Metabolist – December 2013

Cancer metabolism

p53 status determines the role of autophagy in pancreatic tumour development
Mathias T. Rosenfeldt, Jim O’Prey, Jennifer P. Morton, Colin Nixon, Gillian MacKay, Agata Mrowinska, Amy Au, Taranjit Singh Rai, Liang Zheng, Rachel Ridgway, Peter D. Adams, Kurt I. Anderson, Eyal Gottlieb, Owen J. Sansom & Kevin M. Ryan

Tumour-associated mutant p53 drives the Warburg effect
Cen Zhang, Juan Liu, Yingjian Liang, Rui Wu, Yuhan Zhao, Xuehui Hong, Meihua Lin, Haiyang Yu, Lianxin Liu, Arnold J. Levine, Wenwei Hu and Zhaohui Feng

Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia.
Fan J, Kamphorst JJ, Mathew R, Chung MK, White E, Shlomi T, Rabinowitz JD.

The Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation
Jane Ding, Tai Li, Xiangwei Wang, Erhu Zhao, Jeong-Hyeon Choi, Liqun Yang, Yunhong Zha, Zheng Dong, Shuang Huang, John M. Asara, Hongjuan Cui, Han-Fei Ding

A New Specific Succinate-Glutamate Metabolomic Hallmark in Sdhx-Related Paragangliomas
Alessio Imperiale, François-Marie Moussallieh, Frédéric Sebag, Laurent Brunaud, Anne Barlier, Karim Elbayed, Philippe Bachellier, Bernard Goichot, Karel Pacak, Izzie-Jacques Namer, David Taïeb

Metabolic inhibitors

Targeting cisplatin-resistant human tumor cells with metabolic inhibitors.
Sullivan EJ, Kurtoglu M, Brenneman R, Liu H, Lampidis TJ.

Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth
Barbara Wegiel, David Gallo, Eva Csizmadia, Clair Harris, John Belcher, Gregory M. Vercellotti, Nuno Penacho, Pankaj Seth, Vikas Sukhatme, Asif Ahmed, Pier Paolo Pandolfi, Leszek Helczynski, Anders Bjartell, Jenny Liao Persson, and Leo E. Otterbein

Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells

Inhibition of Lipolysis by Mercaptoacetate and Etomoxir Specifically Sensitize Drug-Resistant Lung Adenocarcinoma Cell to Paclitaxel
Li, Jiajin; Zhao, Shiyan; Zhou, Xiang; Zhang, Teng; Zhao, Li; Miao, Ping; Song, Shaoli; Sun, Xiaoguang; Liu, Jianjun; Zhao, Xiaoping; Huang, Gang

Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction.
Long Y, Tsai WB, Wangpaichitr M, Tsukamoto T, Savaraj N, Feun LG, Kuo MT.

Glucose promotes breast cancer aggression and reduces metformin efficacy
Reema Wahdan-Alaswad, Zeying Fan, Susan M Edgerton, Bolin Liu, Xin-Sheng Deng, Sigrid Salling Arnadottir, Jennifer K Richer, Steven M Anderson and Ann D Thor

Combined Targeting of PDK1 and EGFR Triggers Regression of Glioblastoma by Reversing the Warburg Effect
Kiran Kumar Velpula, Arnima Bhasin, Swapna Asuthkar, and  Andrew J. Tsung

Starvation / ischemia

Increased sensitivity to glucose starvation correlates with downregulation of glycogen phosphorylase isoform PYGB in tumor cell lines resistant to 2-deoxy-D-glucose.
hilips KB, Kurtoglu M, Leung HJ, Liu H, Gao N, Lehrman MA, Murray TG, Lampidis TJ.

Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway
P-P Liu, J Liao, Z-J Tang, W-J Wu, J Yang, Z-L Zeng, Y Hu, P Wang, H-Q Ju, R-H Xu and P Huang

Akt isoforms differentially protect against stroke-induced neuronal injury by regulating mTOR activities
Rong Xie, Michelle Cheng, Mei Li, Xiaoxing Xiong, Marcel Daadi, Robert M Sapolsky and Heng Zhao

Autosis is a Na+,K+-ATPase–regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia–ischemia
Yang Liu, Sanae Shoji-Kawata, Rhea M. Sumpter, Jr., Yongjie Wei, Vanessa Ginet, Liying Zhang, Bruce Posner, Khoa A. Tran, Douglas R. Green, Ramnik J. Xavier, Stanley Y. Shaw, Peter G. H. Clarke, Julien Puyal, and Beth Levine


Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity
Andrea Casazza, Damya Laoui, Mathias Wenes, Sabrina Rizzolio, Nicklas Bassani, Marco Mambretti, Sofie Deschoemaeker, Jo A. Van Ginderachter, Luca Tamagnone, Massimiliano Mazzone

CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth
Noel A Warfel, Nathan G Dolloff, David T Dicker, Jozef Malysz and Wafik S El-Deiry

Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling
Simran S. Sabharwal, Gregory B. Waypa, Jeremy D. Marks and Paul T. Schumacker

ER stress and hypoxia response pathways interact to potentiate HIF-1 transcriptional activity on targets like VEGF
Ethel R. Pereira, Karen Frudd, Walid Awad, and Linda M. Hendershot


Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy
Hai-Xin Yuan, Ryan C Russell and Kun-Liang Guan

Amino acids activate mTOR complex1 without changing Rag GTPase guanyl nucleotide charging
Noriko Oshiro, Joseph Rapley, and Joseph Avruch

