MetaboList – October 2014

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Cancer metabolism
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PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
Valerie S. LeBleu, Joyce T. O’Connell, Karina N. Gonzalez Herrera, Harriet Wikman, Klaus Pantel, Marcia C. Haigis, Fernanda Machado de Carvalho, Aline Damascena,  Ludmilla Thome Domingos Chinen, Rafael M. Rocha, John M. Asara & Raghu Kalluri
http://www.nature.com/ncb/journal/v16/n10/full/ncb3039.html?WT.ec_id=NCB-201410

The SIRT1/HIF2α Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
Cyril Corbet, Nihed Draoui, Florence Polet, Adan Pinto, Xavier Drozak, Olivier Riant, and Olivier Feron
http://cancerres.aacrjournals.org/content/74/19/5507.abstract?etoc

p73 regulates serine biosynthesis in cancer
I Amelio, E K Markert, A Rufini, A V Antonov, B S Sayan, P Tucci, M Agostini, T C Mineo, A J Levine and G Melino
http://www.nature.com/onc/journal/v33/n42/abs/onc2013456a.html?WT.ec_id=ONC-201410

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1
Xiaoyu Ma, Chenchen Li, Linchong Sun, De Huang, Tingting Li, Xiaoping He, Gongwei Wu, Zheng Yang, Xiuying Zhong, Libing Song, Ping Gao and Huafeng Zhang
http://www.nature.com/ncomms/2014/141010/ncomms6212/full/ncomms6212.html?WT.ec_id=NCOMMS-20141015

Metabolic Vulnerabilities in Endometrial Cancer
Frances L. Byrne, Ivan K.H. Poon, Susan C. Modesitt, Jose L. Tomsig, Jenny D.Y. Chow, Marin E. Healy, William D. Baker, Kristen A. Atkins, Johnathan M. Lancaster, Douglas C. Marchion, Kelle H. Moley, Kodi S. Ravichandran, Jill K. Slack-Davis, and Kyle L. Hoehn
http://cancerres.aacrjournals.org/content/74/20/5832.abstract?etoc

Colorectal Cancer Detection Using Targeted Serum Metabolic Profiling
Jiangjiang Zhu, Danijel Djukovic, Lingli Deng, Haiwei Gu, Farhan Himmati, E. Gabriela Chiorean, and Daniel Raftery
http://pubs.acs.org/doi/abs/10.1021/pr500494u

Glioma Cells with the IDH1 Mutation Modulate Metabolic Fractional Flux through Pyruvate Carboxylase
Jose L. Izquierdo-Garcia, Larry M. Cai, Myriam M. Chaumeil, Pia Eriksson, Aaron E. Robinson, Russell O. Pieper, Joanna J. Phillips, Sabrina M. Ronen
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0108289

Ovarian tumor-initiating cells display a flexible metabolism
Angela S. Anderson, Paul C. Roberts, Madlyn I. Frisard, Matthew W. Hulver
http://www.sciencedirect.com/science/article/pii/S0014482714003668

Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial–mesenchymal transition
Atsushi Hamabe, Masamitsu Konno, Nobuhiro Tanuma, Hiroshi Shima, Kenta Tsunekuni, Koichi Kawamoto, Naohiro Nishida, Jun Koseki, Koshi Mimori, Noriko Gotoh, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori, and Hideshi Ishii
http://www.pnas.org/content/111/43/15526.abstract.html?etoc

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Anti-metabolic drugs
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Inhibition of Cancer Cell Proliferation by PPARγ Is Mediated by a Metabolic Switch that Increases Reactive Oxygen Species Levels
Nishi Srivastava, Rahul K. Kollipara, Dinesh K. Singh, Jessica Sudderth, Zeping Hu, Hien Nguyen, Shan Wang, Caroline G. Humphries, Ryan Carstens, Kenneth E. Huffman, Ralph J. DeBerardinis, Ralf Kittler
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00369-6?elsca1=etoc&elsca2=email&elsca3=1550-4131_20141007_20_4_&elsca4=Cell%20Press

Enhanced Antitumor Immunity Contributes to the Radio-Sensitization of Ehrlich Ascites Tumor by the Glycolytic Inhibitor 2-Deoxy-D-Glucose in Mice
Abdullah Farooque, Niharika Singh, Jawahar Singh Adhikari, Farhat Afrin, Bilikere Srinivasa Rao Dwarakanath
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0108131

Depletion of the central metabolite NAD leads to oncosis mediated cell death
Christopher Del Nagro, Yang Xiao, Linda Rangell, Mike Reichelt, and Thomas O’Brien
http://www.jbc.org/content/early/2014/10/29/jbc.M114.580159.abstract

