MetaboList – September 2014

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Nutrient sensing / Starvation / Ischemia
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The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism
Chen-Song Zhang, Bin Jiang, Mengqi Li, Mingjiang Zhu, Yongying Peng, Ya-Lin Zhang, Yu-Qing Wu, Terytty Yang Li, Yu Liang, Zailian Lu, Guili Lian, Qing Liu, Huiling Guo, Zhenyu Yin, Zhiyun Ye, Jiahuai Han, Jia-Wei Wu, Huiyong Yin, Shu-Yong Lin, Sheng-Cai Lin
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00279-4

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy
Chun A. Changou, Yun-Ru Chen, Li Xing, Yun Yen, Frank Y. S. Chuang, R. Holland Cheng, Richard J. Bold, David K. Ann, and Hsing-Jien Kung
http://www.pnas.org/content/111/39/14147.abstract.html?etoc

Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion
Naval P. Shanware, Kevin Bray, Christina H. Eng, Fang Wang, Maximillian Follettie, Jeremy Myers, Valeria R. Fantin and Robert T. Abraham
http://www.nature.com/ncomms/2014/140918/ncomms5900/full/ncomms5900.html

Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling
Min Peng, Na Yin, Ming O. Li
http://www.cell.com/cell/abstract/S0092-8674(14)01108-8

MAPK14/p38α-dependent modulation of glucose metabolism affects ROS levels and autophagy during starvation
Enrico Desideri, Rolando Vegliante, Simone Cardaci, Ridvan Nepravishta, Maurizio Paci and Maria Rosa Ciriolo
https://www.landesbioscience.com/journals/autophagy/article/29456/

ARRB1/β-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia
Pei Wang, Tian-Ying Xu, Kai Wei, Yun-Feng Guan, Xia Wang, Hui Xu, Ding-Feng Su, Gang Pei and Chao-Yu Miao
https://www.landesbioscience.com/journals/autophagy/article/29203/

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Cancer Metabolism
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Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis
Ying-Hua Wang, William J. Israelsen, Dongjun Lee, Vionnie W.C. Yu, Nathaniel T. Jeanson, Clary B. Clish, Lewis C. Cantley, Matthew G. Vander Heiden, David T. Scadden
http://www.cell.com/cell/abstract/S0092-8674(14)01038-1

Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth
Lei Wang, Hua Xiong, Fengxia Wu, Yingjie Zhang, Ji Wang, Liyan Zhao, Xiaolan Guo, Li-Ju Chang, Yong Zhang, M. James You, Shahriar Koochekpour, Mohammad Saleem, Haojie Huang, Junxuan Lu, Yibin Deng
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00637-8

ATF4 and N‐Myc coordinate glutamine metabolism in MYCN‐amplified neuroblastoma cells through ASCT2 activation
P Ren, M Yue, D Xiao, R Xiu, L Gan, H Liu, G Qing
http://onlinelibrary.wiley.com/doi/10.1002/path.4429/abstract

ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis
Xue-Song Liu, Jenna E. Haines, Elie K. Mehanna, Matthew D. Genet, Issam Ben-Sahra, John M. Asara, Brendan D. Manning, and Zhi-Min Yuan
http://genesdev.cshlp.org/content/28/17/1917.abstract?etoc

A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value
Wen-Lian Chen, Jing-Han Wang, Ai-Hua Zhao, Xin Xu, Yi-Huang Wang, Tian-Lu Chen, Jun-Min Li, Jian-Qing Mi, Yong-Mei Zhu, Yuan-Fang Liu, Yue-Ying Wang, Jie Jin, He Huang, De-Pei Wu, Yan Li, Xiao-Jing Yan, Jin-Song Yan, Jian-Yong Li, Shuai Wang, Xiao-Jun Huang, Bing-Shun Wang, Zhu Chen, Sai-Juan Chen, and Wei Jia
http://bloodjournal.org/content/124/10/1645.abstract?etoc

Plk1 Phosphorylation of PTEN Causes a Tumor-Promoting Metabolic State
Zhiguo Li, Jie Li, Pengpeng Bi, Ying Lu, Grant Burcham, Bennett D. Elzey, Timothy Ratliff, Stephen F. Konieczny, Nihal Ahmad, Shihuan Kuang, and Xiaoqi Liu
http://mcb.asm.org/content/34/19/3642.abstract?etoc

Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival
Christina L. Roland, Thiruvengadam Arumugam, Defeng Deng, Shi He Liu, Bincy Philip, Sobeyda Gomez, William R. Burns, Vijaya Ramachandran, Huamin Wang, Zobeida Cruz-Monserrate, and Craig D. Logsdon
http://cancerres.aacrjournals.org/content/74/18/5301.abstract?etoc

Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop
Aleksandra Pandyra, Peter J. Mullen, Manpreet Kalkat, Rosemary Yu, Janice T. Pong, Zhihua Li, Suzanne Trudel, Karl S. Lang, Mark D. Minden, Aaron D. Schimmer, and Linda Z. Penn
http://cancerres.aacrjournals.org/content/74/17/4772.abstract?etoc

IDH1 R132H Mutation Generates a Distinct Phospholipid Metabolite Profile in Glioma
Morteza Esmaeili, Bob C. Hamans, Anna C. Navis, Remco van Horssen, Tone F. Bathen, Ingrid S. Gribbestad, William P. Leenders, and Arend Heerschap
http://cancerres.aacrjournals.org/content/74/17/4898.abstract?etoc

Targeting Epstein–Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy
L Xiao, Z-y Hu, X Dong, Z Tan, W Li, M Tang, L Chen, L Yang, Y Tao, Y Jiang, J Li, B Yi, B Li, S Fan, S You, X Deng, F Hu, L Feng, A M Bode, Z Dong, L-q Sun and Y Cao
http://www.nature.com/onc/journal/v33/n37/abs/onc201432a.html?WT.ec_id=ONC-201409

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Hypoxia / HIFs
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HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression
De Huang, Tingting Li, Xinghua Li, Long Zhang, Linchong Sun, Xiaoping He, Xiuying Zhong, Dongya Jia, Libing Song, Gregg L. Semenza, Ping Gao, Huafeng Zhang
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00704-9

Hypoxia-induced Bmi1 promotes renal tubular epithelial cell–mesenchymal transition and renal fibrosis via PI3K/Akt signal
Rui Du, Lin Xia, Xiaoxuan Ning, Limin Liu, Wenjuan Sun, Chen Huang, Hanmin Wang, and Shiren Sun
http://www.molbiolcell.org/content/25/17/2650.abstract?etoc

Hypoxia inducible factor-1α suppresses Peroxiredoxin 3 expression to promote proliferation of CCRCC cells
Hao Xi, Yao-Hui Gao, Dong-Yan Han, Qian-Yu Li, Li-Jin Feng, Wei Zhang, Guo Ji, Jia-Cheng Xiao, Hui-Zhen Zhang, Qing Wei
http://www.sciencedirect.com/science/article/pii/S0014579314005791

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET
Erinn B. Rankin, Katherine C. Fuh, Laura Castellini, Kartik Viswanathan, Elizabeth C. Finger, Anh N. Diep, Edward L. LaGory, Mihalis S. Kariolis, Andy Chan, David Lindgren, Håkan Axelson, Yu R. Miao, Adam J. Krieg, and Amato J. Giaccia
http://www.pnas.org/content/111/37/13373.abstract.html?etoc

Autophagy promotes paclitaxel resistance of cervical cancer cells: involvement of Warburg effect activated hypoxia-induced factor 1-α-mediated signaling
X Peng, F Gong, Y Chen, Y Jiang, J Liu, M Yu, S Zhang, M Wang, G Xiao and H Liao
http://www.nature.com/cddis/journal/v5/n8/abs/cddis2014297a.html?WT.ec_id=CDDIS-201408

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AMPK / mTOR
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Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP
F. Romana Auciello, Fiona A. Ross, Naoko Ikematsu, D. Grahame Hardie
http://www.sciencedirect.com/science/article/pii/S0014579314005742

