MetaboList – August 2014

Cancer metabolism

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation
Joyce V. Lee, Alessandro Carrer, Supriya Shah, Nathaniel W. Snyder, Shuanzeng Wei, Sriram Venneti, Andrew J. Worth, Zuo-Fei Yuan, Hee-Woong Lim, Shichong Liu, Ellen Jackson, Nicole M. Aiello, Naomi B. Haas, Timothy R. Rebbeck, Alexander Judkins, Kyoung-Jae Won, Lewis A. Chodosh, Benjamin A. Garcia, Ben Z. Stanger, Michael D. Feldman, Ian A. Blair, Kathryn E. Wellen

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.
Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, Yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming J, Cantley LC, DePinho RA, Draetta GF.

Blocking Lipid Synthesis Overcomes Tumor Regrowth and Metastasis after Antiangiogenic Therapy Withdrawal
Nor Eddine Sounni, Jonathan Cimino, Silvia Blacher, Irina Primac, Alice Truong, Gabriel Mazzucchelli, Alexandra Paye, David Calligaris, Delphine Debois, Pascal De Tullio, Bernard Mari, Edwin De Pauw, Agnes Noel

A Mitochondrial Switch Promotes Tumor Metastasis
Paolo E. Porporato, Valéry L. Payen, Jhudit Pérez-Escuredo, Christophe J. De Saedeleer, Pierre Danhier, Tamara Copetti, Suveera Dhup, Morgane Tardy, Thibaut Vazeille, Caroline Bouzin, Olivier Feron, Carine Michiels, Bernard Gallez, Pierre Sonveaux

Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation
Anna Pastò, Chiara Bellio, Giorgia Pilotto, Vincenzo Ciminale, Micol Silic-Benussi, Giulia Guzzo, Andrea Rasola, Chiara Frasson, Giorgia Nardo, Elisabetta Zulato, Maria Ornella Nicoletto, Mariangela Manicone, Stefano Indraccolo and Alberto Amadori[]=2010

Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment
D Ciavardelli, C Rossi, D Barcaroli, S Volpe, A Consalvo, M Zucchelli, A De Cola, E Scavo, R Carollo, D D’Agostino, F Forlì, S D’Aguanno, M Todaro, G Stassi, C Di Ilio, V De Laurenzi and A Urbani

Differential Expression of Enzymes Associated with Serine/Glycine Metabolism in Different Breast Cancer Subtypes
Sang Kyum Kim, Woo Hee Jung, Ja Seung Koo

BRCA1 Induces Major Energetic Metabolism Reprogramming in Breast Cancer Cells
Maud Privat, Nina Radosevic-Robin, Corinne Aubel, Anne Cayre, Frédérique Penault-Llorca, Geoffroy Marceau, Vincent Sapin, Yves-Jean Bignon, Daniel Morvan

Glycerol-3-Phosphate Acyltranferase-2 Behaves as a Cancer Testis Gene and Promotes Growth and Tumorigenicity of the Breast Cancer MDA-MB-231 Cell Line
Magali Pellon-Maison, Mauro A. Montanaro, Ezequiel Lacunza, Maria B. Garcia-Fabiani, Mercedes C. Soler-Gerino, Elizabeth R. Cattaneo, Ivana Y. Quiroga, Martin C. Abba, Rosalind A. Coleman, Maria R. Gonzalez-Baro

PDK4 Promotes Tumorigenesis Through Activation of CREB-RHEB-mTORC1 Signaling Cascade
Zhibo Liu, Xinxin Chen, Ying Wang, Haiyong Peng, Yanan Wang, Yanling Jing, and Hongbing Zhang

Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer
Roy D, Mondal S, Wang C, He X, Khurana A, Giri S, Hoffmann R, Jung D, Kim SH, Chini EN, Periera JC, Folmes CD, Mariani A, Dowdy SC, Bakkum-Gamez JN, Riska SM, Oberg AL, Karoly ED, Bell LN, Chien J, Shridhar V

Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global Reprogramming of Metabolic Networks
Sofia Lisanti, Michele Tavecchio, Young Chan Chae, Qin Liu, Angela K. Brice, Madhukar L. Thakur, Lucia R. Languino, Dario C. Altieri

GLUT3 is induced during epithelial-mesenchymal transition and promotes tumor cell proliferation in non-small cell lung cancer
Masin M, Vazquez J, Rossi S, Groeneveld S, Samson N, Schwalie PC, Deplancke B, Frawley LE, Gouttenoire J, Moradpour D, Oliver TG, Meylan  E

Down-regulation of the Antisense Mitochondrial ncRNAs is a Unique Vulnerability of Cancer Cells and a Potential Target for Cancer Therapy
Soledad Vidaurre, Christopher Fitzpatrick, Verónica A. Burzio, Macarena Briones, Claudio Villota, Jaime Villegas, Javiera Echenique, Luciana Oliveira-Cruz, Mariela Araya, Vincenzo Borgna, Teresa Socías, Constanza Lopez, Rodolfo Avila, and Luis O. Burzio

Metabolic enzymes

Lysine Acetylation Activates 6-Phosphogluconate Dehydrogenase to Promote Tumor Growth
Changliang Shan, Shannon Elf, Quanjiang Ji, Hee-Bum Kang, Lu Zhou, Taro Hitosugi, Lingtao Jin, Ruiting Lin, Liang Zhang, Jae Ho Seo, Jianxin Xie, Meghan Tucker, Ting-Lei Gu, Jessica Sudderth, Lei Jiang, Ralph J. DeBerardinis, Shaoxiong Wu, Yuancheng Li, Hui Mao, Peng R. Chen, Dongsheng Wang, Georgia Zhuo Chen, Sagar Lonial, Martha L. Arellano, Hanna J. Khoury, Fadlo R. Khuri, Benjamin H. Lee, Daniel J. Brat, Keqiang Ye, Titus J. Boggon, Chuan He, Sumin Kang, Jun Fan, Jing Chen

Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding, and promotes the Warburg effect
Jun Fan, Hee-Bum Kang, Changliang Shan, Shannon Elf, Ruiting Lin, Jianxin Xie, Ting-Lei Gu, Mike Aguiar, Scott Lonning, Tae-Wook Chung, Martha Arellano, Hanna J. Khoury, Dong M. Shin, Fadlo R. Khuri, Titus J. Boggon, Sumin Kang, and Jing Chen

Pyruvate Kinase M2 in Blood Circulation Facilitates Tumor Growth by Promoting Angiogenesis
Liangwei Li, Yinwei Zhang, Jingjuan Qiao, Jenny J. Yang, and Zhi-Ren Liu

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step
Alexander A Shestov, Xiaojing Liu, Zheng Ser, Ahmad A Cluntun, Yin P Hung, Lei Huang, Dongsung Kim, Anne Le, Gary Yellen, John G Albeck, Jason W Locasale

6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27
A Yalcin, B F Clem, Y Imbert-Fernandez, S C Ozcan, S Peker, J O’Neal, A C Klarer, A L Clem, S Telang and J Chesney

Nutrient sensing – LKB1/AMPK/mTOR

Nitrogen Source Activates TOR Complex 1 via Glutamine and Independently of Gtr/Rag
Daniele Stracka, Szymon Jozefczuk, Florian Rudroff, Uwe Sauer, and Michael N. Hall

The TSC Complex Is Required for the Benefits of Dietary Protein Restriction on Stress Resistance In Vivo
Eylul Harputlugil, Christopher Hine, Dorathy Vargas, Lauren Robertson, Brendan D. Manning, James R. Mitchell

Promoter sequences direct cytoplasmic localization and translation of mRNAs during starvation in yeast
Brian M. Zid & Erin K. O’Shea

The hexosamine biosynthesis pathway and O-GlcNAcylation maintain insulin-stimulated PI3K-PKB phosphorylation and tumour cell growth after short-term glucose deprivation (pages 3591–3608)
David R. Jones, Willem-Jan Keune, Karen E. Anderson, Len R. Stephens, Phillip T. Hawkins and Nullin Divecha

