MetaboList – January 2014

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Cancer metabolism
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Reciprocal Regulation of HIF-1a and LincRNA-p21 Modulates the Warburg Effect
Fan Yang, Huafeng Zhang, Yide Mei, Mian Wu
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00829-0

Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways
Yasuhito Onodera, Jin-Min Nam, Mina J. Bissell
http://www.jci.org/articles/view/63146

MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis
Atsushi Terunuma, Nagireddy Putluri, Prachi Mishra, Ewy A. Mathé, Tiffany H. Dorsey, Ming Yi, Tiffany A. Wallace, Haleem J. Issaq, Ming Zhou, J. Keith Killian, Holly S. Stevenson, Edward D. Karoly, King Chan, Susmita Samanta, DaRue Prieto, Tiffany Y.T. Hsu, Sarah J. Kurley, Vasanta Putluri, Rajni Sonavane, Daniel C. Edelman, Jacob Wulff, Adrienne M. Starks, Yinmeng Yang, Rick A. Kittles, Harry G. Yfantis, Dong H. Lee, Olga B. Ioffe, Rachel Schiff, Robert M. Stephens, Paul S. Meltzer, Timothy D. Veenstra, Thomas F. Westbrook, Arun Sreekumar, Stefan Ambs
http://www.jci.org/articles/view/71180

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer
Roland Nilsson, Mohit Jain, Nikhil Madhusudhan, Nina Gustafsson Sheppard, Laura Strittmatter, Caroline Kampf, Jenny Huang, Anna Asplund and Vamsi K. Mootha
http://www.nature.com/ncomms/2014/140123/ncomms4128/full/ncomms4128.html

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Hypoxia
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Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population
Damya Laoui, Eva Van Overmeire, Giusy Di Conza, Chiara Aldeni, Jiri Keirsse, Yannick Morias, Kiavash Movahedi, Isabelle Houbracken, Elio Schouppe, Yvon Elkrim, Oussama Karroum, Bénédicte Jordan, Peter Carmeliet, Conny Gysemans, Patrick De Baetselier, Massimiliano Mazzone, and Jo A. Van Ginderachter
http://cancerres.aacrjournals.org/content/74/1/24.abstract.html?etoc

Hypoxia Induces VEGF-C Expression in Metastatic Tumor Cells via a HIF-1α-Independent Translation-Mediated Mechanism
Florent Morfoisse, Anna Kuchnio, Clement Frainay, Anne Gomez-Brouchet, Marie-Bernadette Delisle, Stefano Marzi, Anne-Catherine Helfer, Fransky Hantelys, Francoise Pujol, Julie Guillermet-Guibert, Corinne Bousquet, Mieke Dewerchin, Stephane Pyronnet, Anne-Catherine Prats, Peter Carmeliet, Barbara Garmy-Susini
http://www.cell.com/cell-reports/abstract/S2211-1247(13)00756-0

Restricted Expression of miR-30c-2-3p and miR-30a-3p in Clear Cell Renal Cell Carcinomas Enhances HIF2α Activity
Lijoy K. Mathew, Samuel S. Lee, Nicolas Skuli, Shilpa Rao, Brian Keith, Katherine L. Nathanson, Priti Lal, and M. Celeste Simon
http://cancerdiscovery.aacrjournals.org/content/4/1/53.abstract.html?etoc

Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets
Maria Grazia Cipolleschi, Ilaria Marzi, Roberta Santini, David Fredducci, Maria Cristina Vinci, Massimo D’Amico, Elisabetta Rovida, Theodora Stivarou, Eugenio Torre, Persio Dello Sbarba, Barbara Stecca and Massimo Olivotto
https://www.landesbioscience.com/journals/cc/article/27031/

Extensive regulation of the non‐coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2
Hani Choudhry, Johannes Schödel, Spyros Oikonomopoulos, Carme Camps,  Steffen Grampp, Adrian L Harris, Peter J Ratcliffe, Jiannis Ragoussis, and David R Mole
http://EMBOr.embopress.org/content/15/1/70.abstract.html?etoc

MicroRNA-145 inhibits the growth, invasion, metastasis and angiogenesis of neuroblastoma cells through targeting hypoxia-inducible factor 2 alpha
H Zhang, J Pu, T Qi, M Qi, C Yang, S Li, K Huang, L Zheng and Q Tong
http://www.nature.com/onc/journal/v33/n3/abs/onc2012574a.html

Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway
Gang Wan, Weidong Xie, Zhenyan Liu, Wei Xu, Yuanzhi Lao, Nunu Huang, Kai Cui, Meijian Liao, Jie He, Yuyang Jiang, Burton B Yang, Hongxi Xu, Naihan Xu and Yaou Zhang
http://dx.doi.org/10.4161/auto.26534

Tight control of Hypoxia Inducible Factor (HIF)-alpha transient dynamics is essential for cell survival in hypoxia
James Bagnall, Joseph Leedale, Sarah Taylor, David G. Spiller, Michael R. H. White, Kieran J. Sharkey, Rachel N. Bearon, and Violaine See
http://www.jbc.org/content/early/2014/01/06/jbc.M113.500405.abstract

Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells
Daniele M. Gilkes, Lisha Xiang, Sun Joo Lee, Pallavi Chaturvedi, Maimon E. Hubbi, Denis Wirtz, and Gregg L. Semenza
http://www.pnas.org/content/111/3/E384.abstract.html?etoc

The Apoptosis Repressor with a CARD Domain (ARC) Gene Is a Direct Hypoxia-Inducible Factor 1 Target Gene and Promotes Survival and Proliferation of VHL-Deficient Renal Cancer Cells
Olga V. Razorenova, Laura Castellini, Renata Colavitti, Laura E. Edgington, Monica Nicolau, Xin Huang, Barbara Bedogni, Edward M. Mills, Matthew Bogyo, and Amato J. Giaccia
http://mcb.asm.org/cgi/content/abstract/34/4/739?etoc

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Metabolic stress, drugs
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GCN2-Dependent Metabolic Stress Is Essential for Endotoxemic Cytokine Induction and Pathology
Haiyun Liu, Lei Huang, Jillian Bradley, Kebin Liu, Kankana Bardhan, David Ron, Andrew L. Mellor, David H. Munn, and Tracy L. McGaha
http://mcb.asm.org/cgi/content/abstract/34/3/428?etoc

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris
José A. Martina, Heba I. Diab, Li Lishu, Lim Jeong-A, Simona Patange, Nina Raben, and Rosa Puertollano
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;7/309/ra9

The synergism of MCL1 and glycolysis on pediatric acute lymphoblastic leukemia cell survival and prednisolone resistance
Ingrid M. Ariës, Bo R. Hansen, Troels Koch, Rosanna van den Dungen, William E. Evans, Rob Pieters and Monique L. den Boer
http://www.haematologica.org/content/98/12/1905.long

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mTOR, AMPK
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mTOR Inhibition Specifically Sensitizes Colorectal Cancers with KRAS or BRAF Mutations to BCL-2/BCL-XL Inhibition by Suppressing MCL-1
Anthony C. Faber, Erin M. Coffee, Carlotta Costa, Anahita Dastur, Hiromichi Ebi, Aaron N. Hata, Alan T. Yeo, Elena J. Edelman, Youngchul Song, Ah Ting Tam, Jessica L. Boisvert, Randy J. Milano, Jatin Roper, David P. Kodack, Rakesh K. Jain, Ryan B. Corcoran, Miguel N. Rivera, Sridhar Ramaswamy, Kenneth E. Hung, Cyril H. Benes, and Jeffrey A. Engelman
http://cancerdiscovery.aacrjournals.org/content/4/1/42.abstract.html?etoc

Assessing PIK3CA and PTEN in Early-Phase Trials with PI3K/AKT/mTOR Inhibitors
Filip Janku, David S. Hong, Siqing Fu, Sarina A. Piha-Paul, Aung Naing, Gerald S. Falchook, Apostolia M. Tsimberidou, Vanda M. Stepanek, Stacy L. Moulder, J. Jack Lee, Rajyalakshmi Luthra, Ralph G. Zinner, Russell R. Broaddus, Jennifer J. Wheler, Razelle Kurzrock
http://www.cell.com/cell-reports/abstract/S2211-1247(13)00793-6

A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition
Hailing Cheng, Pixu Liu, Fan Zhang, Erbo Xu, Lynn Symonds, Carolynn E. Ohlson, Roderick T. Bronson, Sauveur-Michel Maira, Emmanuelle Di Tomaso, Jane Li, Andrea P. Myers, Lewis C. Cantley, Gordon B. Mills, and Jean J. Zhao
http://cancerres.aacrjournals.org/content/74/1/15.abstract.html?etoc

Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells
Chenggang Li, Po-Shun Lee, Yang Sun, Xiaoxiao Gu, Erik Zhang, Yanan Guo, Chin-Lee Wu, Neil Auricchio, Carmen Priolo, Jing Li, Alfredo Csibi, Andrey Parkhitko, Tasha Morrison, Anna Planaguma, Shamsah Kazani, Elliot Israel, Kai-Feng Xu, Elizabeth Petri Henske, John Blenis, Bruce D. Levy, David Kwiatkowski, and Jane J. Yu
http://jem.rupress.org/content/211/1/15?etoc

Ral and Rheb GTPase Activating Proteins Integrate mTOR and GTPase Signaling in Aging, Autophagy, and Tumor Cell Invasion
Timothy D. Martin, Xiao-Wei Chen, Rebecca E.W. Kaplan, Alan R. Saltiel, Cheryl L. Walker, David J. Reiner, Channing J. Der
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00872-1

Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK
Xiaona Liu, Rishi Raj Chhipa, Shabnam Pooya, Matthew Wortman, Sara Yachyshin, Lionel M. L. Chow, Ashish Kumar, Xuan Zhou, Ying Sun, Brian Quinn, Christopher McPherson, Ronald E. Warnick, Ady Kendler, Shailendra Giri, Jeroen Poels, Koenraad Norga, Benoit Viollet, Gregory A. Grabowski, and Biplab Dasgupta
http://www.pnas.org/content/111/4/E435.abstract.html?etoc

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Miscellaneous
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PKM2 Regulates Chromosome Segregation and Mitosis Progression of Tumor Cells
Yuhui Jiang, Xinjian Li, Weiwei Yang, David H. Hawke, Yanhua Zheng, Yan Xia, Kenneth Aldape, Chongyang Wei, Fang Guo, Yan Chen, Zhimin Lu
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00826-5

Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis
Sandra Schoors, Katrien De Bock, Anna Rita Cantelmo, Maria Georgiadou, Bart Ghesquière, Sandra Cauwenberghs, Anna Kuchnio, Brian W. Wong, Annelies Quaegebeur, Jermaine Goveia, Francesco Bifari, Xingwu Wang, Raquel Blanco, Bieke Tembuyser, Ivo Cornelissen, Ann Bouché, Stefan Vinckier, Santiago Diaz-Moralli, Holger Gerhardt, Sucheta Telang, Marta Cascante, Jason Chesney, Mieke Dewerchin, Peter Carmeliet
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00457-9

A low-dose arsenic induced p53-mediated metabolic mechanism of radiotherapy protection
Suthakar Ganapathy, Shaowen Xiao, Mei Yang, Min Qi, Doo Eun Choi, Chul S. Ha, John B. Little, and Zhi-Min Yuan
http://www.jbc.org/content/early/2014/01/03/jbc.M113.531020.abstract?papetoc

Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose
Tiago B Rodrigues, Eva M Serrao, Brett W C Kennedy, De-En Hu, Mikko I Kettunen & Kevin M Brindle
http://www.nature.com/nm/journal/v20/n1/full/nm.3416.html

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Reviews
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Changing appetites: the adaptive advantages of fuel choice
Illana A. Stanley, Sofia M. Ribeiro, Alfredo Giménez-Cassina, Erik Norberg, Nika N. Danial
http://www.cell.com/trends/cell-biology/abstract/S0962-8924(13)00131-1

To be, or not to be: functional dilemma of p53 metabolic regulation.
Wang SJ, Gu W.
http://journals.lww.com/co-oncology/pages/articleviewer.aspx?year=2014&issue=01000&article=00013&type=abstract

The Many Faces of Sirtuins: Sirtuins and the Warburg effect
Leonard Guarente
http://www.nature.com/nm/journal/v20/n1/full/nm.3438.html

Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis
Lindsay E. Wu, Ana P. Gomes, David A. Sinclair
http://www.cell.com/cancer-cell/abstract/S1535-6108(13)00534-5

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Previews
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Synaptic Plasticity and the Warburg Effect
Pierre J. Magistretti
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00507-X

Hold the Sugar
Aberrant glucose metabolism may be the cause—not just a consequence—of the malignant phenotype.
http://stm.sciencemag.org/content/6/218/218ec7.short

The Sugar-Cancer Connection in 3D
A three-dimensional culture model shows that increased glycolysis can initiate and maintain malignant phenotypes.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;7/310/ec29

Metabolic Reprogramming with a Long Noncoding RNA
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;7/309/ec16

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