Combined SFK/mTOR Inhibition Prevents Rapamycin-Induced Feedback Activation of AKT and Elicits Efficient Tumor Regression
Jennifer L. Yori, Kristen L. Lozada, Darcie D. Seachrist, Jonathan D. Mosley, Fadi W. Abdul-Karim, Christine N. Booth, Chris A. Flask, and Ruth A. Keri
http://cancerres.aacrjournals.org/content/74/17/4762.abstract?etoc

mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression
Z Chen, Y Zhang, C Jia, Y Wang, P Lai, X Zhou, Y Wang, Q Song, Jun Lin, Z Ren, Q Gao, Z Zhao, H Zheng, Z Wan, T Gao, A Zhao, Y Dai and X Bai
http://www.nature.com/onc/journal/v33/n37/abs/onc2013402a.html

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Metformin
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Mechanism of Metformin-dependent Inhibition of mTOR and Ras Activity in Pancreatic Cancer: Role of Sp Transcription Factors
Vijayalekshmi Nair, Sandeep Sreevalsan, Riyaz Basha, Maen Abdelrahim, Ala Abudayyeh, Aline Rodrigues Hoffman, and Stephen H. Safe
http://www.jbc.org/content/early/2014/08/20/jbc.M114.592576.abstract

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
Hannah R. Bridges, Andrew J. Y. Jones, Michael N. Pollak and Judy Hirst
http://www.biochemj.org/bj/462/bj4620475.htm

Metformin directly acts on mitochondria to alter cellular bioenergetics
Andrzejewski S, Gravel S, Pollak M, St-Pierre J
http://www.cancerandmetabolism.com/content/2/1/12/abstract

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Cachexia
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A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia
Michele Petruzzelli, Martina Schweiger, Renate Schreiber, Ramon Campos-Olivas, Maria Tsoli, John Allen, Michael Swarbrick, Stefan Rose-John, Mercedes Rincon, Graham Robertson, Rudolf Zechner, Erwin F. Wagner
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00276-9

Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia
Shukla SK, Gebregiworgis T, Purohit V, Chaika NV, Gunda V, Radhakrishnan P, Mehla K, Pipinos II, Powers R, Yu F, Singh PK
http://www.cancerandmetabolism.com/content/2/1/18/abstract

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Miscellaneous
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Glucose metabolism is inhibited by caspases upon the induction of apoptosis
L A Pradelli, E Villa, B Zunino, S Marchetti and J-E Ricci
http://www.nature.com/cddis/journal/v5/n9/abs/cddis2014371a.html?WT.ec_id=CDDIS-201409

Deficient Chaperone-Mediated Autophagy in Liver Leads to Metabolic Dysregulation
Jaime L. Schneider, Yousin Suh, Ana Maria Cuervo
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00274-5

mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Shih-Chin Cheng, Jessica Quintin, Robert A. Cramer, Kelly M. Shepardson, Sadia Saeed, Vinod Kumar, Evangelos J. Giamarellos-Bourboulis, Joost H. A. Martens, Nagesha Appukudige Rao, Ali Aghajanirefah, Ganesh R. Manjeri, Yang Li, Daniela C. Ifrim, Rob J. W. Arts, Brian M. J. W. van der Meer, Peter M. T. Deen, Colin Logie, Luke A. O’Neill, Peter Willems, Frank L. van de Veerdonk, Jos W. M. van der Meer,Aylwin Ng, Leo A. B. Joosten, Cisca Wijmenga, Hendrik G. Stunnenberg, Ramnik J. Xavier, Mihai G. Netea
http://www.sciencemag.org/content/345/6204/1250684.abstract?utm_campaign=email-sci-toc

Bcl-6 directly represses the gene program of the glycolysis pathway
Kenneth J Oestreich, Kaitlin A Read, Sarah E Gilbertson, Kenneth P Hough, Paul W McDonald,  Veena Krishnamoorthy & Amy S Weinmann
http://www.nature.com/ni/journal/v15/n10/full/ni.2985.html

TIGAR Has a Dual Role in Cancer Cell Survival through Regulating Apoptosis and Autophagy
Jia-Ming Xie, Bin Li, Hong-Pei Yu, Quan-Geng Gao, Wei Li, Hao-Rong Wu, and Zheng-Hong Qin
http://cancerres.aacrjournals.org/content/74/18/5127.abstract?etoc