The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila
Y Wei and M A Lilly

An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential
Jonathan M. Goodwin, Robert U. Svensson, Hua Jane Lou, Monte M. Winslow, Benjamin E. Turk
and Reuben J. Shaw

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis
Sayaka Inokuchi-Shimizu, Eek Joong Park, Yoon Seok Roh, Ling Yang, Bi Zhang, Jingyi Song, Shuang Liang, Michael Pimienta, Koji Taniguchi, Xuefeng Wu, Kinji Asahina, William Lagakos, Mason R. Mackey, Shizuo Akira, Mark H. Ellisman, Dorothy D. Sears, Jerrold M. Olefsky, Michael Karin, David A. Brenner, Ekihiro Seki

Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21
Marion Cornu, Wolfgang Oppliger, Verena Albert, Aaron M. Robitaille, Francesca Trapani, Luca Quagliata, Tobias Fuhrer, Uwe Sauer, Luigi Terracciano, and Michael N. Hall

Recovery from Rapamycin: Drug-insensitive activity of yeast TORC1 supports residual proliferation that dilutes rapamycin among progeny cells
Stephanie K. Evans, Karl E. V. Burgess, and Joseph V. Gray

Ischemia / hypoxia

Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia–cell cycle dual reporter
Anne Le, Zachary E. Stine, Christopher Nguyen, Junaid Afzal, Peng Sun, Max Hamaker, Nicholas M. Siegel, Arvin M. Gouw, Byung-hak Kang, Shu-Han Yu, Rory L. Cochran, Kurt A. Sailor, Hongjun Song, and Chi V. Dang

Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype
G Cantarella, G Pignataro, G Di Benedetto, S Anzilotti, A Vinciguerra, O Cuomo, G F Di Renzo, C Parenti, L Annunziato and R Bernardini

Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-α
W Sun, W Jelkmann and R Depping

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
Ting Wang, Daniele M. Gilkes, Naoharu Takano, Lisha Xiang, Weibo Luo, Corey J. Bishop, Pallavi Chaturvedi, Jordan J. Green, and Gregg L. Semenza

Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
Maimon E. Hubbi, Daniele M. Gilkes, Hongxia Hu, Kshitiz, Ishrat Ahmed, and Gregg L. Semenza

Single-Cell Imaging of Bioenergetic Responses to Neuronal Excitotoxicity and Oxygen and Glucose Deprivation
Niamh M.C. Connolly, Heiko Düssmann, Ujval Anilkumar, Heinrich J. Huber, and Jochen H.M. Prehn

PGC1β Activates an Antiangiogenic Program to Repress Neoangiogenesis in Muscle Ischemia
Vikas Yadav, Antonios Matsakas, Sabina Lorca, Vihang A. Narkar

Inhibition of monocarboxylate transporter-4 depletes stem-like glioblastoma cells and inhibits HIF transcriptional response in a lactate-independent manner
K S Lim, K J Lim, A C Price, B A Orr, C G Eberhart and E E Bar

Quantifying Metabolic Heterogeneity in Head and Neck Tumors in Real Time: 2-DG Uptake Is Highest in Hypoxic Tumor Regions
Erica C. Nakajima, Charles Laymon, Matthew Oborski, Weizhou Hou, Lin Wang, Jennifer R. Grandis, Robert L. Ferris, James M. Mountz, Bennett Van Houten


Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance
Gizem Karsli-Uzunbas, Jessie Yanxiang Guo, Sandy Price, Xin Teng, Saurabh V Laddha, Sinan Khor, Nada Y. Kalaany, Tyler Jacks, Chang S. Chan, JoshuaD. Rabinowitz, and Eileen White

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations
Annan Yang, N.V. Rajeshkumar, Xiaoxu Wang, Shinichi Yabuuchi, Brian M. Alexander, Gerald C. Chu, Daniel D. Von Hoff, Anirban Maitra, and Alec C.Kimmelman

