MetaboList – June 2014

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Cancer metabolism
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Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects
Andrew R. Mullen, Zeping Hu, Xiaolei Shi, Lei Jiang, Lindsey K. Boroughs, Zoltan Kovacs, Richard Boriack, Dinesh Rakheja, Lucas B. Sullivan, W. Marston Linehan, Navdeep S. Chandel, Ralph J. DeBerardinis
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00339-8

Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
Lifeng Yang, Tyler Moss, Lingegowda S Mangala, Juan Marini, Hongyun Zhao, Stephen Wahlig, Guillermo Armaiz‐Pena, Dahai Jiang, Abhinav Achreja, Julia Win, Rajesha Roopaimoole, Cristian Rodriguez‐Aguayo, Imelda Mercado‐Uribe, Gabriel Lopez‐Berestein, Jinsong Liu, Takashi Tsukamoto, Anil K. Sood, Prahlad T Ram, Deepak Nagrath
http://msb.embopress.org/content/10/5/728

Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer
Vincent Zecchini, Basetti Madhu, Roslin Russell, Nelma Pértega‐Gomes, Anne Warren, Edoardo Gaude, Joana Borlido, Rory Stark, Heather Ireland‐Zecchini, Roheet Rao, Helen Scott, Joan Boren, Charlie Massie, Mohammad Asim, Kevin Brindle, John Griffiths, Christian Frezza, David E Neal, and Ian G Mills
http://EMBOJ.embopress.org/content/33/12/1365?etoc

Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: Trichostatin A as a case study
Gema Alcarraz-Vizána, Susana Sánchez-Tena, Mary Pat Moyer, Marta Cascante
http://www.sciencedirect.com/science/article/pii/S0304416513005539

Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane
Epstein  T, Xu  L, Gillies  RJ, Gatenby  RA
http://www.cancerandmetabolism.com/content/2/1/7/abstract

Nitric oxide is a positive regulator of the Warburg effect in ovarian cancer cells
C A Caneba, L Yang, J Baddour, R Curtis, J Win, S Hartig, J Marini and D Nagrath
http://www.nature.com/cddis/journal/v5/n6/abs/cddis2014264a.html

Noninvasive Urinary Metabolomic Profiling Identifies Diagnostic and Prognostic Markers in Lung Cancer
Ewy A. Mathé, Andrew D. Patterson, Majda Haznadar, Soumen K. Manna, Kristopher W. Krausz, Elise D. Bowman, Peter G. Shields, Jeffrey R. Idle, Philip B. Smith, Katsuhiro Anami, Dickran G. Kazandjian, Emmanuel Hatzakis, Frank J. Gonzalez, and Curtis C. Harris
http://cancerres.aacrjournals.org/content/74/12/3259.abstract.html?etoc

Metabolic Profiling Reveals PAFAH1B3 as a Critical Driver of Breast Cancer Pathogenicity
Melinda M. Mulvihill,Daniel I. Benjamin,Xiaodan Ji, Erwan Le Scolan, Sharon M. Louie, Alice Shieh, McKenna Green, Tara Narasimhalu,Patrick J. Morris, Kunxin Luo, Daniel K. Nomura
http://www.cell.com/chemistry-biology/abstract/S1074-5521%2814%2900178-1

Tyr-94 Phosphorylation Inhibits Pyruvate Dehydrogenase Phosphatase 1 and Promotes Tumor Growth
Changliang Shan, Hee-Bum Kang, Shannon Elf, Jianxin Xie, Ting-Lei Gu, Mike Aguiar, Scott Lonning, Taro Hitosugi, Tae-Wook Chung, Martha Arellano, Hanna J. Khoury, Dong M. Shin, Fadlo R. Khuri, Titus J. Boggon, and Jun Fan
http://www.jbc.org/content/early/2014/06/24/jbc.M114.581124.abstract

Lactate dehydrogenase A silencing in IDH mutant gliomas
Charles Chesnelong, Myriam M. Chaumeil, Michael D. Blough, Mohammad Al-Najjar, Owen D. Stechishin, Jennifer A. Chan, Russell O. Pieper, Sabrina M. Ronen, Samuel Weiss, H. Artee Luchman and J. Gregory Cairncross
http://neuro-oncology.oxfordjournals.org/content/16/5/686

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Drugs and metabolic targeting
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The glutaminase activity of l-asparaginase is not required for anticancer activity against ASNS-negative cells
Wai Kin Chan, Philip L. Lorenzi, Andriy Anishkin, Preeti Purwaha, David M. Rogers, Sergei Sukharev, Susan B. Rempe, and John N. Weinstein
http://bloodjournal.org/content/123/23/3596.abstract.html?etoc

Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile
Cristina Oliveras-Ferraros, Alejandro Vazquez-Martin, Elisabet Cuyàs, Bruna Corominas-Faja, Esther Rodríguez-Gallego, Salvador Fernández-Arroyo, Begoña Martin-Castillo, Jorge Joven, Javier A Menendez
https://www.landesbioscience.com/journals/cc/article/27982/

