MetaboList – April 2014

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Drugs and anti-metabolic treatments
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Arginine Starvation Impairs Mitochondrial Respiratory Function in ASS1-Deficient Breast Cancer Cells
Fuming Qiu, Yun-Ru Chen, Xiyong Liu, Cheng-Ying Chu, Li-Jiuan Shen, Jinghong Xu, Shikha Gaur, Henry Jay Forman, Hang Zhang, Shu Zheng, Yun Yen, Jian Huang, Hsing-Jien Kung, and David K. Ann
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;7/319/ra31

Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile
Cristina Oliveras-Ferraros, Alejandro Vazquez-Martin, Elisabet Cuyàs, Bruna Corominas-Faja, Esther Rodríguez-Gallego, Salvador Fernández-Arroyo, Begoña Martin-Castillo, Jorge Joven and Javier A Menendez
http://dx.doi.org/10.4161/cc.27982

Role of activating transcription factor 3 protein ATF3 in necrosis and apoptosis induced by 5-fluoro-2′-deoxyuridine
Akira Sato, Kentaro Nakama, Hiroki Watanabe, Akito Satake, Akihiro Yamamoto, Takuya Omi, Akiko Hiramoto, Mitsuko Masutani, Yusuke Wataya and Hye-Sook Kim
http://onlinelibrary.wiley.com/doi/10.1111/febs.12752/abstract

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism
Alden C Klarer, Julie O’Neal, Yoannis Imbert-Fernandez, Amy Clem, Steve R Ellis, Jennifer Clark, Brian Clem, Jason Chesney, Sucheta Telang
http://www.cancerandmetabolism.com/content/2/1/2

A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process
Shawn D Stuart, Alexandra Schauble, Sunita Gupta, Adam D Kennedy, Brian R Keppler, Paul M Bingham, Zuzana Zachar
http://www.cancerandmetabolism.com/content/2/1/4

Deoxyglucose prevents neurodegeneration in culture by eliminating microglia.
Anna Vilalta, Guy C Brown
http://www.ncbi.nlm.nih.gov/pubmed/24669778

Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms
Jia Liu, Ning Wu, Leina Ma, Ming Liu, Ge Liu, Yuyan Zhang, Xiukun Lin
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0091606

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Nutrient sensing / ischemia / hypoxia
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Glucose starvation inhibits autophagy via vacuolar hydrolysis and induces plasma membrane internalization by down regulating recycling
[yeast]
Michael J. Lang, Jorge Y. Martinez-Marquez, Derek C. Prosser, Laura R. Ganser, Destiney Buelto, Beverly Wendland, and Mara C. Duncan
http://www.jbc.org/content/early/2014/04/21/jbc.M113.525782.abstract

Crystal structures of GCN2 C-terminal domains suggest regulatory differences in yeast and mammals
Hongzhen He, Isha Singh, Sheree A. Wek, Souvik Dey, Thomas D. Baird, Ronald C. Wek, and Millie M. Georgiadis
http://www.jbc.org/content/early/2014/04/09/jbc.M114.560789.abstract

N-glycan Remodeling on Glucagon Receptor is an Effector of Nutrient-sensing by the Hexosamine Biosynthesis Pathway
Anita Johswich, Christine Longuet, Judy Pawling, Anas Abdel Rahman, Michael Ryczko, Daniel J. Drucker, and James W. Dennis
http://www.jbc.org/content/early/2014/04/17/jbc.M114.563734.abstract

Enhanced Arginine Methylation of Programmed Cell Death 4 during Nutrient Deprivation Promotes Tumor Cell Viability
Marta M. Fay, James M. Clegg, Kimberly A. Uchida, Matthew A. Powers, and Katharine S. Ullman
http://www.jbc.org/content/early/2014/04/24/jbc.M113.541300.abstract

Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress
Gregory LaMonte, Xiaohu Tang, Julia Ling-Yu Chen, Jianli Wu, Chien-Kuang Ding, Melissa M Keenan, Carolyn Sangokoya, Hsiu-Ni Kung, Olga Ilkayeva, László G Boros, Christopher B Newgard, Jen-Tsan Chi
http://www.cancerandmetabolism.com/content/1/1/23

Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival
Mireille Khacho, Michelle Tarabay, David Patten, Pamela Khacho, Jason G. MacLaurin, Jennifer Guadagno, Richard Bergeron, Sean P. Cregan, Mary-Ellen Harper, David S. Park and Ruth S. Slack 
http://www.nature.com/ncomms/2014/140401/ncomms4550/full/ncomms4550.html

Modulation of hypoxia-signaling pathways by extracellular linc-RoR
Kenji Takahashi, Irene K. Yan, Hiroaki Haga, and Tushar Patel
http://jcs.biologists.org/content/127/7/1585.abstract.html?etoc

MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis
Q Chen, J Xu, L Li, H Li, S Mao, F Zhang, K Zen, C-Y Zhang and Q Zhang
http://www.nature.com/cddis/journal/v5/n3/abs/cddis201492a.html

Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury
S Y Kim, M S Shim, K-Y Kim, R N Weinreb, L A Wheeler and W-K Ju
http://www.nature.com/cddis/journal/v5/n3/abs/cddis201480a.html

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Cancer metabolism
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A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect
Paula Lopez-Serra, Miguel Marcilla, Alberto Villanueva, Antonio Ramos-Fernandez, Anna Palau, Lucía Leal, Jessica E. Wahi, Fernando Setien-Baranda, Karolina Szczesna, Catia Moutinho, Anna Martinez-Cardus, Holger Heyn, Juan Sandoval, Sara Puertas, August Vidal, Xavier Sanjuan, Eva Martinez-Balibrea, Francesc Viñals, Jose C. Perales, Jesper B. Bramsem, Torben F. Ørntoft, Claus L. Andersen, Josep Tabernero, Ultan McDermott, Matthew B. Boxer, Matthew G. Vander Heiden, Juan Pablo Albar & Manel Esteller
http://www.nature.com/ncomms/2014/140403/ncomms4608/full/ncomms4608.html

Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis
Tiffany J. Parmenter, Margarete Kleinschmidt, Kathryn M. Kinross, Simon T. Bond, Jason Li, Mohan R. Kaadige, Aparna Rao, Karen E. Sheppard, WillyHugo, Gulietta M. Pupo, Richard B. Pearson, Sean L. McGee, Georgina V. Long, Richard A. Scolyer, Helen Rizos, Roger S. Lo, Carleen Cullinane, Donald E. Ayer, Antoni Ribas, Ricky W. Johnstone, Rodney J. Hicks, and Grant A. McArthur
http://cancerdiscovery.aacrjournals.org/content/4/4/423.abstract.html?etoc

Bioenergetic properties of human sarcoma cells help define sensitivity to metabolic inhibitors
Sameer H Issaq, Beverly A Teicher and Anne Monks
http://dx.doi.org/10.4161/cc.28010

IGF-I Regulates Redox Status in Breast Cancer Cells by Activating the Amino Acid Transport Molecule xC^−
Yuzhe Yang and Douglas Yee
http://cancerres.aacrjournals.org/content/74/8/2295.abstract.html?etoc

HSP40 Interacts with Pyruvate Kinase M2 and Regulates Glycolysis and Cell Proliferation in Tumor Cells
Liangqian Huang, Zhenhai Yu, Teng Zhang, Xiaoping Zhao, Gang Huang
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0092949

miR-181a mediates metabolic shift in colon cancer cells via the PTEN/AKT pathway   
Zhonghua Wei, Long Cui, Zubing Mei, Min Liu, Daoxiang Zhang
http://www.sciencedirect.com/science/article/pii/S0014579314002567

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AMPK/mTOR
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Loss of TSC2 confers resistance to ceramide and nutrient deprivation
G G Guenther, G Liu, M U Ramirez, R J McMonigle, S M Kim, A N McCracken, Y Joo, I Ushach, N L Nguyen and A L Edinger
http://www.nature.com/onc/journal/v33/n14/abs/onc2013139a.html

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells
Simon A. Hawley, Fiona A. Ross, Graeme J. Gowans, Priyanka Tibarewal, Nicholas R. Leslie and D. Grahame Hardie
http://www.biochemj.org/bj/459/bj4590275.htm

Glucose de-repression by yeast AMP-activated protein kinase SNF1 is controlled via at least two independent steps
Raúl García-Salcedo, Timo Lubitz, Gemma Beltran, Karin Elbing, Ye Tian, Simone Frey, Olaf Wolkenhauer, Marcus Krantz, Edda Klipp and Stefan Hohmann
http://onlinelibrary.wiley.com/doi/10.1111/febs.12753/abstract

Folliculin Regulates Ampk-Dependent Autophagy and Metabolic Stress Survival
Elite Possik, Zahra Jalali, Yann Nouët, Ming Yan, Marie-Claude Gingras, Kathrin Schmeisser, Lorena Panaite, Fanny Dupuy, Dmitri Kharitidi, Laëtitia Chotard, Russell G. Jones, David H. Hall, Arnim Pause
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1004273

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Miscellaneous
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Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status
Byung Cheon Lee, Alaattin Kaya, Siming Ma, Gwansu Kim, Maxim V. Gerashchenko, Sun Hee Yim, Zhen Hu, Lawrence G. Harshman and Vadim N. Gladyshev
http://www.nature.com/ncomms/2014/140407/ncomms4592/full/ncomms4592.html

