MetaboList – February 2014

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Cancer metabolism
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Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth
Ramon C. Sun, Nicholas C. Denko
http://www.cell.com/cell-metabolism/abstract/S1550-4131(13)00493-2

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α
Brandon Faubert, Emma E. Vincent, Takla Griss, Bozena Samborska, Said Izreig, Robert U. Svensson, Orval A. Mamer, Daina Avizonis, David B. Shackelford, Reuben J. Shaw, and Russell G. Jones
http://www.pnas.org/content/111/7/2554.abstract.html?etoc

Cysteine Catabolism: A Novel Metabolic Pathway Contributing to Glioblastoma Growth
Antony Prabhu, Bhaswati Sarcar, Soumen Kahali, Zhigang Yuan, Joseph J. Johnson, Klaus-Peter Adam, Elizabeth Kensicki, and Prakash Chinnaiyan
http://cancerres.aacrjournals.org/content/74/3/787.abstract.html?etoc

Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
Joanne R. Doherty, Chunying Yang, Kristen E.N. Scott, Michael D. Cameron,  Mohammad Fallahi, Weimin Li, Mark A. Hall, Antonio L. Amelio, Jitendra K.  Mishra, Fangzheng Li, Mariola Tortosa, Heide Marika Genau, Robert J. Rounbehler, Yunqi Lu, Chi V. Dang, K. Ganesh Kumar, Andrew A. Butler, Thomas D. Bannister, Andrea T. Hooper, Keziban Unsal-Kacmaz, William R. Roush, and John L. Cleveland
http://cancerres.aacrjournals.org/content/74/3/908.abstract.html?etoc

Missense mutations in pyruvate kinase M2 promote cancer metabolism, oxidative endurance, anchorage independence and tumor growth in a dominant negative manner
Mohd Askandar Iqbal, Farid Ahmad Siddiqui, Noor Chaman, Vibhor Gupta, Bhupender Kumar, Prakasam Gopinath, and Rameshwar N. K. Bamezai
http://www.jbc.org/content/early/2014/02/03/jbc.M113.515742.abstract

Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity
Hopperton, Kattryn E.; Duncan, Robin E.; Bazinet, Richard P.; Archer, Michael C
http://www.sciencedirect.com/science/article/pii/S0014482713004667

Follicular Adenomas Exhibit a Unique Metabolic Profile. 1H NMR Studies of Thyroid Lesions
Stanisław Deja, Tomasz Dawiskiba, Waldemar Balcerzak, Magdalena Orczyk-Pawiłowicz, Mateusz Głód, Dorota Pawełka, Piotr Młynarz
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0084637

miR-122 Targets Pyruvate Kinase M2 and Affects Metabolism of Hepatocellular Carcinoma
Angela M. Liu, Zhi Xu, Felix H. Shek, Kwong-Fai Wong, Nikki P. Lee, Ronnie T. Poon, Jinfei Chen, John M. Luk
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0086872

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Hypoxia / ischemia
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Interaction between PARP-1 and HIF-2α in the hypoxic response
A Gonzalez-Flores, R Aguilar-Quesada, E Siles, S Pozo, M I Rodríguez-Lara, L López –Jiménez, M López-Rodríguez, A Peralta-Leal, D Villar, D Martín-Oliva, L del Peso, E Berra and F J Oliver
http://www.nature.com/onc/journal/v33/n7/abs/onc20139a.html

A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells
Ivraym B. Barsoum, Chelsea A. Smallwood, D. Robert Siemens, and Charles H. Graham
http://cancerres.aacrjournals.org/content/74/3/665.abstract.html?etoc

Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer
Caroline Kuiper, Gabi Dachs, Delwyn Munn, Margaret Currie, Bridget Robinson, John Frederick Pearson, and Margreet C M Vissers
http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00010/full

MicroRNA-137 is a Novel Hypoxia-responsive MicroRNA that Inhibits Mitophagy via Regulation of Two Mitophagy Receptors FUNDC1 and NIX
Wen Li, Xingli Zhang, Haixia Zhuang, He-ge Chen, Yinqin Chen, Weili Tian, Wenxian Wu, Ying Li, Sijie Wang, Liangqing Zhang, Yusen Chen, Longxuan Li, Bin Zhao, Senfang Sui, Zhe Hu, and Du Feng
http://www.jbc.org/content/early/2014/02/26/jbc.M113.537050.abstract

Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms
[autophagy, mTOR]
Haijing Yan, Xiangnan Zhang, Weiwei Hu, Jing Ma, Weiwei Hou, Xingzhou Zhang, Xiaofen Wang, Jieqiong Gao, Yao Shen, Jianxin Lv, Hiroshi Ohtsu, Feng Han, Guanghui Wang and Zhong Chen
http://www.nature.com/ncomms/2014/140225/ncomms4334/full/ncomms4334.html

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Starvation
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Site-specific activation of AKT protects cells from death induced by glucose deprivation
M Gao, J Liang, Y Lu, H Guo, P German, S Bai, E Jonasch, X Yang, G B Mills and Z Ding
http://www.nature.com/onc/journal/v33/n6/abs/onc20132a.html

Glucose deprivation induces reticulum stress by the PERK pathway and caspase-7- and calpain-mediated caspase-12 activation
Selene García de la Cadena , Karla Hernández-Fonseca , Ignacio Camacho-Arroyo & Lourdes Massieu
http://link.springer.com/article/10.1007/s10495-013-0930-7

Hexokinase-II Positively Regulates Glucose Starvation-Induced Autophagy through TORC1 Inhibition
David J. Roberts, Valerie P. Tan-Sah, Eric Y. Ding, Jeffery M. Smith, Shigeki Miyamoto
http://www.cell.com/molecular-cell/abstract/S1097-2765(13)00929-5

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mTOR
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Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
Suchithra Menon, Christian C. Dibble, George Talbott, Gerta Hoxhaj, Alexander J. Valvezan, Hidenori Takahashi, Lewis C. Cantley, Brendan D. Manning
http://www.cell.com/abstract/S0092-8674(14)00012-9

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2
Constantinos Demetriades, Nikolaos Doumpas, Aurelio A. Teleman
http://www.cell.com/abstract/S0092-8674(14)00076-2

Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and  Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2
Esther Lopez-Rivera, Padmini Jayaraman, Falguni Parikh, Michael A. Davies, Suhendan Ekmekcioglu, Sudeh Izadmehr, Denái R. Milton, Jerry E. Chipuk, Elizabeth A. Grimm, Yeriel Estrada, Julio Aguirre-Ghiso, and Andrew G. Sikora
http://cancerres.aacrjournals.org/content/74/4/1067.abstract.html?etoc

Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells
DOI: http://dx.doi.org/10.4161/cc.27355
Anya Alayev, Yang Sun, Rose B Snyder, Sara Malka Berger, Jane J Yu and Marina K Holz

Crosstalk between the Tor and Gcn2 pathways in response to different stresses
DOI: http://dx.doi.org/10.4161/cc.27270
Gro Elise Rødland, Tonje Tvegård, Erik Boye and Beáta Grallert

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AMPK
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A Redox-Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 during Energy Starvation
Dan Shao, Shin-ichi Oka, Tong Liu, Peiyong Zhai, Tetsuro Ago, Sebastiano Sciarretta, Hong Li, Junichi Sadoshima
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00002-3

AMP-Activated Protein Kinase α2 Protects Against Liver Injury from Metastasized Tumors via Reduced Glucose Deprivation-Induced Oxidative Stress
Shu-Lan Qiu, Zhi-Cheng Xiao, Chun-Mei Piao, Ying-Lin Xian, Li-Xin Jia, Young-Fen Qi, Jiahuai Han, You-Yi Zhang, and Jie Du
http://www.jbc.org/content/early/2014/02/10/jbc.M113.543447.abstract

Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity
Vanessa P. Houde, Maria Stella Ritorto, Robert Gourlay, Joby Varghese, Paul Davies, Natalia Shpiro, Kei Sakamoto and Dario R. Alessi
http://www.biochemj.org/bj/458/bj4580041.htm

Crosstalk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK)
John W. Bullen, Jeremy L. Balsbaugh, Dipanjan Chanda, Jeffrey Shabanowitz, Donald F. Hunt, Dietbert Neumann, and Gerald W. Hart
http://www.jbc.org/content/early/2014/02/21/jbc.M113.523068.abstract

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Miscellaneous
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Metastasis Suppressor KISS1 Seems to Reverse the Warburg Effect by Enhancing Mitochondrial Biogenesis
Wen Liu, Benjamin H. Beck, Kedar S. Vaidya, Kevin T. Nash, Kyle P. Feeley, Scott W. Ballinger, Keke M. Pounds, Warren L. Denning, Anne R. Diers, Aimee Landar, Animesh Dhar, Tomoo Iwakuma, and Danny R. Welch
http://cancerres.aacrjournals.org/content/74/3/954.abstract.html?etoc

