MetaboList – March 2014

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Cancer Metabolism
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Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex.
Fan J, Shan C, Kang H, Elf S, Xie J, Tucker M, Gu TL, Aguiar M, Lonning S, Chen H, Mohammadi M, Britton LM, Garcia BA, Alečković M, Kang Y, Kaluz S, Devi N, Van Meir EG, Hitosugi T, Seo JH, Lonial S, Gaddh M, Arellano M, Khoury HJ, Khuri FR, Boggon TJ, Kang S, Chen J.
http://www.cell.com/molecular-cell/abstract/S1097-2765%2814%2900032-X

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness
Shuhua Yue, Junjie Li, Seung-Young Lee, Hyeon Jeong Lee, Tian Shao, Bing Song, Liang Cheng, Timothy A. Masterson, Xiaoqi Liu, Timothy L. Ratliff, Ji-Xin Cheng
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00025-4

SAICAR Induces Protein Kinase Activity of PKM2 that Is Necessary for Sustained Proliferative Signaling of Cancer Cells
Kirstie E. Keller, Zainab M. Doctor, Zachary W. Dwyer, Young-Sam Lee
http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00160-9

Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma
Fengting Yan, Lapo Alinari, Mark E. Lustberg, Ludmila Katherine Martin, Hector M. Cordero-Nieves, Yeshavanth Banasavadi-Siddegowda, Selene Virk, Jill Barnholtz-Sloan, Erica Hlavin Bell, Jeffrey Wojton, Naduparambil K. Jacob, Arnab Chakravarti, Michal O. Nowicki, Xin Wu, Rosa Lapalombella, Jharna Datta, Bo Yu, Kate Gordon, Amy Haseley, John T. Patton, Porsha L. Smith, John Ryu, Xiaoli Zhang, Xiaokui Mo, Guido Marcucci, Gerard Nuovo, Chang-Hyuk Kwon, John C. Byrd, E. Antonio Chiocca, Chenglong Li, Said Sif, Samson Jacob, Sean Lawler, Balveen Kaur, and Robert A. Baiocchi
http://cancerres.aacrjournals.org/content/74/6/1752.abstract.html?etoc

Ras-induced epigenetic inactivation of Ras-related associated with diabetes gene (RRAD) promotes glucose uptake in a human ovarian cancer model
Yan Wang, Guiling Li, Fengbiao Mao, Xianfeng Li, Qi Liu, Lin Chen, Lu Lv, Wei Dai, Guan Wang, Enfeng Zhao, Kai-Fu Tang, and Zhong Sheng Sun
http://www.jbc.org/content/early/2014/03/19/jbc.M113.527671.abstract

Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway
Takehiro Yamamoto, Naoharu Takano, Kyoko Ishiwata, Mitsuyo Ohmura, Yoshiko Nagahata, Tomomi Matsuura, Aki Kamata, Kyoko Sakamoto, Tsuyoshi Nakanishi, Akiko Kubo, Takako Hishiki and Makoto Suematsu
http://www.nature.com/ncomms/2014/140317/ncomms4480/full/ncomms4480.html

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Starvation / drugs / ischemia
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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
Kıvanç Birsoy, Richard Possemato, Franziska K. Lorbeer, Erol C. Bayraktar, Prathapan Thiru, Burcu Yucel, Tim Wang, Walter W. Chen, Clary B. Clish & David M. Sabatini
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13110.html

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A
Guillermo Mariño, Federico Pietrocola, Tobias Eisenberg, Yongli Kong, Shoaib Ahmad Malik, Aleksandra Andryushkova, Sabrina Schroeder, Tobias Pendl, Alexandra Harger, Mireia Niso-Santano, Naoufal Zamzami, Marie Scoazec, Silvère Durand, David P. Enot, Álvaro F. Fernández, Isabelle Martins, Oliver Kepp, Laura Senovilla, Chantal Bauvy, Eugenia Morselli, Erika Vacchelli, Martin Bennetzen, Christoph Magnes, Frank Sinner, Thomas Pieber, Carlos López-Otín, Maria Chiara Maiuri, Patrice Codogno, Jens S. Andersen, Joseph A. Hill, Frank Madeo, Guido Kroemer
http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00077-X

Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan
Tobias Eisenberg, Sabrina Schroeder, Aleksandra Andryushkova, Tobias Pendl, Victoria Küttner, Anuradha Bhukel, Guillermo Mariño, Federico Pietrocola, Alexandra Harger, Andreas Zimmermann, Tarek Moustafa, Adrian Sprenger, Evelyne Jany, Sabrina Büttner, Didac Carmona-Gutierrez, Christoph Ruckenstuhl, Julia Ring, Wieland Reichelt, Katharina Schimmel, Tina Leeb, Claudia Moser, Stefanie Schatz, Lars-Peter Kamolz, Christoph Magnes, Frank Sinner, Simon Sedej, Kai-Uwe Fröhlich, Gabor Juhasz, Thomas R. Pieber, Jörn Dengjel, Stephan J. Sigrist, Guido Kroemer, Frank Madeo
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00066-7

Astrocytic Mitochondrial Membrane Hyperpolarization following Extended Oxygen and Glucose Deprivation
Andrej Korenić, Johannes Boltze, Alexander Deten, Myriam Peters, Pavle Andjus, Lidija Radenović
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0090697

Ischemia-Like Oxygen and Glucose Deprivation Mediates Down-regulation of Cell Surface γ-Aminobutyric AcidB Receptors via the ER Stress-Induced Transcription Factor CHOP
http://www.jbc.org/content/early/2014/03/25/jbc.M114.550517.abstract

Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication
David A. Nathanson, Amanda L. Armijo, Michelle Tom, Zheng Li, Elizabeth Dimitrova, Wayne R. Austin, Julian Nomme, Dean O. Campbell, Lisa Ta, Thuc M. Le, Jason T. Lee, Ryan Darvish, Ari Gordin, Liu Wei, Hsiang-I Liao, Moses Wilks, Colette Martin, Saman Sadeghi, Jennifer M. Murphy, Nidal Boulos, Michael E. Phelps, Kym F. Faull, Harvey R. Herschman, Michael E. Jung, Johannes Czernin, Arnon Lavie, and Caius G. Radu
http://jem.rupress.org/content/211/3/473?etoc

Biochemical, Cellular and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1
Mindy I. Davis, Stefan Gross, Min Shen, Kimberly S. Straley, Rajan Pragani, Wendy A. Lea, Janeta Popovici-Muller, Byron DeLaBarre, Erin Artin, Natasha Thorne, Douglas S. Auld, Zhuyin Li, Lenny Dang, Matthew B. Boxer, and Anton Simeonov
http://www.jbc.org/content/early/2014/03/25/jbc.M113.511030.abstract

Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy-derived amino acids
Mayurbhai Himatbhai Sahani, Eisuke Itakura and Noboru Mizushima
http://dx.doi.org/10.4161/auto.27344

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Methods
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Transient state microscopy probes patterns of altered oxygen consumption in cancer cells
Thiemo Spielmann, Lei Xu, Annica K. B. Gad, Sofia Johansson and Jerker Widengren
http://onlinelibrary.wiley.com/doi/10.1111/febs.12709/abstract

A Novel Radiotracer to Image Glycogen Metabolism in Tumors by Positron Emission Tomography
Timothy H. Witney, Laurence Carroll, Israt S. Alam, Anil Chandrashekran, Quang-Dé Nguyen, Roberta Sala, Robert Harris, Ralph J. DeBerardinis, Roshan Agarwal, and Eric O. Aboagye
http://cancerres.aacrjournals.org/content/74/5/1319.abstract.html?etoc

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Hypoxia and HIF
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Hypoxia-Inducible Factor 3 Is an Oxygen-Dependent Transcription Activator and Regulates a Distinct Transcriptional Response to Hypoxia
Peng Zhang, Qing Yao, Ling Lu, Yun Li, Po-Ju Chen, Cunming Duan
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00111-9