Targeting Mitochondrial Oxidative Metabolism in Melanoma Causes Metabolic
Compensation through Glucose and Glutamine Utilization
Ji-Hong Lim, Chi Luo, Francisca Vazquez, and Pere Puigserver
http://cancerres.aacrjournals.org/content/74/13/3535.abstract.html?etoc

NVP-BEZ235, a dual PI3K/mTOR inhibitor, induces cell death through alternate routes in prostate cancer cells depending on the PTEN genotype
Seung-Woo Hong , Jae-Sik Shin , Jai-Hee Moon , Ye-Seul Kim , Jooyoung Lee , Eun Kyoung Choi , Seung-Hee Ha , Dae Hee Lee , Ha Na Chung , Jeong Eun Kim , Kyu-pyo Kim , Yong Sang Hong , Jae-Lyun Lee , Wang-Jae Lee , Eun Kyung Choi , Jung Shin Lee , Dong-Hoon Jin & Tae Won Kim
http://link.springer.com/article/10.1007/s10495-014-0973-4

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Metabolic stress
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Mitochondrial PEPCK is a Pro-Survival, ER-Stress Response Gene Involved in Tumor Cell Adaptation to Nutrient Availability
Andrés Méndez-Lucas, Petra Hyroššová, Laura Novellasdemunt, Francesc Viñals and Jose C. Perales
http://www.jbc.org/content/early/2014/06/27/jbc.M114.566927.abstract

Ribosomal protein–Mdm2–p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation
Yong Liu, Yizhou He, Aiwen Jin, Andrey P. Tikunov, Lishi Zhou, Laura A. Tollini, Patrick Leslie, Tae-Hyung Kim, Lei O. Li, Rosalind A. Coleman, Zhennan Gu, Yong Q. Chen, Jeffrey M. Macdonald, Lee M. Graves, and Yanping Zhang
http://www.pnas.org/content/111/23/E2414.abstract.html?eto

Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo
Nicole S. Hou, Aljona Gutschmidt, Daniel Y. Choi, Keouna Pather, Xun Shi, Jennifer L. Watts, Thorsten Hoppe, and Stefan Taubert
http://www.pnas.org/content/111/22/E2271.abstract.html?etoc

The FoxO–BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress
A Lin, J Yao, L Zhuang, D Wang, J Han, E W-F Lam, TCGA Research Network and B Gan
http://www.nature.com/onc/journal/v33/n24/full/onc2013273a.html

Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress
Yi‐Ping Wang, Li‐Sha Zhou, Yu‐Zheng Zhao, Shi‐Wen Wang, Lei‐Lei Chen, Li‐Xia Liu, Zhi‐Qiang Ling, Fu‐Jun Hu, Yi‐Ping Sun, Jing‐Ye Zhang, Chen Yang, Yi Yang, Yue Xiong, Kun‐Liang Guan, and Dan Ye
http://EMBOJ.embopress.org/content/33/12/1304?etoc

Oxidative Stress Activates SIRT2 to Deacetylate and Stimulate Phosphoglycerate Mutase
Yanping Xu, Fulong Li, Lei Lv, Tingting Li, Xin Zhou, Chu-Xia Deng, Kun-Liang Guan, Qun-Ying Lei, and Yue Xiong
http://cancerres.aacrjournals.org/content/74/13/3630.abstract.html?etoc

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Ischemia / hypoxia
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Endoplasmic reticulum refilling and mitochondrial calcium extrusion promoted in neurons by NCX1 and NCX3 in ischemic preconditioning are determinant for neuroprotection
M J Sisalli, A Secondo, A Esposito, V Valsecchi, C Savoia, G F Di Renzo, L Annunziato and A Scorziello
http://www.nature.com/cdd/journal/v21/n7/abs/cdd201432a.html

NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2α
Jennifer L. Gregg, Robert M. Turner II, Guimin Chang, Disha Joshi, Ye Zhan, Li Chen, and Jodi K. Maranchie
http://cancerres.aacrjournals.org/content/74/13/3501.abstract.html?etoc

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AMPK, mTOR
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Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation
Ge Zhou, Jiping Wang, Mei Zhao, Tong-Xin Xie, Noriaki Tanaka, Daisuke Sano, Ameeta A. Patel, Alexandra M. Ward, Vlad C. Sandulache, Samar A. Jasser, Heath D. Skinner, Alison Lea Fitzgerald, Abdullah A. Osman, Yongkun Wei, Xuefeng Xia, Zhou Songyang, Gordon B. Mills, Mien-Chie Hung, Carlos Caulin, Jiyong Liang, Jeffrey N. Myers
http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00358-X

The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation
Ming Yan, Marie-Claude Gingras, Elaine A. Dunlop, Yann Nouët, Fanny Dupuy, Zahra Jalali, Elite Possik, Barry J. Coull, Dmitri Kharitidi, Anders Bondo Dydensborg, Brandon Faubert, Miriam Kamps, Sylvie Sabourin, Rachael S. Preston, David Mark Davies, Taren Roughead, Laëtitia Chotard, Maurice A.M. van Steensel, Russell Jones, Andrew R. Tee, Arnim Pause
http://www.jci.org/articles/view/71749

Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program
Olga V. Leontieva, Zoya N. Demidenko, and Mikhail V. Blagosklonny
http://www.pnas.org/content/111/24/8832.abstract.html?etoc

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Miscellaneous
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CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation
Emmanuel Martin, Noé Palmic, Sylvia Sanquer, Christelle Lenoir, Fabian Hauck, Cédric Mongellaz, Sylvie Fabrega, Patrick Nitschké, Mauro Degli Esposti, Jeremy Schwartzentruber, Naomi Taylor, Jacek Majewski, Nada Jabado, Robert F. Wynn, Capucine Picard, Alain Fischer, Peter D. Arkwright & Sylvain Latour
http://www.nature.com/nature/journal/v510/n7504/full/nature13386.html

A vaccine targeting mutant IDH1 induces antitumour immunity
Theresa Schumacher, Lukas Bunse, Stefan Pusch et al
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13387.html

Cytosolic Branched Chain Aminotransferase (BCATc) Regulates mTORC1 Signaling and Glycolytic Metabolism in CD4+ T cells
Elitsa A. Ananieva, Chirag H. Patel, Charles H. Drake, Jonathan D. Powell, and Susan M. Hutson
http://www.jbc.org/content/early/2014/05/20/jbc.M114.554113.abstract

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
Randall M. Chin, Xudong Fu, Melody Y. Pai, Laurent Vergnes, Heejun Hwang, Gang Deng, Simon Diep, Brett Lomenick, Vijaykumar S. Meli, Gabriela C. Monsalve, Eileen Hu, Stephen A. Whelan, Jennifer X. Wang, Gwanghyun Jung, Gregory M. Solis, Farbod Fazlollahi, Chitrada Kaweeteerawat, Austin Quach, Mahta Nili, Abby S. Krall, Hilary A. Godwin, Helena R. Chang, Kym F. Faull, Feng Guo, Meisheng Jiang, Sunia A. Trauger, Alan Saghatelian, Daniel Braas, Heather R. Christofk, Catherine F. Clarke, Michael A. Teitell, Michael Petrascheck, Karen Reue, Michael E. Jung, Alison R. Frand & Jing Huang
http://www.nature.com/nature/journal/v510/n7505/full/nature13264.html?WT.ec_id=NATURE-20140619

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Reviews
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Caloric restriction and cancer: molecular mechanisms and clinical implications
Ophélie Meynet, Jean-Ehrland Ricci
http://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(14)00080-X

Regulation of mTORC1 by amino acids
Liron Bar-Peled, David M. Sabatini
http://www.cell.com/trends/cell-biology/abstract/S0962-8924(14)00036-1

Metabolomic strategies for the identification of new enzyme functions and metabolic pathways
Gareth A Prosser, Gerald Larrouy‐Maumus, and Luiz Pedro S de Carvalho
http://EMBOr.embopress.org/content/15/6/657?etoc

Mitochondria as signaling organelles
Chandel NS
http://www.biomedcentral.com/1741-7007/12/34

A Systems Biology Road Map for the Discovery of Drugs Targeting Cancer Cell Metabolism
Lilia Alberghina, Daniela Gaglio, Rosa Maria Moresco, Maria Carla Gilardi, Cristina Messa and Marco Vanoni
http://www.eurekaselect.com/112240/article

mTORC2 in the center of cancer metabolic reprogramming
Kenta Masui, Webster K. Cavenee, Paul S. Mischel
http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(14)00072-1

Unsuspected task for an old team: Succinate, fumarate and other Krebs cycle acids in metabolic remodeling
Paule Bénit, Eric Letouzé, Malgorzata Rak, Laetitia Aubry, Nelly Burnichon, Judith Favier, Anne-Paule Gimenez-Roqueplo, Pierre Rustin
http://www.sciencedirect.com/science/article/pii/S0005272814001005

Targeted Cancer Therapeutics: Biosynthetic and Energetic Pathways Characterized by Metabolomics and the Interplay with Key Cancer Regulatory Factors
Ngoc-Ha T. Dang, Arvind K. Singla, Emily M. Mackay, Frank R. Jirik and Aalim M. Weljie
http://www.eurekaselect.com/112239/article

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Previews / other
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Overcoming Drug Development Bottlenecks With Repurposing: Repurposing biguanides to target energy metabolism for cancer treatment
Michael Pollak
http://www.nature.com/nm/journal/v20/n6/full/nm.3596.html

Is glutamine depletion needed in ALL disease?
Vassilios I. Avramis
http://bloodjournal.hematologylibrary.org/content/123/23/3532

SIRT2 controls the pentose phosphate switch
Lindsay E Wu and David A Sinclair
http://EMBOJ.embopress.org/content/33/12/1287?etoc

Webinar: Nutrient Availability in Stem Cells
Valter Longo & David M. Sabatini
Wednesday, July 23, 2014  http://bit.ly/1pFbJBb

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