MetaboList – July 2014

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Metabolism and cancer
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Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells
Caroline A. Lewis, Seth J. Parker, Brian P. Fiske, Douglas McCloskey, Dan Y. Gui, Courtney R. Green, Natalie I. Vokes, Adam M. Feist, Matthew G. Vander Heiden, Christian M. Metallo
http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00402-X

Fructose-1,6-bisphosphatase opposes renal carcinoma progression
Bo Li, Bo Qiu, David S. M. Lee, Zandra E. Walton, Joshua D. Ochocki, Lijoy K. Mathew, Anthony Mancuso, Terence P. F. Gade, Brian Keith, Itzhak Nissim & M. Celeste Simon
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13557.html

Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis
Tania Valencia, Ji Young Kim, Shadi Abu-Baker, Jorge Moscat-Pardos, Christopher S. Ahn, Miguel Reina-Campos, Angeles Duran, Elias A. Castilla, Christian M. Metallo, Maria T. Diaz-Meco, Jorge Moscat
http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00219-0

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
Oscar R. Colegio, Ngoc-Quynh Chu, Alison L. Szabo, Thach Chu, Anne Marie Rhebergen, Vikram Jairam, Nika Cyrus, Carolyn E. Brokowski, Stephanie C. Eisenbarth, Gillian M. Phillips, Gary W. Cline, Andrew J. Phillips & Ruslan Medzhitov
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13490.html

Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery
Sandro Santagata, Livia S. Eberlin, Isaiah Norton, David Calligaris, Daniel R. Feldman, Jennifer L. Ide, Xiaohui Liu, Joshua S. Wiley, Matthew L. Vestal, Shakti H. Ramkissoon, Daniel A. Orringer, Kristen K. Gill, Ian F. Dunn, Dora Dias-Santagata, Keith L. Ligon, Ferenc A. Jolesz, Alexandra J. Golby, R. Graham Cooks, and Nathalie Y. R. Agar
http://www.pnas.org/content/111/30/11121.abstract.html?etoc

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer
Kira T Pate, Chiara Stringari, Stephanie Sprowl‐Tanio, Kehui Wang, Tara TeSlaa, Nate P Hoverter, Miriam M McQuade, Chad Garner, Michelle A Digman, Michael A Teitell, Robert A Edwards, Enrico Gratton, and Marian L Waterman
http://EMBOJ.embopress.org/content/33/13/1454?etoc

Mitochondrial Retrograde Signaling Mediated by UCP2 Inhibits Cancer Cell Proliferation and Tumorigenesis
Pauline Esteves, Claire Pecqueur, Céline Ransy, Catherine Esnous, Véronique Lenoir, Frédéric Bouillaud, Anne-Laure Bulteau, Anne Lombès, Carina Prip-Buus, Daniel Ricquier, and Marie-Clotilde Alves-Guerra
http://cancerres.aacrjournals.org/content/74/14/3971.abstract.html?etoc

KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells
Diarmuid M. Moran, Patricia B. Trusk, Karen Pry, Keren Paz, David Sidransky and Sarah S. Bacus
http://mct.aacrjournals.org/content/13/6/1611.abstract

Alteration of the lipid profile in lymphomas induced by MYC overexpression
Livia S. Eberlin, Meital Gabay, Alice C. Fan, Arvin M. Gouw, Robert J. Tibshirani, Dean W. Felsher, and Richard N. Zare
http://www.pnas.org/content/111/29/10450.abstract.html?etoc

ATP-Dependent Lon Protease Controls Tumor Bioenergetics by Reprogramming Mitochondrial Activity
Pedro M. Quirós, Yaiza Español, Rebeca Acín-Pérez, Francisco Rodríguez, Clea Bárcena, Kenta Watanabe, Enrique Calvo, Marta Loureiro, M. Soledad Fernández-García, Antonio Fueyo, Jesús Vázquez, José Antonio Enríquez, Carlos López-Otín
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00486-0

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Drugs
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Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells
Andreas Janzer, Natalie J. German, Karina N. Gonzalez-Herrera, John M. Asara, Marcia C. Haigis, and Kevin Struhl
http://www.pnas.org/content/111/29/10574.abstract.html?etoc

