MetaboList – November 2013

Cancer metabolism

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology
Erik R. Nelson, Suzanne E. Wardell, Jeff S. Jasper, Sunghee Park, Sunil Suchindran, Matthew K. Howe, Nicole J. Carver, Ruchita V. Pillai, Patrick M. Sullivan, Varun Sondhi, Michihisa Umetani, Joseph Geradts, Donald P. McDonnell

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of Braf^V600E–Driven Lung Tumors
Anne M. Strohecker, Jessie Yanxiang Guo, Gizem Karsli-Uzunbas, Sandy M. Price, Guanghua Jim Chen, Robin Mathew, Martin McMahon, and Eileen White

Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells
P M Tedeschi, E K Markert, M Gounder, H Lin, D Dvorzhinski, S C Dolfi, L L-Y Chan, J Qiu, R S DiPaola, K M Hirshfield, L G Boros, J R Bertino, Z N Oltvai and A Vazquez

Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer
Katherine M Aird, Hua Li, Frances Xin, Panagiotis A Konstantinopoulos and Rugang Zhang

Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling
Alexander V. Zhdanov, Alicia H.C. Waters, Anna V. Golubeva, Ruslan I. Dmitriev, Dmitri B. Papkovsky

Rapid diagnosis and prognosis of de novo acute myeloid leukemia by serum metabonomic analysis.
Wang Y, Zhang L, Chen WL, Wang JH, Li N, Li JM, Mi JQ, Zhang WN, Li Y, Wu SF, Jin J, Wang YG, Huang H, Chen Z, Chen SJ, Tang H.

Anti-metabolic treatments

Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia
Lise Willems, Nathalie Jacque, Arnaud Jacquel, Nathalie Neveux, Thiago Trovati Maciel, Mireille Lambert, Alain Schmitt, Laury Poulain, Alexa S. Green, Madalina Uzunov, Olivier Kosmider, Isabelle Radford-Weiss, Ivan Cruz Moura, Patrick Auberger, Norbert Ifrah, Valérie Bardet, Nicolas Chapuis, Catherine Lacombe, Patrick Mayeux, Jérôme Tamburini, and Didier Bouscary

Phenformin enhances the therapeutic benefit of BRAFV600E inhibition in melanoma
Ping Yuan, Koichi Ito, Rolando Perez-Lorenzo, Christina Del Guzzo, Jung Hyun Lee, Che-Hung Shen, Marcus W. Bosenberg, Martin McMahon, Lewis C. Cantley, and Bin Zheng

Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer
Cecilia Marini, Barbara Salani, Michela Massollo, Adriana Amaro, Alessia Isabella Esposito, Anna Maria Orengo, Selene Capitanio, Laura Emionite, Mattia Riondato, Gianluca Bottoni, Cinzia Massara, Simona Boccardo, Marina Fabbi, Cristina Campi, Silvia Ravera, Giovanna Angelini, Silvia Morbelli, Michele Cilli, Renzo Cordera, Mauro Truini, Davide Maggi, Ulrich Pfeffer and Gianmario Sambuceti

Glycolysis Inhibition Sensitizes Non-Small Cell Lung Cancer with T790M Mutation to Irreversible EGFR Inhibitors via Translational Suppression of Mcl-1 by AMPK Activation
Sun Mi Kim, Mi Ran Yun, Yun Kyoung Hong, Flavio Solca, Joo-Hang Kim, Hyun-Jung Kim, and Byoung Chu Cho

Recombinant human arginase induced caspase-dependent apoptosis and autophagy in non-Hodgkin’s lymphoma cells
X Zeng, Y Li, J Fan, H Zhao, Z Xian, Y Sun, Z Wang, S Wang, G Zhang and D Ju

Metformin Targets the Metabolic Achilles Heel of Human Pancreatic Cancer Stem Cells
Enza Lonardo, Michele Cioffi, Patricia Sancho, Yolanda Sanchez-Ripoll, Sara Maria Trabulo, Jorge Dorado, Anamaria Balic, Manuel Hidalgo, Christopher Heeschen


Optical metabolic imaging identifies glycolytic levels, subtypes, and early-treatment response in breast cancer.
Walsh AJ, Cook RS, Manning HC, Hicks DJ, Lafontant A, Arteaga CL, Skala MC.

Tissue metabolite profiling identifies differentiating and prognostic biomarkers for prostate carcinoma
Klaus Jung, Regina Reszka, Beate Kamlage, Bianca Bethan, Carsten Stephan, Michael Lein, Glen Kristiansen

Delivery Rate Affects Uptake of a Fluorescent Glucose Analog in Murine Metastatic Breast Cancer
Narasimhan Rajaram, Amy E. Frees, Andrew N. Fontanella, Jim Zhong, Katherine Hansen, Mark W. Dewhirst, Nirmala Ramanujam


mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
Masahiro Morita, Simon-Pierre Gravel, Valérie Chénard, Kristina Sikström, Liang Zheng, Tommy Alain, Valentina Gandin, Daina Avizonis, Meztli Arguello, Chadi Zakaria, Shannon McLaughlan, Yann Nouet, Arnim Pause, Michael Pollak, Eyal Gottlieb, Ola Larsson, Julie St-Pierre, Ivan Topisirovic, Nahum Sonenberg