Architecture of mammalian respiratory complex I
Kutti R. Vinothkumar, Jiapeng Zhu & Judy Hirst
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13686.html

ARTD1/PARP1 Negatively Regulates Glycolysis by Inhibiting Hexokinase 1 Independent of NAD+ Depletion
Elise Fouquerel, Eva M. Goellner, Zhongxun Yu, Jean-Philippe Gagné, Michelle Barbi de Moura, Tim Feinstein, David Wheeler, Philip Redpath, Jianfeng Li, Guillermo Romero, Marie Migaud, Bennett Van Houten, Guy G. Poirier, Robert W. Sobol
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00712-8

HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H+ ATPase
F M Fogarty, J O’Keeffe, A Zhadanov, D Papkovsky, V Ayllon and R O’Connor
http://www.nature.com/onc/journal/v33/n38/abs/onc2013403a.html

ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development
Hayato Nakagawa, Atsushi Umemura, Koji Taniguchi, Joan Font-Burgada, Debanjan Dhar, Hisanobu Ogata, Zhenyu Zhong, Mark A. Valasek, Ekihiro Seki, Juan Hidalgo, Kazuhiko Koike, Randal J. Kaufman, Michael Karin
http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00277-3

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Reviews
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Metabolic control of cell death
Douglas R. Green, Lorenzo Galluzzi, Guido Kroemer
http://www.sciencemag.org/content/345/6203/1250256.abstract

Endothelial cell metabolism: parallels and divergences with cancer cell metabolism
Verdegem D, Moens S, Stapor P, Carmeliet P
http://www.cancerandmetabolism.com/content/2/1/19/abstract

Genetically Modeled Mice with Mutations in Mitochondrial Metabolic Enzymes for the Study of Cancer
Jose I Piruat and África Millán-Uclés
http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00200/full

Action at a Distance: Allostery and the Development of Drugs to Target Cancer Cell Metabolism
Byron DeLaBarre, Jonathan Hurov, Giovanni Cianchetta, Stuart Murray, Lenny Dang
http://www.cell.com/chemistry-biology/abstract/S1074-5521%2814%2900282-8

Obesity, Cholesterol Metabolism, and Breast Cancer Pathogenesis
Donald P. McDonnell, Sunghee Park, Matthew T. Goulet, Jeff Jasper, Suzanne E. Wardell, Ching-yi Chang, John D. Norris, John R. Guyton, and Erik R. Nelson
http://cancerres.aacrjournals.org/content/74/18/4976.abstract?etoc

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Opinion / Previews
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Q&A: targeting autophagy in cancer—a new therapeutic?
White E
http://www.cancerandmetabolism.com/content/2/1/14/abstract

Endoplasmic Reticulum Stress: At the Crossroads of Inflammation and Metabolism in Hepatocellular Carcinoma Development
Marion Maurel, Afshin Samali, Eric Chevet
http://www.cell.com/cancer-cell/abstract/S1535-6108(14)00336-5

Inhibition of autophagy attenuates pancreatic cancer growth independent of TP53/TRP53 status
Annan Yang and Alec C Kimmelman
https://www.landesbioscience.com/journals/autophagy/article/29961/

Arginine deprivation and autophagic cell death in cancer
Peter Wojciech Szlosarek
http://www.pnas.org/content/111/39/14015.extract.html?etoc

Inhibiting HIF with Fructose-1,6-Bisphosphastase
http://stke.sciencemag.org/content/7/343/ec253.abstract?utm_campaign=email-sig-toc

Loss of Fructose-1,6-Bisphosphatase 1 Is Critical for Renal Carcinoma
http://cancerdiscovery.aacrjournals.org/content/4/9/984.2.abstract?etoc

mTORC1 Regulates Proteasome-Mediated Protein Degradation
http://cancerdiscovery.aacrjournals.org/content/4/9/984.1.abstract?etoc

Targeting Lipogenesis Blocks Adaptation to Antiangiogenic Therapy
http://cancerdiscovery.aacrjournals.org/content/4/9/OF16.abstract?etoc

p62 Loss Reprograms Stromal Metabolism to Promote Tumor Growth
http://cancerdiscovery.aacrjournals.org/content/4/9/OF17.abstract?etoc

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