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Starvation
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Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion
Ji Zhang, Jing Fan, Sriram Venneti, Justin R. Cross, Toshimitsu Takagi, Bhavneet Bhinder, Hakim Djaballah, Masayuki Kanai, Emily H. Cheng, Alexander R. Judkins, Bruce Pawel, Julie Baggs, Sara Cherry, Joshua D. Rabinowitz, Craig B. Thompson
http://www.cell.com/molecular-cell/abstract/S1097-2765(14)00673-X

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1
Lynne Chantranupong, Rachel L. Wolfson, Jose M. Orozco, Robert A. Saxton, Sonia M. Scaria, Liron Bar-Peled, Eric Spooner, Marta Isasa, Steven P. Gygi, David M. Sabatini
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00782-7?elsca1=etoc&elsca2=email&elsca3=2211-1247_20141009_9_1_&elsca4=Cell%20Press

Rapid Glucose Depletion Immobilizes Active Myosin V on Stabilized Actin Cables
Li Xu, Anthony Bretscher
http://www.cell.com/current-biology/abstract/S0960-9822(14)01137-3?elsca1=etoc&elsca2=email&elsca3=0960-9822_20141020_24_20_&elsca4=Cell%20Press

Let-7 Coordinately Suppresses Components of the Amino Acid Sensing Pathway to Repress mTORC1 and Induce Autophagy
Amy N. Dubinsky, Somasish Ghosh Dastidar, Cynthia L. Hsu, Rabaab Zahra, Stevan N. Djakovic, Sonia Duarte, Christine C. Esau, Brian Spencer, Travis D. Ashe, Kimberlee M. Fischer, Deidre A. MacKenna, Bryce L. Sopher, Eliezer Masliah, Terry Gaasterland, B. Nelson Chau, Luis Pereira de Almeida, Bradley E. Morrison, Albert R. La Spada
http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00398-2

SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation
Shanshan Pang, Dana A. Lynn, Jacqueline Y. Lo, Jennifer Paek and Sean P. Curran
http://www.nature.com/ncomms/2014/141006/ncomms6048/full/ncomms6048.html?WT.ec_id=NCOMMS-20141008

An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability
Hong-Bo Pang, Gary B. Braun, Tomas Friman, Pedro Aza-Blanc, Manuel E. Ruidiaz, Kazuki N. Sugahara, Tambet Teesalu and Erkki Ruoslahti
http://www.nature.com/ncomms/2014/141003/ncomms5904/full/ncomms5904.html?WT.ec_id=NCOMMS-20141008

Molecular Basis for the Ribosome Functioning as an L-Tryptophan Sensor
Lukas Bischoff, Otto Berninghausen, Roland Beckmann
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00779-7

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AMPK / mTOR
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The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation
Alfredo Csibi, Gina Lee, Sang-Oh Yoon, Haoxuan Tong, Didem Ilter, Ilaria Elia, Sarah-Maria Fendt, Thomas M. Roberts, John Blenis
http://www.sciencedirect.com/science/article/pii/S0960982214009853

Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex
Ning Liang, Chi Zhang, Patricia Dill, Ganna Panasyuk, Delphine Pion, Vonda Koka, Morgan Gallazzini, Eric N. Olson, Hilaire Lam, Elizabeth P. Henske, Zheng Dong, Udayan Apte, Nicolas Pallet, Randy L. Johnson, Fabiola Terzi, David J. Kwiatkowski, Jean-Yves Scoazec, Guido Martignoni, and Mario Pende
http://jem.rupress.org/content/211/11/2249?etoc

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein
Michael DeRan, Jiayi Yang, Che-Hung Shen, Eric C. Peters, Julien Fitamant, Puiyee Chan, Mindy Hsieh, Shunying Zhu, John M. Asara, Bin Zheng, Nabeel Bardeesy, Jun Liu, Xu Wu
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00819-5?elsca1=etoc&elsca2=email&elsca3=2211-1247_20141023_9_2_&elsca4=Cell%20Press

AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1
Hee Yun, Seolhui Park, Min-Jung Kim, Woo Kyeom Yang, Dong Uk Im, Ki Ryeol Yang, Jongki Hong, Wonchae Choe, Insug Kang, Sung Soo Kim and Joohun Ha
http://onlinelibrary.wiley.com/doi/10.1111/febs.12949/abstract?campaign=woletoc