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc
Kenta Masui, Kazuhiro Tanaka, David Akhavan, Ivan Babic, Beatrice Gini, Tomoo Matsutani, Akio Iwanami, Feng Liu, Genaro R. Villa, Yuchao Gu, Carl Campos, Shaojun Zhu, Huijun Yang, William H. Yong, Timothy F. Cloughesy, Ingo K. Mellinghoff, Webster K. Cavenee, Reuben J. Shaw, Paul S. Mischel

mTOR regulates phagosome and entotic vacuole fission
Matej Krajcovic, Shefali Krishna, Leila Akkari, Johanna A. Joyce, and Michael Overholtzer

Chemoproteomic Analysis of Inter-Tissue and Inter-Species Isoform Diversity of AMP-Activated Protein Kinase (AMPK)
Jiang Wu, Dinesh Puppala, Xidong Feng, Mara Monetti, Amanda Lee Lapworth,and Kieran F. Geoghegan

Genetic and Pharmacologic Inhibition of mTORC1 Promotes EMT by a TGF-β–Independent Mechanism
Ivan Mikaelian, Mouhannad Malek, Rudy Gadet, Jean Viallet, Amandine Garcia, Anaïs Girard-Gagnepain, Cédric Hesling, Germain Gillet, Philippe Gonzalo, Ruth Rimokh, and Marc Billaud

Hyper-activation of mTORC1 Promotes Breast Cancer Progression through Enhancing Glucose Starvation-induced Autophagy and Akt Signaling
Yongqiang Chen, Huijun Wei, Fei Liu, and Jun-Lin Guan

TORC1 Inhibits GSK3-Mediated Elo2 Phosphorylation to Regulate Very Long Chain Fatty Acid Synthesis and Autophagy
Christine Zimmermann, Aline Santos, Kenneth Gable, Sharon Epstein, Charulatha Gururaj, Pierre Chymkowitch, Dennis Pultz, Steven V. Rødkær, Lorena Clay, Magnar Bjørås, Yves Barral, Amy Chang, Nils J. Færgeman, Teresa M. Dunn, Howard Riezman, Jorrit M. Enserink

Starvation / hypoxia

Glucose Deprivation Converts Poly(ADP-ribose) Polymerase-1 Hyperactivation into a Transient Energy Producing Process
Daniela Buonvicino, Laura Formentini, Giulia Cipriani, and Alberto Chiarugi

HINCUTs in cancer: hypoxia-induced noncoding ultraconserved transcripts
J Ferdin, N Nishida, X Wu, M S Nicoloso, M Y Shah, C Devlin, H Ling, M Shimizu, K Kumar, M A Cortez, M Ferracin, Y Bi, D Yang, B Czerniak, W Zhang, T D Schmittgen, M P Voorhoeve, M J Reginato, M Negrini, R V Davuluri, T Kunej, M Ivan and G A Calin

Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets
Maria Grazia Cipolleschi, Ilaria Marzi, Roberta Santini, David Fredducci, Maria Cristina Vinci, Massimo D’Amico, Elisabetta Rovida, Theodora Stivarou, Eugenio Torre, Persio Dello Sbarba, Barbara Stecca and Massimo Olivotto

Regulation of IL-1β–induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways
Carsten C. Scholz, Miguel A. S. Cavadas, Murtaza M. Tambuwala, Emily Hams, Javier Rodríguez, Alex von Kriegsheim, Philip Cotter, Ulrike Bruning, Padraic G. Fallon, Alex Cheong, Eoin P. Cummins, and Cormac T. Taylor


Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization
Lei Lv, Yan-Ping Xu, Di Zhao, Fu-Long Li, Wei Wang, Naoya Sasaki, Ying Jiang, Xin Zhou, Ting-Ting Li, Kun-Liang Guan, Qun-Ying Lei, Yue Xiong

Nuclear localization of aldolase A correlates with cell proliferation
Piotr Mamczur, Andrzej Gamian, Jerzy Kolodziej, Piotr Dziegiel, Dariusz Rakus

Emergence of spatial structure in the tumor microenvironment due to the Warburg effect
Carlos Carmona-Fontaine, Vanni Bucci, Leila Akkari, Maxime Deforet, Johanna A. Joyce, and Joao B. Xavier

Hyperglycemia Enhances the Proliferation of Non-Tumorigenic and Malignant Mammary Epithelial Cells through Increased leptin/IGF1R Signaling and Activation of AKT/mTOR
Rebecca Lopez, Arunkumar Arumugam, Riya Joseph, Kanika Monga, Thiyagarajan Boopalan, Pamela Agullo, Christina Gutierrez, Sushmita Nandy, Ramadevi Subramani, Jose Manuel de la Rosa, Rajkumar Lakshmanaswamy

Reviews / comments

The multiple connections between pRB and cell metabolism
Brandon N Nicolay, Nicholas J Dyson

Metabolic regulation of the cell cycle
In Hye Lee, Toren Finkel

p73 keeps metabolic control in balance
Francesca Cutruzzolà, Luciana Avigliano and Eleonora Candi

A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation
Peng Jiang, Wenjing Du and Xiaolu Yang

Tumor-Promoting and -Suppressive Roles of Autophagy in the Same Mouse Model of Braf^V600E-Driven Lung Cancer
Song Chen and Jun-Lin Guan

Cholesterol Forges Link Between Obesity and Breast Cancer
Jocelyn Kaiser

Metabolism: Nuclear or cytoplasmic?
Two papers examine the nuclear and cytoplasmic function of PKM2.

Asparaginase unveils glutamine-addicted AML
Ismael Samudio and Marina Konopleva

Signalling: Finding the GAPs in mTORC1 signalling