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
Xi Chen, Dimitrios Iliopoulos, Qing Zhang, Qianzi Tang, Matthew B. Greenblatt, Maria Hatziapostolou, Elgene Lim, Wai Leong Tam, Min Ni, Yiwen Chen, Junhua Mai, Haifa Shen, Dorothy Z. Hu, Stanley Adoro, Bella Hu, Minkyung Song, Chen Tan, Melissa D. Landis, Mauro Ferrari, Sandra J. Shin, Myles Brown, Jenny C. Chang, X. Shirley Liu & Laurie H. Glimcher
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13119.html

Cancer Cells Exploit eIF4E2-Directed Synthesis of Hypoxia Response Proteins to Drive Tumor Progression
James Uniacke, J. Kishan Perera, Gabriel Lachance, Camille B. Francisco,
and Stephen Lee
http://cancerres.aacrjournals.org/content/74/5/1379.abstract.html?etoc

Transcriptional repression of hypoxia-inducible factor-1 (HIF-1) by the  protein arginine methyltransferase PRMT1
Véronique N. Lafleur, Stéphane Richard, and Darren E. Richard
http://www.molbiolcell.org/content/25/6/925.abstract.html?etoc

STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells
M R Pawlus, L Wang and C-J Hu
http://www.nature.com/onc/journal/v33/n13/abs/onc2013115a.html

RUNX3 inhibits hypoxia-inducible factor-1α protein stability by interacting with prolyl hydroxylases in gastric cancer cells
S H Lee, S C Bae, K W Kim and Y M Lee
http://www.nature.com/onc/journal/v33/n11/abs/onc201376a.html

Acute hypoxia produces a superoxide burst in cells.
Pablo Hernansanz-Agustín, Alicia Izquierdo-Álvarez, Francisco J Sánchez-Gómez, Elena Ramos, Tamara Villa-Piña, Santiago Lamas, Anna Bogdanova, Antonio Martínez-Ruiz
http://www.sciencedirect.com/science/article/pii/S0891584914001282

Delayed innocent bystander cell death following hypoxia in Caenorhabditis elegans
C-L Sun, E Kim and C M Crowder
http://www.nature.com/cdd/journal/v21/n4/abs/cdd2013176a.html

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mTOR / AMPK
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Roles for PI(3,5)P2 in nutrient sensing through TORC1
Natsuko Jin, Kai Mao, Yui Jin, Gela Tevzadze, Emily J. Kauffman, Sujin Park, Dave Bridges, Robbie Loewith, Alan R. Saltiel, Daniel J. Klionsky, and Lois S. Weisman
http://www.molbiolcell.org/content/25/7/1171.abstract.html?etoc

Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2
Chen Wang, Lingfeng Qin, Thomas D. Manes, Nancy C. Kirkiles-Smith, George Tellides, and Jordan S. Pober
http://jem.rupress.org/content/211/3/395?etoc

Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells
Jane Atkin, Lenka Halova, Jennifer Ferguson, James R. Hitchin, Agata Lichawska-Cieslar, Allan M. Jordan, Jonathon Pines, Claudia Wellbrock, and Janni Petersen
http://jcs.biologists.org/content/127/6/1346.abstract.html?etoc

Crosstalk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation
Sungki Hong, Bin Zhao, David B. Lombard, Diane C. Fingar, and Ken Inoki
http://www.jbc.org/content/early/2014/03/20/jbc.M113.520734.abstract

Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors
G S Ducker, C E Atreya, J P Simko, Y K Hom, M R Matli, C H Benes, B Hann, E K Nakakura, E K Bergsland, D B Donner, J Settleman, K M Shokat and R S Warren
http://www.nature.com/onc/journal/v33/n12/abs/onc201392a.html