Metabolic control of YAP and TAZ by the mevalonate pathway
Giovanni Sorrentino, Naomi Ruggeri, Valeria Specchia,  Michelangelo Cordenonsi, Miguel Mano, Sirio Dupont, Andrea Manfrin, Eleonora Ingallina, Roberta Sommaggio, Silvano Piazza, Antonio Rosato, Stefano Piccolo & Giannino Del Sal
http://www.nature.com/ncb/journal/v16/n4/full/ncb2936.html

In vivo inhibition of the mitochondrial H^+‐ATP synthase in neurons promotes metabolic preconditioning
Laura Formentini, Marta P Pereira, Laura Sánchez‐Cenizo, Fulvio Santacatterina, José J Lucas, Carmen Navarro, Alberto Martínez‐Serrano, and José M Cuezva
http://EMBOJ.embopress.org/content/33/7/762?etoc

Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response
R Lall, S Ganapathy, M Yang, S Xiao, T Xu, H Su, M Shadfan, J M Asara, C S Ha, I Ben-Sahra, B D Manning, J B Little and Z-M Yuan
http://www.nature.com/cdd/journal/v21/n5/abs/cdd201424a.html

Adenovirus E4ORF1-Induced MYC Activation Promotes Host Cell Anabolic Glucose Metabolism and Virus Replication
Minh Thai, Nicholas A. Graham, Daniel Braas, Michael Nehil, Evangelia Komisopoulou, Siavash K. Kurdistani, Frank McCormick, Thomas G. Graeber, Heather R. Christofk
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00113-2

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Reviews
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Serine and glycine metabolism in cancer
Ivano Amelio, Francesca Cutruzzolá, Alexey Antonov, Massimiliano Agostini, Gerry Melino
http://www.cell.com/trends/biochemical-sciences/abstract/S0968-0004%2814%2900028-0

Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment
A Casazza, G Di Conza, M Wenes, V Finisguerra, S Deschoemaeker and M Mazzone
http://www.nature.com/onc/journal/v33/n14/abs/onc2013121a.html

TIGAR, TIGAR, burning bright
Pearl Lee, Karen H Vousden, Eric C Cheung
http://www.cancerandmetabolism.com/content/2/1/1

Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways
Norma Masson, Peter J Ratcliffe
http://www.cancerandmetabolism.com/content/2/1/3

Perspectives of the AMP-activated kinase (AMPK) signalling pathway in thyroid cancer
Bruno Moulin Andrade and Denise Pires de Carvalho
http://www.bioscirep.org/bsr/034/e105/bsr034e105.htm

Pyruvate kinase M2 and cancer: an updated assessment
Mohd Askandar Iqbal, Vibhor Gupta, Prakasam Gopinath, Sybille Mazurek, Rameshwar N.K. Bamezai
http://www.sciencedirect.com/science/article/pii/S001457931400297X

Glutamate as chemotactic fuel for diffuse glioma cells; are they glutamate suckers? 
Sanne A.M. van Lith, Anna C. Navis, Kiek Verrijp, Simone P. Niclou, Rolf Bjerkvig, Pieter Wesseling, Bastiaan Tops, Remco Molenaar, Cornelis J.F. van Noorden, William P.J. Leenders
http://www.sciencedirect.com/science/article/pii/S0304419X14000407

Nutrient-driven O-GlcNAc cycling – think globally but act locally
Katryn R. Harwood and John A. Hanover
http://jcs.biologists.org/content/127/9/1857.abstract.html?etoc

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Comments / other
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Q&A: Targeting metabolism to diagnose and treat cancer
Ralph J DeBerardinis
http://www.cancerandmetabolism.com/content/2/1/5

Metabolic Dysregulation in Melanoma: Cause or Consequence?
Rizwan Haq
http://cancerdiscovery.aacrjournals.org/content/4/4/390.abstract.html?etoc

Liver X receptor: from metabolism to cancer
Nicolas Venteclef and Pascal Ferré
http://www.biochemj.org/bj/459/bj459e001.htm

mTORC2 dictates Warburg effect and drug resistance
DOI: http://dx.doi.org/10.4161/cc.28377
Kenta Masui, Webster K Cavenee and Paul S Mischel

Post-translational modification: Sweetening protein quality control
http://www.nature.com/nrm/journal/v15/n5/full/nrm3787.html

Cell Press Webinar – Metabolomics: Following the Carbons that Fuel Cancer
Ralph DeBerardinis, Eyal Gottlieb and Christian Metallo
http://bit.ly/1fpfUcT

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