Crosstalk between the Tor and Gcn2 pathways in response to different stresses
Gro Elise Rødland, Tonje Tvegård, Erik Boye and Beáta Grallert

p53/TAp63 and AKT Regulate mTORC1 Signaling through two Independent Parallel Pathways in the Presence of DNA Damage
Maren Cam, Hemant K. Bid, Linlin Xiao, Gerard P. Zambetti, Peter J. Houghton, and Hakan Cam

Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiae
[pentose phosphate pathway]
Joseph I. Kliegman, Dorothea Fiedler, Colm J. Ryan, Yi-Fan Xu, Xiao-yang Su, David Thomas, Max C. Caccese, Ada Cheng, Michael Shales, Joshua D. Rabinowitz, Nevan J. Krogan, Kevan M. Shokat

T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming
Kai Yang, Sharad Shrestha, Hu Zeng, Peer W.F. Karmaus, Geoffrey Neale, Peter Vogel, David A. Guertin, Richard F. Lamb, Hongbo Chi


AMP-Activated Protein Kinase Induces p53 by Phosphorylating MDMX and Inhibiting Its Activity
Guifen He, Yi-Wei Zhang, Jun-Ho Lee, Shelya X. Zeng, Yunyuan V. Wang, Zhijun Luo, X. Charlie Dong, Benoit Viollet, Geoffrey M. Wahl, and Hua Lu

Implication of transcriptional repression in compound C-induced apoptosis in cancer cells
Dai, RY; Zhao, XF; Li, JJ; Chen, R; Luo, ZL; Yu, LX; Chen, SK; Zhang,
CY; Duan, CY; Liu, YP; Feng, CH; Xia, XM; Li, H; Fu, J; Wang, HY

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
Morgan D Fullerton, Sandra Galic, Katarina Marcinko, Sarah Sikkema, Thomas Pulinilkunnil, Zhi-Ping Chen, Hayley M O’Neill, Rebecca J Ford, Rengasamy Palanivel, Matthew O’Brien, D Grahame Hardie, S Lance Macaulay, Jonathan D Schertzer, Jason R B Dyck, Bryce J van Denderen, Bruce E Kemp & Gregory R Steinberg

Structural basis of AMPK regulation by small molecule activators
Bing Xiao, Matthew J. Sanders, David Carmena, Nicola J. Bright, Lesley F. Haire, Elizabeth Underwood, Bhakti R. Patel, Richard B. Heath, Philip A. Walker, Stefan Hallen, Fabrizio Giordanetto, Stephen R. Martin, David Carling and Steven J. Gamblin


Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal
Tingting Li, Mengxi Liu, Xu Feng, Zhen Wang, Indrani Das, Yanping Xu, Xin Zhou, Yiping Sun, Kun-Liang Guan, Yue Xiong, and Qun-Ying Lei

Controllability in Cancer Metabolic Networks According to Drug Targets as Driver Nodes
Yazdan Asgari, Ali Salehzadeh-Yazdi, Falk Schreiber, Ali Masoudi-Nejad

Non-invasive in-cell determination of free cytosolic [NAD+]/[NADH] ratios using hyperpolarized glucose show large variations in metabolic phenotypes
Caspar Elo Christensen, Magnus Karlsson, Jakob R. Winther, Pernille Rose Jensen, and Mathilde H. Lerche


2-Hydroxyglutarate is not a metabolite; d-2-hydroxyglutarate and l-2-hydroxyglutarate are!
Eduard A. Struys

Reply to Struys: Role of biomarker of 2-hydroxyglutarate in acute myeloid leukemia
Yang Shen, Jing-Han Wang, Wen-Lian Chen, Wei Jia, Sai-Juan Chen, and Zhu Chen


Autophagy-Mediated Tumor Promotion
Jessie Yanxiang Guo, Bing Xia, Eileen White

Hypoxia and metabolism in cancer.
Karim Bensaad, Adrian L. Harris

How does the metabolism of tumour cells differ from that of normal cells?
Nívea Dias Amoêdo, Juan Perez Valencia, Mariana Figueiredo Rodrigues, Antonio Galina and Franklin David Rumjanek

Unfolded Protein Response Signaling and Metabolic Diseases
Jaemin Lee and Umut Ozcan

Targeting Breast Cancer Metabolism: A Metabolic Control Analysis Approach
Ettore Murabito

Mitochondrial Dysfunction in Cancer
Michelle L Boland, Aparajita H Chourasia, and Kay F Macleod

Lactate Dehydrogenase A in Cancer: A Promising Target for Diagnosis and Therapy
Miao, Ping; Sheng, Shile; Sun, Xiaoguang; Liu, Jianjun; Huang, Gang

Single-Cell Metabolomics: Analytical and Biological Perspectives
R. Zenobi


Metformin trims fats to restore insulin sensitivity
Reuben J Shaw

A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation
Peng Jiang, Wenjing Du and Xiaolu Yang

Incomplete and transitory decrease of glycolysis: A new paradigm for anti-angiogenic therapy?
Sandra Schoors, Anna Rita Cantelmo, Maria Georgiadou, Peter Stapor, Xingwu Wang, Annelies Quaegebeur, Sandra Cauwenberghs, Brian W Wong, Francesco Bifari, Ilaria Decimo, Luc Schoonjans, Katrien De Bock, Mieke Dewerchin and Peter Carmeliet

Mitochondrial metabolism in TCA cycle mutant cancer cells
Lucas B Sullivan and Navdeep S Chandel

Cholesterol and Cancer;6/304/ec292

K433 Acetylation Switches PKM2 to a Nuclear Kinase

Regulation of PKM2 Activity Enables Metabolic Adaptation in Tumors