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Hypoxia, HIF-1
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Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation
Karim Bensaad, Elena Favaro, Caroline A. Lewis, Barrie Peck, Simon Lord, Jennifer M. Collins, Katherine E. Pinnick, Simon Wigfield, Francesca M. Buffa, Ji-Liang Li, Qifeng Zhang, Michael J.O. Wakelam, Fredrik Karpe, Almut Schulze, Adrian L. Harris
http://www.cell.com/cell-reports/abstract/S2211-1247(14)00732-3?elsca1=etoc&elsca2=email&elsca3=2211-1247_20141009_9_1_&elsca4=Cell%20Press

Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation
M Abu-Remaileh and R I Aqeilan
http://www.nature.com/cdd/journal/v21/n11/abs/cdd201495a.html?WT.ec_id=CDD-201411

Phosphorylation-dependent mitochondrial translocation of MAP4 is an early step in hypoxia-induced apoptosis in cardiomyocytes
J Hu, Z Chu, J Han, Q Zhang, D Zhang, Y Dang, J Ren, H C Chan, J Zhang and Y Huang
http://www.nature.com/cddis/journal/v5/n9/abs/cddis2014369a.html?WT.ec_id=CDDIS-201409

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen
Hanna Tarhonskaya, Rasheduzzaman Chowdhury, Ivanhoe K. H. Leung, Nikita D. Loik, James S. O. McCullagh, Timothy D. W. Claridge, Christopher J. Schofield and Emily Flashman
http://www.biochemj.org/bj/463/bj4630363.htm

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Miscellaneous
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Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase
Ruzica Bago, Nazma Malik, Michael J. Munson, Alan R. Prescott, Paul Davies, Eeva Sommer, Natalia Shpiro, Richard Ward, Darren Cross, Ian G. Ganley and Dario R. Alessi
http://www.biochemj.org/bj/463/bj4630413.htm

Gluconeogenesis in cancer: Door wide open
Katharina Leithner, Andelko Hrzenjak, and Horst Olschewski
http://www.pnas.org/content/111/42/E4394.full

Reply to Leithner et al.: Focus on phopshoenolpyruvate carboxykinase (PEPCK): A target of the p53-SIRT6-FoxO1 axis
Zhiming Li and Wei-Guo Zhu
http://www.pnas.org/content/111/42/E4395.full

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Reviews
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Angiogenesis revisited – role and therapeutic potential of targeting endothelial metabolism
Peter Stapor, Xingwu Wang, Jermaine Goveia, Stijn Moens, and Peter Carmeliet
http://jcs.biologists.org/content/127/20/4331.abstract?etoc

Chromatin: a capacitor of acetate for integrated regulation of gene expression and cell physiology
Siavash K Kurdistani
http://www.sciencedirect.com/science/article/pii/S0959437X14000550

Cancer Metabolism and Elevated O-GlcNAc in Oncogenic Signaling.
Zhiyuan Ma and Keith Vosseller
http://www.jbc.org/content/early/2014/10/21/jbc.R114.577718.abstract

Nutrient Regulation of Cellular Metabolism & Physiology by O-GlcNAcylation
Gerald W. Hart
http://www.jbc.org/content/early/2014/10/21/jbc.R114.609776.abstract

Cancer cachexia: understanding the molecular basis
Josep M. Argilés, Sílvia Busquets, Britta Stemmler & Francisco J. López-Soriano
http://www.nature.com/nrc/journal/v14/n11/full/nrc3829.html

Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles’ heel?
Simran S. Sabharwal & Paul T. Schumacker
http://www.nature.com/nrc/journal/v14/n11/abs/nrc3803.html?lang=en?WT.ec_id=NRC-201411

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Comments
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Cellular Energetics: Actin and Myosin Abstain from ATP during Starvation
Destiney Buelto, Mara C. Duncan
http://www.cell.com/current-biology/abstract/S0960-9822(14)01119-1?elsca1=etoc&elsca2=email&elsca3=0960-9822_20141020_24_20_&elsca4=Cell%20Press

Rewiring the Metabolism of Cancer Cells. Nancy R. Gough
http://stke.sciencemag.org/content/7/347/ec282.abstract?utm_campaign=email-sig-toc

Metformin and respiratory chain complex I: the last piece of the puzzle?
Eric Fontaine
http://www.biochemj.org/bj/463/bj463e003.htm

Metabolic reprogramming in disseminated cells
http://www.nature.com/nrc/journal/v14/n11/full/nrc3842.html?WT.ec_id=NRC-201411

Leukaemia: Fine-tuning metabolism
http://www.nature.com/nrc/journal/v14/n11/full/nrc3839.html?WT.ec_id=NRC-201411

Metabolism: Reprogramming metabolic flux in glioma
http://www.nature.com/nrc/journal/v14/n11/full/nrc3840.html?WT.ec_id=NRC-201411

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