104-5

Effects of vitamin B6 metabolism on oncogenesis, tumor progression and therapeutic responses
L Galluzzi, E Vacchelli, J Michels, P Garcia, O Kepp, L Senovilla, I Vitale and G Kroemer
http://www.nature.com/onc/journal/v32/n42/full/onc2012623a.html

 
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Previews / comments
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Hypoxia Signaling—License to Metastasize
Sakari Vanharanta and Joan Massagué
http://cancerdiscovery.aacrjournals.org/content/3/10/1103.abstract.html?etoc

Glycolysis Back in the Limelight: Systemic Targeting of HK2 Blocks Tumor Growth
Susana Ros and Almut Schulze
http://cancerdiscovery.aacrjournals.org/content/3/10/1105.abstract.html?etoc

Nuclear PKM2 regulates the Warburg effect
Weiwei Yang and Zhimin Lu
http://dx.doi.org/10.4161/cc.26182

Rapamycin Resistance: mTORC1 Substrates Hold Some of the Answers
Sang-Oh Yoon, Philippe P. Roux
http://www.cell.com/current-biology/abstract/S0960-9822(13)01036-1

TSC on the peroxisome controls mTORC1
Don Benjamin and Michael N. Hall
http://www.nature.com/ncb/journal/v15/n10/full/ncb2849.html

Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRASG12D-driven lung tumors
Jessie Yanxiang Guo and Eileen White
https://www.landesbioscience.com/journals/autophagy/article/26123/

Metabolism: IDH2 drives cancer in vivo
http://www.nature.com/nrc/journal/v13/n11/full/nrc3619.html

Astrin Maintains Balanced mTORC1 Signaling under Cellular Stress
http://cancerdiscovery.aacrjournals.org/content/3/10/OF12.abstract.html?etoc

IDH1 Is a Druggable Target in Acute Myeloid Leukemia
http://cancerdiscovery.aacrjournals.org/content/3/10/OF24.abstract.html?etoc

Targeting Hexokinase 2 May Block Cancer Glucose Metabolism
http://cancerdiscovery.aacrjournals.org/content/3/10/OF25.abstract.html?etoc

Connecting Energy Status to Proliferation
By phosphorylating the kinase B-Raf, the energy-responsive kinase AMPK inhibits signals that lead to cell proliferation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;6/299/ec265

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