Yeast AMP-Activated Protein Kinase Monitors Glucose Concentration Changes as well as Absolute Glucose Levels
Loubna Bendrioua, Maria Smedh, Joachim Almquist, Marija Cvijovic, Mats Jirstrand, Mattias Goksor, Caroline B. Adiels, and Stefan Hohmann
http://www.jbc.org/content/early/2014/03/13/jbc.M114.547976.abstract

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Miscellaneous
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Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells.
Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC.
http://www.jimmunol.org/content/early/2014/03/07/jimmunol.1302062

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKε supports the anabolic demands of dendritic cell activation
Bart Everts, Eyal Amiel, Stanley Ching-Cheng Huang, Amber M Smith, Chih-Hao Chang, Wing Y Lam, Veronika Redmann, Tori C Freitas, Julianna Blagih, Gerritje J W van der Windt, Maxim N Artyomov, Russell G Jones, Erika L Pearce & Edward J Pearce
http://www.nature.com/ni/journal/v15/n4/full/ni.2833.html

Identification of TP53-induced glycolysis and apoptosis regulator (TIGAR) as the phosphoglycolate-independent 2,3-bisphosphoglycerate phosphatase
Isabelle Gerin, Gaëtane Noël, Jennifer Bolsée, Olivier Haumont, Emile Van Schaftingen and Guido T. Bommer
http://www.biochemj.org/bj/458/bj4580439.htm

Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices
Anton I Ivanov, Anton E Malkov, Tatsiana Waseem, Marat Mukhtarov, Svetlana Buldakova, Olena Gubkina, Misha Zilberter and Yuri Zilberter
http://www.nature.com/jcbfm/journal/v34/n3/abs/jcbfm2013222a.html

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases
Hanna Tarhonskaya, Anna M. Rydzik, Ivanhoe K. H. Leung, Nikita D. Loik, Mun Chiang Chan, Akane Kawamura, James S. O. McCullagh, Timothy D. W. Claridge, Emily Flashman and Christopher J. Schofield
http://www.nature.com/ncomms/2014/140305/ncomms4423/full/ncomms4423.html

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Reviews
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Rapamycin: One Drug, Many Effects
Jing Li, Sang Gyun Kim, John Blenis
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00007-2

Metformin: A metabolic disruptor and anti-diabetic drug to target human leukemia
Célia Rosilio, Issam Ben-Sahra, Frédéric Bost, Jean-François Peyron
http://www.cancerletters.info/article/S0304-3835%2814%2900032-9/abstract

Analytical metabolomics-based approaches to pancreatic cancer
Di Gangi, I.M., Vrhovsek, U., Pazienza, V., Mattivi, F.
http://www.sciencedirect.com/science/article/pii/S0165993614000053

Metabolic requirements for the maintenance of self-renewing stem cells
Keisuke Ito & Toshio Suda
http://www.sciencemag.org/content/343/6177/1322.short

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Comments / other
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Cholesteryl Esters: Fueling the Fury of Prostate Cancer
Barrie Peck, Almut Schulze
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00068-0

Please Keep Me 2uned to PKM2
Steven L. McKnight
http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00167-1

TIGAR’s promiscuity
Juan P. Bolaños
http://www.biochemj.org/bj/458/bj458e005.htm

Shedding light on the asparaginase galaxy
Carmelo Rizzari
http://bloodjournal.hematologylibrary.org/content/123/13/1976.full.html?etoc

Cholesterol and Cancer, in the Balance
Sandrine Silvente-Poirot and Marc Poirot
http://www.sciencemag.org/content/343/6178/1445.short

Cholesterol Metabolite Linked to Breast Cancer
http://cancerdiscovery.aacrjournals.org/content/4/3/OF4.abstract.html?etoc

High cholesterol in prostate tumours
http://www.nature.com/nature/journal/v507/n7491/full/507143c.html

Journal club: A new protein kinase cascade
How the activities of AMPK and LKB1 were first observed
D. Grahame Hardie
http://www.nature.com/nrm/journal/v15/n4/full/nrm3771.html

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