The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism
Mohamed A. Soliman, Anas M. Abdel Rahman, Dudley A. Lamming, Kivanç Birsoy, Judy Pawling, Maria E. Frigolet, Huogen Lu, I. George Fantus, Adrian Pasculescu, Yong Zheng, David M. Sabatini, James W. Dennis, and Tony Pawson
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;7/313/ra17

Estradiol stimulates glucose metabolism via 6-phosphofructo-2-kinase (PFKFB3)
Yoannis Imbert-Fernandez, Brian F. Clem, Julie O’Neal, Daniel A. Kerr, Robert Spaulding, Lilibeth Lanceta, Amy L. Clem, Sucheta Telang, and Jason Chesney
http://www.jbc.org/content/early/2014/02/10/jbc.M113.529990.abstract

SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1α–Dependent Glycolysis
Guangwei Liu, Yujing Bi, Bo Shen, Hui Yang, Yan Zhang, Xiao Wang, Huanrong Liu, Yun Lu, Jiongbo Liao, Xi Chen, and Yiwei Chu
http://cancerres.aacrjournals.org/content/74/3/727.abstract.html?etoc

De novo fatty acid synthesis at the mitotic exit is required to complete cellular division
Natalia Scaglia, Svitlana Tyekucheva, Giorgia Zadra, Cornelia Photopoulos and Massimo Loda
http://dx.doi.org/10.4161/cc.27767

Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence
D Gitenay, C Wiel, H Lallet-Daher, D Vindrieux, S Aubert, L Payen, H Simonnet and D Bernard
http://www.nature.com/cddis/journal/v5/n2/abs/cddis201463a.html

Lost in Transition: Start-Up of Glycolysis Yields Subpopulations of Nongrowing Cells
Johan H. van Heerden, Meike T. Wortel, Frank J. Bruggeman, Joseph J. Heijnen, Yves J. M. Bollen, Robert Planqué, Josephus Hulshof, Tom G. O’Toole, S. Aljoscha Wahl, Bas Teusink
http://www.sciencemag.org/content/343/6174/1245114.abstract

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Reviews
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The wonders of 2-deoxy-d-glucose.
Haibin Xi, Metin Kurtoglu, Theodore J. Lampidis
http://onlinelibrary.wiley.com/doi/10.1002/iub.1251/abstract

Making new contacts: the mTOR network in metabolism and signalling crosstalk
Mitsugu Shimobayashi & Michael N. Hall
http://www.nature.com/nrm/journal/v15/n3/abs/nrm3757.html

Cancer as a metabolic disease (part II).
Thomas N.Seyfried, Roberto E.Flores, Angela M.Poff and Dominic P.D’Agostino http://carcin.oxfordjournals.org/content/early/2013/12/11/carcin.bgt480.abstract

Metabolism addiction in pancreatic cancer
R Blum and Y Kloog
http://www.nature.com/cddis/journal/v5/n2/abs/cddis201438a.html

Gerometabolites: The pseudohypoxic aging side of cancer oncometabolites
Javier A Menendez, Tomás Alarcón and Jorge Joven
http://dx.doi.org/10.4161/cc.28079

Managing lipid metabolism in proliferating cells: New perspective for metformin usage in cancer therapy
Daniele Lettieri Barbato, Rolando Vegliante, Enrico Desideri, Maria Rosa Ciriolo
http://www.sciencedirect.com/science/article/pii/S0304419X14000195

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Comments / other
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Autophagy promotes BrafV600E-driven lung tumorigenesis by preserving mitochondrial metabolism
DOI: http://dx.doi.org/10.4161/auto.27320
Anne M Strohecker and Eileen White

Mitochondrial metabolism in TCA cycle mutant cancer cells
DOI: http://dx.doi.org/10.4161/cc.27513
Lucas B Sullivan and Navdeep S Chandel

mTORC1: Turning Off Is Just as Important as Turning On
Don Benjamin, Michael N. Hall
http://www.cell.com/abstract/S0092-8674(14)00151-2

Too Sweet for Autophagy: Hexokinase Inhibition of mTORC1 Activates Autophagy
Mondira Kundu
http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00124-5

Interview
Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar
Cantley LC
http://www.biomedcentral.com/1741-7007/12/8

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