Tumor Vessel Normalization by Chloroquine Independent of Autophagy
Hannelore Maes, Anna Kuchnio, Aleksandar Peric, Stijn Moens, Kris Nys, Katrien De Bock, Annelies Quaegebeur, Sandra Schoors, Maria Georgiadou, Jasper Wouters, Stefan Vinckier, Hugo Vankelecom, Marjan Garmyn, Anne-Clémence Vion, Freddy Radtke, Chantal Boulanger, Holger Gerhardt, Elisabetta Dejana, Mieke Dewerchin, Bart Ghesquière, Wim Annaert, Patrizia Agostinis, Peter Carmeliet

Ecdysone and Mediator Change Energy Metabolism to Terminate Proliferation in Drosophila Neural Stem Cells
Catarina C.F. Homem, Victoria Steinmann, Thomas R. Burkard, Alexander Jais, Harald Esterbauer, Juergen A. Knoblich

Glucose availability and glycolytic metabolism dictate glycosphingolipid levels
Morgan Stathem1 Subathra Marimuthu, Julie O’Neal, Jeffrey C. Rathmell, Jason A. Chesney, Levi J. Beverly and Leah J. Siskind

Metabolic Reprogramming towards Aerobic Glycolysis Correlates with Greater Proliferative Ability and Resistance to Metabolic Inhibition in CD8 versus CD4 T Cells
Yilin Cao, Jeffrey C. Rathmell, Andrew N. Macintyre

Reconstruction of Insulin Signal Flow from Phosphoproteome and Metabolome Data
Katsuyuki Yugi, Hiroyuki Kubota, Yu Toyoshima, Rei Noguchi, Kentaro Kawata, Yasunori Komori, Shinsuke Uda, Katsuyuki Kunida, Yoko Tomizawa, Yosuke Funato, Hiroaki Miki, Masaki Matsumoto, Keiichi I. Nakayama, Kasumi Kashikura, Keiko Endo, Kazutaka Ikeda, Tomoyoshi Soga, Shinya Kuroda

Hyperpolarized [1-^13C] Glutamate: A Metabolic Imaging Biomarker of IDH1 Mutational Status in Glioma
Myriam M. Chaumeil, Peder E.Z. Larson, Sarah M. Woods, Larry Cai, Pia Eriksson, Aaron E. Robinson, Janine M. Lupo, Daniel B. Vigneron, Sarah J.Nelson, Russell O. Pieper, Joanna J. Phillips, and Sabrina M. Ronen


Post-translational modifications and the Warburg effect
T Hitosugi and J Chen

Nutrient Regulation of Signaling, Transcription, and Cell Physiology by O-GlcNAcylation
Stéphan Hardivillé, Gerald W. Hart

The pentose phosphate pathway and cancer
Krushna C. Patra, Nissim Hay

Phospholipase D and the Maintenance of Phosphatidic Acid Levels for Regulation of Mammalian Target of Rapamycin (mTOR)
David A. Foster, Darin Salloum, Deepak Menon, and Maria A. Frias

Glutamate as chemotactic fuel for diffuse glioma cells: Are they glutamate suckers?
Sanne A.M. van Lith, Anna C. Navis, Kiek Verrijp, Simone P. Niclou, Rolf Bjerkvig, Pieter Wesseling, Bastiaan Tops, Remco Molenaar, Cornelis J.F. van Noorden, William P.J. Leenders

The metabolic cooperation between cells in solid cancer tumors
Philippe Icard, Perrine Kafara, Jean-Marc Steyaert, Laurent Schwartz, Hubert Lincet

Previews / highlights

The cystine/glutamate antiporter: when too much of a good thing goes bad
Kathryn J. Reissner

Control of Gluconeogenesis by Metformin: Does Redox Trump Energy Charge?
Joseph A. Bauremail, Morris J. Birnbaum

Cancer metabolism: Lipid addiction

c-Myc and AP4: a relay team for metabolic reprogramming of CD8+ T cells
Peer W F Karmaus & Hongbo Chi

Tumorigenesis: FBP1 is suppressed in kidney tumours

Cachexia: Running on empty

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