A High-Throughput Fluorimetric Assay for 2-Hydroxyglutarate Identifies Zaprinast as a Glutaminase Inhibitor
Adnan Elhammali, Joseph E. Ippolito, Lynne Collins, Jan Crowley, Jayne Marasa, and David Piwnica-Worms
http://cancerdiscovery.aacrjournals.org/content/4/7/828.abstract.html?etoc

Glycolysis inhibition and its effect in doxorubicin resistance in neuroblastoma
Jonathan F. Bean, Yi-Yong Qiu, Songtao Yu, Sandra Clark, Fei Chu, Mary Beth Madonna
http://www.jpedsurg.org/article/S0022-3468%2814%2900046-3/abstract

Decoding the dynamics of cellular metabolism and the action of 3-bromopyruvate and 2-deoxyglucose using pulsed stable isotope-resolved metabolomics
Pietzke M, Zasada C, Mudrich S, Kempa S
http://www.cancerandmetabolism.com/content/2/1/9/abstract

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Nutrient sensing / starvation
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Akt Phosphorylation and Regulation of Transketolase Is a Nodal Point for Amino Acid Control of Purine Synthesis
Arindam Saha, Stephen Connelly, Jingjing Jiang, Shunhui Zhuang, Deron T. Amador, Tony Phan, Renate B. Pilz, Gerry R. Boss
http://www.sciencedirect.com/science/article/pii/S1097276514004523

Glucose Regulates Mitochondrial Motility via Milton Modification by O-GlcNAc Transferase
Gulcin Pekkurnaz, Jonathan C. Trinidad, Xinnan Wang, Dong Kong, Thomas L. Schwarz
http://www.cell.com/cell/abstract/S0092-8674(14)00728-4

Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration
C J De Saedeleer, P E Porporato, T Copetti, J Pérez-Escuredo, V L Payen, L Brisson, O Feron and P Sonveaux
http://www.nature.com/onc/journal/v33/n31/abs/onc2013454a.html

Reciprocal regulation of autophagy and dNTP pools in human cancer cells
Wei Chen, Lisheng Zhang, Keqiang Zhang, Bingsen Zhou, Mei-Ling Kuo, Shuya Hu, Linling Chen, Michelle Tang, Yun-Ru Chen, Lixin Yang, David K Ann and Yun Yen
http://dx.doi.org/10.4161/auto.28954

A MEK-Dependent Transcriptional Program Controls Activation of the Early Growth Response 1 (EGR1) Gene During Amino Acid Limitation
Jixiu Shan, Mukundh N. Balasubramanian, William Donelan, Lingchen Fu, Jaclyn Hayner, Maria-Cecilia Lopez, Henry V. Baker, and Michael S. Kilberg
http://www.jbc.org/content/early/2014/07/15/jbc.M114.565028.abstract

Modeling cancer glycolysis under hypoglycemia, and the role played by the differential expression of glycolytic isoforms
Alvaro Marín-Hernández, Sayra Y. López-Ramírez, Isis Del Mazo-Monsalvo, Juan C. Gallardo-Pérez, Sara Rodríguez-Enríquez, Rafael Moreno-Sánchez and Emma Saavedra
http://onlinelibrary.wiley.com/doi/10.1111/febs.12864/abstract?campaign=woletoc

TOR complex 2-Ypk1 signaling is an essential positive regulator of the general amino acid control response and autophagy
Ariadne Vlahakis, Martin Graef, Jodi Nunnari, and Ted Powers
http://www.pnas.org/content/111/29/10586.abstract.html?etoc

MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation
Lara Barrio, Andrés Dekanty, Marco Milán
http://www.cell.com/cell-reports/abstract/S2211-1247%2814%2900489-6

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Hypoxia
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Cancer-associated Isocitrate Dehydrogenase 1 (IDH1) R132H Mutation and D-2-hydroxyglutarate Stimulate Glutamine Metabolism under Hypoxia
Zachary J. Reitman, Christopher G. Duncan, Ethan Poteet, Ali Winters, Liang-Jun Yan, David M. Gooden, Ivan Spasojevic, Laszlo G. Boros, Shao Hua Yang, and Hai Yan
http://www.jbc.org/content/early/2014/07/01/jbc.M114.575183.abstract

MDM2 regulates hypoxic HIF1α stability in an E3 ligase proteasome and PTEN-PI-3 kinase-AKT dependent manner
Shweta Joshi, Alok R. Singh, and Donald L. Durden
http://www.jbc.org/content/early/2014/06/30/jbc.M114.587493.abstract

The Oncometabolite Fumarate Promotes Pseudohypoxia Through Noncannonical Activation of NF-κB Signaling
Karthigayan Shanmugasundaram, Bijaya Nayak, Eun-Hee Shim, Carolina B. Livi, Karen Block, and Sunil Sudarshan
http://www.jbc.org/content/early/2014/07/15/jbc.M114.568162.abstract

Silencing of the DNA Mismatch Repair Gene MLH1 Induced by Hypoxic Stress in a Pathway Dependent on the Histone Demethylase LSD1
Yuhong Lu, Narendra Wajapeyee, Mitchell S. Turker, Peter M. Glazer
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00519-1

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mTOR / AMPK
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Coordinated regulation of protein synthesis and degradation by mTORC1
Yinan Zhang, Justin Nicholatos, John R. Dreier, Stéphane J. H. Ricoult, Scott B. Widenmaier, Gökhan S. Hotamisligil, David J. Kwiatkowski, Brendan D. Manning
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13492.html

Akt-Dependent Activation of mTORC1 Involves Phosphorylation of mTOR by IKKalpha
Han C. Dan, Aaron Ebbs, Manolis Pasparakis, Terry Van Dyke, Daniela S. Basseres, and Albert S. Baldwin
http://www.jbc.org/content/early/2014/07/02/jbc.M114.554881.abstract

REDD1 enhances protein phosphatase 2A–mediated dephosphorylation of Akt to repress mTORC1 signaling
Michael D. Dennis, Catherine S. Coleman, Arthur Berg, Leonard S. Jefferson, and Scot R. Kimball
http://stke.sciencemag.org/content/7/335/ra68.abstract

5′-AMP-Activated Protein Kinase (AMPK) Supports the Growth of Aggressive Experimental Human Breast Cancer Tumors
Keith R. Laderoute, Joy M. Calaoagan, Wan-ru Chao, Dominic Dinh, Nicholas Denko, Sarah Duellman, Jessica Kalra, Xiaohe Liu, Ioanna Papandreou, Lidia Sambucetti, and Laszlo G. Boros
http://www.jbc.org/content/early/2014/07/03/jbc.M114.576371.abstract

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Metabolism and proliferation
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A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation
Gopinath Sutendra, Adam Kinnaird, Peter Dromparis, Roxane Paulin, Trevor H. Stenson, Alois Haromy, Kyoko Hashimoto, Nancy Zhang, Eric Flaim, Evangelos D. Michelakis
http://www.cell.com/cell/abstract/S0092-8674(14)00674-6

PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1
Raquel Requejo-Aguilar, Irene Lopez-Fabuel, Emilio Fernandez, Luis M. Martins, Angeles Almeida and Juan P. Bolaños
http://www.nature.com/ncomms/2014/140724/ncomms5514/full/ncomms5514.html

c-Myc programs fatty acid metabolism and dictates acetyl CoA abundance and fate
Lia R. Edmunds, Lokendra Sharma, Audry Kang, Jie Lu, Jerry Vockley, Shrabani Basu, Radha Uppala, Eric S. Goetzman, Megan E. Beck, Donald Scott, and Edward V. Prochownik
http://www.jbc.org/content/early/2014/07/22/jbc.M114.580662.abstract

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Miscellaneous
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Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
Serkan Kir, James P. White, Sandra Kleiner, Lawrence Kazak, Paul Cohen, Vickie E. Baracos & Bruce M. Spiegelman
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13528.html

Rag GTPases are cardioprotective by regulating lysosomal function
Young Chul Kim, Hyun Woo Park, Sebastiano Sciarretta, Jung-Soon Mo, Jenna L. Jewell, Ryan C. Russell, Xiaohui Wu, Junichi Sadoshima and Kun-Liang Guan
http://www.nature.com/ncomms/2014/140701/ncomms5241/full/ncomms5241.html

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis
Liangchun Yang, Min Xie, Minghua Yang, Yan Yu, Shan Zhu, Wen Hou, Rui Kang, Michael T. Lotze, Timothy R. Billiar, Haichao Wang, Lizhi Cao and Daolin Tang
http://www.nature.com/ncomms/2014/140714/ncomms5436/full/ncomms5436.html

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
David O’Sullivan, Gerritje J.W. van der Windt, Stanley Ching-Cheng Huang, Jonathan D. Curtis, Chih-Hao Chang, Michael D. Buck, Jing Qiu, Amber M. Smith, Wing Y. Lam, Lisa M. DiPlato, Fong-Fu Hsu, Morris J. Birnbaum, Edward J. Pearce, Erika L. Pearce
http://www.cell.com/immunity/abstract/S1074-7613(14)00224-6

Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification
Leal Oburoglu, Saverio Tardito, Vanessa Fritz, Ste´phanie C. de Barros,1 Peggy Merida,1 Marco Craveiro,
Joa˜o Mamede, Gaspard Cretenet, Ce´dric Mongellaz, Xiuli An, Dorota Klysz, Jawida Touhami,
Myriam Boyer-Clavel, Jean-Luc Battini, Vale´rie Dardalhon, Vale´rie S. Zimmermann, Narla Mohandas,
Eyal Gottlieb, Marc Sitbon, Sandrina Kinet, and Naomi Taylor
http://www.sciencedirect.com/science/article/pii/S1934590914002501

Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis
T He, S Haapa-Paananen, V O Kaminskyy, P Kohonen, V Fey, B Zhivotovsky, O Kallioniemi and M Perälä
http://www.nature.com/onc/journal/v33/n27/abs/onc2013313a.html

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Reviews
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Defects in mitochondrial metabolism and cancer
Gaude E, Frezza C
http://www.cancerandmetabolism.com/content/2/1/10/abstract

AMPK at the Nexus of Energetics and Aging
Kristopher Burkewitz, Yue Zhang, William B. Mair
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00106-5

Transcriptional regulation of the stress response by mTOR
Jose Aramburu, M. Carmen Ortells, Sonia Tejedor, Maria Buxadé, and Cristina López-Rodríguez
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;7/332/re2

Phospholipase D and the Maintenance of Phosphatidic Acid Levels for Regulation of mTOR
David A Foster, Darin Salloum, Deepak Menon, and Maria Frias
http://www.jbc.org/content/early/2014/07/02/jbc.R114.566091.abstract

Targeting Mitochondrial Metabolism by Inhibiting Autophagy in BRAF-DrivenCancers
Anne M. Strohecker and Eileen White
http://cancerdiscovery.aacrjournals.org/content/4/7/766.abstract.html?etoc

Keeping the eIF2 alpha kinase Gcn2 in check
Beatriz A. Castilho, Renuka Shanmugam, Richard C. Silva, Rashmi Ramesh, Benjamin M. Himme, Evelyn Sattlegger
http://www.sciencedirect.com/science/article/pii/S0167488914001244

Sirtuins in stress response: guardians of the genome
L Bosch-Presegué and A Vaquero
http://www.nature.com/onc/journal/v33/n29/full/onc2013344a.html

Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells
Andrea Rasola, Len Neckers, Didier Picard
http://www.cell.com/trends/cell-biology/abstract/S0962-8924(14)00050-6

Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment
Daniel Ackerman, M. Celeste Simon
http://www.cell.com/trends/cell-biology/fulltext/S0962-8924(14)00087-7

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Comments
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Wnt meets Warburg: another piece in the puzzle?
Craig B Thompson
http://EMBOJ.embopress.org/content/33/13/1420?etoc

Localization of NADPH Production: A Wheel within a Wheel
Oliver D.K. Maddocks, Christiaan F. Labuschagne, Karen H. Vousden
http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00570-X

Metabolic Asymmetry in Cancer: A “Balancing Act” that Promotes Tumor Growth
Ubaldo E. Martinez-Outschoorn, Federica Sotgia, Michael P. Lisanti
http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00271-2

A Mitochondrial Expatriate: Nuclear Pyruvate Dehydrogenase
Vincent C.J. de Boer, Sander M. Houten
http://www.cell.com/cell/abstract/S0092-8674(14)00750-8

Intraoperative mass spectrometry of tumor metabolites
Whitney B. Pope
http://www.pnas.org/content/111/30/10906.extract.html?etoc

Stromal metabolism has paracrine effects
http://www.nature.com/nrc/journal/v14/n8/full/nrc3794.html

Reduce Tumors with a Low-Carb Diet
http://stke.sciencemag.org/content/7/336/ec203.abstract

FLCN Regulates Metabolic Reprogramming via AMPK Signaling to HIF1α
http://cancerdiscovery.aacrjournals.org/content/4/7/OF16.abstract.html?etoc

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